The conception of Bildung-Psychology and the potential of its structural model

Bildungspsychologie beschäftigt sich aus psychologischer Perspektive mit Bildungsprozessen sowie mit den Bedingungen, die diese Prozesse gemäß psychologischer Theorien beeinflussen. Drei Dimensionen stecken den thematischen Rahmen des Faches ab: (I) die individuelle Bildungskarriere, welche die gesamte Lebensspanne inkludiert, (II) die Aufgabenbereiche sowie (III) die relevanten Handlungsebenen. Die Potentiale der Bildungspsychologie und ihres Strukturmodells werden anhand eines Beispiels zur Gewaltprävention in Schulen illustriert. (DIPF/Orig.)Bildung-Psychology is dealing with educational processes as well as with the conditions influencing these processes. This is always done from the perspective of psychology. The thematic frame of this discipline is defined by three dimensions: (I) the chronological educational career of an individual, (II) the fields of activities and (III) the several levels of these activities. The potential of Bildung-Psychology and its structural model will be illustrated using the sample case of violence prevention in school. (DIPF/Orig.

Vaccination with SARS-CoV-2 variants of concern protects mice from challenge with wild-type virus.

Funder: open philanthropy projectFunder: jpb foundationVaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been highly efficient in protecting against Coronavirus Disease 2019 (COVID-19). However, the emergence of viral variants that are more transmissible and, in some cases, escape from neutralizing antibody responses has raised concerns. Here, we evaluated recombinant protein spike antigens derived from wild-type SARS-CoV-2 and from variants B.1.1.7, B.1.351, and P.1 for their immunogenicity and protective effect in vivo against challenge with wild-type SARS-CoV-2 in the mouse model. All proteins induced high neutralizing antibodies against the respective viruses but also induced high cross-neutralizing antibody responses. The decline in neutralizing titers between variants was moderate, with B.1.1.7-vaccinated animals having a maximum fold reduction of 4.8 against B.1.351 virus. P.1 induced the most cross-reactive antibody responses but was also the least immunogenic in terms of homologous neutralization titers. However, all antigens protected from challenge with wild-type SARS-CoV-2 in a mouse model

The Iowa Homemaker vol.18, no.6

A College Girl’s Creed by Ruth Jensen, page 1 Tea Timing in Taste by Harriet Beyer, page 2 You and I and Radio by Berniece Williams, page 3 Your Fortune in Fashion by Ruth Hubley Thayer, page 4 Flashes from the Field of Research by Myrtle Campbell, page 5 From Cellulose to Satin by Audrey Wells, page 6 Sally Suggests Wardrobe Resolutions by Barbara Field, page 7 What’s New in Home Economics edited by Marjorie Pettinger, page 8 Good Light for Good Sight by Virginia Thompson, page 10 Centerpiece Styles by Nancy Fifield, page 11 Explore Your Vocation by Helen Greene, page 12 Alums in the News by Grace Strohmeier, page 13 Behind Bright Jackets edited by Winnifred Cannon, page 14 Does Your Vocabulary Date You? by Eleanor White, page 15 Keeping Posted by the editor, page 1

The Iowa Homemaker vol.18, no.9

Collegiate Exchange by Edith Wahrenbrock, page 1 Spring Sports in the Spot Light by Jean Ary, page 2 Camera Cuisine by Virginia Rundberg, page 3 Freshmen are Vitamin Conscious by Eleanor White, page 4 Around the World in Home Economics by Ruth Stutz, page 5 Style Notes for Spring by Barbara Field, page 6 Fur Facts by Betty Feyder, page 7 What’s New in Home Economics edited by Marjorie Pettinger, page 8 Behind Bright Jackets edited by June Adams, page 10 Figure Juggling by Dorothy Goeppinger, page 11 Alums in the News by Grace Strohmeier, page 12 Cures for Room-atism by Loretta Kelly, page 13 Enter – Spring! By Ruth Jensen, page 14 Help Yourself to a Helpful Hint by Dorothy Anne Roost, page 15 Application Aids by Dorothy Finnessey, page 16 Keeping Posted by the editor, page 1

Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase

Most organisms synthesise the B(6) vitamer pyridoxal 5-phosphate (PLP) via the glutamine amidotransferase PLP synthase, a large enzyme complex of 12 Pdx1 synthase subunits with up to 12 Pdx2 glutaminase subunits attached. Deletion analysis revealed that the C-terminus has four distinct functionalities: assembly of the Pdx1 monomers, binding of the pentose substrate (ribose 5-phosphate), formation of the reaction intermediate I(320), and finally PLP synthesis. Deletions of distinct C-terminal regions distinguish between these individual functions. PLP formation is the only function that is conferred to the enzyme by the C-terminus acting in trans, explaining the cooperative nature of the complex

TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance

Abstract Ligands addressed to the mitochondrial Translocator Protein (TSPO) have been suggested as cell death/life and steroidogenesis modulators. Thus, TSPO ligands have been proposed as drug candidates in several diseases; nevertheless, a correlation between their binding affinity and in vitro efficacy has not been demonstrated yet, questioning the specificity of the observed effects. Since drug-target residence time is an emerging parameter able to influence drug pharmacological features, herein, the interaction between TSPO and irDE-MPIGA, a covalent TSPO ligand, was investigated in order to explore TSPO control on death/life processes in a standardized glioblastoma cell setting. After 90 min irDE-MPIGA cell treatment, 25 nM ligand concentration saturated irreversibly all TSPO binding sites; after 24 h, TSPO de-novo synthesis occurred and about 40 % TSPO binding sites resulted covalently bound to irDE-MPIGA. During cell culture treatments, several dynamic events were observed: (a) early apoptotic markers appeared, such as mitochondrial membrane potential collapse (at 3 h) and externalization of phosphatidylserine (at 6 h); (b) cell viability was reduced (at 6 h), without cell cycle arrest. After digitonin-permeabilized cell suspension treatment, a modulation of mitochondrial permeability transition pore was evidenced. Similar effects were elicited by the reversible TSPO ligand PIGA only when applied at micromolar dose. Interestingly, after 6 h, irDE-MPIGA cell exposure restored cell survival parameters. These results highlighted the ligand-target residence time and the cellular setting are crucial parameters that should be taken into account to understand the drug binding affinity and efficacy correlation and, above all, to translate efficiently cellular drug responses from bench to bedside

Risk and safety requirements for diagnostic and therapeutic procedures in allergology : World Allergy Organization Statement

Peer reviewe