10 research outputs found
Cdk Phosphorylation of a Nucleoporin Controls Localization of Active Genes through the Cell Cycle
The localization of active genes to the nuclear periphery is regulated through the cell cycle by Cdk1 phosphorylation of a single nuclear pore protein
Providing Risk of the Environment’s Changing Climate Threats for Galleries, Libraries, Archives, & Museums (PROTECCT-GLAM) Data File
The data file was created as part of the IMLS-funded project, PROTECCT-GLAM: Risk of The Environment’s Changing Climate Threats for Galleries, Libraries, Archives, and Museums in an effort to gather the identities and georeferences of all galleries, libraries, archives, and museums located within the United States.
The data file includes 22,388 archives, 21,189 libraries, and 29,781 museums
Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway
Effects of Jumping Exercise on Muscular Power in Older Adults: A Meta-Analysis.
Background Jump training (JT) can be used to enhance the ability of skeletal muscle to exert maximal force in as short a time as possible. Despite its usefulness as a method of performance enhancement in athletes, only a small number of studies have investigated its effects on muscle power in older adults.
Objectives The aims of this meta-analysis were to measure the effect of JT on muscular power in older adults (≥ 50 years), and to establish appropriate programming guidelines for this population.
Data sources The data sources utilised were Google Scholar, PubMed, and Microsoft Academic.
Study eligibility criteria Studies were eligible for inclusion if they comprised JT interventions in healthy adults (≥ 50 years) who were free of any medical condition that could impair movement.
Study appraisal and synthesis methods The inverse variance random-effects model for meta-analyses was used because it allocates a proportionate weight to trials based on the size of their individual standard errors and facilitates analysis while accounting for heterogeneity across studies. Effect sizes (ESs), calculated from a measure of muscular power, were represented by the standardised mean difference and were presented alongside 95% confidence intervals (CIs).
Results Thirteen training groups across nine studies were included in this meta-analysis. The magnitude of the main effect was 'moderate' (0.66, 95% CI 0.33, 0.98). ESs were larger in non-obese participants (body mass index [BMI] < 30 vs. ≥ 30 kg/m²; 1.03 [95% CI 0.34, 1.73] vs. 0.53 [95% CI - 0.03, 1.09]). Among the studies included in this review, just one reported an acute injury, which did not result in the participant ceasing their involvement. JT was more effective in programmes with more than one exercise (range 1-4 exercises; ES = 0.74 [95% CI - 0.49, 1.96] vs. 0.53 [95% CI 0.29, 0.78]), more than two sets per exercise (range 1-4 sets; ES = 0.91 [95% CI 0.04, 1.77] vs. 0.68 [95% CI 0.15, 1.21]), more than three jumps per set (range 1-14 jumps; ES = 1.02 [95% CI 0.16, 1.87] vs. 0.53 [95% CI - 0.03, 1.09]) and more than 25 jumps per session (range 6-200 jumps; ES = 0.88 [95% CI 0.05, 1.70] vs. 0.49 [95% CI 0.14, 0.83]).
Conclusions JT is safe and effective in older adults. Practitioners should construct varied JT programmes that include more than one exercise and comprise more than two sets per exercise, more than three jumps per set, and 60 s of recovery between sets. An upper limit of three sets per exercise and ten jumps per set is recommended. Up to three training sessions per week can be performed
Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
Evidence is presented that the linked histone modifications H2B ubiquitylation and H3 methylation play an important role in preventing the ectopic association of silencing proteins with telomere-distant euchromatic genes important for the cellular response to heat