Thyratron-switched modular CO2 TEA laser for infrared photochemical studies.

A thyratron-switched ultraviolet pre-ionised CO2 TEA laser consisting of four modules connected in series has been designed and constructed. The laser can be operated in the TEM 00 mode and is able to produce 2.5 J per pulse. The design and operation of the laser as a tool for infrared studies is discussed together with an evaluation of the effect of operating parameters on output characteristics

High repetition rate Q-switched CO2 laser.

A rotating mirror Q-switched CO2 laser was designed and constructed for use as an excitation source in infrared fluorescence studies. Output power of 33 W was reached in the continuous wave (CW) mode. In the pulsed mode peak powers of 3 kW and pulse widths of 200 ns FWHM have been measured. The repetition rate may be varied between 275 and 1000 Hz and single line operation is selectable with a diffraction grating. The design is compact and economical. The laser has shown freedom from electrical noise and average power stability of the order of 1 per cent; it has operated reliably for more than 1000 hours with a minimum of maintenance

Real time Faraday spectrometer

This invention is comprised of a charged particle spectrometer that contains a detection system which embodies the benefits of both foil-light emissions and faraday cups, yet it does not interfere with the particle beam. 5 Figs. (GHH

Large-scale H I in nearby radio galaxies - II. The nature of classical low-power radio sources

An important aspect of solving the long-standing question as to what triggers various types of active galactic nuclei (AGN) involves a thorough understanding of the overall properties and formation history of their host galaxies. This is the second in a series of papers that systematically study the large-scale properties of cold neutral hydrogen (H I) gas in nearby radio galaxies. The main goal is to investigate the importance of gas-rich galaxy mergers and interactions among radio-loud AGN. In this paper, we present results of a complete sample of classical low-power radio galaxies. We find that extended Fanaroff & Riley type-I radio sources are generally not associated with gas-rich galaxy mergers or ongoing violent interactions, but occur in early-type galaxies without large (>rsim 108 M⊙) amounts of extended neutral hydrogen gas. In contrast, enormous discs/rings of H I gas (with sizes up to 190 kpc and masses up to 2 × 1010 M⊙) are detected around the host galaxies of a significant fraction of the compact radio sources in our sample. This segregation in H I mass with radio-source size likely indicates that either these compact radio sources are confined by large amounts of gas in the central region or that their fuelling is inefficient and different from the fuelling process of classical FR I radio sources. To first order, the overall H I properties of our complete sample (detection rate, mass and morphology) appear similar to those of radio-quiet early-type galaxies. If confirmed by better statistics, this would imply that low-power radio-AGN activity may be a short and recurrent phase that occurs at some point during the lifetime of many early-type galaxies

The Struve-Sahade effect in the optical spectra of O-type binaries I. Main-sequence systems

We present a spectroscopic analysis of four massive binary systems that are known or are good candidates to display the Struve-Sahade effect (defined as the apparent strengthening of the secondary spectrum of the binary when the star is approaching, and the corresponding weakening of the lines when it is receding). We use high resolution optical spectra to determine new orbital solutions and spectral types of HD 165052, HD 100213, HD 159176 and DH Cep. As good knowledge of the fundamental parameters of the considered systems is necessary to examine the Struve-Sahade effect. We then study equivalent width variations in the lines of both components of these binaries during their orbital cycle. In the case of these four systems, variations appear in the equivalent widths of some lines during the orbital cycle, but the definition given above can any longer be valid, since it is now clear that the effect modifies the primary spectrum as much as the secondary spectrum. Furthermore, the lines affected, and the way in which they are affected, depend on the considered system. For at least two of them (HD 100213 and HD 159176) these variations probably reflect the ellipsoidal variable nature of the system.Comment: 12 pages, 20 figures, in press A&

Nephrological aspects of surgical weight correction in morbid obesity

Obesity, including morbid obesity, is a growing worldwide problem. The adverse effect of obesity on the kidneys is associated with the development of comorbid conditions, such as insulin resistance (IR), metabolic syndrome (MS), diabetes mellitus (DM), arterial hypertension (AH), which are the recognized risk factors of chronic kidney disease (СKD). Obesity also causes direct kidney damage with the development of non-immune focal segmental glomerulosclerosis. The leading pathophysiological mechanisms of kidney damage in obesity are intrarenal hemodynamic disorders with the formation of hyperfiltration and damaging effects of adipokines produced by adipose tissue. Bariatric surgery (BS) has taken a leading position in the treatment of morbid obesity, demonstrating its effectiveness not only in long-term weight loss, but also in the correction of IR, MS, DM, AH. Nephroprotective effect of significant and persistent weight loss is caused by the elimination of hyperfiltration and damaging effect of adipokines. Results of the observational studies of the immediate and long-term effects of BS have demonstrated positive renal outcomes, in particular, the decrease in albuminuria/proteinuria, the improvement or stabilization of glomerular filtration rate, the delay of end-stage renal failure development; surgical correction of body weight in dialysis patients with morbid obesity lets them realize subsequent kidney transplantation. Large, randomized prospective studies with a longer follow-up are needed; analysis of the long-term renal consequences of BS in obesity patients with pre-existing renal impairment, including dialysis patients, is required; stratification of the BS risk of renal complications (acute kidney damage, nephrolithiasis, nephrocalcinosis) and effective strategy for managing these risks need to be developed

The Banana Project. III. Spin-orbit Alignment in the Long-period Eclipsing Binary NY Cephei

Binaries are not always neatly aligned. Previous observations of the DI Her system showed that the spin axes of both stars are highly inclined with respect to one another and the orbital axis. Here we report on a measurement of the spin-axis orientation of the primary star of the NY Cep system, which is similar to DI Her in many respects: it features two young early-type stars (~6 Myr, B0.5V+B2V), in an eccentric and relatively long-period orbit (e=0.48, P=15.d3). The sky projections of the rotation vector and the spin vector are well-aligned (beta_p = 2 +- 4 degrees), in strong contrast to DI Her. Although no convincing explanation has yet been given for the misalignment of DI Her, our results show that the phenomenon is not universal, and that a successful theory will need to account for the different outcome in the case of NY Cep.Comment: accepted for publication in Ap

Neutral Gas Outflows and Inflows in Infrared-Faint Seyfert Galaxies

Previous studies of the Na I D interstellar absorption line doublet have shown that galactic winds occur in most galaxies with high infrared luminosities. However, in infrared-bright composite systems where a starburst coexists with an active galactic nucleus (AGN), it is unclear whether the starburst, the AGN, or both are driving the outflows. The present paper describes the results from a search for outflows in 35 infrared-faint Seyferts with 10^9.9 < L_IR/L_sun < 10^11, or, equivalently, star formation rates (SFR) of ~0.4 -- 9 solar masses per year, to attempt to isolate the source of the outflow. We find that the outflow detection rates for the infrared-faint Seyfert 1s (6%) and Seyfert 2s (18%) are lower than previously reported for infrared-luminous Seyfert 1s (50%) and Seyfert 2s (45%). The outflow kinematics of infrared-faint and infrared-bright Seyfert 2 galaxies resemble those of starburst galaxies, while the outflow velocities in Seyfert 1 galaxies are significantly larger. Taken together, these results suggest that the AGN does not play a significant role in driving the outflows in most infrared-faint and infrared-bright systems, except the high-velocity outflows seen in Seyfert 1 galaxies. Another striking result of this study is the high rate of detection of inflows in infrared-faint galaxies (39% of Seyfert 1s, 35% of Seyfert 2s), significantly larger than in infrared-luminous Seyferts (15%). This inflow may be contributing to the feeding of the AGN in these galaxies, and potentially provides more than enough material to power the observed nuclear activity over typical AGN lifetimes.Comment: 17 pages, 12 figures, published in ApJ (article updated 12/30/09

Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests

The increase in cellular radiosensitivity by EGF receptor (EGFR) inhibition has been shown to be attributable to the induction of a G1-arrest in p53-proficient cells. Because EGFR targeting in combination with radiotherapy is used to treat head and neck squamous cell carcinomas (HNSCC) which are predominantly p53 mutated, we tested the effects of EGFR targeting on cellular radiosensitivity, proliferation, apoptosis, DNA repair and cell cycle control using a large panel of HNSCC cell lines. In these experiments EGFR targeting inhibited signal transduction, blocked proliferation and induced radiosensitization but only in some cell lines and only under normal (pre-plating) conditions. This sensitization was not associated with impaired DNA repair (53BP1 foci) or induction of apoptosis. However, it was associated with the induction of a lasting G2-arrest. Both, the radiosensitization and the G2-arrest were abrogated if the cells were re-stimulated (delayed plating) with actually no radiosensitization being detectable in any of the 14 tested cell lines. Therefore we conclude that EGFR targeting can induce a reversible G2 arrest in p53 deficient HNSCC cells, which does not consequently result in a robust cellular radiosensitization. Together with recent animal and clinical studies our data indicate that EGFR inhibition is no effective strategy to increase the radiosensitivity of HNSCC cells.</p

Observation of light echoes around very young stars

The goal of the paper is to present new results on light echoes from young stellar objects. Broad band CCD images were obtained over three months at one-to-two week intervals for the field of NGC 6726, using the large field-of-view remotely-operated telescope on top of Cerro Burek. We detected scattered light echoes around two young, low-amplitude, irregular variable stars. Observations revealed not just one, but multiple light echoes from brightness pulses of the T Tauri star S CrA and the Herbig Ae/Be star R CrA. Analysis of S CrA's recurring echoes suggests that the star is located 138 +/- 16 pc from Earth, making these the closest echoes ever detected. The environment that scatters the stellar light from S CrA is compatible with an incomplete dust shell or an inclined torus some 10,000 AU in radius and containing $\sim$ $2 \times 10^{-3}$ M_{\sun} of dust. The cause of such concentration at $\sim$ 10,000AU from the star is unknown. It could be the remnant of the envelope from which the star formed, but the distance of the cloud is remarkably similar to the nominal distance of the Oort cloud to the Sun, leading us to also speculate that the dust (or ice) seen around S CrA might have the same origin as the Solar System Oort cloud.Comment: A&A, in press Received: 16 March 2010 / Accepted: 01 June 201