Los "traficantes de cultura": sobre agentes y enseñanza de la literatura

En el siguiente artículos surgen las siguientes preguntas: ¿podrá el profesor de literatura resolver esa difícil negociación entre el placer de leer (y escribir) y la tarea de enseñar?, ¿podrá impedir que se borre, neutralice o entorpezca ese primer vínculo lector?; ¿“barajar nuevamente las cartas”; es decir, volver sobre sus propias prácticas para reflexionar, desde un enfoque cualitativo, sobre los modos de leer de los alumnos? En estos interrogantes subyacen otros planteos. En primer lugar, habría que repreguntarse por el rol del docente y su labor como agente social: ¿es un agente?, ¿por qué?, ¿qué se entiende por tal? En segundo lugar, y esto en relación al profesor de literatura en particular: ¿cuál ha sido y es su relación con las teorías?, ¿qué se entiende por tales relaciones?, ¿cuáles son esas teorías que han “moldeado” a ese sujeto “pedagogizado”, como si fueran recetas a seguir?, ¿qué cuestionar de las mismas?, ¿a qué otros marcos les podemos dar cabida en nuestras prácticas y que tal vez no han tenido presencia porque permanecieron solapados por otros discursos legitimados y hegemónicos? Las reflexiones que se ofrecen a continuación son un intento de responder a estos interrogantes.Sección: Maquinaciones. ArtículosDepartamento de Letra

Waxy casts in the urinary sediment of patients with different types of glomerular diseases: Results of a prospective study

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Contribution of L-Arginine supplementation during gestation on sow productive performance and on sow microbial faecal profile

Arginine plays an important role during reproduction, however, the amount of supplementation in sow diet is still uncertain. The aim of the study was to verify the efficacy of a gestating diet enriched or not with a low dose of L-arginine (Arg) on sow productive performance in terms of numbers and weight of piglets at birth and at weaning, frequency of intrauterine growth retardation (IUGR) and piglets' mortality, sow placenta weight and salivary humoral immunity and intestinal microbial balance of the sows. 205 sows (Landrace x Large White) were divided into two experimental groups: a control group (CON) (102 sows) and a group supplemented with 0.25% of Arg (ARG) for the whole pregnancy period. Saliva and faecal samples were collected two days before farrowing and used for immunoglobulins and microbial analysis, respectively. Arg improved the number of total born piglets (p = .043) and tended to improve the number of total born alive (p = .086) and to reduce IUGR % (p = .090) and dead piglets at d0–d3 (p = .088). The weight of placenta and humoral immunity were not influenced by Arg. Arg did not modify the faecal microbial structure (alpha and beta indices) but increased the relative abundance of Bacteroidaceae family and Bacteroides genera (p = .0001). The results support the knowledge that Arg plays a key role in nutrition and physiology of pregnant sows without compromising gut eubiosis.HighlightArg supplementation of sows' gestation diet increased the number of total bornsArg supplementation of sows' gestation diet did not negatively affect the sows' gut eubiosisArg plays a significant role in the nutrition of pregnant sows. Arg supplementation of sows' gestation diet increased the number of total borns Arg supplementation of sows' gestation diet did not negatively affect the sows' gut eubiosis Arg plays a significant role in the nutrition of pregnant sows

Effects of dog-assisted therapies on cognitive mnemonic capabilities in people affected by Alzheimer's disease

Alzheimer’s disease (AD) is the most common cause of dementia in humans and, currently, a valid treatment is lacking. Our goal is to demonstrate the importance and benefits of the relationship with companion animals (considered as co-therapists), intended as a means of facilitating social relations and promoting evident wellbeing in AD patients. The study involved 30 randomly chosen patients with Alzheimer’s disease (group T) and three dogs. The group participated in a total of 24 animal-assisted interventions (AAIs) sessions over a span of 12 weeks, using the Mini-Mental State Examination (MMSE), Wellness and Cognitive Ability Questionnaire (Brief Assessment Cognition or BAC), and Alzheimer’s Disease Assessment Scale (ADAS) as assessment tests. A second group (group C), consisting of 10 people with AD, was enrolled as control group and underwent the same assessment tests but did not benefit from the presence of the dogs. Tests were carried out at time T0 (before starting sessions), T1 (end of sessions), and T2 (two months after last session). People belonging to group T achieved an overall improvement in their perceived state of wellbeing, even on a cognitive and mnemonic plane. However, two months after the end of the sessions, the test results in people suffering from AD decreased towards the baseline (T0). The study shows how such progress can be achieved through activities based on the relationship with an animal, as long as the animal is a steady presence in the life of the patient receiving the intervention. Dogs involved in other dog-assisted therapies have been found suitable also for assisting patients with AD

Angiogenesis in hand chondroma: an immunohistochemical study.

Hand chondroma is a particular cartilagineous tumour, being clinically benign, but morphologically malignant. This study investigates the expression of VEGF together with other growth factors and proliferation markers such as TGF&bT2, Ki-67, TNF, FGF1, P53 in 8 cases of hand chondroma treated with courettage, in order to define the ethiopathogenesis of this tumour and the clinical significance of the resulting immunohistochemical profile, with particular respect to angiogenesis. VEGF was expressed in all cases; 5 cases were positive for TFGβ2 and 3 for PDGF. None of the other factors was expressed. On the basis of histologic results a specific model of tumour progression based on the indicators of angiogenesis could be related to hand tumours, in which VEGF expression should be the first stadium of the tumour aggressiveness, and the following PDGF, TGF 2 expression should be accompanied with a morphological outline worsening. Nevertheless the non constant expression of these indicators and the absent expression of proliferated indicators can explain the scant tendency to the relapse in presence of accurate curettage. It is important to remember that the cellular polymorphism typical of the cartilaginous tumours does not allow the application of an only oncogenesis model

Ehlers–Danlos Syndrome in an Adult Woman: A Hidden Syndrome

Ehlers–Danlos syndrome is a rare disease and a diagnostic challenge. This case report serves to remind the clinician that it is important to identify all affected patients in order to prevent complications

Innovative, effective and sustainable technology and logistics for forest residual biomass

Luken kirjat, raportit, oppaat ja esitteet. Summary of the INFRES project results201

Common variants in breast cancer risk loci predispose to distinct tumor subtypes.

BACKGROUND: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. METHODS: Among 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes. RESULTS: Eighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions. CONCLUSION: This report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive breast cancer patients and resistance to tamoxifen treatment. Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13 germline mutations and breast cancer risk in a previous study consisting of 3,270 familial non-BRCA1/2 breast cancer cases and 2,327 controls from the Netherlands. Although both recurrent HOXB13 mutations p.G84E and p.R217C were not associated with breast cancer risk, the risk estimation for p.R217C was not very precise. To provide more conclusive evidence regarding the role of HOXB13 in breast cancer susceptibility, we here evaluated the association between HOXB13 mutations and increased breast cancer risk within 81 studies of the international Breast Cancer Association Consortium containing 68,521 invasive breast cancer patients and 54,865 controls. Both HOXB13 p.G84E and p.R217C did not associate with the development of breast cancer in European women, neither in the overall analysis (OR = 1.035, 95% CI = 0.859-1.246, P = 0.718 and OR = 0.798, 95% CI = 0.482-1.322, P = 0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes. Thus, although involved in breast cancer progression, HOXB13 is not a material breast cancer susceptibility gene.Peer reviewe

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk.

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95%CI = 1.18-1.33) for Europeans, and an OR per SD = 1.15 (95%CI = 1.02-1.29) for Asians. The absolute lifetime risks of CBC, accounting for death as competing risk, were 12.4% for European women at the 10th percentile and 20.5% at the 90th percentile of PRS313. We found no evidence of confounding by or interaction with individual characteristics, characteristics of the primary tumor, or treatment. The C-index for the PRS313 alone was 0.563 (95%CI = 0.547-0.586). In conclusion, PRS313 is an independent factor associated with CBC risk and can be incorporated into CBC risk prediction models to help improve stratification and optimize surveillance and treatment strategies