New Star Forming Galaxies at z\approx 7 from WFC3 Imaging

The addition of Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST) has led to a dramatic increase in our ability to study the z>6 Universe. The increase in the near-infrared (NIR) sensitivity of WFC3 over previous instruments has enabled us to reach apparent magnitudes approaching 29 (AB). This allows us to probe the rest-frame ultraviolet (UV) continuum, redshifted into the NIR at $z>6$. Taking advantage of the large optical depths at this redshift, resulting in the Lyman-alpha break, we use a combination of WFC3 imaging and pre-existing Advanced Camera for Surveys (ACS) imaging to search for z approx 7 over 4 fields. Our analysis reveals 29 new z approx 7 star forming galaxy candidates in addition to 16 pre-existing candidates already discovered in these fields. The improved statistics from our doubling of the robust sample of z-drop candidates confirms the previously observed evolution of the bright end of the luminosity function.Comment: 15 pages, accepted in MNRA

Spectroscopy of z ~ 7 candidate galaxies: using Lyman α to constrain the neutral fraction of hydrogen in the high-redshift universe

Following our previous spectroscopic observations of z > 7 galaxies with Gemini/Gemini Near Infra-Red Spectrograph (GNIRS) and Very Large Telescope (VLT)/XSHOOTER, which targeted a total of eight objects, we present here our results from a deeper and larger VLT/FOcal Reducer and Spectrograph (FORS2) spectroscopic sample of Wide Field Camera 3 selected z > 7 candidate galaxies. With our FORS2 setup we cover the 737–1070 nm wavelength range, enabling a search for Lyman α in the redshift range spanning 5.06–7.80. We target 22 z-band dropouts and find no evidence of Lyman α emission, with the exception of a tentative detection (<5σ, which is our adopted criterion for a secure detection) for one object. The upper limits on Lyman α flux and the broad-band magnitudes are used to constrain the rest-frame equivalent widths for this line emission. We analyse our FORS2 observations in combination with our previous GNIRS and XSHOOTER observations, and suggest that a simple model where the fraction of high rest-frame equivalent width emitters follows the trend seen at z = 3-6.5 is inconsistent with our non-detections at z ∼ 7.8 at the 96 per cent confidence level. This may indicate that a significant neutral H I fraction in the intergalactic medium suppresses Lyman α, with an estimated neutral fraction χHI∼0.5, in agreement with other estimates

The ultraviolet properties of star-forming galaxies - I. HST WFC3 observations of very high redshift galaxies

The acquisition of deep near-IR imaging with Wide Field Camera 3 on the Hubble Space Telescope has provided the opportunity to study the very high redshift Universe. For galaxies up to z≈ 7.7 sufficient wavelength coverage exists to probe the rest-frame ultraviolet (UV) continuum without contamination from either Lyman α emission or the Lyman α break. In this work we use near-infrared (near-IR) imaging to measure the rest-frame UV continuum colours of galaxies at 4.7 < z < 7.7. We have carefully defined a colour–colour selection to minimize any inherent bias in the measured UV continuum slope for the drop-out samples. For the highest redshift sample (6.7 < z < 7.7), selected as zf850lp-band drop-outs, we find mean UV continuum colours approximately equal to zero (AB), consistent with a dust-free, solar metallicity, star-forming population (or a moderately dusty population of low metallicity). At lower redshift we find that the mean UV continuum colours of galaxies (over the same luminosity range) are redder, and that galaxies with higher luminosities are also slightly redder on average. One interpretation of this is that lower redshift and more luminous galaxies are dustier; however, this interpretation is complicated by the effects of the star formation history and metallicity and potentially the initial mass function on the UV continuum colours

Constraining the bright-end of the UV luminosity function for z 7-9 galaxies: results from CANDELS/GOODS-South

The recent Hubble Space Telescope near-infrared imaging with the Wide-Field Camera #3 (WFC 3) of the Great Observatories Origins Deep Survey South (GOODS-S) field in the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) programme covering nearly 100 arcmin2, along with already existing Advanced Camera for Surveys optical data, makes possible the search for bright galaxy candidates at redshift z ≈ 7–9 using the Lyman break technique. We present the first analysis of z′-drop z ≈ 7 candidate galaxies in this area, finding 19 objects. We also analyse Y-drops at z ≈ 8, trebling the number of bright (HAB < 27 mag) Y-drops from our previous work, and compare our results with those of other groups based on the same data. The bright high-redshift galaxy candidates we find serve to better constrain the bright end of the luminosity function at those redshift, and may also be more amenable to spectroscopic confirmation than the fainter ones presented in various previous work on the smaller fields (the Hubble Ultra Deep Field and the WFC 3 Early Release Science observations). We also look at the agreement with previous luminosity functions derived from WFC 3 drop-out counts, finding a generally good agreement, except for the luminosity function of Yan et al. at z ≈ 8, which is strongly ruled out

Inferred Hα flux as a star formation rate indicator at z ∼ 4–5: implications for dust properties, burstiness, and the z = 4–8 star formation rate functions

We derive Hα fluxes for a large spectroscopic and photometric-redshift-selected sample of sources over GOODSNorth and South in the redshift range z = 3.8–5.0 with deep Hubble Space Telescope (HST), Spitzer/IRAC, and ground-based observations. The Hα flux is inferred based on the offset between the IRAC 3.6 μm flux and that predicted from the best-fit spectral energy distribution (SED). We demonstrate that the Hα flux correlates well with dust-corrected UV star formation rate (SFR) and therefore can serve as an independent SFR indicator. However, we also find a systematic offset in the SFR SFR H UV a +b ratios for z ∼ 4–5 galaxies relative to local relations (assuming the same dust corrections for nebular regions and stellar light). We show that we can resolve the modest tension in the inferred SFRs by assuming bluer intrinsic UV slopes (increasing the dust correction), a rising star formation history, or assuming a low-metallicity stellar population with a hard ionizing spectrum (increasing the LHa SFR ratio). Using Hα as an SFR indicator, we find a normalization of the star formation main sequence in good agreement with recent SED-based determinations and also derive the SFR functions at z ~ 4 8– . In addition, we assess for the first time the burstiness of star formation in z ~ 4 galaxies on <100 Myr timescales by comparing UV and Hα-based sSFRs; their one-to-one relationship argues against significantly bursty star formation histories

Galaxy formation in the Planck cosmology - III. The high-redshift universe

We present high-redshift predictions of the star formation rate distribution function (SFRDF), UV luminosity function (UVLF), galactic stellar mass function (GSMF), and specific star formation rates (sSFRs) of galaxies from the latest version of the Munich semi-analytic model L-GALAXIES. We find a good fit to both the shape and normalization of the SFRDF at z = 4–7, apart from a slight underprediction at the low-SFR end at z = 4. Likewise, we find a good fit to the faint number counts for the observed UVLF at brighter magnitudes our predictions lie below the observations, increasingly so at higher redshifts. At all redshifts and magnitudes, the raw (unattenuated) number counts for the UVLF lie above the observations. Because of the good agreement with the SFR we interpret our underprediction as an overestimate of the amount of dust in the model for the brightest galaxies, especially at high redshift. While the shape of our GSMF matches that of the observations, we lie between (conflicting) observations at z = 4–5, and underpredict at z = 6–7. The sSFRs of our model galaxies show the observed trend of increasing normalization with redshift, but do not reproduce the observed mass dependence. Overall, we conclude that the latest version of L-GALAXIES, which is tuned to match observations at z ≤ 3, does a fair job of reproducing the observed properties of galaxies at z ≥ 4. More work needs to be done on understanding observational bias at high redshift, and upon the dust model, before strong conclusions can be drawn on how to interpret remaining discrepancies between the model and observations

Mortality among residents of shelters, rooming houses, and hotels in Canada: 11 year follow-up study

Objective To examine mortality in a representative nationwide sample of homeless and marginally housed people living in shelters, rooming houses, and hotels

PAI-1 is a Critical Upstream Regulator of the TGF-β1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-β synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-β/EGFR signaling promotes cell migration and induces expression of both proteases and protease inhibitors that regulate stromal remodeling resulting in acquisition of an invasive phenotype. TGF-β1+EGF stimulation increases the production of several matrix metalloproteinases (MMPs) in human SCC. Among the most prominent is MMP-10 which is known to be elevated in SCC in situ. Activation of stromal plasminogen appears to be critical in triggering downstream MMP activity. Paradoxically, PAI-1, the major physiological inhibitor of plasmin generation, is also up-regulated under these conditions and is an early event in progression of incipient epidermal SCC. A model is proposed in which TGF-β1+EGF-dependent MMP-10 elevation directs focalized matrix remodeling events that promote epithelial cell plasticity and tissue invasion. Increased PAI-1 expression serves to temporally and spatially modulate plasmin-initiated pericellular proteolysis, further facilitating epithelial invasive potential. Defining the complex signaling mechanisms that maintain this elegant balance is critical to developing potential therapeutics for the treatment of human cutaneous malignancies

Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades

Spatial and temporal regulation of the pericellular proteolytic environment by local growth factors, such as EGF and TGF-β, initiates a wide repertoire of cellular responses coupled to a plasmin/matrix metalloproteinase (MMP) dependent stromal-remodeling axis. Cell motility and invasion, tumor metastasis, wound healing, and organ fibrosis, for example, represent diverse events controlled by expression of a subset of genes that encode various classes of tissue remodeling proteins. These include members of the serine protease and MMP families that functionally constitute a complex system of interacting protease cascades and titrated by their respective inhibitors. Several structural components of the extracellular matrix are upregulated by TGF-β as are matrix-active proteases (e.g., urokinase (uPA), plasmin, MMP-1, -3, -9, -10, -11, -13, -14). Stringent controls on serine protease/MMP expression and their topographic activity are essential for maintaining tissue homeostasis. Targeting individual elements in this highly interactive network may lead to novel therapeutic approaches for the treatment of cancer, fibrotic diseases, and chronic wounds