37 research outputs found
Memoria y guion completo del videojuego “Despierta”
Ficha técnica del videojuego
- Título del videojuego: Despierta
- Género del videojuego: Aventura gráfica con toques de humor.
- Plataformas objetivo: PC, Xbox One, Playstation 4, Nintendo Switch y móviles.
- Edad orientativa hacia la que se dirige el juego: jugadores mayores de 10 años (necesario un nivel adecuado de lectura y cierta lógica e imaginación para resolver los puzles).
- Storyline: >.Web del videojuego completo en el CD disponible en la Biblioteca de Comunicación (TFM 756)Universidad de Sevilla. Grado en guión, narrativa y creación audiovisua
Evaluación de proyectos en asignaturas de automatización y robótica
En este trabajo se presenta la implantación de un
sistema de evaluación de proyectos en diversas
asignaturas de nuestro departamento relacionadas
con la automatización y la robótica. La propuesta
docente presentada se basa en la realización por
parte de los alumnos de un proyecto abierto de
automatización en grupo, en el cual no sólo tienen
que diseñar la solución, sino también el problema.
La naturaleza abierta del proyecto y el gran número
de alumnos, motivó el reparto de los diferentes
grupos entre los diferentes profesores de la
asignatura. Cada grupo de alumnos tiene al menos
dos tutorías con su profesor para acordar el
problema a resolver para poder adecuar la
complejidad y alcance a los objetivos de la
asignatura. La evaluación de los proyectos se realiza
mediante una presentación oral el mismo día que el
examen escrito de las convocatorias oficiales. La
metodología propuesta ha sido implantada con éxitos
en diversas asignaturas y han participado más de
600 alumnos durante los últimos años con una gran
aceptación tanto por parte del profesorado como de
los alumnos
On the thermal stability of the nanostructured tungsten coatings
Tungsten is a candidate to be used as plasma facing materials in future fusion nuclear reactors. There, the material has to withstand large radiation fluxes and thermal loads. Nowadays, nanostructured tungsten (NW) seems to exhibit a better radiation-resistance than the coarse grained. However, the thermal stability of NW is still an open question. On these bases, the thermal stability of NW coatings is studied in the temperature range from 1000 to 1473 K. For this purpose, Samples were isothermally annealed in vacuum at temperatures from 298 to 1473 K. The morphological and microstructural properties of the samples were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM) and X-Ray diffraction (XRD), respectively. For T 100 K, nanostructures start to grow in a bimodal fashion with activation energy of 0259 eV, reaching a submicron-sized threshold at T approximate to 1473 K
Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo
A G4C2 hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TG3C2 repeat expansion is associated with spinocerebellar ataxia 36 (SCA36). Both expansions are widely expressed, form RNA foci, and can undergo repeat-associated non-ATG (RAN) translation to form similar dipeptide repeat proteins (DPRs). Yet, these diseases result in the degeneration of distinct subsets of neurons. We show that the expression of these repeat expansions in mice is sufficient to recapitulate the unique features of each disease, including this selective neuronal vulnerability. Furthermore, only the G4C2 repeat induces the formation of aberrant stress granules and pTDP-43 inclusions. Overall, our results demonstrate that the pathomechanisms responsible for each disease are intrinsic to the individual repeat sequence, highlighting the importance of sequence-specific RNA-mediated toxicity in each disorder
High-resolution hepatitis C virus subtyping using NS5B deep sequencing and phylogeny, an alternative to current methods
HepatitisCvirus(HCV)is classified into seven major genotypesand67 subtypes. Recent studies haveshownthat inHCVgenotype 1-infected
patients, response rates to regimens containingdirect-acting antivirals(DAAs)are subtype dependent. Currently available genotypingmethods
have limited subtyping accuracy.Wehave evaluated theperformanceof adeep-sequencing-basedHCVsubtyping assay, developed for the
454/GS-Junior platform, in comparisonwith thoseof two commercial assays (VersantHCVgenotype 2.0andAbbott Real-timeHCVGenotype
II)andusingdirectNS5Bsequencing as a gold standard (direct sequencing), in 114 clinical specimenspreviously tested by first-generation
hybridization assay (82 genotype 1and32 with uninterpretable results). Phylogenetic analysis of deep-sequencing reads matched subtype
1 callingbypopulation Sanger sequencing(69%1b,31%1a) in 81 specimensandidentified amixed-subtype infection (1b/3a/1a) in one sample.
Similarly,amongthe 32previously indeterminate specimens, identical genotypeandsubtype results were obtained by directanddeep
sequencing in all but four samples with dual infection. In contrast, both VersantHCVGenotype 2.0andAbbott Real-timeHCVGenotype II
failed subtype 1 calling in 13 (16%) samples eachandwere unable to identify theHCVgenotype and/or subtype inmore than half of the nongenotype
1 samples.Weconcluded that deep sequencing ismore efficient forHCVsubtyping than currently available methodsandallows
qualitative identificationofmixed infectionsandmay bemorehelpfulwith respect to informing treatment strategies withnewDAA-containing
regimens across allHCVsubtypesThis study has been supported by CDTI (Centro para el Desarrollo Tecnológico
Industrial), Spanish Ministry of Economics and Competitiveness
(MINECO), IDI-20110115; MINECO projects SAF 2009-10403; and
also by the Spanish Ministry of Health, Instituto de Salud Carlos III (FIS)
projects PI10/01505, PI12/01893, and PI13/00456. CIBERehd is funded
by the Instituto de Salud Carlos III, Madrid, Spain. Work at CBMSO was
supported by grant MINECO-BFU2011-23604, FIPSE, and Fundación
Ramón Areces.
X. Forns received unrestricted grant support from Roche and has
acted as advisor for MSD, Gilead, and Abbvie. M. Alvarez-Tejado, J. Gregori,
and J. M. Muñoz work in Roche Diagnostic
Nanostructured tungsten as a first wall material for the future nuclear fusion reactors
The lack of materials able to withstand the severe radiation conditions (high thermal loads and atomistic damage) expected in fusion reactors is the actual bottle neck for fusion to become a reality. The main requisite for plasma facing materials (PFM) is to have excellent structural stability since severe cracking or mass loss would hamper their protection role which turns out to be unacceptable. Additional practical requirements for plasma facing materials are among others: (i) high thermal shock resistance, (ii) high thermal conductivity (iii) high melting point (iv) low physical and chemical sputtering, and (v) low tritium retention
Capabilities of Nanostructured Tungsten for Plasma Facing Material
One of the bottle necks for fusion to become a reality is the lack of materials able to withstand the harsh conditions taken place in a reactor environment. In particular, plasma facing materials (PFM) have to resist large radiation fluxes and thermal loads. Nowadays, tungsten is one of the most attractive materials proposed for PFM. However, it is known that the irradiation of tungsten with H leads to surface blistering and subsequent cracking and exfoliation which is unacceptable. In particular, these effects have been observed to be more severe when W is subjected to pulse irradiation
Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival
Acute tubular necrosis (ATN) caused by ischemia/reperfusion (I/R) during renal transplantation delays allograft function. Identification of factors that mediate protection and/or epithelium recovery could help to improve graft outcome. We studied the expression, regulation and role of hypoxia inducible factor 1-alpha (HIF-1 α), using in vitro and in vivo experimental models of I/R as well as human post-transplant renal biopsies. We found that HIF-1 α is stabilized in proximal tubule cells during ischemia and unexpectedly in late reperfusion, when oxygen tension is normal. Both inductions lead to gene expression in vitro and in vivo. In vitro interference of HIF-1 α promoted cell death and in vivo interference exacerbated tissue damage and renal dysfunction. In pos-transplant human biopsies, HIF-1 α was expressed only in proximal tubules which exhibited normal renal structure with a significant negative correlation with ATN grade. In summary, using experimental models and human biopsies, we identified a novel HIF-1 α induction during reperfusion with a potential critical role in renal transplant
Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial
Background:
Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment.
Methods:
This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal.
Results:
Enrolment began in 2016, and the study is expected to end in 2020.
Conclusions:
This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission.
Clinical trial reference number:
EudraCT 2015-001410-1
Adelante / Endavant
Séptimo desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere "Purificación Escribano" de la Universitat Jaume