62 research outputs found
Revisiting Solvent Additives for the Fabrication of Polymer:Fullerene Solar Cells: Exploring a Series of Benzaldehydes
Communication in the Third Dimension: Song Perch Height of Rivals Affects Singing Response in Nightingales
Many animals use long-range signals to compete over mates and resources. Optimal transmission can be achieved by choosing efficient signals, or by choosing adequate signalling perches and song posts. High signalling perches benefit sound transmission and reception, but may be more risky due to exposure to airborne predators. Perch height could thus reflect male quality, with individuals signalling at higher perches appearing as more threatening to rivals. Using playbacks on nightingales (Luscinia megarhynchos), we simulated rivals singing at the same height as residents, or singing three metres higher. Surprisingly, residents increased song output stronger, and, varying with future pairing success, overlapped more songs of the playback when rivals were singing at the same height than when they were singing higher. Other than expected, rivals singing at the same height may thus be experienced as more threatening than rivals singing at higher perches. Our study provides new evidence that territorial animals integrate information on signalling height and thus on vertical cues in their assessment of rivals
Multi-atom quasiparticle scattering interference for superconductor energy-gap symmetry determination
Complete theoretical understanding of the most complex superconductors requires a detailed knowledge of the symmetry of the superconducting energy-gap Δ, for all momenta k on the Fermi surface of every band α. While there are a variety of techniques for determining |Δ|, no general method existed to measure the signed values of Δ. Recently, however, a technique based on phase-resolved visualization of superconducting quasiparticle interference (QPI) patterns, centered on a single non-magnetic impurity atom, was introduced. In principle, energy-resolved and phase-resolved Fourier analysis of these images identifies wavevectors connecting all k-space regions where Δ has the same or opposite sign. But use of a single isolated impurity atom, from whose precise location the spatial phase of the scattering interference pattern must be measured, is technically difficult. Here we introduce a generalization of this approach for use with multiple impurity atoms, and demonstrate its validity by comparing the Δ it generates to the Δ determined from single-atom scattering in FeSe where s± energy-gap symmetry is established. Finally, to exemplify utility, we use the multi-atom technique on LiFeAs and find scattering interference between the hole-like and electron-like pockets as predicted for Δ of opposite sign
Large-scale analysis of frequency modulation in birdsong data bases
DS & MP are supported by an EPSRC Leadership Fellowship EP/G007144/1. Our thanks to Alan McElligott for helpful advice while preparing the manuscript; Sašo Muševič for discussion and for making his DDM software available; and Rémi Gribonval and team at INRIA Rennes for discussion and software development during a research visit
Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
OBJECTIVE—Type 2 diabetes is a common complex disorder with environmental and genetic components. We used a candidate gene–based approach to identify single nucleotide polymorphism (SNP) variants in 222 candidate genes that influence susceptibility to type 2 diabetes
Nematic pairing from orbital-selective spin fluctuations in FeSe
FeSe is an intriguing iron-based superconductor. It presents an unusual nematic state without magnetism and can be tuned to increase the critical superconducting temperature. Recently it has been observed a noteworthy anisotropy of the superconducting gaps. Its explanation is intimately related to the understanding of the nematic transition itself. Here, we show that the spin-nematic scenario driven by orbital-selective spin fluctuations provides a simple scheme to understand both phenomena. The pairing mediated by anisotropic spin modes is not only orbital selective but also nematic, leading to stronger pair scattering across the hole and X electron pocket. The delicate balance between orbital ordering and nematic pairing points also to a marked k z dependence of the hole\u2013gap anisotropy
Tissue-specific alternative splicing of TCF7L2
Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D). However, the mechanisms by which these non-coding variants increase risk for T2D are not well-established. We used 13 expression assays to survey mRNA expression of multiple TCF7L2 splicing forms in up to 380 samples from eight types of human tissue (pancreas, pancreatic islets, colon, liver, monocytes, skeletal muscle, subcutaneous adipose tissue and lymphoblastoid cell lines) and observed a tissue-specific pattern of alternative splicing. We tested whether the expression of TCF7L2 splicing forms was associated with single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, located within introns 3 and 4 of the gene and most strongly associated with T2D. Expression of two splicing forms was lower in pancreatic islets with increasing counts of T2D-associated alleles of the SNPs: a ubiquitous splicing form (P = 0.018 for rs7903146 and P = 0.020 for rs12255372) and a splicing form found in pancreatic islets, pancreas and colon but not in other tissues tested here (P = 0.009 for rs12255372 and P = 0.053 for rs7903146). Expression of this form in glucose-stimulated pancreatic islets correlated with expression of proinsulin (r2 = 0.84–0.90, P < 0.00063). In summary, we identified a tissue-specific pattern of alternative splicing of TCF7L2. After adjustment for multiple tests, no association between expression of TCF7L2 in eight types of human tissue samples and T2D-associated genetic variants remained significant. Alternative splicing of TCF7L2 in pancreatic islets warrants future studies. GenBank Accession Numbers: FJ010164–FJ010174
A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10
Song type sharing in common nightingales, Luscinia megarhynchos, and its implications for cultural evolution
The sharing of song types between males of the same local population is a common phenomenon in some songbird species. One presumed advantage of such sharing is that it enables ‘song matching’ (i.e. responding to an interactant with the song he just sang or another song of the interactant’s repertoire). Song sharing probably arises through song learning, whereby males of some species prefer acquiring songs shared in the local population. However, such a preference may lead to uniformity of repertoires, devaluating the signal value of shared songs. Here we investigated repertoire composition in a local population of nightingales. More precisely, we analysed the number of song types shared by a given number of males and compared the finding with different simulated models of song acquisition. We found that proportions of both (songs shared by many males as well as songs sung by a single male only) were clearly more common than expected. We also simulated the cultural evolution of the population’s repertoire. The results of these simulations supported our conclusion from the simulation of song acquisition that unshared songs arise through invention of novel song types or modification of existing ones, although we cannot rule out that unshared songs also appear through immigration of males. Our findings suggest that nightingales have a preference to acquire both shared song types, which enable matching the songs of opponents, and unshared or ‘invented’ new song types, which may help to avoid being matched by opponents.
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