A tolerable candle: the low-ν\nu method with LHC neutrinos

The Forward Physics Facility (FPF) plans to use neutrinos produced at the Large Hadron Collider (LHC) to make a variety of measurements at previously unexplored TeV energies. Its primary goals include precision measurements of the neutrino cross section and using the measured neutrino flux both to uncover information about far-forward hadron production and to search for various beyond standard model scenarios. However, these goals have the potential to conflict: extracting information about the flux or cross section relies upon an assumption about the other. In this manuscript, we demonstrate that the FPF can use the low-$\nu$ method -- a technique for constraining the flux shape by isolating neutrino interactions with low energy transfer to the nucleus -- to break this degeneracy. We show that the low-$\nu$ method is effective for extracting the $\nu_{\mu}$ flux shape, in a model-independent way. We discuss its application for extracting the $\bar{\nu}_{\mu}$ flux shape, but find that this is significantly more model dependent. Finally, we explore the precision to which the $\nu_{\mu}$ flux shape could be constrained at the FPF, for a variety of proposed detector options. We find that the precision would be sufficient to discriminate between various realistic flux models

Una dieta enriquecida con CLA mejora el daño a órganos asociados al síndrome metabólico en ratas hipertensas espontáneas

The purpose of this study was to provide evidence that dietary CLA can prevent the pathogenesis of metabolic syndrome in tissue structure, suggesting potential benefits in the onset of this syndrome. Wistar male spontaneous hypertensive rats (SHR), were classified into two groups that were fed a standard diet for eight weeks: one with 7.5% sunflower oil (V-SHR group), and the other with 6% sunflower oil and 1.5% CLA (CLA-SHR group). A control healthy group consisted of Kyoto-Wistar male rats fed the standard diet with 7.5% sunflower oil. The animals were sacrificed, and sections of liver, kidneys and aorta were fixed in 10% formaldehyde, and then stained with Hematoxylin and Eosin. Only in the V-SHR group, the stain of the aorta indicated irregular endothelial morphology; liver parenchyma was characterized by an infiltration of inflammatory neutrophils, fibrosis, thickening of the portal vein epithelium, hepatocyte hyperplasia and steatosis. The renal tissue of this group evidenced hyperplasia in the cells of the endothelial of Bowman´s capsule. Abnormal histological changes were not observed in either the control group or the rats fed with CLA, suggesting a protective role of CLA in the onset of metabolic syndrome.El objetivo del presente estudio fue proporcionar evidencia que el CLA dietario puede evitar la patogénesis del síndrome metabólico en la estructura tisular, lo que sugiere beneficios potenciales en el desarrollo de este síndrome. Dos grupos de ratas Wistar macho espontáneamente hipertensas (SHR) fueron alimentadas con una dieta normal por 8 semanas: una dieta contenía 7.5% de aceite de girasol (grupo VSHR), y el otro contenía 6% de aceite de girasol y 1.5% de CLA (grupo CLA-SHR). A un grupo testigo sano de ratas macho Kyoto-Wistar les fue proporcionada una dieta normal con 7.5% de aceite de girasol. Los animales fueron sacrificados y se tomaron secciones de hígado, riñones y aorta, las cuales fueron fijadas en formaldehído al 10% y teñidas con Hematoxilina y Eosina. Las tinciones de aorta mostraron morfología irregular del endotelio en la aorta solo en el grupo V-SHR; el parénquima hepático se caracterizó por infiltración de neutrófilos inflamatorios, fibrosis y engrosamiento del epitelio de la vena porta, hiperplasia hepática y esteatosis. El tejido renal de este mismo grupo evidenció hiperplasia en las células del endotelio de la cápsula de Bowman. No se observaron cambios anormales histológicos tanto en el grupo testigo como en el alimentado con CLA, lo que sugiere un papel protector del CLA en el desarrollo del síndrome metabólico

Estudio de las condiciones de síntesis de geopolímeros con escoria de cobre, por activación con hidróxido de sodio

El objetivo de este estudio es evaluar la susceptibilidad de la escoria de cobre (EC) a ser activada, con NaOH 12 M en la obtención de geopolímeros, GPs-EC; para su uso en la producción de materiales de construcción. Por medio del cálculo del índice de basicidad, las relaciones Si:Al y H₂O:Na₂,O y, el módulo Na:Al. Para las condiciones de síntesis, se variaron la temperatura y el tiempo para la reacción; así como, las condiciones de precurado y de curado en un ambiente húmedo. La caracterización se siguió con FRX, DRX, FTIR y Microscopía Óptica. La consolidación de GPs-EC se obtuvo con un tiempo de reacción a 22ºC, por 20 min y vibración de 10 min; precurado de 24 h y curado a 70ºC por 24 h,en un ambiente húmedo. Los GPs-EC desarrollaron una resistencia a la compresión de 11 MPa similar a la de los paneles de construcción.The aim of this study is to evaluate the susceptibility of copper slag to be activated with sodium hydroxide at concentration of 12 M to obtain geopolymers, GPs-EC; for its use as construction materials. Through the calculation of its basicity index, the Si:Al and H₂O:Na₂O ratios and Na:Al module. In the conditions of synthesis were varied the temperature and time of the alkaline reaction. The precuring and curing conditions were developed in a humid environment. Finally, the compression resistance was evaluated. The characterization was followed with XFR, XRD, FRX FTIR, and Optical Microscopy. The consolidation of GPs-EC was obtained with a reaction time at 22ºC, for 20 min and, vibration of 10 min; time of precuring at 24 h, in clase molds and, the curing conditions at 70ºC for 24h, in a humid environment. The GPs-EC developed a compressive resistance of 11MPa, similar to panels of construction

Restauración de las olmedas ibéricas (Ulmus minor y U. laevis) en zonas riparias de la Comunidad de Madrid

El proyecto LIFE+ “Olmos Vivos” (LIFE13 BIO/ES/000556) tiene como objetivo la restauración de unas formaciones vegetales, las olmedas, que por diversos motivos prácticamente han desaparecido del paisaje forestal español, a pesar de haber poseído un alto valor ecológico y cultural. La grafiosis ha constituido una de las enfermedades forestales más devastadoras, y supuso la práctica desaparición de las olmedas ibéricas de Ulmus minor . En el caso de Ulmus laevis , la alteración de su hábitat ligado a zonas temporalmente encharcadas y riberas ha provocado que las poblaciones españolas se encuentren en riesgo de desaparición. Gracias a la obtención de siete clones de U. minor resistentes a la grafiosis como fruto del Programa del Olmo (UPM-MAGRAMA), el presente proyecto permitirá reintroducir la especie en diversas localizaciones de ribera de los ríos Jarama y Tajo. Asimismo, se plantarán brinzales obtenidos de agrupaciones relícticas de U. laevis , con el fin de aumentar sus poblaciones y conservar sus recursos genéticos, en terrenos de naturaleza silícea de las riberas del río Jarama y Arroyo Viñuelas. El desarrollo del proyecto, de cinco años y tres meses de duración 2014-2019), prevé la plantación de unas 16 700 plantas. Al mismo tiempo se recuperará en nuestras ciudades y pueblos la presencia del olmo, mediante plantaciones con fines divulgativos en entornos urbanos y paseos históricos, para devolver así el protagonismo cultural a un árbol que siempre estuvo entre nosotros, presidiendo las reuniones en las plazas y acompañando con su sombra en muchos caminos de nuestra geografía

Desarrollo de una herramienta para la evaluación de los examen tipo test y sus aplicaciones en la mejora de la calidad y en los criterios de evaluación de estos exámenes

Depto. de Radiología, Rehabilitación y FisioterapiaFac. de MedicinaFALSEsubmitte

Implementation and first results of the KM3NeT real-time core-collapse supernova neutrino search

The KM3NeT research infrastructure is unconstruction in the Mediterranean Sea. KM3NeT will study atmospheric and astrophysical neutrinos with two multi-purpose neutrino detectors, ARCA and ORCA, primarily aimed at GeV–PeV neutrinos. Thanks to the multi-photomultiplier tube design of the digital optical modules, KM3NeT is capable of detecting the neutrino burst from a Galactic or near-Galactic core-collapse supernova. This potential is already exploitable with the first detection units deployed in the sea. This paper describes the real-time implementation of the supernova neutrino search, operating on the two KM3NeT detectors since the first months of 2019. A quasi-online astronomy analysis is introduced to study the time profile of the detected neutrinos for especially significant events. The mechanism of generation and distribution of alerts, as well as the integration into the SNEWS and SNEWS 2.0 global alert systems, are described. The approach for the follow-up of external alerts with a search for a neutrino excess in the archival data is defined. Finally, an overview of the current detector capabilities and a report after the first two years of operation are given.Acknowledgements The authors acknowledge the financial support of the funding agencies: Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Européenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Paris Île-de-France Region, France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG, FR-18-1268), Georgia; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell’Università e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy; Ministry of Higher Education Scientific Research and Professional Training, ICTP through Grant AF-13, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; The National Science Centre, Poland (2015/18/E/ST2/00758); National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia, Innovación, Investigación y Universidades (MCIU): Programa Estatal de Generación de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Generalitat Valenciana: Prometeo (PROMETEO/2020/019), Grisolía (ref. GRISOLIA/2018/119) and GenT (refs. CIDEGENT/2018/034, /2019/043, /2020/049) programs, Junta de Andalucía (ref. A-FQM-053-UGR18), La Caixa Foundation (ref. LCF/BQ/IN17/11620019), EU: MSC program (ref. 101025085), Spain

Characteristics of patients with type 2 diabetes mellitus newly treated with GLP-1 receptor agonists (CHADIG Study): a cross-sectional multicentre study in Spain

Objective: Several glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1Ra) have been made recently available in Spain for type 2 diabetes mellitus (DM2) treatment. There are no published data on the clinical and sociodemographic profile of patients initiating treatment with GLP-1Ra in Spain. Our objective was to understand these patients' characteristics in a real-world clinical practice setting. Design: Cross-sectional observational study. Setting: Spanish specialist outpatient clinics. Participants: 403 adults with DM2 initiating GLP-1Ra treatment were included. Primary and secondary outcome measures: Sociodemographic and DM2-related clinical data, including treatment at and after GLP-1Ra initiation and comorbidities, were collected. Results: Evaluable patients (n=403; 50.9% female) were included ( July 2013 to March 2014) at 24 centres by 53 specialists (47 endocrinology, 6 internal medicine), with the following profile (value±SD): age (58.3±10.4 years), diabetes duration (9.9±7 years), body mass index (BMI; 36.2±5.5) and glycated haemoglobin (HbA1c; 8.4±1.4%); 14% had HbA1c≤7%. Previous antidiabetic treatment: 53.8% only oral antidiabetic drugs (OADs), 5.2% insulin and 40% insulin and OAD; of those receiving OAD, 35% single drug, 38.2% 2 drugs and 24% 3 drugs. Concomitant to GLP-1Ra, 55.3% were only on OAD, 36.2% on insulin and OAD, and 7.2% only on insulin. Of those receiving OAD, the GLP-1Ra was mainly associated with 1 drug (65%) or 2 drugs (31.8%). GLP-1Ra are frequently added to existing antidiabetic drugs, with dipeptidyl peptidase-4 inhibitors being the OAD most frequently switched (45% receiving 1 before starting GLP-1Ra, only 2.7% receiving it concomitantly). Conclusions: In Spain, GLP-1Ra therapy is usually started in combination with OADs or OADs and insulin. These drugs are used in relatively young patients often not reaching therapeutic goals with other treatment combinations, roughly a decade after diagnosis and with a relatively high BMI. The latter could be explaine

Clinical validation of risk scoring systems to predict risk of delayed bleeding after EMR of large colorectal lesions

[Background and Aims]: The Endoscopic Resection Group of the Spanish Society of Endoscopy (GSEED-RE) model and the Australian Colonic Endoscopic Resection (ACER) model were proposed to predict delayed bleeding (DB) after EMR of large superficial colorectal lesions, but neither has been validated. We validated and updated these models.[Methods]: A multicenter cohort study was performed in patients with nonpedunculated lesions ≥20 mm removed by EMR. We assessed the discrimination and calibration of the GSEED-RE and ACER models. Difficulty performing EMR was subjectively categorized as low, medium, or high. We created a new model, including factors associated with DB in 3 cohort studies.[Results]: DB occurred in 45 of 1034 EMRs (4.5%); it was associated with proximal location (odds ratio [OR], 2.84; 95% confidence interval [CI], 1.31-6.16), antiplatelet agents (OR, 2.51; 95% CI, .99-6.34) or anticoagulants (OR, 4.54; 95% CI, 2.14-9.63), difficulty of EMR (OR, 3.23; 95% CI, 1.41-7.40), and comorbidity (OR, 2.11; 95% CI, .99-4.47). The GSEED-RE and ACER models did not accurately predict DB. Re-estimation and recalibration yielded acceptable results (GSEED-RE area under the curve [AUC], .64 [95% CI, .54-.74]; ACER AUC, .65 [95% CI, .57-.73]). We used lesion size, proximal location, comorbidity, and antiplatelet or anticoagulant therapy to generate a new model, the GSEED-RE2, which achieved higher AUC values (.69-.73; 95% CI, .59-.80) and exhibited lower susceptibility to changes among datasets.[Conclusions]: The updated GSEED-RE and ACER models achieved acceptable prediction levels of DB. The GSEED-RE2 model may achieve better prediction results and could be used to guide the management of patients after validation by other external groups. (Clinical trial registration number: NCT 03050333.)Research support for this study was received from “La Caixa/Caja Navarra” Foundation (ID 100010434;project PR15/11100006)

Recent highlights from GENIE v3

Funder: u.s. department of energy; doi: http://dx.doi.org/10.13039/100000015AbstractThe release of GENIE v3.0.0 was a major milestone in the long history of the GENIE project, delivering several alternative comprehensive neutrino interaction models, improved charged-lepton scattering simulations, a range of beyond the Standard Model simulation capabilities, improved experimental interfaces, expanded core framework capabilities, and advanced new frameworks for the global analysis of neutrino scattering data and tuning of neutrino interaction models. Steady progress continued following the release of GENIE v3.0.0. New tools and a large number of new physics models, comprehensive model configurations, and tunes have been made publicly available and planned for release in v3.2.0. This article highlights some of the most recent technical and physics developments in the GENIE v3 series.</jats:p

Impact of hospital characteristics on implementation of a Pediatric Early Warning System in resource-limited cancer hospitals

BackgroundPediatric Early Warning Systems (PEWS) aid in identification of deterioration in hospitalized children with cancer but are underutilized in resource-limited settings. Proyecto EVAT is a multicenter quality improvement (QI) collaborative in Latin America to implement PEWS. This study investigates the relationship between hospital characteristics and time required for PEWS implementation.MethodsThis convergent mixed-methods study included 23 Proyecto EVAT childhood cancer centers; 5 hospitals representing quick and slow implementers were selected for qualitative analysis. Semi-structured interviews were conducted with 71 stakeholders involved in PEWS implementation. Interviews were recorded, transcribed and translated to English, then coded using a priori and novel codes. Thematic content analysis explored the impact of hospital characteristics and QI experience on time required for PEWS implementation and was supplemented by quantitative analysis exploring the relationship between hospital characteristics and implementation time.ResultsIn both quantitative and qualitative analysis, material and human resources to support PEWS significantly impacted time to implementation. Lack of resources produced various obstacles that extended time necessary for centers to achieve successful implementation. Hospital characteristics, such as funding structure and type, influenced PEWS implementation time by determining their resource-availability. Prior hospital or implementation leader experience with QI, however, helped facilitate implementation by assisting implementers predict and overcome resource-related challenges.ConclusionsHospital characteristics impact time required to implement PEWS in resource-limited childhood cancer centers; however, prior QI experience helps anticipate and adapt to resource challenges and more quickly implement PEWS. QI training should be a component of strategies to scale-up use of evidence-based interventions like PEWS in resource-limited settings