Recensiones [Revista de Historia Económica Año XV Primavera-Verano 1997 n. 2 pp. 415-455]

Concepción de Castro. Campomanes. Estado y reformismo ilustrado (Por Ángel García Sanz).-- Ricardo Rodríguez González. Mercaderes castellanos del Siglo de Oro (Por Bernardo Hernández).-- Carmen García García. La crisis de las Haciendas locales. De la reforma administrativa a la reforma fiscal (1743-1845) (Por Carlos de la Hoz).-- Vicente Pinilla Navarro. Entre la inercia y el cambio. El sector agrario aragonés, 1850-1935 (Por José Miguel Martínez Carrión).-- Manuel González Portilla y otros. Ferrocarriles y desarrollo. Red y mercados en el País Vasco, 1856-1914 (Por Carlos Larrinaga Rodríguez).-- Manuel González Portilla (dir.). Bilbao en la formación del País Vasco contemporáneo (Economía, población y ciudad) (Por Montserrat Gárate Ojanguren).-- Barry Eichengreen. Globalizing Capital (Por Concepción García-Iglesias Soto).-- Giorgio Morí, Luigi Rosa, Giuseppe Galasso, Valerio Castronovo y iovanni Zanetti (eds.). Storia dell'industria elettrica in Italia (Por Gregorio Núñez Romero-Balmas).-- Jeremy Bentham. Colonies, commerce and constitucional law. Rid yourselves ofultramaria and other writings on Spain andSpanish America (Por Carlos Rodríguez Braun).-- Víctor Bulmer-Thomás. The Economic History of Latín America Since Independence (Por Daniel Díaz Fuentes)Publicad

100 años investigando el mar. El IEO en su centenario (1914-2014).

Se trata de un libro que pretende divulgar a la sociedad las principales investigaciones multidisciplinares llevadas a cabo por el Instituto Español de Oceanografía durante su primer siglo de vida, y dar a conocer la historia del organismo, de su Sede Central y de los nueve centros oceanográficos repartidos por los litorales mediterráneo y atlántico, en la península y archipiélagos.Kongsberg 20

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

100 años investigando el mar. El IEO en su centenario (1914-2014).

Se trata de un libro que pretende divulgar a la sociedad las principales investigaciones multidisciplinares llevadas a cabo por el Instituto Español de Oceanografía durante su primer siglo de vida, y dar a conocer la historia del organismo, de su Sede Central y de los nueve centros oceanográficos repartidos por los litorales mediterráneo y atlántico, en la península y archipiélagos.Kongsberg 200Postprin