Dual database strategy and implementation

In expanding from an application-oriented hierarchical database model information system to a system integrated with information-oriented relational database model, IBM offers its IMS/DB2 dual database strategy. There are also other non-IBM database technologies challenging DB2 as the only alternative for IMS installation. Automobile industries themselves are going through such a transition in developing their fourth-generation information systems. A couple major automobile corporations with IMS-based information systems are brought up as examples. These corporations have developed their design strategies and system architectures. Such an integration has influence upon the operating environment and the decision support for the end-user-driven information retrieval applications.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26914/1/0000480.pd

Municipal biowaste treatment plants contribute to the contamination of the environment with residues of biodegradable plastics with putative higher persistence potential

Biodegradable plastics (BDP) are expected to mineralize easily, in particular under conditions of technical composting. However, the complexity of the sample matrix has largely prevented degradation studies under realistic conditions. Here composts and fertilizers from state-of-the-art municipal combined anaerobic/aerobic biowaste treatment plants were investigated for residues of BDP. We found BDP fragments > 1 mm in significant numbers in the final composts intended as fertilizer for agriculture and gardening. Compared to pristine compostable bags, the recovered BDP fragments showed differences in their material properties, which potentially renders them less prone to further biodegradation. BDP fragments < 1 mm were extracted in bulk and came up to 0.43 wt% of compost dry weight. Finally, the liquid fertilizer produced during the anaerobic treatment contained several thousand BDP fragments < 500 µm per liter. Hence, our study questions, if currently available BDP are compatible with applications in areas of environmental relevance, such as fertilizer production

Natural extensions and entropy of α\alpha-continued fractions

We construct a natural extension for each of Nakada's $\alpha$-continued fractions and show the continuity as a function of $\alpha$ of both the entropy and the measure of the natural extension domain with respect to the density function $(1+xy)^{-2}$. In particular, we show that, for all $0 < \alpha \le 1$, the product of the entropy with the measure of the domain equals $\pi^2/6$. As a key step, we give the explicit relationship between the $\alpha$-expansion of $\alpha-1$ and of $\alpha$

Changes of intracellular sodium and potassium ion concentrations in frog spinal motoneurons induced by repetitive synaptic stimulation

A post-tetanic membrane hyperpolarization following repetitive neuronal activity is a commonly observed phenomenon in the isolated frog spinal cord as well as in neurons of other nervous tissues. We have now used double-barrelled Na+- and K+-ion-sensitive microelectrodes to measure the intracellular Na+- and K+-concentrations and also the extracellular K+-concentration of lumbar spinal motoneurons during and after repetitive stimulation of a dorsal root. The results show that the posttetanic membrane hyperpolarization occurred at a time when the intracellular [Na+] reached its maximal value, intracellular [K+] had its lowest level and extracellular [K+] was still elevated. The hyperpolarization was blocked by ouabain and reduced by Li+. These data support the previous suggestion that an electrogenic Na+/K+ pump mode may be the mechanism underlying the post-tetanic membrane hyperpolarization

Fine structure, magnetic field and heating of sunspot penumbrae

We interpret penumbral filaments as due to convection in field-free, radially aligned gaps just below the visible surface of the penumbra, intruding into a nearly potential field above. This solves the classical discrepancy between the large heat flux and the low vertical velocities observed in the penumbra. The presence of the gaps causes strong small-scale fluctuations in inclination, azimuth angle and field strength, but without strong forces acting on the gas. The field is nearly horizontal in a region around the cusp-shaped top of the gap, thereby providing an environment for Evershed flows. We identify this region with the recently discovered dark penumbral cores. Its darkness has the same cause as the dark lanes in umbral light-bridges, reproduced in numerical simulations by Nordlund and Stein (2005). We predict that the large vertical and horizontal gradients of the magnetic field inclination and azimuth in the potential field model will produce the net circular polarization seen in observations. The model also explains the significant elevation of bright filaments above their surroundings. It predicts that dark areas in the penumbra are of two different kinds: dark filament cores containing the most inclined (horizontal) fields, and regions between bright filaments, containing the least inclined field lines.Comment: submitted to A&

A Membrane Defect in the Pathogenesis of the Smith-Lemli-Opitz Syndrome

The Smith-Lemli-Opitz syndrome (SLOS) is an often lethal birth defect resulting from mutations in the gene responsible for the synthesis of the enzyme 3beta-hydroxy-steroid-Delta7-reductase, which catalyzes the reduction of the double bond at carbon 7 on 7-dehydrocholesterol (7-DHC) to form unesterified cholesterol. We hypothesize that the deficiency in cholesterol biosynthesis and subsequent accumulation of 7-DHC in the cell membrane leads to defective composition, organization, dynamics, and function of the cell membrane. Using skin fibroblasts obtained from SLOS patients, we demonstrate that the SLOS membrane has increased 7-DHC and reduced cholesterol content and abnormal membrane fluidity. X-ray diffraction analyses of synthetic membranes prepared to mimic SLOS membranes revealed atypical membrane organization. In addition, calcium permeability is markedly augmented, whereas membrane-bound Na+/K+ATPase activity, folate uptake, inositol-1,4,5-trisphosphate signaling, and cell proliferation rates are markedly suppressed. These data indicate that the disturbance in membrane sterol content in SLOS, likely at the level of membrane caveolae, directly contributes to the widespread tissue abnormalities in this disease

Striation and convection in penumbral filaments

Observations with the 1-m Swedish Solar Telescope of the flows seen in penumbral filaments are presented. Time sequences of bright filaments show overturning motions strikingly similar to those seen along the walls of small isolated structures in the active regions. The filaments show outward propagating striations with inclination angles suggesting that they are aligned with the local magnetic field. We interpret it as the equivalent of the striations seen in the walls of small isolated magnetic structures. Their origin is then a corrugation of the boundary between an overturning convective flow inside the filament and the magnetic field wrapping around it. The outward propagation is a combination of a pattern motion due to the downflow observed along the sides of bright filaments, and the Evershed flow. The observed short wavelength of the striation argues against the existence of a dynamically significant horizontal field inside the bright filaments. Its intensity contrast is explained by the same physical effect that causes the dark cores of filaments, light bridges and `canals'. In this way striation represents an important clue to the physics of penumbral structure and its relation with other magnetic structures on the solar surface. We put this in perspective with results from the recent 3-D radiative hydrodynamic simulations.Comment: Accepted for publication in A&

Fusion In The Era Of Burning Plasma Studies: Workforce Planning For 2004-2014

This is the final report of a panel set up by the U.S. Department of Energy (DOE) Fusion Energy Sciences Advisory Committee (FESAC) in response to a charge letter from Dr. Raymond Orbach (Appendix A), asking FESAC to addressed the issue of workforce development in the U.S. fusion program. This report, submitted to FESAC March 29, 2004 and subsequently approved by them (Appendix B), presents FESAC\u27s response to that charge

Does a colour-coded blood pressure diary improve blood pressure control for patients in general practice: The CoCo trial

BACKGROUND: Insufficient blood pressure control is a frequent problem despite the existence of effective treatment. Insufficient adherence to self-monitoring as well as to therapy is a common reason. Blood pressure self-measurement at home (Home Blood Pressure Measurement, HBPM) has positive effects on treatment adherence and is helpful in achieving the target blood pressure. Only a few studies have investigated whether adherence to HBPM can be improved through simple measures resulting also in better blood pressure control. OBJECTIVE: Improvement of self-monitoring and improved blood pressure control by using a new colour-coded blood pressure diary. OUTCOME: Primary outcome: Change in systolic and/or diastolic blood pressure 6 months after using the new colour-coded blood pressure diary.Secondary outcome: Adherence to blood pressure self-measurement (number of measurements/entries). METHODS/DESIGN: Randomised controlled study.Population: 138 adult patients in primary care with uncontrolled hypertension despite therapy. The control group uses a conventional blood pressure diary; the intervention group uses the new colour-coded blood pressure diary (green, yellow, red according a traffic light system). EXPECTED RESULTS/CONCLUSION: The visual separation and entries in three colour-coded areas reflecting risk (green: blood pressure in the target range 140/>90 mmHg, red: blood pressure in danger zone > 180 mmHg/>110 mmHg) lead to better self-monitoring compared with the conventional (non-colour-coded) blood pressure booklet. The colour-coded, visualised information supports improved perception (awareness and interpretation) of blood pressure and triggers correct behaviour, in the means of improved adherence to the recommended treatment as well as better communication between patients and doctors resulting in improved blood pressure control. TRIAL REGISTRATION: ClinicalTrials.gov ID NCT01013467