65 research outputs found
MeV Right-handed Neutrinos and Dark Matter
We consider the possibility of having a MeV right-handed neutrino as a dark
matter constituent. The initial reason for this study was the 511 keV spectral
line observed by the satellite experiment INTEGRAL: could it be due to an
interaction between dark matter and baryons? Independently of this, we find a
number of constraints on the assumed right-handed interactions. They arise in
particular from the measurements by solar neutrino experiments. We come to the
conclusion that such particles interactions are possible, and could reproduce
the peculiar angular distribution, but not the rate of the INTEGRAL signal.
However, we stress that solar neutrino experiments are susceptible to provide
further constraints in the future.Comment: 7 pages, figure 1 changed, added reference
Calibration and Characterization of the IceCube Photomultiplier Tube
Over 5,000 PMTs are being deployed at the South Pole to compose the IceCube
neutrino observatory. Many are placed deep in the ice to detect Cherenkov light
emitted by the products of high-energy neutrino interactions, and others are
frozen into tanks on the surface to detect particles from atmospheric cosmic
ray showers. IceCube is using the 10-inch diameter R7081-02 made by Hamamatsu
Photonics. This paper describes the laboratory characterization and calibration
of these PMTs before deployment. PMTs were illuminated with pulses ranging from
single photons to saturation level. Parameterizations are given for the single
photoelectron charge spectrum and the saturation behavior. Time resolution,
late pulses and afterpulses are characterized. Because the PMTs are relatively
large, the cathode sensitivity uniformity was measured. The absolute photon
detection efficiency was calibrated using Rayleigh-scattered photons from a
nitrogen laser. Measured characteristics are discussed in the context of their
relevance to IceCube event reconstruction and simulation efforts.Comment: 40 pages, 12 figure
Limits on the high-energy gamma and neutrino fluxes from the SGR 1806-20 giant flare of December 27th, 2004 with the AMANDA-II detector
On December 27th 2004, a giant gamma flare from the Soft Gamma-ray Repeater
1806-20 saturated many satellite gamma-ray detectors. This event was by more
than two orders of magnitude the brightest cosmic transient ever observed. If
the gamma emission extends up to TeV energies with a hard power law energy
spectrum, photo-produced muons could be observed in surface and underground
arrays. Moreover, high-energy neutrinos could have been produced during the SGR
giant flare if there were substantial baryonic outflow from the magnetar. These
high-energy neutrinos would have also produced muons in an underground array.
AMANDA-II was used to search for downgoing muons indicative of high-energy
gammas and/or neutrinos. The data revealed no significant signal. The upper
limit on the gamma flux at 90% CL is dN/dE < 0.05 (0.5) TeV^-1 m^-2 s^-1 for
gamma=-1.47 (-2). Similarly, we set limits on the normalization constant of the
high-energy neutrino emission of 0.4 (6.1) TeV^-1 m^-2 s^-1 for gamma=-1.47
(-2).Comment: 14 pages, 3 figure
First year performance of the IceCube neutrino telescope
The first sensors of the IceCube neutrino observatory were deployed at the South Pole during the austral summer of 2004-2005 and have been producing data since February 2005. One string of 60 sensors buried in the ice and a surface array of eight ice Cherenkov tanks took data until December 2005 when deployment of the next set of strings and tanks began. We have analyzed these data, demonstrating that the performance of the system meets or exceeds design requirements. Times are determined across the whole array to a relative precision of better than 3 ns, allowing reconstruction of muon tracks and light bursts in the ice, of air-showers in the surface array and of events seen in coincidence by surface and deep-ice detectors separated by up to 2.5 km
Measurement of acoustic attenuation in South Pole ice
Using the South Pole Acoustic Test Setup (SPATS) and a retrievable transmitter deployed in holes drilled for the IceCube experiment, we have measured the attenuation of acoustic signals by South Pole ice at depths between 190 m and 500 m. Three data sets, using different acoustic sources, have been analyzed and give consistent results. The method with the smallest systematic uncertainties yields an amplitude attenuation coefficient α = 3.20 ± 0.57 kmâ1 between 10 and 30 kHz, considerably larger than previous theoretical estimates. Expressed as an attenuation length, the analyses give a consistent result for λ ⥠1/α of âŒ300 m with 20% uncertainty. No significant depth or frequency dependence has been found
Limits to the muon flux from neutralino annihilations in the Sun with the AMANDA detector
A search for an excess of muon-neutrinos from neutralino annihilations in the
Sun has been performed with the AMANDA-II neutrino detector using data
collected in 143.7 days of live-time in 2001. No excess over the expected
atmospheric neutrino background has been observed. An upper limit at 90%
confidence level has been obtained on the annihilation rate of captured
neutralinos in the Sun, as well as the corresponding muon flux limit at the
Earth, both as functions of the neutralino mass in the range 100 GeV-5000 GeV.Comment: 13 pages, 3 figures. Submitted to Astropart. Phy
Solar Energetic Particle Spectrum on 13 December 2006 Determined by IceTop
On 13 December 2006 the IceTop air shower array at the South Pole detected a
major solar particle event. By numerically simulating the response of the
IceTop tanks, which are thick Cherenkov detectors with multiple thresholds
deployed at high altitude with no geomagnetic cut-off, we determined the
particle energy spectrum in the energy range 0.6 to 7.6 GeV. This is the first
such spectral measurement using a single instrument with a well defined viewing
direction. We compare the IceTop spectrum and its time evolution with
previously published results and outline plans for improved resolution of
future solar particle spectra.Comment: To appear in Astrophysical Journal Letters, 6 pages, 4 figure
Time-integrated Searches for Point-like Sources of Neutrinos with the 40-string IceCube Detector
Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing
New protein functions can require complex sequence changes, but the minimal path is not well understood. The guanylate kinase enzyme (GKenz), which catalyzes phosphotransfer from ATP to GMP, evolved into the GK domain (GKdom), a protein-binding domain found in membrane associate guanylate kinases that function in mitotic spindle orientation and cell adhesion. Using an induced polarity assay for GKdom function, we show that a single serine to proline mutation is sufficient to switch extant GKenz into a functional GKdom. The mutation blocks catalysis (GKenz function) but allows protein binding and spindle orientation (GKdom function). Furthermore, whereas the GKenz undergoes a large closing motion upon GMP binding, fluorescence quenching and NMR demonstrate that the S â P mutation inhibits GMP-induced GK movements. Disrupting GK closing with a mutation at a different position also leads to GKdom function, suggesting that blocking the GKenz closing motion is sufficient for functional conversion of GKenz to GKdom. Although subtle changes in protein function can require complex sequence paths, our work shows that entirely new functions can arise from single mutations that alter protein dynamics
Definition, at the molecular level, of a thyroglobulin-acetylcholinesterase shared epitope: study of its pathophysiological significance in patients with Graves' ophthalmopathy.
The nature of the putative autoantigen in Graves' ophthalmopathy (Go) remains an enigma but the sequence similarity between thyroglobulin (Tg) and acetylcholinesterase (ACHE) provides a rationale for epitopes which are common to the thyroid gland and the eye orbit. In an attempt to define the shared epitope, we have screened a lambda gt 11 human thyroid cDNA library using a polyclonal antibody to Torpedo ACHE and isolated two clones, which upon sequencing, were shown to contain Tg segments, corresponding to portions of the C terminal part of the molecule which has a high similarity with ACHE. Having demonstrated the existence of an epitope common to Tg and ACHE, the clones have been further tested and found to be positive in lysis plaque assays with 1/10 sera from patients with Hashimoto's thyroiditis (HT), 8/8 from patients with Graves' ophthalmopathy and 0/8 normal sera. We have investigated the physiological significance of this common epitope by in situ immunolocalization studies in which the polyclonal antibody to Torpedo ACHE (which was used for screening the library) and immunoglobulins (Igs) from 6 Go patients tested were shown to bind to end plate regions of human foetal muscle fibres which were concurrently shown to be rich in cholinesterase activity: Igs from 3 normal individuals and 2 patients with Hashimoto's thyroiditis did not bind. The results demonstrate and characterize an epitope which is common to Tg and ACHE and show that Go patients Igs contain antibodies which bind to muscle end plates rich in cholinesterase. The significance of these findings to the pathogenesis of Go is discussed.Journal Articleinfo:eu-repo/semantics/publishe
- âŠ