Decision-making in school-age sport measured through a digital tool

El objetivode este estudioha sido doble. Por un lado, diseñar y crear un software de evaluación de toma de decisionesen edad escolar, en base a aspectos espacio-temporales, contextualizado en voleibol, denominado “Juego Interactivo de Voleibol”. Por otro lado, analizar y establecersu fiabilidad y validez. El software diseñado se aplicó a una muestra de 132 escolares (64 niños y 68 niñas) de entre 10 y 13 años, de los centros educativos públicos de Educación Primaria y Secundaria de las localidades sevillanas de Arahal y Paradas(España). Para determinar la fiabilidad se estudió la consistencia interna a través del coeficiente alfa de Cronbach. Para calcular el número óptimo de repeticiones se utilizó el Coeficiente de Correlación Intraclase. La validez se comprobó en base a la evaluación de un grupo de 5 expertos. Los resultados indicaron que este nuevo software de evaluación alcanza altos niveles de fiablidad y validez.The aim of this study was twofold. On the one hand, the design and creation of an evaluation software for decision-making in school-age children based on spatial-temporal aspects in the context of volleyball called ‘Interactive Volleyball Game’. On the other hand, the analysis and establishment of its reliability and validity. The designed software was applied to a sample of 132 students (64 boys and 68 girls) aged between 10 and 13 years in public Elementary and Secondary Education schools ofSeville towns, Arahal and Paradas (Spain). To determine the reliability, internal consistency was studied through Cronbach's alpha. The intraclasscorrelation coefficient (ICC) was also analyzed to calculate the optimal number of repetitions for future research. The validity was tested based on the assessment of a group of 5 experts. The results indicated that this new evaluation software reaches high levels of reliability and validity

Decisional profile, gender and sports practice in sports at school age

El objetivo de este estudio ha sido determinar el perfil decisional de chicos y chicas en edad escolar basado en aspectos espacio-temporales a través del software «Juego Interactivo de Voleibol» (JIVB®), en función de diferentes variables: dificultad espacio-temporal, tipo de práctica deportiva, edad, sexo y tiempo de práctica deportiva. La muestra ha sido conformada por la totalidad de los clubes de categoría infantil de la ciudad de Sevilla de las modalidades de balonmano, voleibol y atletismo, así como de alumnado de Enseñanza Secundaria Obligatoria (ESO) de un Instituto de Enseñanza Secundaria que no practicaba más actividad físico-deportiva que la realizada en sus clases de educación física. Además, para completar la muestra a nivel deportivo se optó por incluir a un club de voleibol y a un club de atletismo de poblaciones limítrofes con Sevilla capital, quedando la muestra final constituida por 109 participantes, de ambos sexos, de 12-14 años. Para determinar el perfil decisional se utilizó el JIVB® y se llevaron a cabo análisis descriptivos e inferenciales. Los resultados muestran que no existen diferencias significativas en la capacidad de toma de decisiones, aunque sí se puede hablar de tendencias.The objective of this study was to determine the decisional profile of school-age boys and girls based on spatiotemporal aspects through the software "Interactive Volleyball Game" (JIVB®), based on different variables: spatio-temporal difficulty, type of sports practice, age, sex and time of sports practice. The sample has been made up of all the children's category clubs in the city of Seville in the modalities of handball, volleyball and athletics, as well as students of Compulsory Secondary Education (ESO) of a Secondary Education Institute that did not practice anymore physical-sporting activity than the one carried out in their physical education classes. In addition, to complete the sample at the sporting level, it was decided to include a volleyball club and an athletics club from neighboring towns with Seville, leaving the final sample consisting of 109 participants, of both sexes, aged 12-14 years. To determine the decisional profile, the JIVB® was used and descriptive and inferential analyzes were carried out. The results show that there are no significant differences in decision-making capacity, although it is possible to speak of trends

The NWP Activities at AEMET (Spain): 28th ALADIN Workshop & HIRLAM ASM

Póster presentado en: Joint 28th ALADIN Workshop & HIRLAM All Staff Meeting, celebrado del 16 al 20 de abril de 2018 en Toulouse (Francia)

Blunted Expansion of Regulatory T Lymphocytes Is Associated With Increased Bacterial Translocation in Patients With Major Depressive Disorder

Background: Major Depressive Disorder (MDD) is associated with both proinflammatory and adaptive immune response abnormalities. Regulatory T lymphocytes (Tregs), a subtype of CD4+ T cells, are relevant for maintaining immune-inflammatory system homeostasis and control of inflammation such as the kind potentially induced by the interactions between the intestinal microbiome and gut mucosa. We investigated the Treg population and its distribution along their stages of differentiation/activation, as well as its function in MDD patients without concomitant diseases. We also studied the potential association between Treg alterations, intestinal barrier damage, and bacterial translocation. Methods: 30 MDD patients and 20 healthy controls were studied. The levels of circulating CD25FoxP3+ Tregs and their distribution on the naïve (TN), effector (TE), central (TCM), and effector memory(TEM) differentiation/activation stages were analyzed using polychromatic flow cytometry. Chemokine receptors (CCR) 2, 5, and 6, and the intracytoplasmic IL-10 expression by the Tregs were also analyzed. The serum IL-10 was measured using Luminex. The serum levels of zonulin and the intestinal fatty acid-binding protein (I-FABP), both markers of gut barrier function, and the LPS-binding protein (LBP), a marker of bacterial translocation, were measured using an enzyme-linked immunosorbent assay. Results: MDD patients had increased number of circulating Tregs cells with enhanced number of Tregs at the TN, TE, TCM, and TEM stages. The percentage of Tregs cells at TN stage was significantly higher in MDD patients. The percentage of Tregs that expressed CCR2 and CCR6 was increased as well as those expressing IL-10. MDD patients had significantly increased levels of circulating I-FABP and LBP. MDD patients with high LBP levels had a significant reduction in the number of circulating Tregs compared to normal-LBP MDD patients. Conclusions: MDD patients showed an expansion of circulating Tregs and their CD25highFoxP3+ and CD25lowFoxP3+ subsets throughout the different stages of CD4+ T lymphocyte differentiation/activation. Tregs also showed an increased frequency of cells expressing CCR6 and CCR2. IL-10 Treg production was also enhanced in MDD patients that concurrently had increased serum IL-10 levels. However, this Treg expansion was blunted in MDD patients with gut barrier damage and increased bacterial translocation.Instituto de Salud Carlos IIIComunidad de Madri

Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP

Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014–2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 ± 2.5 years. The median EEN duration was 8 weeks (IQR 6.6–8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn’s Disease activity index [wPCDAI] 15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6–8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn’s disease regardless of the location of disease and disease activityS

Temporal relationship of serum markers and tissue damage during acute intestinal ischemia/reperfusion

OBJECTIVE: It is essential to identify a serological marker of injury in order to study the pathophysiology of intestinal ischemia reperfusion. In this work, we studied the evolution of several serological markers after intestinal ischemia reperfusion injury in rats. The markers of non-specific cell damage were aspartate aminotransferase, alanine aminotransaminase, and lactic dehydrogenase, the markers of inflammation were tumor necrosis factor alpha, interleukin-6, and interleukin-1 beta, and the markers of intestinal mucosal damage were intestinal fatty acid binding protein and D-lactate. We used Chius classification to grade the histopathological damage. METHODS: We studied 35 Wistar rats divided into groups according to reperfusion time. The superior mesenteric artery was clamped for 30 minutes, and blood and biopsies were collected at 1, 3, 6, 12, 24, and 48 hours after reperfusion. We plotted the mean ¡ standard deviation and compared the baseline and maximum values for each marker using Student’s t-test. RESULTS: The maximum values of interleukin-1 beta and lactic dehydrogenase were present before the maximal histopathological damage. The maximum tumor necrosis factor alpha and D-lactate expressions coincided with histopathological damage. Alanine aminotransaminase and aspartate aminotransferase had a maximum expression level that increased following the histopathological damage. The maximum expressions of interluken-6 and intestinal fatty acid binding protein were not significantly different from the Sham treated group. CONCLUSION: For the evaluation of injury secondary to acute intestinal ischemia reperfusion with a 30 minute ischemia period, we recommend performing histopathological grading, quantification of D-lactate, which is synthesized by intestinal bacteria and is considered an indicator of mucosal injury, and quantification of tumor necrosis factor alpha as indicators of acute inflammation three hours after reperfusion

European Journalism Observatory- a platform for training and professional networks in the Faculty of Information Sciences

The launching of a Spanish platform within the Observatory will serve as a training laboratory for undergraduate and graduate students of the Faculty of Information Sciences at the same time as for establishing a professional media network in and outside Spain. The European Journalism Observatory (EJO) is a network of 14 non-profit media research institutes in 11 countries where Spain continue to be the missing element. All researchers in the EJO network actively strive to transfer their knowledge to the media industry as well as interested publics outside the scientific community, as a platform to enable online availability of at least a portion of many publications in several languages

Izaña Atmospheric Research Center. Activity Report 2015-2016

This report is a summary of the many activities at the Izaña Atmospheric Research Center to the broader community. The combination of operational activities, research and development in state-of-the-art measurement techniques, calibration and validation and international cooperation encompass the vision of WMO to provide world leadership in expertise and international cooperation in weather, climate, hydrology and related environmental issues

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe