Organic production systems in Northern highbush blueberries

The production of highbush blueberries is increasing worldwide. Organic production of blueberries in Sweden is presently very limited but is expected to have a great potential to expand as the berries are popular and have a good shelf life. The fact that blueberries require acid soils raises several questions concerning suitable substrates in combination with mycorrhizal inoculation and fertilization in organic production systems. Field and pot experiments have been established during 2011 and 2012 with the aim of developing a sustainable production system for high quality organic blueberries. After the second experimental year, total fruit yields were similar for plants grown in a plastic tunnel and in the open field. Yields were not affected by the addition of 10% forest soil to the peat-based substrate. Inoculation with ericoid mycorrhizal fungi had little effect on shoot length in a greenhouse pot experiment. Blueberries may be particularly suitable for organic production as the need for fertilizers is low combined with a relatively low disease pressure on the blueberry crop in the Nordic countries. The Swedish blueberry production might be expected to expand in the near future. The development of a successful and resource-efficient growing system for organic blueberries may encourage new blueberry growers to chose organic production

An analysis of the Bayesian track labelling problem

In multi-target tracking (MTT), the problem of assigning labels to tracks (track labelling) is vastly covered in literature, but its exact mathematical formulation, in terms of Bayesian statistics, has not been yet looked at in detail. Doing so, however, may help us to understand how Bayes-optimal track labelling should be performed or numerically approximated. Moreover, it can help us to better understand and tackle some practical difficulties associated with the MTT problem, in particular the so-called ``mixed labelling'' phenomenon that has been observed in MTT algorithms. In this memorandum, we rigorously formulate the optimal track labelling problem using Finite Set Statistics (FISST), and look in detail at the mixed labeling phenomenon. As practical contributions of the memorandum, we derive a new track extraction formulation with some nice properties and a statistic associated with track labelling with clear physical meaning. Additionally, we show how to calculate this statistic for two well-known MTT algorithms

Extending the range of error estimates for radial approximation in Euclidean space and on spheres

We adapt Schaback's error doubling trick [R. Schaback. Improved error bounds for scattered data interpolation by radial basis functions. Math. Comp., 68(225):201--216, 1999.] to give error estimates for radial interpolation of functions with smoothness lying (in some sense) between that of the usual native space and the subspace with double the smoothness. We do this for both bounded subsets of R^d and spheres. As a step on the way to our ultimate goal we also show convergence of pseudoderivatives of the interpolation error.Comment: 10 page

On the utility of dreaming: a general model for how learning in artificial agents can benefit from data hallucination

We consider the benefits of dream mechanisms – that is, the ability to simulate new experiences based on past ones – in a machine learning context. Specifically, we are interested in learning for artificial agents that act in the world, and operationalize “dreaming” as a mechanism by which such an agent can use its own model of the learning environment to generate new hypotheses and training data. We first show that it is not necessarily a given that such a data-hallucination process is useful, since it can easily lead to a training set dominated by spurious imagined data until an ill-defined convergence point is reached. We then analyse a notably successful implementation of a machine learning-based dreaming mechanism by Ha and Schmidhuber (Ha, D., & Schmidhuber, J. (2018). World models. arXiv e-prints, arXiv:1803.10122). On that basis, we then develop a general framework by which an agent can generate simulated data to learn from in a manner that is beneficial to the agent. This, we argue, then forms a general method for an operationalized dream-like mechanism. We finish by demonstrating the general conditions under which such mechanisms can be useful in machine learning, wherein the implicit simulator inference and extrapolation involved in dreaming act without reinforcing inference error even when inference is incomplete

Mixed Representation RPA Calculation for Octupole Excitations on Superdeformed Sates in the 40Ca and Neutron-Rich Sulfur Regions

By means of the mixed representation RPA based on the Skyrme-Hartree-Fock mean field, we investigate low-frequency octupole excitations built on the superdeformed (SD) states in the N=Z nuclei around 40Ca and the neutron-rich Sulfur isotopes. The RPA calculation is carried out fully self-consistently on the three-dimensional Cartesian mesh in a box, and yields a number of low-frequency octupole vibrations built on the SD states in 32S, 36Ar, 40Ca and 44Ti. In particular, a strongly collective K^\pi=1^- octupole vibration is suggested to appear on top of the SD state in 40Ca. For 48,50S close to the neutron drip line, we find that the low-lying state created by the excitation of a single neutron from a loosely bound low Omega level to a high Omega resonance level acquires an extremely strong octupole transition strength due to the spatially very extended structure of the particle-hole wave functions.Comment: 22 pages, 7 figure

Phonons in random alloys: the itinerant coherent-potential approximation

We present the itinerant coherent-potential approximation(ICPA), an analytic, translationally invariant and tractable form of augmented-space-based, multiple-scattering theory in a single-site approximation for harmonic phonons in realistic random binary alloys with mass and force-constant disorder. We provide expressions for quantities needed for comparison with experimental structure factors such as partial and average spectral functions and derive the sum rules associated with them. Numerical results are presented for Ni_{55} Pd_{45} and Ni_{50} Pt_{50} alloys which serve as test cases, the former for weak force-constant disorder and the latter for strong. We present results on dispersion curves and disorder-induced widths. Direct comparisons with the single-site coherent potential approximation(CPA) and experiment are made which provide insight into the physics of force-constant changes in random alloys. The CPA accounts well for the weak force-constant disorder case but fails for strong force-constant disorder where the ICPA succeeds.Comment: 19 pages, 12 eps figures, uses RevTex

Improved power for TB phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods

The research leading to these results has received funding from the Swedish Research Council (grant number 521-2011-3442) in addition to the Innovative Medicines Initiative Joint Undertaking (www.imi.europe.eu) under grant agreement no. 115337, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies’ in kind contribution.Background : The demand for new anti-TB drugs is high, but development programmes are long and costly. Consequently there is a need for new strategies capable of accelerating this process. Objectives : To explore the power to find statistically significant drug effects using a model-based pharmacokinetic–pharmacodynamic approach in comparison with the methods commonly used for analysing TB Phase IIa trials. Methods : Phase IIa studies of four hypothetical anti-TB drugs (labelled A, B, C and D), each with a different mechanism of action, were simulated using the multistate TB pharmacometric (MTP) model. cfu data were simulated over 14 days for patients taking once-daily monotherapy at four different doses per drug and a reference (10 mg/kg rifampicin). The simulated data were analysed using t-test, ANOVA, mono- and bi-exponential models and a pharmacokinetic–pharmacodynamic model approach (MTP model) to establish their respective power to find a drug effect at the 5% significance level. Results : For the pharmacokinetic–pharmacodynamic model approach, t-test, ANOVA, mono-exponential model and bi-exponential model, the sample sizes needed to achieve 90% power were: 10, 30, 75, 20 and 30 (drug A); 30, 75, 245, 75 and 105 (drug B); 70, >1250, 315, >1250 and >1250 (drug C); and 30, 110, 710, 170 and 185 (drug D), respectively. Conclusions : A model-based design and analysis using a pharmacokinetic–pharmacodynamic approach can reduce the number of patients required to determine a drug effect at least 2-fold compared with current methodologies. This could significantly accelerate early-phase TB drug development.Publisher PDFPeer reviewe

Results of matching valve and root repair to aortic valve and root pathology

ObjectiveFor patients with aortic root pathology and aortic valve regurgitation, aortic valve replacement is problematic because no durable bioprosthesis exists, and mechanical valves require lifetime anticoagulation. This study sought to assess outcomes of combined aortic valve and root repair, including comparison with matched bioprosthesis aortic valve replacement.MethodsFrom November 1990 to January 2005, 366 patients underwent modified David reimplantation (n = 72), root remodeling (n = 72), or valve repair with sinotubular junction tailoring (n = 222). Active follow-up was 99% complete, with a mean of 5.6 ± 4.0 years (maximum 17 years); follow-up for vital status averaged 8.5 ± 3.6 years (maximum 19 years). Propensity-adjusted models were developed for fair comparison of outcomes.ResultsThirty-day and 5-, 10-, and 15-year survivals were 98%, 86%, 74%, and 58%, respectively, similar to that of the US matched population and better than that after bioprosthesis aortic valve replacement. Propensity-score–adjusted survival was similar across procedures (P > .3). Freedom from reoperation at 30 days and 5 and 10 years was 99%, 92%, and 89%, respectively, and was similar across procedures (P > .3) after propensity-score adjustment. Patients with tricuspid aortic valves were more likely to be free of reoperation than those with bicuspid valves at 10 years (93% vs 77%, P = .002), equivalent to bioprosthesis aortic valve replacement and superior after 12 years. Bioprostheses increasingly deteriorated after 7 years, and hazard functions for reoperation crossed at 7 years.ConclusionsValve preservation (rather than replacement) and matching root procedures have excellent early and long-term results, with increasing survival benefit at 7 years and fewer reoperations by 12 years. We recommend this procedure for experienced surgical teams