73 research outputs found

    A Kinetic Study of Ovalbumin Fibril Formation:The Importance of Fragmentation and End-Joining

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    AbstractThe ability to control the morphologies of biomolecular aggregates is a central objective in the study of self-assembly processes. The development of predictive models offers the surest route for gaining such control. Under the right conditions, proteins will self-assemble into fibers that may rearrange themselves even further to form diverse structures, including the formation of closed loops. In this study, chicken egg white ovalbumin is used as a model for the study of fibril loops. By monitoring the kinetics of self-assembly, we demonstrate that loop formation is a consequence of end-to-end association between protein fibrils. A model of fibril formation kinetics, including end-joining, is developed and solved, showing that end-joining has a distinct effect on the growth of fibrillar mass density (which can be measured experimentally), establishing a link between self-assembly kinetics and the underlying growth mechanism. These results will enable experimentalists to infer fibrillar morphologies from an appropriate analysis of self-assembly kinetic data

    Measurement of Lambda polarization from Z decays

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    Search for excited leptons at 130-140 GeV

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    Search for supersymmetric particles in e+e−e^+e^- collisions at centre-of-mass energies of 130 and 136 GeV

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    Measurement of Lambda polarization from Z decays

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    Four-jet final state production in e+e−e^+e^- collisions at center-of-mass energies of 130 and 136 GeV

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    Study of the Bs0Bˉs0B^0_s \bar{B}^0_s oscillation frequency using Ds−l+D^-_s l^+ combinations in Z decays

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    The first two centuries of colonial agriculture in the cape colony: A historiographical review∗

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    Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

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    The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described
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