34 research outputs found
Desorption Kinetics of O and CO from Graphitic Carbon Surfaces
The desorption of O/CO from graphitic carbon surfaces is investigated using a one-dimensional model describing the adsorbate interactions with the surface phonon bath. The kinetics of desorption are described through the solution of a master equation for the time-dependent population of the adsorbate in an oscillator state, which is modified through thermal fluctuations at the surface. The interaction of the adsorbate with the surface phonons is explicitly captured by using the computed phonon density Of states (PDOS) of the surface. The coupling of the adsorbate with the phonon bath results in the transition of the adsorbate up and down a vibrational ladder. The adsorbate-surface interaction is represented in the model using a Morse potential, which allows for the desorption process to be directly modeled as a transition from bound to free (continuum) state. The PDOS is a property of the material and the lattice; and is highly sensitive to the presence of defects. The effect of etch pits along with random surface defects on the PDOS is considered in the present work. The presence of defects causes a redshift and broadening of the PDOS, which in turn changes the phonon frequency modes available for adsorbate coupling at the surface. Using the realistic PDOS distributions, the phonon-induced desorption (PID) model was used to compute the transition and desorption rates for both pristine and defective systems. Mathissens rule is used to compute the phonon relaxation time for pristine and defective systems based on the phonon scattering times for each of the different scattering processes. First, the desorption rates of the pristine system is fitted against the experimental values to obtain the Morse potential parameters for each of the observed adatoms. These Morse potential parameters are used along with the defective PDOS and phonon relaxation time to compute the desorption rates for the defective system. The defective system rates (both transition and desorption) were consistently lower in comparison with the pristine system. The difference between the transition rates is more significant at lower initial states due to higher energy spacing between the levels. In the case of the desorption rates, the difference between the defective and pristine system is more significant at higher temperatures. The desorption rates for each of the system shows an order of magnitude decrease with the strongly bound systems exhibiting the greatest reduction in the desorption rates
Zirconium Carbide Oxidation and Passivation for Nuclear Fuel Applications
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Investigation of the High-Energy Oxidation of FiberForm from DSMC Analysis of Molecular Beam Experiments
A collaborative effort between the University of Illinois at Urbana-Champaign (UIUC), NASA Ames Research Center (ARC) and Montana State University (MSU) succeeded at developing a new finite-rate carbon oxidation model from molecular beam scattering experiments on vitreous carbon (VC). We now aim to use the direct simulation Monte Carlo (DSMC) code SPARTA to apply the model to each fiber of the porous fibrous Thermal Protection Systems (TPS) material FiberForm (FF). The detailed micro-structure of FF was obtained from X-ray micro-tomography and then used in DSMC. Both experiments and simulations show that the CO/O products ratio increased at all temperatures from VC to FF. We postulate this is due to the larger number of collisions an O atom encounters inside the porous FF material compared to the flat surface of VC. For the simulations, we particularly focused on the lowest and highest temperatures studied experimentally, 1023 K and 1823 K, and found good agreement between the finite-rate DSMC simulations and experiments
Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach
Abstract
Background
Exposures to toxic metals and deficiencies in essential metals disrupt placentation and may contribute to preeclampsia. However, effects of exposure to combinations of metals remain unknown.
Objective
We investigated the relationship between urinary trace metals, circulating angiogenic biomarkers, and preeclampsia using the LIFECODES birth cohort.
Methods
Urine samples collected during pregnancy were analyzed for 17 trace metals and plasma samples were analyzed for soluble fms-like tyrosine-1 (sFlt-1) and placental growth factor (PlGF). Cox proportional hazard models were used to estimate the hazard ratios (HR) of preeclampsia associated with urinary trace metals. Linear regression models were used to estimate the relationship between urinary trace metals and angiogenic biomarkers. Principal components analysis (PCA) was used to identify groups of metals and interactions between principal components (PCs) loaded by toxic and essential metals were examined.
Results
In single-contaminant models, several toxic and essential metals were associated with lower PlGF and higher sFlt-1/PlGF ratio. Detection of urinary chromium was associated with preeclampsia: HR (95% Confidence Interval [CI]) = 3.48 (1.02, 11.8) and an IQR-increase in urinary selenium was associated with reduced risk of preeclampsia (HR: 0.28, 95% CI: 0.08, 0.94). Using PCA, 3 PCs were identified, characterized by essential metals (PC1), toxic metals (PC2), and seafood-associated metals (PC3). PC1 and PC2 were associated with lower PlGF levels, but not preeclampsia risk in the overall cohort.
Conclusions
Trace urinary metals may be associated with adverse profiles of angiogenic biomarkers and preeclampsia.https://deepblue.lib.umich.edu/bitstream/2027.42/152235/1/12940_2019_Article_503.pd
Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens A Randomized Clinical Trial
IMPORTANCE Fenfluramine treatment may reduce monthly convulsive seizure frequency in
patients with Dravet syndrome who have poor seizure control with their current
stiripentol-containing antiepileptic drug regimens.
OBJECTIVE To determine whether fenfluramine reduced monthly convulsive seizure
frequency relative to placebo in patients with Dravet syndrome who were taking
stiripentol-inclusive regimens.
DESIGN, SETTING, AND PARTICIPANTS This double-blind, placebo-controlled, parallel-group
randomized clinical trial was conducted in multiple centers. Eligible patients were children
aged 2 to 18 years with a confirmed clinical diagnosis of Dravet syndrome who were receiving
stable, stiripentol-inclusive antiepileptic drug regimens.
INTERVENTIONS Patients with 6 or more convulsive seizures during the 6-week baseline
period were randomly assigned to receive fenfluramine, 0.4 mg/kg/d (maximum, 17 mg/d),
or a placebo. After titration (3 weeks), patients’ assigned dosages were maintained for
12 additional weeks. Caregivers recorded seizures via a daily electronic diary.
MAIN OUTCOMES AND MEASURES The primary efficacy end point was the change in mean
monthly convulsive seizure frequency between fenfluramine and placebo during the
combined titration and maintenance periods relative to baseline.
RESULTS A total of 115 eligible patients were identified; of these, 87 patients (mean [SD], age
9.1 [4.8] years; 50 male patients [57%]; mean baseline frequency of seizures, approximately
25 convulsive seizures per month) were enrolled and randomized to fenfluramine,
0.4 mg/kg/d (n = 43) or placebo (n = 44). Patients treated with fenfluramine achieved a
54.0% (95% CI, 35.6%-67.2%; P < .001) greater reduction in mean monthly convulsive
seizure frequency than those receiving the placebo. With fenfluramine, 54% of patients
demonstrated a clinically meaningful (50%) reduction in monthly convulsive seizure
frequency vs 5% with placebo (P < .001). The median (range) longest seizure-free interval
was 22 (3.0-105.0) days with fenfluramine and 13 (1.0-40.0) days with placebo (P = .004).
The most common adverse events were decreased appetite (19 patients taking fenfluramine
[44%] vs 5 taking placebo [11%]), fatigue (11 [26%] vs 2 [5%]), diarrhea (10 [23%] vs 3 [7%]),
and pyrexia (11 [26%] vs 4 [9%]). Cardiac monitoring demonstrated no clinical or
echocardiographic evidence of valvular heart disease or pulmonary arterial hypertension.
CONCLUSIONS AND RELEVANCE Fenfluramine demonstrated significant improvements in
monthly convulsive seizure frequency in patients with Dravet syndrome whose conditions
were insufficiently controlled with stiripentol-inclusive antiepileptic drug regimens.
Fenfluramine was generally well tolerated. Fenfluramine may represent a new treatment
option for Dravet syndrome.
TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT0292689
Differential effects of hunger and satiety on insular cortex and hypothalamic functional connectivity
The insula cortex and hypothalamus are implicated in eating behaviour, and contain receptor sites for peptides and hormones controlling energy balance. The insula encompasses multi-functional subregions, which display differential anatomical and functional connectivities with the rest of the brain. This study aimed to analyse the effect of fasting and satiation on the functional connectivity profiles of left and right anterior, middle, and posterior insula, and left and right hypothalamus. It was hypothesized that the profiles would be altered alongside changes in homeostatic energy balance. Nineteen healthy participants underwent two 7-min resting state functional magnetic resonance imaging scans, one when fasted and one when satiated. Functional connectivity between the left posterior insula and cerebellum/superior frontal gyrus, and between left hypothalamus and inferior frontal gyrus was stronger during fasting. Functional connectivity between the right middle insula and default mode structures (left and right posterior parietal cortex, cingulate cortex), and between right hypothalamus and superior parietal cortex was stronger during satiation. Differences in blood glucose levels between the scans accounted for several of the altered functional connectivities. The insula and hypothalamus appear to form a homeostatic energy balance network related to cognitive control of eating; prompting eating and preventing overeating when energy is depleted, and ending feeding or transferring attention away from food upon satiation. This study provides evidence of a lateralized dissociation of neural responses to energy modulations
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Drag reduction using trapped bubbles on a submerged flat plate surface
Drag reduction using an array of thousands of tiny trapped bubbles on a submerged flat plate was investigated. The objective was to determine if viscous drag reduction could be obtained by replacing portions of the solid no-slip surface of the plate with areas of near-slip formed by the bubbles. Drag measurements were obtained for two different trapped bubble configurations. The first configuration involved a large bubble trapped on the bottom surface of a horizontally mounted plate, which provides insight as to the maximum drag reduction obtainable using the trapped bubble concept. The second configuration involved a trapped bubble array (TBA), which uses electrolysis to grow and maintain bubbles on the plate surface in thousands of tiny conductive holes. The TBA experiments are conducted on a vertically mounted plate, which demonstrates the versatility of this drag reduction method. Drag measurements over a range of Reynolds numbers were made on different plate configurations using three independent measurement techniques; the reliability of these results are demonstrated by agreement among the measured drag values as well as good agreement with an analytic turbulent flat plate solution. The large trapped bubble configuration showed an increase in drag reduction with increasing Reynolds number and demonstrated a maximum drag reduction of 32% corresponding to a slip bubble region covering 35% of the wetted plate surface. The trapped bubble array results were inconclusive. Total drag measurements on the plate agree among themselves and with the turbulent flat plate solution; however uncertainty analysis revealed drag measurement accuracy of only ±0.02 N at best using the proximity sensor measurement system. In general, the difference in drag on the flat plate with and without bubbles as indicated by the proximity sensor was less than 0.02 N, thus it is impossible to determine if the tiny trapped bubbles did indeed provide drag reduction. The temporal evolution of drag reduction using the trapped bubble array was also studied, but changes in drag appeared to be within the noise of the drag measurements. Finally, the efficiency of this drag reduction method was investigated in the laboratory setting. The trapped bubbles used in this drag reduction method are formed on the plate surface by electrolysis in the conductive holes, but not all of the gas produced in this process collects to form the trapped bubbles, and some energy is dissipated due to resistance in the water. To quantify the efficiency of this system, bubble formation efficiency plots (which map power input as a function of time to fill the bubble plate) were analytically determined and compared to the actual time to fill the bubble plate for various power input levels. The system approaches maximum (~95%) efficiency at lower power input levels (7.22 W/m2), requiring approximately 15 minutes to fill the bubble plate; conversely, the plate approaches 50% efficiency at high power input level (262 W/m2) while the plate fills within 2 minutes.Aerospace Engineering and Engineering Mechanic
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Development of a hybrid DSMC/CFD method for hypersonic boundary layer flow over discrete surface roughness
textThis work is focused on the development of a hybrid DSMC/CFD solver to examine hypersonic boundary layer flow over discrete surface roughness. The purpose of these investigations is to identify and quantify the non-equilibrium effects that influence the roughness-induced disturbance field and surface quantities of interest for engineering applications. To this end, a new hybrid framework is developed for high-fidelity hybrid solutions involving five-species air hypersonic boundary layer flow applications.
A novel approach is developed for DSMC particle generation at a hybrid interface for gas mixtures with internal degrees of freedom. The appropriate velocity distribution function is formulated in the framework of Generalized Chapman-Enskog Theory, and includes contributions from species mass diffusion, shear stress and heat fluxes (both translational and internal) on the perturbation of the equilibrium distribution function. This formulation introduces new breakdown parameters for use in hybrid DSMC/CFD applications, and the new sampling algorithm allows for the generation of DSMC internal energies from the appropriate non-equilibrium distribution for the first time in the literature. The contribution of the internal heat fluxes to the overall perturbation is found to be of the same order as the stress tensor components, underscoring the importance of DSMC particle generation from the Generalized Chapman-Enskog distribution.
A detailed comparison of the transport coefficients is made between the DSMC and CFD solvers, and a general best-fit approach is developed for the consistent treatment of diffusion, viscosity and thermal conductivity for a five-species air gas mixture. The DSMC VHS/VSS model parameters are calibrated through an iterative fitting approach using the Nelder-Mead Simplex Algorithm. The VSS model is found to provide the best fit (within 5% over the temperature range) to the transport models used in the CFD solver. The best-fit five-species air parameters are provided for general use by the DSMC community, either for hybrid applications or to provide improved consistency in general DSMC/CFD applications.
This hybrid approach has been applied to examine hypersonic boundary layer flow over discrete surface roughness for a variety of roughness geometries and flow conditions. An (asymmetric) elongated hump geometry and (symmetric) diamond shaped roughness geometry are examined at high and low altitude conditions. Detailed comparisons among the hybrid solution and the CFD no-slip and slip wall solutions were made to examine the differences in surface heating, translational/vibrational non-equilibrium in the flow near the roughness, and the vortex structures in the wake through the Q-criterion. In all cases examined, the hybrid solution predicts a lower peak surface heating to the roughness compared to either CFD solution, and a higher peak surface heating in the wake due to vortex heating. The observed differences in vortex heating are a result of the predicted vortex structures which are highlighted using the Q-criterion. The disturbance field modeled by the hybrid solution organizes into a system of streamwise-oriented vortices which are slightly stronger and have a greater spanwise extent compared to the CFD solutions. As a general trend, it was observed that these differences in the predicted heating by the hybrid and CFD solutions increase with increasing Knudsen number. This trend is found for both peak heating values on the roughness and in the wake.Aerospace Engineerin