An Archived Multi Objective Simulated Annealing Method to Discover Biclusters in Microarray Data

With the advent of microarray technology it has been possible to measure thousands of expression values of genes in a single experiment. Analysis of large scale geonomics data, notably gene expression, has initially focused on clustering methods. Recently, biclustering techniques were proposed for revealing submatrices showing unique patterns. Biclustering or simultaneous clustering of both genes and conditions is challenging particularly for the analysis of high-dimensional gene expression data in information retrieval, knowledge discovery, and data mining. In biclustering of microarray data, several objectives have to be optimized simultaneously and often these objectives are in conflict with each other. A multi objective model is very suitable for solving this problem. Our method proposes a algorithm which is based on multi objective Simulated Annealing for discovering biclusters in gene expression data. Experimental result in bench mark data base present a significant improvement in overlap among biclusters and coverage of elements in gene expression and quality of biclusters

The application of Ants' society algorithm for Management of resources in continuous bilateral auction

Background: The main purpose of this paper is to improve the efficiency of grid computing by means of Ants' society algorithm. Application of this algorithm in various problem led to an improvement in efficiency and reduction in processing time. This enables us to use this algorithm in grid computing. Economic solutions in the field of management of heterogeneous resources for grid computing showed significant performance. The main idea was economic solutions for product exchange in market. This paper aims to introduce a new method for bilateral auction scenario by means of genetic algorithm (GA). In this method, by making resources intelligent, we move the packages of call for proposal so that it can reduce response time as well as being able to supply resources with lower prices. For simplicity in controlling packages, we used the network structure in implementation. Applied structure includes routers and communication of users and auctioners and auctioners and resources owners. The method was implemented using GridSim simulator. This is an open source software written in Java programming language. Results reveal that the method of bilateral auction using GA reduces sale stages and consequently leads to faster responding to requests and also resources are supplied with a lower cost

The hypotensive effect of salt substitutes in stage 2 hypertension:a systematic review and meta-analysis

Background: Hypertension (HTN) is a ubiquitous risk factor for numerous non-communicable diseases, including cardiovascular disease and stroke. There are currently no wholly effective pharmacological therapies for subjects with HTN. However, salt substitutes have emerged as a potential therapy for the treatment of HTN. The aim of the present study was to assess the effect of salt substitutes on reducing systolic blood pressure (SBP) and diastolic BP (DBP), following a meta-analysis of randomized controlled trials. Methods: Studies were found via systematic searches of the Pubmed/Medline, Scopus, Ovid, Google Scholar and Cochrane library. Ten studies, comprised of 11 trials and 1119 participants, were included in the meta-analysis. Results: Pooled weighted mean differences showed significant reductions of SBP (WMD - 8.87 mmHg; 95 CI - 11.19, - 6.55, p < 0.001) and DBP (WMD - 4.04 mmHg; 95 CI - 5.70, - 2.39) with no statistically significant heterogeneity between the 11 included comparisons of SBPs and DBPs. The stratified analysis of trials based on the mean age of participants showed a significant reduction in the mean difference of SBP in both adults (< 65 years old) and elderly (�65 years old). However, the DBP-lowering effect of salt substitutes was only observed in adult patients (WMD - 4.22 mmHg; 95 CI - 7.85, - 0.58), but not in the elderly subjects. Conclusions: These findings suggest that salt-substitution strategies could be used for lowering SBP and DBP in patients with stage 2 HTN; providing a nutritional platform for the treatment, amelioration, and prevention of HTN. © 2020 The Author(s)

Colour Fusion in Face Authentication System Based on Visible and Near Infrared Images

In this paper, face authentication using images taken in visible and near-infrared spectra (NIR) is studied. Visible images are in RGB colour space and near-infrared images are in gray levels colour space. First, the performance of system in each of the primary colour spaces of visible and near-infrared spectrum is evaluated that the verification process is based on the Normalised Correlation measure within the LDA feature space. In order to utilize the information of colour images, the scores associated to an adaptively selected subset of the colour based classifiers are then fused in the decision level. The selection process is based on a sequential search technique called the "plus L and take away R" algorithm. The sum rule and svm rule is used for fusing the related scores. Our extensive experimental studies using the HFB face database demonstrate that using the proposed method, the performance of the system considerably improves as compared to the individual Visible-based or NIR-based face verification systems

n-3 fatty acids as preventive and therapeutic agents in attenuating PCOS complications

To our knowledge, in spite of several trials exploring the beneficial effect of n-3 polyunsaturated fatty acids (PUFA) on polycystic ovary syndrome (PCOS), no comprehensive evidence has investigated the effects of n-3 PUFA consumption on PCOS complications. Therefore, our aim was to conduct a review to investigate the possible effect and related mechanisms. A comprehensive systematic search was conducted in Embase, MED-LINE/PubMed, Google Scholar, and SCOPUS, to identify studies investigating n-3 fatty acids as a preventative or therapeutic agent for the attenuation of PCOS complications. Subsequently, the impact of omega-3 on PCOS, omega-3 and inflammation, omega-3 and insulin resistance, omega-3 and adipokines, omega-3 and lipid metabolism, omega-3 and endothelial function and omega-3 and hormonal factors were discussed. There are multiple mechanisms by which n-3 PUFAs may exert their beneficial effects on PCOS, including anti-obesity, glycemic and hormonal hemostasis, anti-inflammatory, regulation of adipokine production and enhancement of endothelial function. N-3 PUFAs are a promising agent in relieving complications associated with PCOS. Although most of the studies in patients with PCOS reported an improvement in most complications after administration of omega-3 supplements, there is a distinct dearth of studies investigating the dietary intake of these types of fatty acids. Moreover, favorable effects regarding the improvement of dyslipidemia, regulation of adipokines, regulation of hormonal factors and enhancement of endothelial function are limited. Therefore, more trials are warranted to investigate palatable mechanisms for clarifying the metabolic and hormonal effects of these agents in PCOS. © 2019, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved

Blood pressure lowering effects of alpha-lipoic acid supplementation: a meta-analysis of randomized controlled trials

Background: The aim of the present meta-analysis was to detect the effect of a-lipoic acid (ALA) supplementation on systolic and diastolic blood pressure (BP). Material and methods: The related records were selected from several electronic databases from the earliest date 1980 until October 2019. The heterogeneities were assessed by I 2 test (I 2 < 50%) and X 2 test on Cochrane's Q statistic. Standardized mean difference (SMD) and their 95% confidence intervals (CIs) were considered for net change in systolic blood pressure (SBP) and diastolic blood pressure (DBP). Subgroup analyses were also conducted by baseline BP, health status, doses of supplementation, study duration and supplement utilization. Results: As a result, a total of 10 studies with 612 subjects were included in the final analysis. Alpha-lipoic acid supplementation significantly reduced SBP (SMD = –0.50, 95% CI: –0.84, –0.16, p = 0.004) and DBP (SMD = –0.40, 95% CI: –0.71, –0.09, p = 0.01), compared to the controls, with the reduction of 6.1 mm Hg and 3.6 mm Hg of the mean SBP and DBP, respectively. Heterogeneities were explored in both SBP and DBP. Moreover, a statistically significant reduction in BP was detected in elevated BP and hypertensive patients as compared with the normotensive subjects. Conclusion: ALA supplementation could be considered as a BP-lowering agent, especially in subjects with higher blood pressure

Secondary findings from whole-exome sequencing data in families with familial combined hyperlipidemia (FCHL)

Acknowledgements The grant of this study was paid by Mashhad University of Medical Sciences, Mashhad, Iran. Funding This study was funded by Mashhad University of Medical Sciences.Peer reviewedPublisher PD

Zinc Supplements and Bone Health: The Role of the RANKL-RANK Axis as a Therapeutic Target

Background: To this day, empirical data suggests that zinc has important roles in matrix synthesis, bone turnover, and mineralization and its beneficial effects on bone could be mediated through different mechanisms. The influence of zinc on bone turnover could be facilitated via regulating RANKL/RANK/OPG pathway in bone tissue. Therefore, the aim of the study was to conduct a review to investigate the possible effect of the zinc mediated bone remodeling via RANKL/RANK/OPG pathway. Methods: A comprehensive systematic search was performed in MEDLINE/PubMed, Cochrane Library, SCOPUS, and Google Scholar to explore the studies investigating the effect of zinc as a bone remodeling factor via RANKL/RANK/OPG pathway regulation. Subsequently, the details of the pathway and the impact of zinc supplements on RANKL/RANK/OPG pathway regulation were discussed. Results: The pathway could play an important role in bone remodeling and any imbalance between RANKL/RANK/OPG components could lead to extreme bone resorption. Although the outcomes of some studies are equivocal, it is evident that zinc possesses protective properties against bone loss by regulating the RANKL/RANK/OPG pathway. There are several experiments where zinc supplementation resulted in upregulation of OPG expression or decreases RANKL level. However, the results of some studies oppose this. Conclusion: It is likely that sufficient zinc intake will elicit positive effects on bone health by RANKL/RANK/OPG regulation. Although the outcomes of a few studies are equivocal, it seems that zinc can exert the protective properties against bone loss by suppressing osteoclastogenesis via downregulation of RANKL/RANK. Additionally, there are several experiments where zinc supplementation resulted in upregulation of OPG expression. However, the results of limited studies oppose this. Therefore, aside from the positive role zinc possesses in preserving bone mass, further effects of zinc in RANKL/RANK/OPG system requires further animal/human studies. © 2019 Elsevier Gmb