Interhemispheric coupling, the West Antarctic Ice Sheet and warm Antarctic interglacials

Ice core evidence indicates that even though atmospheric CO2 concentrations did not exceed 300 ppm at any point during the last 800 000 years, East Antarctica was at least 3–4 C warmer than preindustrial (CO2 280 ppm) in each of the last four interglacials. During the previous three interglacials, this anomalous warming was short lived (3000 years) and apparently occurred before the completion of Northern Hemisphere deglaciation. Hereafter, we refer to these periods as “Warmer than Present Transients” (WPTs). We present a series of experiments to investigate the impact of deglacial meltwater on the Atlantic Meridional Overturning Circulation (AMOC) and Antarctic temperature. It is well known that a slowed AMOC would increase southern sea surface temperature (SST) through the bipolar seesaw and observational data suggests that the AMOC remained weak throughout the terminations precedingWPTs, strengthening rapidly at a time which coincides closely with peak Antarctic temperature. We present two 800 kyr transient simulations using the Intermediate Complexity model GENIE-1 which demonstrate that meltwater forcing generates transient southern warming that is consistent with the timing of WPTs, but is not sufficient (in this single parameterisation) to reproduce the magnitude of observed warmth. In order to investigate model and boundary condition uncertainty, we present three ensembles of transient GENIE-1 simulations across Termination II (135 000 to 124 000 BP) and three snapshot HadCM3 simulations at 130 000 BP. Only with consideration of the possible feedback of West Antarctic Ice Sheet (WAIS) retreat does it become possible to simulate the magnitude of observed warming

Generic Finite Size Enhancement of Pairing in Mesoscopic Fermi Systems

The finite size dependent enhancement of pairing in mesoscopic Fermi systems is studied under the assumption that the BCS approach is valid and that the two body force is size independent. Different systems are investigated such as superconducting metallic grains and films as well atomic nuclei. It is shown that the finite size enhancement of pairing in these systems is in part due to the presence of a surface which accounts quite well for the data of nuclei and explains a good fraction of the enhancement in Al grains.Comment: Updated version 17/02/0

Destabilization of the thermohaline circulation by transient perturbations to the hydrological cycle

We reconsider the problem of the stability of the thermohaline circulation as described by a two-dimensional Boussinesq model with mixed boundary conditions. We determine how the stability properties of the system depend on the intensity of the hydrological cycle. We define a two-dimensional parameters' space descriptive of the hydrology of the system and determine, by considering suitable quasi-static perturbations, a bounded region where multiple equilibria of the system are realized. We then focus on how the response of the system to finite-amplitude surface freshwater forcings depends on their rate of increase. We show that it is possible to define a robust separation between slow and fast regimes of forcing. Such separation is obtained by singling out an estimate of the critical growth rate for the anomalous forcing, which can be related to the characteristic advective time scale of the system.Comment: 37 pages, 8 figures, submitted to Clim. Dy

Neutron star properties in a chiral SU(3) model

We investigate various properties of neutron star matter within an effective chiral $SU(3)_L \times SU(3)_R$ model. The predictions of this model are compared with a Walecka-type model. It is demonstrated that the importance of hyperon degrees are strongly depending on the interaction used, even if the equation of state near saturation density is nearly the same in both models. While the Walecka-type model predicts a strange star core with strangeness fraction $f_S \approx 4/3$, the chiral model allows only for $f_S \approx 1/3$ and predicts that $\Sigma^0$, $\Sigma^+$ and $\Xi^0$ will not exist in star, in contrast to the Walecka-type model.Comment: 13 pages, Revtex, 5 figs include

Acute Hypernatrem ia Increases Functional Connectivity Between the SFO and OVLT: Time Course of the Response

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Pharmacology and clinical drug candidates in redox medicine

SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant molecules, has been unsuccessful. Recent Advances: An alternative emerging approach is to target the enzymatic sources of disease-relevant oxidative stress. Several such enzymes and isoforms have been identified and linked to different pathologies. For some targets, the respective pharmacology is quite advanced, that is, up to late-stage clinical development or even on the market; for others, drugs are already in clinical use, although not for indications based on oxidative stress, and repurposing seems to be a viable option. CRITICAL ISSUES For all other targets, reliable preclinical validation and drug ability are key factors for any translation into the clinic. In this study, specific pharmacological agents with optimal pharmacokinetic profiles are still lacking. Moreover, these enzymes also serve largely unknown physiological functions and their inhibition may lead to unwanted side effects. FUTURE DIRECTIONS The current promising data based on new targets, drugs, and drug repurposing are mainly a result of academic efforts. With the availability of optimized compounds and coordinated efforts from academia and industry scientists, unambiguous validation and translation into proof-of-principle studies seem achievable in the very near future, possibly leading towards a new era of redox medicine

Nuclear Breathing Mode in the Relativistic Mean Field Theory

The breathing-mode giant monopole resonance is studied within the framework of the relativistic mean-field (RMF) theory. Using a broad range of parameter sets, an analysis of constrained incompressibility and excitation energy of isoscalar monopole states in finite nuclei is performed. It is shown that the non-linear scalar self-interaction and the resulting surface properties influence the breathing-mode considerably. It is observed that dynamical surface properties respond differently in the RMF theory than in the Skyrme approach. A comparison is made with the incompressibility derived from the semi-infinite nuclear matter and with constrained nonrelativistic Skyrme Hartree-Fock calculaions.Comment: Latex (12 pages) and 3 figures (available upon request) J. Phys. G (in press

Assimilative real-time models of HF absorption at high latitudes

Improved real-time HF communications frequency management is required for aircraft on trans-polar routes. Polar cap absorption (PCA) models have therefore been adapted to assimilate real-time measurements of zenithal cosmic radio noise absorption (~ 30 MHz) from a large network of online riometers in Canada and Finland. Two types of PCA model have been developed and improvements to model accuracy following optimisation are quantified. Real-time optimisation is performed by age-weighting riometer measurements in a non-linear regression. This reduces root-mean-square errors (RMSE) from 2-3 dB to less than 1 dB and mean errors to within ±0.2 dB over a wide latitude range. This paper extends previous work by further optimising the models’ dependences on solar-zenith angle to account for differences in the ionospheric response at sunrise and sunset (the Twilight Anomaly). Two models of the rigidity cutoff latitudes are compared and one is optimised in real time by regression to riometer measurements. Whilst measurements from the NASA POES satellites may provide a direct measurement of the rigidity cut-off, it is observed that proton flux measurements from POES often need correcting for relativistic electron contamination for several hours at the start of a PCA event. An optimised real-time absorption model will be integrated into HF ray-tracing propagation predictions relating to measurements of HF signal strengths on a network of HF transmitters and receivers in the high northern latitudes