Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety

<p>Background: Melatonin is extensively used in the USA in a non-regulated manner for sleep disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for the short term treatment of primary insomnia in patients aged 55 years and over. However, a clear definition of the target patient population and well-controlled studies of long-term efficacy and safety are lacking. It is known that melatonin production declines with age. Some young insomnia patients also may have low melatonin levels. The study investigated whether older age or low melatonin excretion is a better predictor of response to PRM, whether the efficacy observed in short-term studies is sustained during continued treatment and the long term safety of such treatment.</p> <p>Methods: Adult outpatients (791, aged 18-80 years) with primary insomnia, were treated with placebo (2 weeks) and then randomized, double-blind to 3 weeks with PRM or placebo nightly. PRM patients continued whereas placebo completers were re-randomized 1:1 to PRM or placebo for 26 weeks with 2 weeks of single-blind placebo run-out. Main outcome measures were sleep latency derived from a sleep diary, Pittsburgh Sleep Quality Index (PSQI), Quality of Life (World Health Organzaton-5) Clinical Global Impression of Improvement (CGI-I) and adverse effects and vital signs recorded at each visit.</p> <p>Results: On the primary efficacy variable, sleep latency, the effects of PRM (3 weeks) in patients with low endogenous melatonin (6-sulphatoxymelatonin [6-SMT] ≤8 μg/night) regardless of age did not differ from the placebo, whereas PRM significantly reduced sleep latency compared to the placebo in elderly patients regardless of melatonin levels (-19.1 versus -1.7 min; P = 0.002). The effects on sleep latency and additional sleep and daytime parameters that improved with PRM were maintained or enhanced over the 6-month period with no signs of tolerance. Most adverse events were mild in severity with no clinically relevant differences between PRM and placebo for any safety outcome.</p> <p>Conclusions: The results demonstrate short- and long-term efficacy and safety of PRM in elderly insomnia patients. Low melatonin production regardless of age is not useful in predicting responses to melatonin therapy in insomnia. The age cut-off for response warrants further investigation.</p&gt

739 observed NEAs and new 2-4m survey statistics within the EURONEAR network

We report follow-up observations of 477 program Near-Earth Asteroids (NEAs) using nine telescopes of the EURONEAR network having apertures between 0.3 and 4.2 m. Adding these NEAs to our previous results we now count 739 program NEAs followed-up by the EURONEAR network since 2006. The targets were selected using EURONEAR planning tools focusing on high priority objects. Analyzing the resulting orbital improvements suggests astrometric follow-up is most important days to weeks after discovery, with recovery at a new opposition also valuable. Additionally we observed 40 survey fields spanning three nights covering 11 sq. degrees near opposition, using the Wide Field Camera on the 2.5m Isaac Newton Telescope (INT), resulting in 104 discovered main belt asteroids (MBAs) and another 626 unknown one-night objects. These fields, plus program NEA fields from the INT and from the wide field MOSAIC II camera on the Blanco 4m telescope, generated around 12,000 observations of 2,000 minor planets (mostly MBAs) observed in 34 square degrees. We identify Near Earth Object (NEO) candidates among the unknown (single night) objects using three selection criteria. Testing these criteria on the (known) program NEAs shows the best selection methods are our epsilon-miu model which checks solar elongation and sky motion and the MPC's NEO rating tool. Our new data show that on average 0.5 NEO candidates per square degree should be observable in a 2m-class survey (in agreement with past results), while an average of 2.7 NEO candidates per square degree should be observable in a 4m-class survey (although our Blanco statistics were affected by clouds). At opposition just over 100 MBAs (1.6 unknown to every 1 known) per square degree are detectable to R=22 in a 2m survey based on the INT data, while our two best ecliptic Blanco fields away from opposition lead to 135 MBAs (2 unknown to every 1 known) to R=23.Comment: Published in Planetary and Space Sciences (Sep 2013

Photoproduction of eta mesons from the neutron: cross sections and double polarization observable E

Photoproduction of $\eta$ mesons from neutrons} \abstract{Results from measurements of the photoproduction of $\eta$ mesons from quasifree protons and neutrons are summarized. The experiments were performed with the CBELSA/TAPS detector at the electron accelerator ELSA in Bonn using the $\eta\to3\pi^{0}\to6\gamma$ decay. A liquid deuterium target was used for the measurement of total cross sections and angular distributions. The results confirm earlier measurements from Bonn and the MAMI facility in Mainz about the existence of a narrow structure in the excitation function of $\gamma n\rightarrow n\eta$. The current angular distributions show a forward-backward asymmetry, which was previously not seen, but was predicted by model calculations including an additional narrow $P_{11}$ state. Furthermore, data obtained with a longitudinally polarized, deuterated butanol target and a circularly polarized photon beam were analyzed to determine the double polarization observable $E$. Both data sets together were also used to extract the helicity dependent cross sections $\sigma_{1/2}$ and $\sigma_{3/2}$. The narrow structure in the excitation function of $\gamma n\rightarrow n\eta$ appears associated with the helicity-1/2 component of the reaction

Feasibility studies of the time-like proton electromagnetic form factor measurements with PANDA at FAIR

The possibility of measuring the proton electromagnetic form factors in the time-like region at FAIR with the \PANDA detector is discussed. Detailed simulations on signal efficiency for the annihilation of $\bar p +p$ into a lepton pair as well as for the most important background channels have been performed. It is shown that precision measurements of the differential cross section of the reaction $\bar p +p \to e^++ e^-$ can be obtained in a wide angular and kinematical range. The individual determination of the moduli of the electric and magnetic proton form factors will be possible up to a value of momentum transfer squared of $q^2\simeq 14$ (GeV/c)$^2$. The total $\bar p +p\to e^++e^-$ cross section will be measured up to $q^2\simeq 28$ (GeV/c)$^2$. The results obtained from simulated events are compared to the existing data. Sensitivity to the two photons exchange mechanism is also investigated.Comment: 12 pages, 4 tables, 8 figures Revised, added details on simulations, 4 tables, 9 figure

Feasibility studies of time-like proton electromagnetic form factors at PANDA at FAIR

Simulation results for future measurements of electromagnetic proton form factors at \PANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel $\bar p p \to e^+ e^-$ is studied on the basis of two different but consistent procedures. The suppression of the main background channel, $\textit{i.e.}$ $\bar p p \to \pi^+ \pi^-$, is studied. Furthermore, the background versus signal efficiency, statistical and systematical uncertainties on the extracted proton form factors are evaluated using two different procedures. The results are consistent with those of a previous simulation study using an older, simplified framework. However, a slightly better precision is achieved in the PandaRoot study in a large range of momentum transfer, assuming the nominal beam conditions and detector performance

New data on γ⃗p⃗→ηp\vec{\gamma} \vec{p}\rightarrow \eta p with polarized photons and protons and their implications for N∗→NηN^* \to N\eta decays

The polarization observables $T, E, P, H$, and $G$ in photoproduction of $\eta$ mesons off protons are measured for photon energies from threshold to $W=2400\,$MeV ($T$), 2280 MeV ($E$), 1620 MeV ($P, H$), or 1820 MeV ($G$), covering nearly the full solid angle. The data are compared to predictions from the SAID, MAID, J\"uBo, and BnGa partial-wave analyses. A refit within the BnGa approach including further data yields precise branching ratios for the $N\eta$ decay of nucleon resonances. A $N\eta$-branching ratio of $0.33\pm 0.04$ for $N(1650)1/2^-$ is found, which reduces the large and controversially discussed $N\eta$-branching ratio difference of the two lowest mass $J^P=1/2^-$-resonances significantly.Comment: 10 pages, 11 figure