82 research outputs found
Minority game with arbitrary cutoffs
We study a model of a competing population of N adaptive agents, with similar
capabilities, repeatedly deciding whether to attend a bar with an arbitrary
cutoff L. Decisions are based upon past outcomes. The agents are only told
whether the actual attendance is above or below L. For L-> N/2, the game
reproduces the main features of Challet and Zhang's minority game. As L is
lowered, however, the mean attendances in different runs tend to divide into
two groups. The corresponding standard deviations for these two groups are very
different. This grouping effect results from the dynamical feedback governing
the game's time-evolution, and is not reproduced if the agents are fed a random
history.Comment: 4 pages (Revtex) + 6 separate pdf figure
Solar Mikheyev-Smirnov-Wolfenstein Effect with Three Generations of Neutrinos
Under the assumption that the density variation of the electrons can be
approximated by an exponential function, the solar Mikheyev-Smirnov-Wolfenstein
effect is treated for three generations of neutrinos. The generalized
hypergeometric functions that result from the exact solution of this problem
are studied in detail, and a method for their numerical evaluation is
presented. This analysis plays a central role in the determination of neutrino
masses, not only the differences of their squares, under the assumption of
universal quark-lepton mixing.Comment: 22 pages, LaTeX, including 2 figure
D-instantons and Closed String Tachyons in Misner Space
We investigate closed string tachyon condensation in Misner space, a toy
model for big bang universe. In Misner space, we are able to condense tachyonic
modes of closed strings in the twisted sectors, which is supposed to remove the
big bang singularity. In order to examine this, we utilize D-instanton as a
probe. First, we study general properties of D-instanton by constructing
boundary state and effective action. Then, resorting to these, we are able to
show that tachyon condensation actually deforms the geometry such that the
singularity becomes milder.Comment: 24 pages, 1 figure, minor change
Brownian motion of a charged particle in electromagnetic fluctuations at finite temperature
The fluctuation-dissipation theorem is a central theorem in nonequilibrium
statistical mechanics by which the evolution of velocity fluctuations of the
Brownian particle under a fluctuating environment is intimately related to its
dissipative behavior. This can be illuminated in particular by an example of
Brownian motion in an ohmic environment where the dissipative effect can be
accounted for by the first-order time derivative of the position. Here we
explore the dynamics of the Brownian particle coupled to a supraohmic
environment by considering the motion of a charged particle interacting with
the electromagnetic fluctuations at finite temperature. We also derive
particle's equation of motion, the Langevin equation, by minimizing the
corresponding stochastic effective action, which is obtained with the method of
Feynman-Vernon influence functional. The fluctuation-dissipation theorem is
established from first principles. The backreaction on the charge is known in
terms of electromagnetic self-force given by a third-order time derivative of
the position, leading to the supraohmic dynamics. This self-force can be argued
to be insignificant throughout the evolution when the charge barely moves. The
stochastic force arising from the supraohmic environment is found to have both
positive and negative correlations, and it drives the charge into a fluctuating
motion. Although positive force correlations give rise to the growth of the
velocity dispersion initially, its growth slows down when correlation turns
negative, and finally halts, thus leading to the saturation of the velocity
dispersion. The saturation mechanism in a suparohmic environment is found to be
distinctly different from that in an ohmic environment. The comparison is
discussed.Comment: accepter by Foundation of Physics, for IARD 6, 200
Evaluating sugarcane families by the method of Dynamic Technique for Order Preference by Similarity to Ideal Solution (DTOPSIS)
The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics
Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a highly heritable disease (h2 = 0.42 ± 0.09). Siblings of POAG cases have a ten-fold increase risk of developing the disease. Intraocular pressure (IOP) and optic nerve head characteristics are used clinically to predict POAG risk. We conducted a genome-wide association meta-analysis of IOP and optic disc parameters and validated our findings in multiple sets of POAG cases and controls. Using imputation to the 1000 genomes (1000G) reference set, we identified 9 new genomic regions associated with vertical cup disc ratio (VCDR) and 1 new region associated with IOP. Additionally, we found 5 novel loci for optic nerve cup area and 6 for disc area. Previously it was assumed that genetic variation influenced POAG either through IOP or via changes to the optic nerve head; here we present evidence that some genomic regions affect both IOP and the disc parameters. We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a. In summary, we have identified several novel genes influencing the major clinical risk predictors of POAG and showed that genetic variation in CDKN1A is important in POAG ris
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression1,2, is known for its association with fasting glucose levels3,4. The evidence of an association with T2D for PEPD5 and HNF4A6,7 has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D
A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration
Background
High myopia (HM), defined as a spherical equivalent refractive error (SER) ≤ −6.00 diopters (D), is a leading cause of sight impairment, through myopic macular degeneration (MMD). We aimed to derive an improved polygenic score (PGS) for predicting children at risk of HM and to test if a PGS is predictive of MMD after accounting for SER.
Methods
The PGS was derived from genome-wide association studies in participants of UK Biobank, CREAM Consortium, and Genetic Epidemiology Research on Adult Health and Aging. MMD severity was quantified by a deep learning algorithm. Prediction of HM was quantified as the area under the receiver operating curve (AUROC). Prediction of severe MMD was assessed by logistic regression.
Findings
In independent samples of European, African, South Asian and East Asian ancestry, the PGS explained 19% (95% confidence interval 17–21%), 2% (1–3%), 8% (7–10%) and 6% (3–9%) of the variation in SER, respectively. The AUROC for HM in these samples was 0.78 (0.75–0.81), 0.58 (0.53–0.64), 0.71 (0.69–0.74) and 0.67 (0.62–0.72), respectively. The PGS was not associated with the risk of MMD after accounting for SER: OR = 1.07 (0.92–1.24).
Interpretation
Performance of the PGS approached the level required for clinical utility in Europeans but not in other ancestries. A PGS for refractive error was not predictive of MMD risk once SER was accounted fo
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals
J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe
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