The Light We Shine into the Grey: A Restorative #MeToo Solution and an Acknowledgement of Those #MeToo Leaves in the Dark

In the past year and a half, American women have publicly discussed experiences of sexual assault, harassment, and—notably—grey-area misconduct in an unprecedented manner. The rhetoric of the #MeToo movement is rife with references to “shining a light” on a set of unexplored issues hitherto obscured in cultural darkness, to following women’s experiences into the grey. What is new about #MeToo, and what likely will be the through line that defines its historical importance, has been its sensitivity to nuance. The grey range of #MeToo misconduct is not a new problem. It is emphatically new, however, as a subject of public discourse. As such, and given the unsettled expectations that noncriminal #MeToo accusations have generated, it invites a new legal solution. This Note proposes that solution in the form of a restorative justice response to greyarea #MeToo misconduct, based on indigenous jurisprudential models

A Note on the \u3ci\u3eFordham Law Review Online\u3c/i\u3e Fall Issue, \u3ci\u3eNovel Perspectives on Due Process\u3c/i\u3e

2019 has seen extensive discussion of due process in the American public sphere. There is a cultural sense of eroding norms, of institutions and procedural protections under threat. In response to the central role of due process in the cultural discourse and to the publication of Ingrid Wuerth’s Article, The Due Process and Other Constitutional Rights of Foreign Nations, in the November Issue of our print edition, Fordham Law Review Online presents a Fall Issue comprised both of response pieces to Professor Wuerth’s Article and of Essays engaging other thorny questions about due process

Equivalence of influenza A virus RNA recovery from nasal swabs when lysing the swab and storage medium versus storage medium alone

Surveillance of healthy individuals at high risk for zoonotic influenza A transmission is important for tracking trends in influenza A epidemiology. Practical measurement methods that maximize viral recovery and produce low variability are essential when low viral loads are expected. For this study, lysing both a nasal swab and its storage medium was compared to lysing the storage medium alone to determine which method results in greater influenza A virus recovery. Independent results from two laboratories suggest that including the swab in the lysis step does not lead to higher influenza A virus recovery, and that recovery is less variable when only the swab storage medium is extracted. These results indicate that simply lysing the swab storage medium is an effective extraction method for nasal swabs collected during studies of influenza A virus exposure among healthy populations

Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom

The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics on sheep scrapie in Europe in the past decade, we have established caprine Prnp gene variation in more than 1100 goats from the United Kingdom and studied the association of Prnp alleles with disease phenotypes in 150 scrapie-positive goats. This investigation confirms the association of the Met142 encoding Prnp allele with increased resistance to preclinical and clinical scrapie. It reveals a novel association of the Ser127 encoding allele with a reduced probability to develop clinical signs of scrapie in goats that are already positive for the accumulation of disease-specific prion protein in brain or periphery. A United Kingdom survey of Prnp genotypes in eight common breeds revealed eleven alleles in over thirty genotypes. The Met142 encoding allele had a high overall mean allele frequency of 22.6%, whereas the Ser127 encoding allele frequency was considerably lower with 6.4%. In contrast, a well known resistance associated allele encoding Lys222 was found to be rare (0.9%) in this survey. The analysis of Prnp genotypes in Mexican Criollas goats revealed nine alleles, including a novel Phe to Leu substitution in codon 201, confirming that high genetic variability of Prnp can be found in scrapie-free populations. Our study implies that it should be feasible to lower scrapie prevalence in goat herds in the United Kingdom by genetic selection

Hepatitis E virus and coliphages in waters proximal to swine concentrated animal feeding operations

North Carolina is the second leading state in pork production in the United States, with over 10 million swine. Swine manure in NC is typically collected and stored in open-pit lagoons before the liquid waste is sprayed onto agricultural fields for disposal. Components of this waste may be able to impact surface water quality with the potential for human exposure. This study examined viruses of public health concern in creeks adjacent to swine concentrated animal feeding operation (CAFO) spray fields. Surface water samples (n = 154) were collected from public access waters in proximity to swine CAFO spray fields for six months and were tested for hepatitis E virus (HEV) and coliphages. HEV was detected in one sample. Somatic coliphages were detected in 98% of samples (geometric mean 24 ± 4.1 PFU per 100 ml), and F + coliphages were detected in 85% of samples (geometric mean 6.8 ± 5.0 PFU per 100 ml). Only 3% (21) of the F + coliphage isolates were RNA phage, and all of the F + RNA coliphages belonged to genogroup I. Although the pervasiveness of swine CAFOs in this area prevented a comparison with samples from un-impacted sites, the near ubiquity of coliphages, as well as the presence of HEV, suggests that current waste management practices may be associated with the dissemination of viruses of public health concern in waters proximal to CAFO spray fields

Precision and accuracy of Dahl-Lea back-calculated smolt lengths from adult scales of Atlantic salmon (Salmo salar L.)

Using tagged and recaptured Atlantic salmon Salmo salar (n = 106) the present analysis shows that the most commonly applied linear back-calculation method for estimating past length, the Dahl-Lea method, resulted in overestimation of the length of large smolts and underestimation of small smolts.  A correction equation (y = 0.53x + 6.23) for estimating true smolt length (y) from lengths back-calculated from adult scale measures (x) to account for these systematic discrepancies is proposed.PostprintPeer reviewe

Pig-2-Bac as a biomarker of occupational exposure to pigs and livestock-associated Staphylococcus aureus among industrial hog operation workers

Over 50 million hogs are raised annually in the United States for consumption, mostly on industrial hog operations (IHOs). Workers at IHOs are exposed to airborne particulates, zoonotic pathogens, and other workplace hazards, but lack of access to IHOs can hinder exposure assessment in epidemiologic studies. Here, we demonstrate the utility of pig-specific Bacteroidales (Pig-2-Bac) as a biomarker of exposure to pigs and pig waste and to help identify sources of Staphylococcus aureus carriage among IHO workers

Bridging senses of place and mobilities scholarships to inform social-ecological systems governance:A research agenda

Uncertainty and change are increasingly commonplace as communities respond to impacts of social-ecological change including climate change, and dangerous levels of pollution. Given the extent of these crises, new approaches are needed to support responses. Here we identify challenges and discuss insights that the nexus of Senses of place (SoP) and mobilities research offers in navigating such uncertainty. We conducted a two-round Delphi, followed by a workshop, and collaborative writing process with a global network of researchers with expertise in either or both SoP and mobilities research. Participants identified five challenges at the place-mobility nexus that emerge when a social-ecological system is disrupted. We use the 2022 Odra River fish die-off to exemplify the identified challenges: 1) accounting for power dynamics, inequalities and motility; 2) doing justice to more-than human actors; 3) integrating multiple and sometimes nested spatial scales; 4) considering temporalities of place and mobilities, and 5) embracing multisensoriality. To address these challenges, we recommend drawing on diverse methods and knowledge co-creation processes that combine more-than-human perspectives, multisensoriality, and engage in the dynamic relations between places to understand people-place disruptions in the face of socio-spatial precarity. Addressing such knowledge gaps requires stronger collaboration of mobilities and place researchers.</p

Bridging senses of place and mobilities scholarships to inform social-ecological systems governance:A research agenda

Uncertainty and change are increasingly commonplace as communities respond to impacts of social-ecological change including climate change, and dangerous levels of pollution. Given the extent of these crises, new approaches are needed to support responses. Here we identify challenges and discuss insights that the nexus of Senses of place (SoP) and mobilities research offers in navigating such uncertainty. We conducted a two-round Delphi, followed by a workshop, and collaborative writing process with a global network of researchers with expertise in either or both SoP and mobilities research. Participants identified five challenges at the place-mobility nexus that emerge when a social-ecological system is disrupted. We use the 2022 Odra River fish die-off to exemplify the identified challenges: 1) accounting for power dynamics, inequalities and motility; 2) doing justice to more-than human actors; 3) integrating multiple and sometimes nested spatial scales; 4) considering temporalities of place and mobilities, and 5) embracing multisensoriality. To address these challenges, we recommend drawing on diverse methods and knowledge co-creation processes that combine more-than-human perspectives, multisensoriality, and engage in the dynamic relations between places to understand people-place disruptions in the face of socio-spatial precarity. Addressing such knowledge gaps requires stronger collaboration of mobilities and place researchers.</p

Author response

The cohesin complex mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA looping). It has been suggested that intra-chromosome loops are generated by extrusion of DNAs through the lumen of cohesin's ring. Scc2 (Nipbl) stimulates cohesin's ABC-like ATPase and is essential for loading cohesin onto chromosomes. However, it is possible that the stimulation of cohesin's ATPase by Scc2 also has a post-loading function, for example driving loop extrusion. Using fluorescence recovery after photobleaching (FRAP) and single- molecule tracking, we show that Scc2 binds dynamically to chromatin, principally through an association with cohesin. Scc2's movement within chromatin is consistent with a 'stop-and-go' or 'hopping' motion. We suggest that a low diffusion coefficient, a low stoichiometry relative to cohesin, and a high affinity for chromosomal cohesin enables Scc2 to move rapidly from one chromosomal cohesin complex to another, performing a function distinct from loading