154 research outputs found
Transverse emittance measurement in 2D and 4D performed on a Low Energy Beam Transport line: benchmarking and data analysis
2D and 4D transverse phase-space of a low-energy ion-beam is measured with
two of the most common emittance scanners. The article covers the description
of the installation, the setup, the settings, the experiment and the benchmark
of the two emittance meters. We compare the results from three series of
measurements and present the advantages and drawbacks of the two systems.
Coupling between phase-space planes, correlations and mitigation of deleterious
effects are discussed. The influence of background noise and aberrations of
trace-space figures on emittance measurements and RMS calculations is
highlighted, especially for low density beams and halos. A new data analysis
method using noise reduction, filtering, and reconstruction of the emittance
figure is described. Finally, some basic concepts of phase-space theory and
application to beam transport are recalled
Precision measurements of the Co -asymmetry parameter in search for tensor currents in weak interactions
The -asymmetry parameter for the Gamow-Teller decay of
Co was measured by polarizing the radioactive nuclei with the brute
force low-temperature nuclear-orientation method. The Co activity was
cooled down to milliKelvin temperatures in a He-He dilution
refrigerator in an external 13 T magnetic field. The particles were
observed by a 500 thick Si PIN diode operating at a temperature of
about 10 K in a magnetic field of 0.6 T. Extensive GEANT4 Monte-Carlo
simulations were performed to gain control over the systematic effects. Our
result, , is in agreement with
the Standard-Model value of , which includes recoil-order
corrections that were addressed for the first time for this isotope. Further,
it enables limits to be placed on possible tensor-type charged weak currents as
well as other physics beyond the Standard Model
A GEANT4 Monte-Carlo Simulation Code for precision beta spectroscopy
The measurement of the beta asymmetry parameter in nuclear beta decay is a
potentially very sensitive tool to search for non V-A components in the
charge-changing weak interaction. To reach the required precision (percent
level) all effects that modify the emission pattern of the beta radiation, i.e.
the geometry of the setup, the effect of the magnetic field on the trajectories
of beta particles as well as (back)scattering in the source, on the sample
holder and on the detector, have to be correctly taken into account in the
analysis of the data. A thorough study of these effects and a new method based
on detailed GEANT4 Monte-Carlo simulations that was developed for this purpose
is presented here. The code was developed for beta asymmetry measurements by
means of the Low Temperature Nuclear Orientation (LTNO) method, but can in
principle be generalized to other experimental setups using other polarization
techniques
The β-decay approach for studying 12C
6 pags., 3 figs. -- 9th International Conference on Clustering Aspects of Nuclear Structure and Dynamics (CLUSTERS'07) 3–7 September 2007, Stratford upon Avon, UKThe β-decays of the mirror nuclei 12B and 12N both populate states in 12C and they are therefore a precious source of information about this nucleus. Due to the selection rules of β-decay only 0+, 1+ and 2+ states are populated. This allows a very clean study of unbound states just above the 3α-threshold with those spin and parities. This probe has been applied in two experiments using two complementary experimental techniques: in the first the three α-particles emitted after β-decay are measured in coincidence in separate detectors using the ISOL method, while in the second method 12B and 12N are implanted in a detector and the summed energy of the three α-particles is measured directly. Preliminary results from the two approaches are presented. © 2008 IOP Publishing Ltd
Measurement of 19Ne spectroscopic properties via a new method of inelastic scattering to study novae
The accuracy of the predictions of the γ flux produced by a classical nova during the first hours after the outburst is limited by the uncertainties on several reaction rates, including the 18F(p,α)15O one. Better constraints on this reaction rate can be obtained by determining the spectroscopic properties of the compound nucleus 19Ne. This was achieved in a new inelastic scattering method using a 19Ne radioactive beam (produced by the GANIL-SPIRAL 1 facility) impinging onto a proton target. The experiment was performed at the VAMOS spectrometer. In this article the performances (excitation energy range covered and excitation energy resolution) and limitations of the new technique are discussed. Excitation energy resolution of σ = 33 keV and low background were obtained with this inverse kinematics method, which will allow extracting the spectroscopic properties of 19Ne
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Impact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry
Background: Atrial fibrillation (AF) and renal impairment share a bidirectional relationship with important pathophysiological interactions. We evaluated the impact of renal impairment in a contemporary cohort of patients with AF. Methods: We utilised the ESC-EHRA EORP-AF Long-Term General Registry. Outcomes were analysed according to renal function by CKD-EPI equation. The primary endpoint was a composite of thromboembolism, major bleeding, acute coronary syndrome and all-cause death. Secondary endpoints were each of these separately including ischaemic stroke, haemorrhagic event, intracranial haemorrhage, cardiovascular death and hospital admission. Results: A total of 9306 patients were included. The distribution of patients with no, mild, moderate and severe renal impairment at baseline were 16.9%, 49.3%, 30% and 3.8%, respectively. AF patients with impaired renal function were older, more likely to be females, had worse cardiac imaging parameters and multiple comorbidities. Among patients with an indication for anticoagulation, prescription of these agents was reduced in those with severe renal impairment, p <.001. Over 24 months, impaired renal function was associated with significantly greater incidence of the primary composite outcome and all secondary outcomes. Multivariable Cox regression analysis demonstrated an inverse relationship between eGFR and the primary outcome (HR 1.07 [95% CI, 1.01–1.14] per 10 ml/min/1.73 m2 decrease), that was most notable in patients with eGFR <30 ml/min/1.73 m2 (HR 2.21 [95% CI, 1.23–3.99] compared to eGFR ≥90 ml/min/1.73 m2). Conclusion: A significant proportion of patients with AF suffer from concomitant renal impairment which impacts their overall management. Furthermore, renal impairment is an independent predictor of major adverse events including thromboembolism, major bleeding, acute coronary syndrome and all-cause death in patients with AF
Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry
Background: Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients. Methods: From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses. Results: Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58–0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52–0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58–0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56–0.98) and composite outcome (aHR: 0.76, 95%CI 0.60–0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome. Conclusions: An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients
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