14 research outputs found
Selective alkylation of pyrimidyl- dianions: Synthesis and purification of 11C labeled thymidine for tumor visualization using positron emission tomography
No full textA remotely controlled production system for routine preparation of [methyl-11C]thymidine
No full textSynthesis of 11C-labelled thymidine for tumor visualization using positron emission tomography
Full text linkA no-carrier added synthesis of [11C]thymidine from cyclotron produced [11C]methyl iodide is presented. The bis-silylated derivative of the lithium salt of 5-bromo-2'-deoxyuridine is treated with [11C]methyl iodide in THF at -50[deg]C giving 20-30 mCi [11C]thymidine in a 40-70% radiochemical yield. Purification is performed by reversed phase chromatography on a C18 column. The whole procedure takes 25 min and the specific activity is about 20-30 mCi/[mu]mol at the end of the synthesis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28118/1/0000567.pd
Radiosyntheses of labeled β-pseudothymidine ([C-11]- and [H-3]methyl) and its biodistribution and metabolism in normal and tumored mice
No full textHigh performance liquid chromatography of Carbon-11 labeled thymidine and its major catabolites for clinical PET studies
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Behind Fluorodeoxy-Glucose: the Role of Positron Emission Tomography/Computed Tomography for Fluorine-18 Labelled PET-Tracer Imaging
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