35 research outputs found
Mitochondrial DNA and trade data support multiple origins of Helicoverpa armigera (Lepidoptera, Noctuidae) in Brazil
- Author
- A Cini
- A Pomari-Fernandes
- AC Djihinto
- AC Frantz
- AM Dickey
- B Pisanu
- B Von Holle
- B Zhang
- BE Tabashnik
- BQ Minh
- C Czepak
- CJ Anderson
- CS Kolar
- E Callaway
- G Cheng
- GF Ficetola
- GP Fitt
- GT Behere
- GT Behere
- HN Zhang
- IB Jakobsen
- J Achaleke
- J Rosenberg
- J Rozas
- JA Arnemann
- JL Lockwood
- K Praebel
- KR Kranthi
- KR Kranthi
- L-T Nguyen
- LD Barbosa
- LM Torres-Vila
- LM Torres-Vila
- M Clement
- M Lopes-da-Silva
- MA Castalanelli
- MG Murúa
- MS Ascunce
- NA Leite
- NJ Armes
- PE Hulme
- PE Hulme
- R Buès
- R Buès
- R Staden
- RI Colautti
- S Downes
- S Downes
- S Nibouche
- SF Altschul
- Sosa-Gómez
- T Mastrangelo
- TC Costa-Lima
- TM Gilligan
- V Vincek
- WT Tay
- WT Tay
- WT Tay
- XF Zhou
- Y Wu
- Y Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
The Old World bollworm Helicoverpa armigera is now established in Brazil but efforts to identify incursion origin(s) and pathway(s) have met with limited success due to the patchiness of available data. Using international agricultural/horticultural commodity trade data and mitochondrial DNA (mtDNA) cytochrome oxidase I (COI) and cytochrome b (Cyt b) gene markers, we inferred the origins and incursion pathways into Brazil. We detected 20 mtDNA haplotypes from six Brazilian states, eight of which were new to our 97 global COI-Cyt b haplotype database. Direct sequence matches indicated five Brazilian haplotypes had Asian, African, and European origins. We identified 45 parsimoniously informative sites and multiple substitutions per site within the concatenated (945 bp) nucleotide dataset, implying that probabilistic phylogenetic analysis methods are needed. High diversity and signatures of uniquely shared haplotypes with diverse localities combined with the trade data suggested multiple incursions and introduction origins in Brazil. Increasing agricultural/horticultural trade activities between the Old and New Worlds represents a significant biosecurity risk factor. Identifying pest origins will enable resistance profiling that reflects countries of origin to be included when developing a resistance management strategy, while identifying incursion pathways will improve biosecurity protocols and risk analysis at biosecurity hotspots including national ports
Cashew nut allergy: clinical relevance and allergen characterisation
- Author
- A Barre
- A Barre
- A Ehlert
- A Ehlert
- A Grigg
- A Harrer
- A Muraro
- António A. Vicente
- AT Clark
- BA Chowdhury
- C Bignardi
- C Bignardi
- C Fernandez
- C Lupinek
- C Radauer
- CK Fæste
- CP Mattison
- CP Mattison
- CY Cho
- Cíntia Mendes
- D El-Qutob
- D Pantoja-Uceda
- DA Moneret-Vautrin
- DM Fleischer
- E Gómez
- E Ros
- E Untersmayr
- EN Mills
- ENC Mills
- ENC Mills
- F Garcia
- F Rancé
- F Wang
- F Wang
- FE Gaskin
- FE Gaskin
- FJ Moreno
- FJ Moreno
- FJ Moreno
- FJ Moreno
- FRG Terras
- G Picariello
- GM Polya
- H Breiteneder
- H Breiteneder
- H Breiteneder
- HH Kshirsagar
- IL Silva De
- IM Lopez-Calleja
- Isabel Mafra
- J Costa
- J Costa
- J Johnson
- J Sealey-Voyksner
- JA Boyce
- JA Jenkins
- JL Brzezinski
- JM Maloney
- JM Robotham
- JM Robotham
- JM Robotham
- Joana Costa
- JPM Valk van der
- JPM Valk van der
- JPM Valk van der
- K Ahn
- KJ Allen
- L Monaci
- L Piknova
- L Zuidmeer
- LN Willison
- LX Xia
- M Davoren
- M Hasegawa
- M Kulis
- M Kulis
- M Kulis
- M Reitsma
- M Su
- M Venkatachalam
- M Vetander
- Maria Beatriz P. P. Oliveira
- MD Chapman
- MP Leon de
- P Blazdell
- P Bégin
- P Bégin
- P Rougé
- P Schubert-Ullrich
- PE Johnson
- PR Shewry
- PR Shewry
- R Koppel
- R Pilolli
- RHK Entink
- RWR Crevel
- RWR Crevel
- RWR Crevel
- S Pafundo
- S Rebe Raz
- S Sato
- S Savvatianos
- S Sindher
- SB Rejeb
- SH Sicherer
- SH Sicherer
- SL Taylor
- SL Taylor
- SM Gendel
- SS Teuber
- SY Chung
- T Mousallem
- TM Le
- V Cunsolo
- V McWilliam
- W Wang
- WM Blom
- XY Guan
- Y Okada
- Y Wei
- YH Wei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2019
- Field of study
Cashew plant (Anacardium occidentale L.) is the most relevant species of the Anacardium genus. It presents high economic value since it is widely used in human nutrition and in several industrial applications. Cashew nut is a well-appreciated food (belongs to the tree nut group), being widely consumed as snacks and in processed foods by the majority of world's population. However, cashew nut is also classified as a potent allergenic food known to be responsible for triggering severe and systemic immune reactions (e.g. anaphylaxis) in sensitised/allergic individuals that often demand epinephrine treatment and hospitalisation. So far, three groups of allergenic proteins have been identified and characterised in cashew nut: Ana o 1 and Ana o 2 (cupin superfamily) and Ana o 3 (prolamin superfamily), which are all classified as major allergens. The prevalence of cashew nut allergy seems to be rising in industrialised countries with the increasing consumption of this nut. There is still no cure for cashew nut allergy, as well as for other food allergies; thus, the allergic patients are advised to eliminate it from their diets. Accordingly, when carefully choosing processed foods that are commercially available, the allergic consumers have to rely on proper food labelling. In this sense, the control of labelling compliance is much needed, which has prompted the development of proficient analytical methods for allergen analysis. In the recent years, significant research advances in cashew nut allergy have been accomplished, which are highlighted and discussed in this review.This work was supported by FCT/MEC through national funds and co-financed by FEDER, under the Partnership Agreement PT2020 with grant no. UID/QUI/50006/2013–POCI/01/ 0145/FEDER/007265. Joana Costa is grateful to FCT post-doctoral grant (SFRH/BPD/102404/2014) financed by POPH-QREN (subsidised by FSE and MCTES).info:eu-repo/semantics/publishedVersio
Inosine triphosphatase allele frequency and association with ribavirin-induced anaemia in Brazilian patients receiving antiviral therapy for chronic hepatitis C
- Author
- Adilson José de Almeida
- Ahmed WH
- Alter MJ
- Cao H
- Carlos Eduardo Brandão-Mello
- Clark PJ
- Cristiane Alves Villela-Nogueira
- Domingo P
- D’Avolio A
- Eliane Bordalo Cathalá Esberard
- Elisabeth Lampe
- Fellay J
- Fraser JH
- Gara N
- Gonçalves PL
- Henrique Sérgio Moraes Coelho
- Hitomi Y
- Hynicka LM
- Kim JS
- Kowdley KV
- Kurosaki M
- Kurosaki M
- Livia Melo Villar
- Maeda T
- Maristella Matos da Costa
- Motomura T
- Naggie S
- Nathália Delvaux
- Ochi H
- Paranaguá-Vezozzo DC
- Patterson JL
- Priscila Pollo Flores
- Rau M
- Rau M
- Rembeck K
- Romero-Gómez M
- Sakamoto N
- Scherzer TM
- Seto WK
- Shipkova M
- Sumi S
- Sung H
- Suzuki F
- Tanaka Y
- Thompson AJ
- Tsubota A
- Vanessa Duarte da Costa
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Molecular characterisation of the NSP4 gene of group A human rotavirus G2P[4] strains circulating in São Paulo, Brazil, from 1994 and 2006 to 2010
- Author
- Araújo IT
- Araújo IT
- Ball JM
- Ball JM
- Benati FJ
- Carvalho-Costa FA
- Ciarlet M
- Deepa R
- Desai R
- Estes MK
- Fredj MBH
- Fumian TM
- González-Ochoa G
- Greenberg HB
- Gurgel RQ
- Gómez MM
- Hall TA
- Horie Y
- Ito H
- Johansen K
- Jéssica Wildgrube Bertol
- Leite JPG
- Liu L
- Maes P
- Marco Aurélio Palazzi Sáfadi
- Maria Clara Duarte Fregolente
- Maria Lucia Rácz
- Maria Silvia Viccari Gatti
- Mascarenhas JDP
- Matthijnssens J
- Matthijnssens J
- Matthijnssens J
- Matthijnssens J
- Matthijnssens J
- Maunula L
- Mori Y
- Munford V
- Munford V
- Márcio José da Silva
- Nozawa CM
- Oliveira A
- O’Brien JA
- Papp H
- Rajasekaran D
- Santos N
- Soares LS
- Sáfadi MAP
- Tamura K
- Tatte VS
- Tavares TM
- Taylor JA
- Thabata Alessandra Ramos Caruzo
- Tian P
- Trojnar E
- Veridiana Munford
- Walker CLF
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Traditional Mapuche ecological knowledge in Patagonia, Argentina: fishes and other living beings inhabiting continental waters, as a reflection of processes of change
- Author
- A Begossi
- A Begossi
- A Begossi
- A Begossi
- A Begossi
- A D’Orbigny
- A Escobar
- A Hajduk
- A Ladio
- A Llagostera
- A Moyano
- A Viedma
- AE Valle Del
- AH Ladio
- AH Soldano
- AJ Bath
- AL Silva Da
- AM Miquelarena
- Ana Ladio
- B Berlin
- B Hernández
- B Vilá
- BA Fernández
- C Briones
- C Brown
- C Eyssartier
- C Folke
- C Villagrán
- CA Fernández
- CR El
- D Feeny
- D Santos Fita
- D Wegrzyn
- E Camac
- E Crivelli
- E Hunn
- E Ostrom
- E Ostrom
- EJ Cano-Contreras
- EM Costa-Neto
- EW Moesbach
- F Berkes
- F Berkes
- F Berkes
- F Berkes
- F Berkes
- F Berkes
- F Berkes
- F Tola
- F Trentini
- FO Zuloaga
- FR Barbarán
- G Galafassi
- G Álvarez
- GC Musters
- GF Scarpa
- GJ Martínez
- GJ Osemeobo
- H Zapater
- HF Magalhães
- I Davidson Hunt
- J Aigo
- J Aigo
- J Bengoa
- J Colding
- J Colding
- J Gómez Otero
- J Hernandez
- J Nantes
- J Valbo-Jørgensen
- JA Cordero
- JB Callicott
- JGW Marques
- JM Nolan
- JM Silveira
- JP Barriga
- JP Barriga
- JS Mourão
- JS Mourão
- Juana Aigo
- L Buria
- L Kropff
- L Prates
- LR Parodi
- M Calvo
- M Espósito
- M Gadgil
- M Gusinde
- M Höft
- M Lozada
- M Lucherini
- M Mermoz
- M Olivera
- M Pascual
- M Vargas-Clavijo
- MA Pascual
- MC Medrano
- ME Grebe
- MF Pinto
- MS Reis
- P Arenas
- P Arenas
- P Coña
- P Descola
- P Navarro Floria
- PH Vigliano
- PJ Fargey
- PZ Mora
- R Guber
- R Lista
- R Rozzi
- R Rozzi
- R Rozzi
- RA Ringuelet
- RC Menni
- RE Johannes
- RE Johannes
- RK Sinha
- RM Casamiquela
- RRN Alves
- S Molares
- S Molares
- S Montecino
- S Ortubay
- SJ Tambiah
- SR Carpenter
- T Marini
- TC Silva
- TD Dillehay
- TM Herrmann
- UP Alburquerque
- V Castro
- V Castro
- V Cussac
- V Reyes-García
- VE Cussac
- VM Toledo
- VS Lema
- Y Kuramochi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
- AEC Ihekwaba
- AEC Ihekwaba
- AF Tramontano
- AH Berg
- AH Koeppen
- AH Koeppen
- AH Tong
- AI Bush
- AI Bush
- AI Bush
- AI Bush
- AI Faden
- AJ Ghio
- AJ Ghio
- AJ Ghio
- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
- AJ Williams
- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
- AP Liappis
- AR Kallianpur
- AR Kallianpur
- AR Martin
- AR Ness
- AR Rechner
- AR Rumbold
- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
- B de Valk
- B De Vries
- B Desoize
- B Drayer
- B Faller
- B Goodell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Huppertz
- B Jayawardhana
- B Kwak
- B Lachili
- B Lipinski
- B Mackenzie
- B Marshall
- B Mignotte
- B Oldenburg
- B Poeggeler
- B Pradines
- B Pradines
- B Regland
- B Russell
- B Schiessl
- B Shipley
- B Skibska
- B Sturm
- B Thorand
- B Wang
- B Wolff
- B Wolozin
- B Wolozin
- B Xu
- B Zhang
- B Zhou
- BA Maddux
- BA Molitoris
- BB Aggarwal
- BB Aggarwal
- BB Aggarwal
- BB Aggarwal
- BB Sizoo
- BB Song
- BB Song
- BC Daniels
- BC Jones
- BD LaMarca
- BH Havsteen
- BI Giasson
- BI Hoffman
- BJ Marshall
- BK Kennedy
- BK Rinehart
- BK Wagner
- BL Halvorsen
- BL Zhao
- BM Babior
- BN Ames
- BP Leung
- BP Oberg
- BP Yu
- BR Kwak
- BR Otto
- BS Chen
- BS van Asbeck
- BT Mossman
- BV Naidu
- BY Tung
- BØ Palsson
- C Arnaud
- C Beaumont
- C Behl
- C Biondi
- C Bolin
- C Bozzini
- C Breymann
- C Brooksbank
- C Bubici
- C Bubici
- C Burdon
- C Camaschella
- C Camaschella
- C Caris
- C Cavdar
- C Chen
- C Delaby
- C Demougeot
- C Finch
- C Fleury
- C García-Ruiz
- C Gasche
- C Gasche
- C Gerhäuser
- C Goble
- C Henry
- C Herce-Pagliai
- C Herder
- C Hershko
- C Hershko
- C Hershko
- C Hershko
- C Jacob
- C Kenyon
- C Knox
- C Kretz-Remy
- C Kunsch
- C Köhle
- C Leadbeater
- C Li
- C Lu
- C Manach
- C Manach
- C Manach
- C Mancuso
- C Moon
- C Moon
- C Mouralian
- C Muscoli
- C Peyssonnaux
- C Peyssonnaux
- C Peyssonnaux
- C Pigeon
- C Popa
- C Quintana
- C Ramassamy
- C Ramassamy
- C Ratledge
- C Rigamonti
- C Ritter
- C Ritter
- C Ritter
- C Savino
- C Savoia
- C Savoia
- C Schmeer
- C Shirky
- C Singh
- C Smith
- C Thrasivoulou
- C Trenkwalder
- C Troeger
- C Urbich
- C Vermylen
- C Vélez-Pardo
- C Vélez-Pardo
- C Wandersman
- C Xu
- CA Combs
- CA Dorrepaal
- CA Genco
- CA Hubel
- CA Hubel
- CA Hubel
- CA Hubel
- CA Lynch
- CA Papaharalambus
- CA Rice-Evans
- CA Rice-Evans
- CA Rice-Evans
- CA Rottkamp
- CC Chen
- CC Chiueh
- CC Hsieh
- CC Neto
- CC Neto
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- CC Winterbourn
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- CH Wang
- CI Cook
- CJ Binder
- CJ Boos
- CJ Burrows
- CJ Chen
- CJ Hukshorn
- CJ Kaupke
- CJ Maynard
- CJ Needham
- CJ Parsa
- CJ Vaughan
- CJA Doelman
- CK Lee
- CK Roberts
- CK Roberts
- CK Sen
- CL Dent
- CM Anderson
- CM Craven
- CN Hales
- CN Lumeng
- CN Roy
- CP Doherty
- CP Martin
- CR Allerson
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- CS Shin
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- CS Yang
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- CW Yang
- CWM Adams
- CY Wang
- CY Wu
- D Agnello
- D Barisani
- D Ben Shachar
- D Berg
- D Berg
- D Blum
- D Closa
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- D DeFaria Yeh
- D Fliser
- D Furlani
- D Galaris
- D Galter
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- D HaMai
- D Hamerman
- D Harman
- D Howe
- D Hristovski
- D Hull
- D Hull
- D Imbert
- D Johnson
- D Kaur
- D Kaur
- D Lapenna
- D Law
- D Meyer
- D Mozaffarian
- D Noble
- D Noble
- D Ponraj
- D Prá
- D Rowley
- D Salvemini
- D Tapscott
- D Thorne
- D Trinder
- D Walz
- D Weininger
- D Yoon
- D Zozulinska
- DA Butterfield
- DA Butterfield
- DA Drechsel
- DA Fell
- DA Fell
- DA Rand
- DA Shoskes
- DA Weinstein
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Kell
- DB Lovejoy
- DB Lovejoy
- DC Lau
- DC Souza-Costa
- DC Whitcomb
- DD Harrison-Findik
- DD Harrison-Findik
- DE Featherstone
- DE Ferrara
- DE Kelley
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- DF Benyo
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- DH Anderson
- DH Goetz
- DH Lee
- DH Lee
- DH Lee
- DH Lee
- DH Lee
- DH Walter
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- DM Bailey
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- DM Frazer
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- DM Miller
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- DM Wrighting
- DN Granger
- DN Leung
- DN Seril
- DN Syed
- Douglas B Kell
- DP Bentley
- DR Bentley
- DR Flower
- DR Janero
- DR Petersen
- DR Richardson
- DR Richardson
- DR Richardson
- DR Richardson
- DR Richardson
- DR Richardson
- DR Rosen
- DR Swanson
- DR Swanson
- DR Zerbino
- DS Cassarino
- DS Grimes
- DS Kalinowski
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- DS Kalinowski
- DS Kalinowski
- DS Warner
- DS Warner
- DS Wilson
- DT Dexter
- DW Kamp
- DW Kamp
- DW Killilea
- DW Lee
- DW Lee
- DW McCarey
- DW Reid
- DW Reif
- DW Swinkels
- DW Swinkels
- DX Bu
- E Aigner
- E Ates
- E Becker
- E Berenshtein
- E Berenshtein
- E Beutler
- E Bonilla
- E Bonilla
- E Butelli
- E Cadenas
- E Calabrese
- E Casanueva
- E Chwelatiuk
- E Corradini
- E Crimi
- E Crimi
- E Devrim
- E DiFederico
- E Donato
- E Floor
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- E Gitto
- E Guneli
- E Heiss
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- E Klipp
- E Lee
- E Lesnefsky
- E Mariani
- E Messaris
- E Middleton
- E Napoli
- E Nemeth
- E Nemeth
- E Nemeth
- E Nemeth
- E Nemeth
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- E Pennisi
- E Sapey
- E Schleicher
- E Schwedhelm
- E Trushina
- EA Ostrakhovitch
- EA Platz
- EA Price
- EB Montgomery Jr
- EC Jury
- ED Rosen
- ED Weinberg
- ED Weinberg
- ED Weinberg
- ED Weinberg
- ED Weinberg
- ED Weinberg
- ED Weinberg
- ED Weinberg
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- EG McGeer
- EH Cao
- EH Kemna
- EH Sharman
- EJ Calabrese
- EJ Calabrese
- EJ Dombrecht
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
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- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Randomized clinical trials of dental bleaching – Compliance with the CONSORT Statement: a systematic review
- Author
- Acosta Gómez AP
- Akarslan ZZ
- Al Shethri S
- Al-Zarea BK
- Alessandra REIS
- Alessandro Dourado LOGUERCIO
- Alexandra Mara de PAULA
- Almeida LCA
- Alomari Q
- Alonso de la Peña V
- Alonso de la Peña V
- Altman DG
- Auschill T
- Auschill TM
- Barbui C
- Barlow A
- Barnes DM
- Basting RT
- Bearn DR
- Berga-Caballero A
- Bernardon JK
- Bernardon JK
- Bernardon JK
- Bianca Medeiros MARAN
- Bizhang M
- Bizhang M
- Bonafé E
- Borenstein M
- Bortolatto JF
- Braun A
- Browning WD
- Browning WD
- Bruhn AM
- Burns PB
- Cairo F
- Callan RS
- Cardoso PC
- Carvalho BCF
- Cerqueira RR
- Chan AW
- Cibirka RM
- Cioffi I
- Collins LZ
- Corbella S
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- Kossatz S
- Kozlovsky A
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- Leonard Jr RH
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- Medeiros MCS
- Mehta D
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- Meireles SS
- Meireles SS
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- Mena-Serrano AP
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- Navarra CO
- Nutter BJ
- Oginni AO
- Ontiveros JC
- Palé M
- Pandis N
- Pandis N
- Papageorgiou SN
- Papathanasiou A
- Papathanasiou A
- Paula EA
- Paula EA
- Paula EA
- Perry R
- Pocock SJ
- Polydorou O
- Posso Moreno SL
- Rajasekharan S
- Reis A
- Reis A
- Reis A
- Reis A
- Rennie D
- Rezende M
- Rezende M
- Rezende M
- Rezende M
- Rezende M
- Rezende M
- Roderjan DA
- Rosenstiel SF
- Santana MAP
- Sarkis-Onofre R
- Schulz KF
- Schulz KF
- Schulz KF
- Schulz KF
- Shahidi H
- Shamseer L
- Shanbhag R
- Sielski C
- Silva FM
- Simon JF
- Sjögren P
- Soares CJ
- Soares DG
- Soares DG
- Strobl A
- Sundfeld RH
- Swift EJ
- Swift Jr EJ
- Swift Jr EJ
- Swift Jr EJ
- T Tavares M
- Tay LY
- Tay LY
- Taíse Alessandra HANZEN
- Tsubura S
- Tsubura S
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- Wetter NU
- Xu X
- Yudhira R
- Zantner C
- Zekonis R
- Zhao K
- Ziebolz D
- Ziemba SL
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
- Andreani Sm
- Andreani Sm
- Andrews B
- Ang A
- Ang A
- Angelieri D
- Angelini M
- Angrisani M
- Anguita F
- Ansaloni L
- Ansari A
- Aravind B
- Archer Je
- Arcuri Ga
- Arcuri Ga
- Aremu Ma
- Arenal-Vera Jj
- Aresu S
- Aresu S
- Argenio G
- Argenti F
- Armellini A
- Arnau M
- Arredondo J
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- Arshad F
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- Ashmore Dl
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- Avanzolini A
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- Ayube-Brown J
- Azabdaftari A
- Azevedo J
- Azevedo Jm
- Baddams Ts
- Badenoch T
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- Biancafarina A
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- Castagnoli G
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- Wilkin R. J. W.
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- Youssef H
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- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Aarestrup J
- Abarca-Gómez L
- Abbasi-Kangevari M
- Abdeen ZA
- Abdrakhmanova S
- Abdul Ghaffar S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abu-Rmeileh NM
- Abubakar Garba J
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Asfoor D
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alieva AV
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alomary SA
- Alomirah HF
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- Publication venue
- Elsevier
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- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity