206 research outputs found
Atomistic origin of high-concentration Ce³⁺ in {100}-faceted Cr- substituted CeO₂ nanocrystals
Improving the potential of promising CeO2-based nanocatalysts in practical applications requires an atomic-scale analysis of the effects of active dopants on the distribution of Ce valence states and the formation of oxygen vacancies (VOs). In this study, a Cr dopant is introduced into the cubic {100}-faceted CeO2 nanocrystals (NCs) with an average size of 7.8 nm via supercritical water. The Cr dopants substitute Ce sites in the amount of approximately 3 mol%. Based on the aberration-corrected STEM-EELS, the effects of Cr dopant on the distribution of cation valence states in the Cr-doped CeO2 NCs are investigated layer by layer across the ultrafine Cr-substituted CeO2 NC perpendicular to the {100} exposed facet. It is found that an increased amount of Ce3+ cations is present in Cr-substituted CeO2 NCs, particularly in the internal atomic layers, compared to the pristine CeO2 NCs. The atomic-scale analysis of the local structure combined with theoretical calculations demonstrates that Cr dopant reduces the formation energy of VOs and increases mobility of oxygen atoms for the nano-sized CeO2. These effects, in principle, result in an improved oxygen storage capacity and provide a fundamental understanding of role of the dopant in the formation and distribution of VOs in the doped CeO2 NCs
Extracting invariant characteristics of sketch maps: Towards place query-by-sketch
In geography, invariant aspects of sketches are essential to study because they reflect the human perception of real-world places. A person's perception of a place can be ex-pressed in sketches. In this article, we quantitatively and qualitatively analyzed the characteristics of single objects and characteristics among objects in sketches and the real world to find reliable invariants that can be used to establish references/correspondences between sketch and world in a matching process. These characteristics include category, shape, name, and relative size of each object. Moreover, quantity and spatial relationships—such as topological, or-dering, and location relationships—among all objects are also analyzed to assess consistency between sketched and actual places. The approach presented in this study extracts the reliable invariants for query-by-sketch and prioritizes their relevance for a sketch-map matching process
STRASSE: A Silicon Tracker for Quasi-free Scattering Measurements at the RIBF
STRASSE (Silicon Tracker for RAdioactive nuclei Studies at SAMURAI
Experiments) is a new detection system under construction for quasi-free
scattering (QFS) measurements at 200-250 MeV/nucleon at the RIBF facility of
the RIKEN Nishina Center. It consists of a charged-particle silicon tracker
coupled with a dedicated thick liquid hydrogen target (up to 150-mm long) in a
compact geometry to fit inside large scintillator or germanium arrays. Its
design was optimized for two types of studies using QFS: missing-mass
measurements and in-flight prompt -ray spectroscopy. This article
describes (i) the resolution requirements needed to go beyond the sensitivity
of existing systems for these two types of measurements, (ii) the conceptual
design of the system using detailed simulations of the setup and (iii) its
complete technical implementation and challenges. The final tracker aims at a
sub-mm reaction vertex resolution and is expected to reach a missing-mass
resolution below 2 MeV in for reactions when combined with
the CsI(Na) CATANA array.Comment: 25 pages, 29 figure
Study of spin-isospin responses of radioactive nuclei with the background-reduced neutron spectrometer, PANDORA
The status of a project to measure spin-isospin responses of neutron drip-line nuclei using a new low-energy neutron detector, PANDORA (Particle Analyzer Neutron Detector Of Real-time Acquisition), is reported. The performance of PANDORA was characterized by the 6He(p,n)6Li reaction in inverse kinematics at the HIMAC facility in Chiba. Observation of the strong transition to the ground state in 6Li is discussed. Preliminary results of 11Li(p,n)11Be and 14Be(p,n)14B experiments in inverse kinematics at RI Beam Factory (RIBF) of RIKEN Nishina Center are also presented including the exotic decay channel of 11Be→9Li + d. Details of the experimental setup based on PANDORA and the SAMURAI large-acceptance magnetic spectrometer, as well as the combined data-acquisition system are described. The neutron-gamma discrimination capability of PANDORA was evaluated, Figure-of-Merit (FoM) values higher than those found in the literature for similar materials were derived from experimental data
Intruder configurations in Ne at the transition into the island of inversion: Detailed structure study of Ne
Detailed -ray spectroscopy of the exotic neon isotope Ne has
been performed for the first time using the one-neutron removal reaction from
Ne on a liquid hydrogen target at 240~MeV/nucleon. Based on an analysis
of parallel momentum distributions, a level scheme with spin-parity assignments
has been constructed for Ne and the negative-parity states are
identified for the first time. The measured partial cross sections and momentum
distributions reveal a significant intruder -wave strength providing
evidence of the breakdown of the and shell gaps. Only a weak,
possible -wave strength was observed to bound final states. Large-scale
shell-model calculations with different effective interactions do not reproduce
the large -wave and small -wave strength observed experimentally,
indicating an ongoing challenge for a complete theoretical description of the
transition into the island of inversion along the Ne isotopic chain
Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model
Abstract
Background
Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19th century. Since then, it undergone considerable development. Our novel approach binds ligands to the tumor cell surface, which stimulates tumor phagocytosis. The therapeutic effect is further amplified by simultaneous application of agonists of Toll-like receptors. We searched for ligands that induce both a strong therapeutic effect and are safe for humans.
Methods
B16-F10 murine melanoma model was used. For the stimulation of phagocytosis, mannan or N-formyl-methionyl-leucyl-phenylalanine, was covalently bound to tumor cells or attached using hydrophobic anchor. The following agonists of Toll-like receptors were studied: monophosphoryl lipid A (MPLA), imiquimod (R-837), resiquimod (R-848), poly(I:C), and heat killed Listeria monocytogenes.
Results
R-848 proved to be the most suitable Toll-like receptor agonist for our novel immunotherapeutic approach. In combination with covalently bound mannan, R-848 significantly reduced tumor growth. Adding poly(I:C) and L. monocytogenes resulted in complete recovery in 83% of mice and in their protection from the re-transplantation of melanoma cells.
Conclusion
An efficient cancer treatment results from the combination of Toll-like receptor agonists and phagocytosis stimulating ligands bound to the tumor cells.http://deepblue.lib.umich.edu/bitstream/2027.42/134739/1/12885_2016_Article_2982.pd
Extending the Southern Shore of the Island of Inversion to F-28
Detailed spectroscopy of the neutron-unbound nucleus F-28 has been performed for the first time following proton/neutron removal from Ne-29/F-29 beams at energies around 230 MeV=nucleon. The invariant-mass spectra were reconstructed for both the F-27((*)) + n and F-26((*)) + 2n coincidences and revealed a series of well-defined resonances. A near-threshold state was observed in both reactions and is identified as the F-28 ground state, with S-n(F-28) = -199(6) keV, while analysis of the 2n decay channel allowed a considerably improved S-n(F-27) = 1620(60) keV to be deduced. Comparison with shell-model predictions and eikonal-model reaction calculations have allowed spin-parity assignments to be proposed for some of the lower-lying levels of F-28. Importantly, in the case of the ground state, the reconstructed F-27 + n momentum distribution following neutron removal from F-29 indicates that it arises mainly from the 1p(3/2) neutron intruder configuration. This demonstrates that the island of inversion around N = 20 includes F-28, and most probably F-29, and suggests that O-28 is not doubly magic
Border of the island of inversion:Unbound states in Ne 29
The nucleus Ne29 is situated at the border of the island of inversion. Despite significant efforts, no bound low-lying intruder f7/2 state, which would place Ne29 firmly inside the island of inversion, has yet been observed. Here, the first investigation of unbound states of Ne29 is reported. The states were populated in Ne30(p,pn) and Na30(p,2p) reactions at a beam energy of around 230 MeV/nucleon, and analyzed in terms of their resonance properties, partial cross sections, and momentum distributions. The momentum distributions are compared to calculations using the eikonal, direct reaction model, allowing ℓ assignments for the observed states. The lowest-lying resonance at an excitation energy of 1.48(4) MeV shows clear signs of a significant ℓ=3 component, giving first evidence for f7/2 single particle strength in Ne29. The excitation energies and strengths of the observed states are compared to shell-model calculations using the sdpf-u-mix interaction.</p
Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine
<p>Abstract</p> <p>Background</p> <p>Congenital Cytomegalovirus (CMV) infection is an important medical problem that has yet no current solution. A clinical trial of CMV glycoprotein B (gB) vaccine in young women showed promising efficacy. Improved understanding of the basis for prevention of CMV infection is essential for developing improved vaccines.</p> <p>Results</p> <p>We genotyped 142 women previously vaccinated with three doses of CMV gB for single nucleotide polymorphisms (SNPs) in TLR 1-4, 6, 7, 9, and 10, and their associated intracellular signaling genes. SNPs in the platelet-derived growth factor receptor (PDGFRA) and integrins were also selected based on their role in binding gB. Specific SNPs in TLR7 and IKBKE (inhibitor of nuclear factor kappa-B kinase subunit epsilon) were associated with antibody responses to gB vaccine. Homozygous carriers of the minor allele at four SNPs in TLR7 showed higher vaccination-induced antibody responses to gB compared to heterozygotes or homozygotes for the common allele. SNP rs1953090 in IKBKE was associated with changes in antibody level from second to third dose of vaccine; homozygotes for the minor allele exhibited lower antibody responses while homozygotes for the major allele showed increased responses over time.</p> <p>Conclusions</p> <p>These data contribute to our understanding of the immunogenetic mechanisms underlying variations in the immune response to CMV vaccine.</p
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