Discovery Of A Molecular Outflow in the Haro 6-10 Star-Forming Region

We present high sensitivity 12CO and 13CO (1-0) molecular line maps covering the full extent of the parsec scale Haro~6-10 Herbig-Haro (HH) flow. We report the discovery of a molecular CO outflow along the axis of parsec-scale HH flow. Previous molecular studies missed the identification of the outflow probably due to their smaller mapping area and the confusing spectral features present towards the object. Our detailed molecular line study of the full 1.6 pc extent of the optical flow shows evidence for both blueshifted and redshifted gas set in motion by Haro~6-10 activity. The molecular outflow is centered at Haro~6-10, with redshifted gas being clumpy and directed towards the northeast, while blueshifted gas is in the southwest direction. The molecular gas terminates well within the cloud, short of the most distant HH objects of the optical flow. Contamination from an unrelated cloud along the same line of sight prevents a thorough study of the blueshifted outflow lobe and the mass distribution at the lowest velocities in both lobes. The cloud core in which Haro~6-10 is embedded is filamentary and flattened in the east-west direction. The total cloud mass is calculated from 13CO(1-0) to be ~200Msun. The lower limit of the mass associated with the outflow is ~0.25Msun.Comment: ApJ Accepted; 9 pages, 8 figures. For high resolution ps file use: http://www.astro.umass.edu/~irena/haro.p

A Pre-Protostellar Core in L1551. II. State of Dynamical and Chemical Evolution

Both analytic and numerical radiative transfer models applied to high spectral resolution CS and N2H+ data give insight into the evolutionary state of L1551 MC. This recently discovered pre-protostellar core in L1551 appears to be in the early stages of dynamical evolution. Line-of-sight infall velocities of >0.1km/s are needed in the outer regions of L1551 MC to adequately fit the data. This translates to an accretion rate of ~ 1e-6 Msun/yr, uncertain to within a factor of 5 owing to unknown geometry. The observed dynamics are not due to spherically symmetric gravitational collapse and are not consistent with the standard model of low-mass star formation. The widespread, fairly uniform CS line asymmetries are more consistent with planar infall. There is modest evidence for chemical depletion in the radial profiles of CS and C18O suggesting that L1551 MC is also chemically young. The models are not very sensitive to chemical evolution. L1551 MC lies within a quiescent region of L1551 and is evidence for continued star formation in this evolved cloud.Comment: 27 pages, 7 figures, ApJ accepte

Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites

The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters RM0 and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography

Neurotični poremećaj kod mladih u postmodernom društvu - sociološki i psihološki aspekti

The paper will discuss the impacts of socio-economic and psychological factors on the neurotic disorder in young population: the way it is manifested in the current socio-cultural context in Serbia. This phenomenon will be presented through a reinterpretation of classical, as well as sociological and psychological theories, based on the idea of social constructivism, seen through the prism of the transformation processes of Serbian society. The aim of the paper is to present the elements and mechanisms by which the postmodern society constructs a social reality, which also changes the meaning and nature of the manifestation of neurosis among young people. In methodological terms, in addition on the aforementioned theoretical concepts, the analysis also relies on Moreno's role theory, psychodrama and sociodrama. In this paper, we will present the basic psychodrama and sociodrama methods and techniques as well as the advantages of their practical application in the treatment of neurotic disorders in young population. Neurotic disorders in youth will be interpreted through various types of social and psychological transitions: 1. transition into adulthood; 2. transition from mental illness to health; 3. socio-economic transition and its consequences for young people in Serbia. In the first part of the paper, the focus is on interpreting the relationship between the postmodern self, the adolescent crisis, and the neurotic disorder. The second part represents the ways in which psychodrama and sociodrama can be practically applied in the treatment of young people with neurotic symptomatology. In the conclusion, we emphasized the advantages of using psychodrama and sociodrama for the purpose of prevention and treatment of the neurotic disorders in young population which is a responsibility not only of the individual and his/ her family, but of the society as a whole.U radu će se razmatrati uticaj socio-ekonomskih i psiholoških činilaca na neurotični poremećaj, kakav se u sadašnjem socio-kulturnom kontekstu manifestuje kod mladih u Srbiji. Ovaj fenomen biće prikazan kroz reinterpretaciju klasičnih i novijih socioloških i psiholoških teorija koje počivaju na ideji socijalnog konstruktivizma, posmatran kroz prizmu transformacijskih procesa kroz koje prolazi srpsko društvo. Cilj rada je da se predstave elementi i mehanizmi kojim postmoderno društvo konstruiše društvenu realnost, čime se menja i samo značenje i priroda manifestacije neuroze kod mladih. U metodološkom smislu, analiza se oslanja, osim na spomenute teorijske koncepte, i na Morenovu teoriju uloga, psihodramu i sociodramu. U radu će biti predstavljene bazične psihodramske i sociodramske metode i tehnike, kao i značaj njihove praktične primene u radu sa neurotičnim poremećajem kod mladih. Neurotični poremećaj kod mladih tumačiće se kroz različite vrste socijalnih i psiholoških tranzicija: Ad.1. Tranziciju u odraslost; Ad.2. Tranziciju od bolesti ka zdravlju; Ad.3 Socio-ekonomsku tranziciju i njene posledice po mlade u Srbiji. Fokus u prvom delu rada je na tumačenju veze između postmodernog selfa, adolescentne krize i neurotičnog poremećaja. Drugi deo rada ukazuje na prednosti praktične primene psihodrame i sociodrame u radu sa mladima sa neurotskom simptomatologijom. U zaključku, istaknute su prednosti primene psihodrame i sociodrame u prevenciji i tretmanu neurotičnog poremećaja kod mladih, što predstavlja odgovornost, ne samo pojedinca i njegove porodice, već i društva u celini

Socijalno-ekonomski aspekti mentalnog zdravlja mladih u Beogradu u kontekstu strateške kulture

Mental health of people is an important individual and social resource, especially in the modern Serbian society, which has problems with demography. Without full mental health, a person is not aware of himself and his abilities, and he cannot develop to his full capacity. Therefore, a person cannot contribute to his own well-being, and also be a productive member of the social community. It is the basis of well-being, both for individuals and a healthy society, as well as one of the sources of strategic culture. The existence of awareness of the mental health problems of the nation, especially the young population, is a segment of strategic culture. There are many factors that affect mental health, and the three main ones are biological, psychological and social factors. Only if we take into account the interaction of these three factors we can talk about mental disorder as a phenomenon. Our goal is to gain the insight into those social, sociological, economic and psychological factors that can produce negative consequences for mental health, in this case the occurrence and development of neurotic disorders in the population of young people in Belgrade. This paper presents the data from the study conducted in 2013, which dealt with socio-economic aspects of neurotic disorder in the youth population in Belgrade. The general goal of the research is to determine which economic and (or) social factors can influence the occurrence of neurotic disorders to these young people. The findings of the research indicate that young people who suffer from neurotic disorders are materially and psychologically dependent on their parents. In the families of the respondents, there is a strong psychological mutual connection, especially in the relationship between the respondent and their mothers. When it comes to family members, the mother is the mainstay of financial, moral and counseling support for the respondents. Psychological dependence on emotional objects of security is one of the important features of neurotic disorder, and in our country it represents a typical pattern of behavior, a culture-based relationship between parents and children.Mentalno zdravlje ljudi je važan individualni i društveni resurs, pogotovo u savremenom srpskom društvu koje ima velikih problema sa demografijom. Bez punog mentalnog zdravlja osoba nije svesna sebe i svojih sposobnosti, te se ne može razviti do svojih punih kapaciteta. Samim tim, ne može doprineti sopstvenom boljitku, ni biti produktivan deo društvene i socijalne zajednice. Mentalno zdravlje je osnova blagostanja, kako za pojedince, tako i za zdravo društvo i predstavlja jedno od izvorišta strateške kulture. Postojanje svesti o problemima mentalnog zdravlja nacije, posebno mlade populacije, predstavlja primarni segment strateške kulture. Mnogo je činilaca koji utiču na mentalno zdravlje, a tri osnovna koja su međusobno isprepletana i uslovljena su: biološki, psihološki i socijalni činioci. Tek ako se uzme u obzir njihovo međudejstvo može se govoriti o mentalnom poremećaju kao fenomenu u svom totalitetu. Fokus ovog rada biće na jednoj od spomenutih perspektiva u proučavanju ove pojave. Cilj je sticanje uvida u one socijalne, sociološke, ekonomske ali i psihološke činioce koji mogu proizvesti negativne posledice na mentalno zdravlje, u ovom slučaju na pojavu i razvoj neurotičnih poremećaja u populaciji mladih ljudi u Beogradu. Biće predstavljeni i podaci istraživanja sprovedenog 2013. godine, koje se bavilo socio-ekonomskim aspektima neurotičnog poremećaja mladih u našoj prestonici. Opšti cilj bio je da se utvrdi koji ekonomski i (ili) socijalni činioci mogu uticati na pojavu ovog neurotičnog poremećaja. Nalazi istraživanja ukazali su na to da su mladi koji pate od ovog poremećaja materijalno i psihološki zavisni od svojih roditelja. U porodicama ispitanika prisutna je jaka psihološka uzajamna vezanost, naročito na relaciji ispitanik-majka. Od svih članova porodice majka je ispitanicima glavni oslonac finansijske, moralne i savetodavne podrške. Psihološka zavisnost od emocionalnih objekata sigurnosti je jedna od važnih odlika neurotičnog poremećaja, a u našoj zemlji predstavlja tipičan obrazac ponašanja, kulturom utemeljen odnos između roditelja i dece

Kinetics of C-reactive protein, interleukin-6 and -10, and phospholipase A2-II in severely traumatized septic patients

Background/Aim. Injury-induced anergy is one of the key factors contributing to trauma victims' high susceptibility to sepsis. This group of patients is mostly of young age and it is therefore essential to be able to predict as accurately as possible the development of septic complications, so appropriate treatment could be provided. The aim of this study was to assess kinetics of interleukin (IL) -6 and -10, phospholipase A2- II and C-reactive protein (CRP) in severely traumatized patients and explore the possibilities for early detection of potentially septic patients. Methods. This prospective study included 65 traumatized patients with injury severity score (ISS) > 18, requiring treatment at surgical intensive care units, divided into two groups: 24 patients without sepsis and 41 patients with sepsis. C-reactive protein, IL-6 and -10 and phospholipase A2 group II, were determined within the first 24 hours, and on the second, third and seventh day of hospitalization. Results. Mean values of IL-6 and phospholipase A2-II in the patients with and without sepsis did not show a statistically significant difference on any assessed time points. In the septic patients with ISS 29-35 and > 35 on the days two and seven a statistically significantly lower level of IL-10 was found, compared with those without sepsis and with the same ISS. C-reactive protein levels were significantly higher in septic patients with ISS 18-28 on the first day. On the second, third and seventh day CRP levels were significantly lower in the groups of septic patients with ISS 29-35 and > 35, than in those with the same ISS but without sepsis. Conclusion. Mean levels of CRP on the first day after the injury may be useful predictor of sepsis development in traumatized patients with ISS score 18-28. Mean levels of CRP on the days two, three and seven after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score more than 28. Mean levels of IL-10 on the second and seventh day after the injury may be a useful predictor of sepsis development in traumatized patients with ISS score > 28

Opšta kreativna sposobnost i aspekti kreativnog mišljenja kod umetnika i neumetnika

U istraživanju je ispitivana razlika između umetnika i neumetnika u pogledu opšte kreativne sposobnosti i različitih aspekata kreativnosti. Uzorak je činilo 128 studenata Univerziteta u Beogradu (66 studenata umetničkih i 62 studenta neumetničkih fakulteta). U istraživanju je korišćen višedimenzionalni test opšte kreativnosti baziran na Gilfordovom modelu kreativnog mišljenja. Ovaj test procenjuje opštu kreativnu sposobnost i četiri aspekta kreativnosti nižeg reda: fluentnost, produktivnost, originalnost i elaboraciju. Rezultati su pokazali da nema razlike između umetnika i neumetnika u pogledu opšte kreativne sposobnosti. Sa druge strane, umetnici imaju bolje postignuće na subskali Originalnost. Dobijeni rezultati sugerišu postojanje opšte kreativne sposobnosti koja nije rezervisana samo za umetnike. Ipak, razlike u postignuću u domenu originalnosti upućuju na postojanje dominantnog načina kreativnog mišljenja u grupi umetnika

Is FS Tau B Driving an Asymmetric Jet?

FS Tau B is one of the few T Tauri stars that possess a jet and a counterjet as well as an optically-visible cavity wall. We obtained images and spectra of its jet-cavity system in the near-infrared H and K bands using Subaru/IRCS and detected the jet and the counterjet in the [Fe II] 1.644 \mu m line for the first time. Within the inner 2" the blueshifted jet is brighter, whereas beyond ~ 5" the redshifted counterjet dominates the [Fe II] emission. The innermost blueshifted knot is spectrally resolved to have a large line width of ~ 110 km/s, while the innermost redshifted knot appears spectrally unresolved. The velocity ratio of the jet to the counterjet is ~ 1.34, which suggests that FS Tau B is driving an asymmetric jet, similar to those found in several T Tauri Stars. Combining with optical observations in the literature, we showed that the blueshifted jet has lower density and higher excitation than the redshifted counterjet. We suggest that the asymmetry in brightness and velocity is the manifestation of a bipolar outflow driving at different mass-loss rates, while maintaining balance of linear momentum. A full explanation to the asymmetry in the FS Tau B system awaits detail modeling and further investigation of the kinematic structure of the wind-associated cavity walls.Comment: 14 pages, 2 figures, 1 table; accepted for publication in ApJ. Aspect ratio changes for Fig.1

Procena renalne eliminacije inhibitora enzima koji konvertuje angiotensin sa odabranim molekulskim deskriptorima

Angiotensin-converting enzyme (ACE) inhibitors modulate the function of the renin-angiotensin-aldosterone system, and they are commonly prescribed antihypertensive drugs especially in patients with renal failure. In this study, the relationships between several molecular properties of eight ACE inhibitors (enalapril, quinapril, fosinopril, ramipril, benazepril, perindopril, moexipril, trandolapril) and their renal elimination data, from relevant literature, were investigated. The 'molecular descriptors of the ACE inhibitors, which included aqueous solubility data (logS); an electronic descriptor, polar surface area (PSA);, a constitutional parameter, molecular mass (Mr); and a geometric descriptor, volume value (Vol), as well as lipophilicity descriptors (logP values), were calculated using different software packages. Simple linear regression analysis showed the best correlation between renal elimination data and lipophilicity descriptor AClogP values (R2 = 0.5742). In the next stage of the study, multiple linear regression was applied to assess a higher correlation between the ACE inhibitors' renal elimination data and lipophilicity, AClogP, with one additional descriptor as an independent variable. Good correlations were established between renal elimination data from the literature and the AClogP lipophilicity descriptor using the constitutional parameter (molecular mass (R2 = 0.7425)) or the geometric descriptor (volume value (R2 = 0.7224)) as an independent variable. the application of computed molecular descriptors in evaluating drug elimination is of great importance in drug research.Inhibitori enzima koji konvertuje angiotenzin (ACE) modifikuju funkciju renin-angiotenzin-aldosteron sistema i predstavljaju često propisane lekova za sniženje pritiska, posebno kod pacijenata sa insuficijencijom bubrega. U ovom radu, za osam odabranih ACE inhibitora (enalapril, kvinapril, fosinopril, ramipril, benazepril, perindopril, moeksipril, trandolapril) ispitan je odnos između osobina njihovih molekula i njihove eliminacije putem bubrega. Za ispitivane inhibitore ACE korišć enjem različitih softverskih paketa izračunate su vrednosti nekoliko molekulskih deskriptora: rastvorljivost u vodi (logS), elektronski deskriptor - polarna površina molekula (PSA), molekulska masa (Mw), geometrijski deskriptor - volumen molekula (Vol) kao i deskriptor lipofilnosti (logP vrednosti). Primenom proste linearne regresione analize najbolja zavisnost dobijena je između podataka o eliminaciji inhibitora ACE putem bubrega i deskriptora lipofilnosti, AClogP vrednosti (R2 = 0.5742). U sledećoj fazi istraživanja primenjena je metoda višestruke regresione analize (MLR) kako bi se dobila bolja zavisnost između podataka o eliminaciji ACE inhibitora putem bubrega i njihove lipofilnosti (AClogP vrednosti) uz primenu dodatnog molekulskog deskriptora kao nezavisno promenljive. Dobre korelacije su dobijene između podataka o eliminaciji putem bubrega i deskriptora lipofilnosti AClogP, uz primenu molekulske mase (R2 = 0.7425) ili zapremine molekula (R2 = 0.7224) kao nezavisno promenljive. Mogućnost primene izračunatih molekulskih deskriptora u proceni eliminacije lekova je od velikog značaja u njihovom istraživanju