Examining Rater Performance on the CELBAN Speaking: A Many-Facets Rasch Measurement Analysis

Internationally educated nurses’ (IENs) English language proficiency is critical to professional licensure as communication is a key competency for safe practice. The Canadian English Language Benchmark Assessment for Nurses (CELBAN) is Canada’s only Canadian Language Benchmarks (CLB) referenced examination used in the context of healthcare regulation. This high-stakes assessment claims proof of proficiency for IENs seeking licensure in Canada and a measure of public safety for nursing regulators. Understanding the quality of rater performance when examination results are used for high-stakes decisions is crucial to maintaining speaking test quality as it involves judgement, and thus requires strong reliability evidence (Koizumi et al., 2017). This study examined rater performance on the CELBAN Speaking component using a Many-Facets Rasch Measurement (MFRM). Specifically, this study identified CELBAN rater reliability in terms of consistency and severity, rating bias, and use of rating scale. The study was based on a sample of 115 raters across eight test sites in Canada and results on 2698 examinations across four parallel versions. Findings demonstrated relatively high inter-rater reliability and intra-rater reliability, and that CLB-based speaking descriptors (CLB 6-9) provided sufficient information for raters to discriminate examinees’ oral proficiency. There was no influence of test site or test version, offering validity evidence to support test use for high-stakes purposes. Grammar, among the eight speaking criteria, was identified as the most difficult criterion on the scale, and the one demonstrating most rater bias. This study highlights the value of MFRM analysis in rater performance research with implications for rater training. This study is one of the first research studies using MFRM with a CLB-referenced high-stakes assessment within the Canadian context.Les compétences linguistiques dans la langue anglaise chez des infirmiers et infirmières ayant reçu leur éducation à l’étranger s’avèrent critiques à l’acquisition du permis professionnel d’exercer leur profession, car les compétences communicatives sont clé à la pratique sécuritaire. L’examen langagier des compétences de langue anglaise The Canadian English Language Benchmark Assessment for Nurses (CELBAN) demeure le seul examen langagier référentiel canadien auquel on fait référence dans le contexte canadien des règlements de contrôle du système de santé. Cet examen à enjeux élevés offre une preuve de compétence langagière de langue anglaise de la part des infirmiers et infirmières ayant reçu leur formation professionnelle à l’étranger et qui sont à la recherche d’un permis pour exercer leur profession au Canada, ainsi qu’une mesure de sécurité publique destinée aux régulateurs de la profession d’infirmiers et infirmières. Comprendre la qualité de la performance des évaluateurs/trices étant donné que les résultats servent à des décisions sur des enjeux importants demeure fondamental au maintien de la qualité de l’épreuve des compétences orales, car celle-ci implique le jugement et donc nécessite de fortes évidences de fiabilité (Koizumi, et coll. 2017). Cette étude a examiné la performance d’évaluateur/trice sur la composante des compétences orales du CELBAN en utilisant la mesure multifacette Rasch (MMFR). Spécifiquement, cette étude a identifié la fiabilité des évaluateurs/trices, la difficulté des critères, le parti pris de l’évaluation et l’usage de l’échelle de classification. Cette étude s’est basée sur un échantillon de 115 évaluateurs/trices dans huit centres d’évaluation au Canada et sur les résultats de 2.698 évaluations dans quatre versions parallèles. Les résultats démontrent une haute fiabilité relative entre évaluateurs/trices ainsi que sur le plan des intraévaluateurs/trices. De plus, les descripteurs des compétences orales de base des Compétences linguistiques canadiennes (CLC 6-9) ont fourni suffisamment d’information afin de permettre aux évaluateurs/trices de préciser le niveau de compétences du candidat / de la candidate. Il n’y a pas eu d’influence du site de l’examen ni de la version de celui-ci, ce qui offre de l’évidence de validité afin d’affirmer l’usage de cette épreuve pour des enjeux importants. La grammaire, une des huit critères, a été relevée comme étant celle la plus difficile sur l’échelle, et celle qui a mis en lumière le plus grand parti pris de la part des évaluateurs/trices. Cette étude accentue la valeur de l’analyse en effectuant la mesure multifacette Rasch dans des recherches de performance ayant des implications pour l’entraînement des évaluateurs/trices. Cette étude est parmi les premières se servant de la MMFR avec une évaluation à enjeux élevés à base des CLC dans le contexte canadien

Towards the cryogenic sliding mechanism for MOONS-ESO

The Multi-Object Optical and Near-Infrared Spectrograph (MOONS) shall be installed at one of the Very Large Telescopes (VLT) at the European Southern Observatory (ESO) in Paranal Chile. The instrument is being designed and built by an international consortium on behalf of ESO. The design is based on a three arms configuration, RI, YJ and H band, where RI and H have two possible resolutions. To achieve this goal it will be necessary to implement a sliding mechanism changing the dispersers, the filters and the cross dispersion prisms. This article describes the cryogenic exchanger mechanism that is under realization and the preliminary mechanical and optical tests that we have done at the cryogenic facility of Arcetri observatory of Florence. Parts of these test are based on interferometric measurements of the optics to study the behaviour of the mechanical supporting structure, and part are based on the cryogenic sliding system that will be used to move approximately 200 Kg of mass for 350 mm of travel range. The cryogenic sliding system, rails, screws, motors, is based on commercial components as the position measurement device that is based on commercial potentiometers. The results of the tests and performances at cryogenic temperature are reported in this paper

People with schizophrenia and depression have a low omega-3 index

Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while \u3e8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk

Dampness and moulds in relation to respiratory and allergic symptoms in children : results from phase two of the International Study of Asthma and Allergies in Childhood, (ISAAC Phase Two)

Many studies report that damp housing conditions are associated with respiratory symptoms. Less is known about mechanisms and possible effect modifiers. Studies of dampness in relation to allergic sensitization and eczema are scarce. Objective We study the influence of damp housing conditions world-wide on symptoms and objective outcomes. Cross-sectional studies of 8–12-year-old children in 20 countries used standardized methodology from Phase Two of the International Study of Asthma and Allergies in Childhood (ISAAC). Symptoms of asthma, rhinitis and eczema, plus residential exposure to dampness and moulds, were ascertained by parental questionnaires (n = 46 051). Skin examination, skin prick tests (n = 26 967) and hypertonic saline bronchial challenge (n = 5713) were performed. In subsamples stratified by wheeze (n = 1175), dust was sampled and analysed for house dust mite (HDM) allergens and endotoxin. Current exposure to dampness was more common for wheezy children (pooled odds ratio 1.58, 95% CI 1.40–1.79) and was associated with greater symptom severity among wheezers, irrespective of atopy. A significant (P < 0.01) adverse effect of dampness was also seen for cough and phlegm, rhinitis and reported eczema, but not for examined eczema, nor bronchial hyperresponsiveness. HDM sensitization was more common in damp homes (OR 1.16, 1.03–1.32). HDM-allergen levels were higher in damp homes and were positively associated with HDM-sensitization, but not wheeze. A consistent association of dampness with respiratory and other symptoms was found in both affluent and non-affluent countries, among both atopic and non-atopic children. HDM exposure and sensitization may contribute, but the link seems to be related principally to non-atopic mechanisms.peer-reviewe

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition

2022 roadmap on neuromorphic computing and engineering

Modern computation based on von Neumann architecture is now a mature cutting-edge science. In the von Neumann architecture, processing and memory units are implemented as separate blocks interchanging data intensively and continuously. This data transfer is responsible for a large part of the power consumption. The next generation computer technology is expected to solve problems at the exascale with 10$^{18}$ calculations each second. Even though these future computers will be incredibly powerful, if they are based on von Neumann type architectures, they will consume between 20 and 30 megawatts of power and will not have intrinsic physically built-in capabilities to learn or deal with complex data as our brain does. These needs can be addressed by neuromorphic computing systems which are inspired by the biological concepts of the human brain. This new generation of computers has the potential to be used for the storage and processing of large amounts of digital information with much lower power consumption than conventional processors. Among their potential future applications, an important niche is moving the control from data centers to edge devices. The aim of this roadmap is to present a snapshot of the present state of neuromorphic technology and provide an opinion on the challenges and opportunities that the future holds in the major areas of neuromorphic technology, namely materials, devices, neuromorphic circuits, neuromorphic algorithms, applications, and ethics. The roadmap is a collection of perspectives where leading researchers in the neuromorphic community provide their own view about the current state and the future challenges for each research area. We hope that this roadmap will be a useful resource by providing a concise yet comprehensive introduction to readers outside this field, for those who are just entering the field, as well as providing future perspectives for those who are well established in the neuromorphic computing community

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.