Normal transport properties for a classical particle coupled to a non-Ohmic bath

We study the Hamiltonian motion of an ensemble of unconfined classical particles driven by an external field F through a translationally-invariant, thermal array of monochromatic Einstein oscillators. The system does not sustain a stationary state, because the oscillators cannot effectively absorb the energy of high speed particles. We nonetheless show that the system has at all positive temperatures a well-defined low-field mobility over macroscopic time scales of order exp(-c/F). The mobility is independent of F at low fields, and related to the zero-field diffusion constant D through the Einstein relation. The system therefore exhibits normal transport even though the bath obviously has a discrete frequency spectrum (it is simply monochromatic) and is therefore highly non-Ohmic. Such features are usually associated with anomalous transport properties

Spin conductance, dynamic spin stiffness and spin diffusion in itinerant magnets

We discuss analogies between the charge- and spin response functions of itinerant magnets. We show that the spin-analog of the charge stiffness is not given by the usual spin stiffness rho_s, but by the dynamic spin stiffness D_s, which is obtained from the dynamic spin conductance G_s (omega) in the limit of vanishing frequency omega. The low-frequency behavior of G_s (omega) is used to define ideal spin conductors, normal spin conductors, and spin insulators. Assuming diffusive spin dynamics, we show that the spin diffusion coefficient is proportional to lim_{omega rightarrow 0} {Re} {G}_s (omega). We exploit this fact to develop a new extrapolation scheme for the spin diffusion coefficient in the paramagnetic phase of the Hubbard model.Comment: Discussion of gauge invariance and difference between transverse and longitudinal response added. Accepted for publication in Phys. Rev.

Finite-Temperature Transport in Finite-Size Hubbard Rings in the Strong-Coupling Limit

We study the current, the curvature of levels, and the finite temperature charge stiffness, D(T,L), in the strongly correlated limit, U>>t, for Hubbard rings of L sites, with U the on-site Coulomb repulsion and t the hopping integral. Our study is done for finite-size systems and any band filling. Up to order t we derive our results following two independent approaches, namely, using the solution provided by the Bethe ansatz and the solution provided by an algebraic method, where the electronic operators are represented in a slave-fermion picture. We find that, in the U=\infty case, the finite-temperature charge stiffness is finite for electronic densities, n, smaller than one. These results are essencially those of spinless fermions in a lattice of size L, apart from small corrections coming from a statistical flux, due to the spin degrees of freedom. Up to order t, the Mott-Hubbard gap is \Delta_{MH}=U-4t, and we find that D(T) is finite for n<1, but is zero at half-filling. This result comes from the effective flux felt by the holon excitations, which, due to the presence of doubly occupied sites, is renormalized to \Phi^{eff}=\phi(N_h-N_d)/(N_d+N_h), and which is zero at half-filling, with N_d and N_h being the number of doubly occupied and empty lattice sites, respectively. Further, for half-filling, the current transported by any eigenstate of the system is zero and, therefore, D(T) is also zero.Comment: 15 pages and 6 figures; accepted for PR

Heat transport by lattice and spin excitations in the spin chain compounds SrCuO_2 and Sr_2CuO_3

We present the results of measurements of the thermal conductivity of the quasi one-dimensional spin S=1/2 chain compound SrCuO_2 in the temperature range between 0.4 and 300 K along the directions parallel and perpendicular to the chains. An anomalously enhanced thermal conductivity is observed along the chains. The analysis of the present data and a comparison with analogous recent results for Sr_2CuO_3 and other similar materials demonstrates that this behavior is generic for cuprates with copper-oxygen chains and strong intrachain interactions. The observed anomalies are attributed to the one-dimensional energy transport by spin excitations (spinons), limited by the interaction between spin and lattice excitations. The energy transport along the spin chains has a non-diffusive character, in agreement with theoretical predictions for integrable models.Comment: 12 pages (RevTeX), 8 figure

Ballistic transport and boundary resistances in inhomogeneous quantum spin chains

Transport phenomena are central to physics, and transport in the many-body and fully-quantum regime is attracting an increasing amount of attention. It has been recently revealed that some quantum spin chains support ballistic transport of excitations at all energies. However, when joining two semi-infinite ballistic parts, such as the XX and XXZ spin-1/2 models, our understanding suddenly becomes less established. Employing a matrix-product-state ansatz of the wavefunction, we study the relaxation dynamics in this latter case. Here we show that it takes place inside a light cone, within which two qualitatively different regions coexist: an inner one with a strong tendency towards thermalization, and an outer one supporting ballistic transport. We comment on the possibility that even at infinite time the system supports stationary currents and displays a non-zero Kapitza boundary resistance. Our study paves the way to the analysis of the interplay between transport, integrability, and local defects

Exploring subtle land use and land cover changes: a framework for future landscape studies

UMR AMAP, équipe 3International audienceLand cover and land use changes can have a wide variety of ecological effects, including significant impacts on soils and water quality. In rural areas, even subtle changes in farming practices can affect landscape features and functions, and consequently the environment. Fine-scale analyses have to be performed to better understand the land cover change processes. At the same time, models of land cover change have to be developed in order to anticipate where changes are more likely to occur next. Such predictive information is essential to propose and implement sustainable and efficient environmental policies. Future landscape studies can provide a framework to forecast how land use and land cover changes is likely to react differently to subtle changes. This paper proposes a four step framework to forecast landscape futures at fine scales by coupling scenarios and landscape modelling approaches. This methodology has been tested on two contrasting agricultural landscapes located in the United States and France, to identify possible landscape changes based on forecasting and backcasting agriculture intensification scenarios. Both examples demonstrate that relatively subtle land cover and land use changes can have a large impact on future landscapes. Results highlight how such subtle changes have to be considered in term of quantity, location, and frequency of land use and land cover to appropriately assess environmental impacts on water pollution (France) and soil erosion (US). The results highlight opportunities for improvements in landscape modelling

Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

Development of semi-automated devices that can reduce the hands-on time and standardize the production of clinical-grade CAR T-cells, such as CliniMACS Prodigy from Miltenyi, is key to facilitate the development of CAR T-cell therapies, especially in academic institutions. However, the feasibility of manufacturing CAR T-cell products from heavily pre-treated patients with this system has not been demonstrated yet. Here we report and characterize the production of 28 CAR T-cell products in the context of a phase I clinical trial for CD19+ B-cell malignancies (NCT03144583). The system includes CD4-CD8 cell selection, lentiviral transduction and T-cell expansion using IL-7/IL-15. Twenty-seven out of 28 CAR T-cell products manufactured met the full list of specifications and were considered valid products. Ex vivo cell expansion lasted an average of 8.5 days and had a mean transduction rate of 30.6 ± 13.44%. All products obtained presented cytotoxic activity against CD19+ cells and were proficient in the secretion of pro-inflammatory cytokines. Expansion kinetics was slower in patient's cells compared to healthy donor's cells. However, product potency was comparable. CAR T-cell subset phenotype was highly variable among patients and largely determined by the initial product. TCM and TEM were the predominant T-cell phenotypes obtained. 38.7% of CAR T-cells obtained presented a TN or TCM phenotype, in average, which are the subsets capable of establishing a long-lasting T-cell memory in patients. An in-depth analysis to identify individual factors contributing to the optimal T-cell phenotype revealed that ex vivo cell expansion leads to reduced numbers of TN, TSCM, and TEFF cells, while TCM cells increase, both due to cell expansion and CAR-expression. Overall, our results show for the first time that clinical-grade production of CAR T-cells for heavily pre-treated patients using CliniMACS Prodigy system is feasible, and that the obtained products meet the current quality standards of the field. Reduced ex vivo expansion may yield CAR T-cell products with increased persistence in vivo

Assessing the efficiency of mother-to-child HIV prevention in low- and middle-income countries using data envelopment analysis

AIDS is one of the most significant health care problems worldwide. Due to the difficulty and costs involved in treating HIV, preventing infection is of paramount importance in controlling the AIDS epidemic. The main purpose of this paper is to explore the potential of using Data Envelopment Analysis (DEA) to establish international comparisons on the efficiency of implementation of HIV prevention programmes. To do this we use data from 52 low- and middle-income countries regarding the prevention of mother-to-child transmission of HIV. Our results indicate that there is a remarkable variation in the efficiency of prevention services across nations, suggesting that a better use of resources could lead to more and improved services, and ultimately, prevent the infection of thousands of children. These results also demonstrate the potential strategic role of DEA for the efficient and effective planning of scarce resources to fight the epidemic

Beneficial insects in agricultural landscapes: faunal, ecological and functional contributions of recent studies in the canton of Geneva (Switzerland)

Description of the subject. In the context of biodiversity maintenance in agricultural environments and of risk reduction related to the use of phytosanitary products, it seems essential to improve our knowledge of the beneficial insects that develop in these ecosystems.Objectives. This article reviews the state of knowledge regarding insect auxiliaries and highlights the main faunal, ecological and functional contributions from recent studies carried out in an agricultural context in Geneva.Method. Data were collected from 2014 to 2019 on several families of predatory and pollinating auxiliaries in various agricultural contexts (extensive grasslands, vineyards, orchards, rapeseed crops, vegetable crops) using Barber, Malaise and emergence traps.Results. 48,921 individual records were collected belonging to 477 species of the main families of auxiliaries. Of these, four species were observed for the first time in Switzerland and 50 in the canton of Geneva. 357 (+/- 75%) of the species had a predatory stage and 103 (+/- 22%) could be regarded as valuable crop auxiliaries. The use of emergence traps made it possible to attest that at least a third of the species, including some rare or threatened species, are able to successfully carry out their life cycles within agricultural environments or to use them as overwintering sites.Conclusions. This review increases our understanding of the composition of the biodiversity of agricultural environments, which constitutes a significant component of biodiversity in Switzerland and in neighboring countries. It also highlights the role of semi-natural habitats as extensive grasslands or inter-rows of vineyards in supporting the development of many rare and sometimes threatened species

Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment

Introduction: Ionizing radiation (IR) is a widely used approach to cancer therapy, ranking second only to surgery in rate of utilization. Responses of cancer patients to radiotherapy depend in part on the intrinsic radiosensitivity of the tumor cells. Thus, promoting tumor cell sensitivity to IR could significantly enhance the treatment outcome and quality of life for patients. Methods: Mammary tumor cells were treated by a 16-base phosphodiester-linked oligonucleotide homologous to the telomere G-rich sequence TTAGGG (T-oligo: GGTTAGGTGTAGGTTT) or a control-oligo (the partial complement, TAACCCTAACCCTAAC) followed by IR. The inhibition of tumor cell growth in vitro was assessed by cell counting and clonogenic cell survival assay. The tumorigenesis of tumor cells after various treatments was measured by tumor growth in mice. The mechanism underlying the radiosensitization by T-oligo was explored by immunofluorescent determination of phosphorylated histone H2AX ($\gamma$H2AX) foci, $\beta$-galactosidase staining, comet and Terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) assays. The efficacy of the combined treatment was assessed in a spontaneous murine mammary tumor model. Results: Pretreatment of tumor cells with T-oligo for 24 hours in vitro enhanced both senescence and apoptosis of irradiated tumor cells and reduced clonogenic potential. Radiosensitization by T-oligo was associated with increased formation and/or delayed resolution of $\gamma$H2AX DNA damage foci and fragmented DNA. T-oligo also caused radiosensitization in two in vivo mammary tumor models. Indeed, combined T-oligo and IR-treatment in vivo led to a substantial reduction in tumor growth. Of further significance, treatment with T-oligo and IR led to synergistic inhibition of the growth of spontaneous mammary carcinomas. Despite these profound antitumor properties, T-oligo and IR caused no detectable side effects under our experimental conditions. Conclusions: Pretreatment with T-oligo sensitizes mammary tumor cells to radiation in both in vitro and in vivo settings with minimal or no normal tissue side effects