Investigations on the anti-diabetic potential of novel marine seaweed Sargassum longiotom against alloxan-induced diabetes mellitus: A pilot study

The present study evaluated the hypoglycemic effect of brown algae Sargassum longiotom in alloxan-induced diabetic rats. After the treatment with S. longiotom extract, there is a significant reduction (p<0.001) in blood glucose when compared with the diabetic control group. Moreover the ethanolic extract of S. longiotom significantly reduces (p<0.001) the levels of   triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol dose dependent manner. Alternatively, it increases the high-density lipoprotein cholesterol level in the treated groups. The values of SGOT, SGPT and ALP have been significantly reduced (p<0.001) in the treated rats when compared to diabetic control. Thus, the present study indicates that the ethanolic extract of seaweed S. longiotom posses very effective hypoglycemic and hypolipidemic effect on the alloxan-induced diabetic rats compared to the reference drug glibenclamide

Investigations on the anti-diabetic potential of novel marine seaweed Sargassum longiotom against alloxan-induced diabetes mellitus: A pilot study

The present study evaluated the hypoglycemic effect of brown algae Sargassum longiotom in alloxan-induced diabetic rats. After the treatment with S. longiotom extract, there is a significant reduction (p<0.001) in blood glucose when compared with the diabetic control group. Moreover the ethanolic extract of S. longiotom significantly reduces (p<0.001) the levels of triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol dose dependent manner. Alternatively, it increases the high-density lipoprotein cholesterol level in the treated groups. The values of SGOT, SGPT and ALP have been significantly reduced (p<0.001) in the treated rats when compared to diabetic control. Thus, the present study indicates that the ethanolic extract of seaweed S. longiotom posses very effective hypoglycemic and hypolipidemic effect on the alloxan-induced diabetic rats compared to the reference drug glibenclamide

Geranii Herba as a Potential Inhibitor of SARS-CoV-2 Main 3CLpro, Spike RBD, and Regulation of Unfolded Protein Response: An In Silico Approach

Background: Since the first patient identified with SARS-CoV-2 symptoms in December 2019, the trend of a spreading coronavirus disease 2019 (COVID-19) infection has remained to date. As for now, there is an urgent need to develop novel drugs or vaccines for the SARS-CoV-2 virus. Methods: Polyphenolic compounds have potential as drug candidates for various diseases, including viral infections. In this study, polyphenolic compounds contained in Geranii Herba were chosen for an in silico approach. The SARS-CoV-2 receptor-binding domain (RBD), 3CLpro (Replicase polyprotein 1ab), and the cell surface receptor glucose-regulated protein 78 (GRP78) were chosen as target proteins. Results: Based on the molecular docking analysis, ellagic acid, gallic acid, geraniin, kaempferitrin, kaempferol, and quercetin showed significant binding interactions with the target proteins. Besides, the molecular dynamic simulation studies support Geranii Herba&rsquo;s inhibition efficiency on the SARS-CoV-2 RBD. We assume that the active compounds in Geranii Herba might inhibit SARS-CoV-2 cell entry through the ACE2 receptor and inhibit the proteolytic process. Besides, these compounds may help to regulate the cell signaling under the unfolded protein response in endoplasmic reticulum stress through the binding with GRP78 and avoid the SARS-CoV-2 interaction. Conclusions: Hence, the compounds present in Geranii Herba could be used as possible drug candidates for the prevention/treatment of SARS-CoV-2 infection

Stereospermum tetragonam as an antidiabetic agent by activating PPARγ and GLUT4

Present study evaluates the anti-diabetic activity of S. tetragonam LC-MS/MS experiments showed the presence of two novel molecules C1 and C2, which were further taken for in silico study against PPARγ. Cell culture studies with A431 cells in the presence of crude aqueous extract showed the elevated level of PPARγ and GLUT4 and also confirmed using in silico studies. Thus, the present study proves the mecode of action of S. tetragonam as an antidiabetic drug