8,574 research outputs found
Extending the range of error estimates for radial approximation in Euclidean space and on spheres
We adapt Schaback's error doubling trick [R. Schaback. Improved error bounds
for scattered data interpolation by radial basis functions. Math. Comp.,
68(225):201--216, 1999.] to give error estimates for radial interpolation of
functions with smoothness lying (in some sense) between that of the usual
native space and the subspace with double the smoothness. We do this for both
bounded subsets of R^d and spheres. As a step on the way to our ultimate goal
we also show convergence of pseudoderivatives of the interpolation error.Comment: 10 page
Improved power for TB phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods
The research leading to these results has received funding from the Swedish Research Council (grant number 521-2011-3442) in addition to the Innovative Medicines Initiative Joint Undertaking (www.imi.europe.eu) under grant agreement no. 115337, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies’ in kind contribution.Background : The demand for new anti-TB drugs is high, but development programmes are long and costly. Consequently there is a need for new strategies capable of accelerating this process. Objectives : To explore the power to find statistically significant drug effects using a model-based pharmacokinetic–pharmacodynamic approach in comparison with the methods commonly used for analysing TB Phase IIa trials. Methods : Phase IIa studies of four hypothetical anti-TB drugs (labelled A, B, C and D), each with a different mechanism of action, were simulated using the multistate TB pharmacometric (MTP) model. cfu data were simulated over 14 days for patients taking once-daily monotherapy at four different doses per drug and a reference (10 mg/kg rifampicin). The simulated data were analysed using t-test, ANOVA, mono- and bi-exponential models and a pharmacokinetic–pharmacodynamic model approach (MTP model) to establish their respective power to find a drug effect at the 5% significance level. Results : For the pharmacokinetic–pharmacodynamic model approach, t-test, ANOVA, mono-exponential model and bi-exponential model, the sample sizes needed to achieve 90% power were: 10, 30, 75, 20 and 30 (drug A); 30, 75, 245, 75 and 105 (drug B); 70, >1250, 315, >1250 and >1250 (drug C); and 30, 110, 710, 170 and 185 (drug D), respectively. Conclusions : A model-based design and analysis using a pharmacokinetic–pharmacodynamic approach can reduce the number of patients required to determine a drug effect at least 2-fold compared with current methodologies. This could significantly accelerate early-phase TB drug development.Publisher PDFPeer reviewe
InAs nanowire transistors with multiple, independent wrap-gate segments
We report a method for making horizontal wrap-gate nanowire transistors with
up to four independently controllable wrap-gated segments. While the step up to
two independent wrap-gates requires a major change in fabrication methodology,
a key advantage to this new approach, and the horizontal orientation more
generally, is that achieving more than two wrap-gate segments then requires no
extra fabrication steps. This is in contrast to the vertical orientation, where
a significant subset of the fabrication steps needs to be repeated for each
additional gate. We show that cross-talk between adjacent wrap-gate segments is
negligible despite separations less than 200 nm. We also demonstrate the
ability to make multiple wrap-gate transistors on a single nanowire using the
exact same process. The excellent scalability potential of horizontal wrap-gate
nanowire transistors makes them highly favourable for the development of
advanced nanowire devices and possible integration with vertical wrap-gate
nanowire transistors in 3D nanowire network architectures.Comment: 18 pages, 5 figures, In press for Nano Letters (DOI below
Influence of corruption on economic growth rate and foreign investments
In order to investigate whether government regulations against corruption can
affect the economic growth of a country, we analyze the dependence between
Gross Domestic Product (GDP) per capita growth rates and changes in the
Corruption Perceptions Index (CPI). For the period 1999-2004 on average for all
countries in the world, we find that an increase of CPI by one unit leads to an
increase of the annual GDP per capita by 1.7 %. By regressing only European
transition countries, we find that CPI = 1 generates increase of the
annual GDP per capita by 2.4 %. We also analyze the relation between foreign
direct investments received by different countries and CPI, and we find a
statistically significant power-law functional dependence between foreign
direct investment per capita and the country corruption level measured by the
CPI. We introduce a new measure to quantify the relative corruption between
countries based on their respective wealth as measured by GDP per capita.Comment: 8 pages, 3 figures, elsart styl
Phonons in random alloys: the itinerant coherent-potential approximation
We present the itinerant coherent-potential approximation(ICPA), an analytic,
translationally invariant and tractable form of augmented-space-based,
multiple-scattering theory in a single-site approximation for harmonic phonons
in realistic random binary alloys with mass and force-constant disorder.
We provide expressions for quantities needed for comparison with experimental
structure factors such as partial and average spectral functions and derive the
sum rules associated with them. Numerical results are presented for Ni_{55}
Pd_{45} and Ni_{50} Pt_{50} alloys which serve as test cases, the former for
weak force-constant disorder and the latter for strong. We present results on
dispersion curves and disorder-induced widths. Direct comparisons with the
single-site coherent potential approximation(CPA) and experiment are made which
provide insight into the physics of force-constant changes in random alloys.
The CPA accounts well for the weak force-constant disorder case but fails for
strong force-constant disorder where the ICPA succeeds.Comment: 19 pages, 12 eps figures, uses RevTex
The UK Research Assessment Exercise (RAE 2008) and retail research output
The 2008 Research Assessment Exercise (RAE) in the United Kingdom provides a further opportunity to consider changing trends and patters in retail research, following on a previous commentary (Dawson et al. 2004). This comparison with shows that pressures continue to mount and are impacting retail knowledge creation and dissemination practices, not least in terms of those engaged in retail research, the topics and approaches utilised, the publication tactics and strategies and thus the standing of retail research in the UK and its reputation internationall
Electromagnetic Cascades and Cascade Nucleosynthesis in the Early Universe
We describe a calculation of electromagnetic cascading in radiation and
matter in the early universe initiated by the decay of massive particles or by
some other process. We have used a combination of Monte Carlo and numerical
techniques which enables us to use exact cross sections, where known, for all
the relevant processes. In cascades initiated after the epoch of big bang
nucleosynthesis -rays in the cascades will photodisintegrate He,
producing He and deuterium. Using the observed He and deuterium
abundances we are able to place constraints on the cascade energy deposition as
a function of cosmic time. In the case of the decay of massive primordial
particles, we place limits on the density of massive primordial particles as a
function of their mean decay time, and on the expected intensity of decay
neutrinos.Comment: compressed and uuencoded postscript. We now include a comparison with
previous work of the photon spectrum in the cascade and the limits we
calculate for the density of massive particles. The method of calculation of
photon spectra at low energies has been improved. Most figures are revised.
Our conclusions are substantially unchange
Towards a first principles description of phonons in NiPt disordered alloys: the role of relaxation
Using a combination of density-functional perturbation theory and the
itinerant coherent potential approximation, we study the effects of atomic
relaxation on the inelastic incoherent neutron scattering cross sections of
disordered NiPt alloys. We build on previous work, where
empirical force constants were adjusted {\it ad hoc} to agree with experiment.
After first relaxing all structural parameters within the local-density
approximation for ordered NiPt compounds, density-functional perturbation
theory is then used to compute phonon spectra, densities of states, and the
force constants. The resulting nearest-neighbor force constants are first
compared to those of other ordered structures of different stoichiometry, and
then used to generate the inelastic scattering cross sections within the
itinerant coherent potential approximation. We find that structural relaxation
substantially affects the computed force constants and resulting inelastic
cross sections, and that the effect is much more pronounced in random alloys
than in ordered alloys.Comment: 8 pages, 3 eps figures, uses revtex
A First Comparison of the responses of a He4-based fast-neutron detector and a NE-213 liquid-scintillator reference detector
A first comparison has been made between the pulse-shape discrimination
characteristics of a novel He-based pressurized scintillation detector
and a NE-213 liquid-scintillator reference detector using an Am/Be mixed-field
neutron and gamma-ray source and a high-resolution scintillation-pulse
digitizer. In particular, the capabilities of the two fast neutron detectors to
discriminate between neutrons and gamma-rays were investigated. The NE-213
liquid-scintillator reference cell produced a wide range of scintillation-light
yields in response to the gamma-ray field of the source. In stark contrast, due
to the size and pressure of the He gas volume, the He-based
detector registered a maximum scintillation-light yield of 750~keV to
the same gamma-ray field. Pulse-shape discrimination for particles with
scintillation-light yields of more than 750~keV was excellent in the
case of the He-based detector. Above 750~keV its signal was
unambiguously neutron, enabling particle identification based entirely upon the
amount of scintillation light produced.Comment: 23 pages, 7 figures, Nuclear Instruments and Methods in Physics
Research Section A review addresse
Spectroscopy of Sc and ab initio calculations of strengths
The GRIFFIN spectrometer at TRIUMF-ISAC has been used to study excited states
and transitions in Sc following the -decay of Ca.
Branching ratios were determined from the measured -ray intensities,
and angular correlations of rays have been used to firmly assign the
spins of excited states. The presence of an isomeric state that decays by an
transition with a strength of 13.6(7)\,W.u. has been confirmed. We
compare with the first {\it ab initio} calculations of ) strengths in
light and medium-mass nuclei from the valence-space in-medium similarity
renormalization group approach, using consistently derived effective
Hamiltonians and operator. The experimental data are well reproduced for
isoscalar transitions when using bare -factors, but the strength of
isovector transitions are found to be underestimated by an order of
magnitude
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