Public Behavior Awareness of Eradicating Mosquito Larvae in Kelambir Village, Pantai Labu District

The existence of Aedes aegypti mosquito larvae that cause dengue fever is caused by the existence of water reservoirs which play a very important role in the density of the Aedes aegypti mosquito vector because the more adequate water reservoirs, the more places Aedes aegypti mosquito larvae can breed. This study aims to discover how the community's knowledge, attitudes, and actions are related to the presence of Aedes aegypti mosquito larvae in Kelambir Village, Pantai Labu District. This research method is a qualitative descriptive study with a population of hamlet I and three kelambir villages. The sample number was 50 respondents with a simple random sampling technique. The results of the study revealed that out of 50 respondents, 32 respondents (64%) had good knowledge, 18 respondents (36) had less knowledge, 29 respondents (58%) had a good attitude, and 21 respondents (42%) had a poor attitude. Twenty-three respondents (46%) lack practice, 27 respondents (54%) have good practice; it is concluded that good knowledge and mosquito larvae are 32 respondents (64%) have a good attitude, and 29 respondents (58%) and good actions. There were larvae as many as 27 respondents (54%).Iit is expected to increase awareness further as well as good and correct actions in overcoming the problem of mosquito larvae which is the cause of the onset of DHF incidence in the community, such as implementing 3M and implementing a clean and healthy lifestyle.Local Government to utilize the results of this study in making a policy for mosquito larvae eradication efforts that are more in-depth and can provide solutions to solving the problem of dengue cases and dengue fever mosquito larvae breeding. It is expected to increase the comparison's awareness and validity to clarify further the research conducte

O RAP na mídia : discurso de resistência?

Orientação: Profa. Dra. Eliana Vianna Brito KozmaDissertação (Mestrado em Lingüística Aplicada) - Departamento de Ciências Sociais e Letras, Universidade de Taubaté, Taubaté, 2008.Made available in DSpace on 2019-07-26T19:32:40Z (GMT). No. of bitstreams: 1 Soraya Mira Reis.pdf: 542100 bytes, checksum: cf19b8fdc0c5a724386a73b5ac1d43d5 (MD5) Previous issue date: 2008Resumo: A presente pesquisa discute a real existência do discurso de resistência nas letras de RAP, a partir dos pressupostos teóricos da Análise do Discurso de linha francesa, e tem como corpus de análise canções dos grupos O RAPPA e Racionais Mc's, comparando-as com outras compostas por alunos do ensino médio de escolas particulares, que não vivem em condições sociais desfavorecidas. O objetivo da pesquisa é propor novas perspectivas na análise de letras desse tipo de música, levando em consideração especificamente o RAP projetado na mídia, e a influência que ele exerce no seu público consumidor, de jovens e adolescentes, uma vez que ele corresponde à ordem do discurso da atualidade.Abstract: The present research discuts the real existence of resistence discourse on RAP's compositions. The methodology used is the Francese Discourse Analyse and have like a analise's courpus the groups "O Rappa" and "Racionais Mc's" 's songs, that are compareds with other songs made by students of private higth school, that don't live in bad conditions of life. The objective of this pesquise is to propose one new perspective on analysis of this kind songs's compositions, worry about, especially with the RAP present on media and the influence that it have on the public, teen agers, since that it corresponds to atual discourse order.Mestrad

ASPEK HUKUM DALAM PENYUSUNAN KONTRAK INTERNASIONAL DI BIDANG PENDIDIKAN ANTARA YAYASAN PENDIDIKAN DENGAN PIHAK NGO'S (NON GOVERNMENT ORGANIZATION'S)

Matsushita Gobel Foundation-Matsushita Gobel Institute (MGF-MGI) and Overseas Vocational Training Association (OVTA), a Japanese Non- Governmental Organization (NGO), have conducted cooperation on education and training sector in Indonesia for many years. In order to accelerate this educational assistance, international contracts are needed. International contract is any kind of contract that involves at least two parties from different countries. This contract also can be done among nations. Furthermore, writers are researching legal aspects that being involved in order to draft the international contracts, which include the law that underpin those contracts and protect the parties from the possibilities of breach of contract. This research collaborate methods of normative juridical, legal literature review and case study. Data is collected through interview, direct observation and legal documentation study. The legal documentation study is focusing the international cooperation contracts between MGF-MGI and OVTA in regard with Asia Pacific Economic Conference�s (APEC�s) Information Technology (IT) courses which was signed on June, 3 th 2009. The research finds several aspects that involved in international contract drafting on educational sector, which are based on Kitab Undang-undang Hukum Perdata (Indonesian Civil Code), series of legal aspects of a contract, operational/ implementation aspects of a contract, legal aspects of an international contract, breach of a contract, legal aspects of force majeure, legal aspects of choice of law and legal aspect of dispute resolution forum. The international Civil Act states that in the case of parties are not choose the International Civil Act as the base of their contract

Interferon-Gamma dan Prokalsitonin Sebagai Prediktor Mortalitas Pada Pasien Sepsis

Latar Belakang. Sepsis merupakan suatu keadaan terjadinya disfungsi organ dan mengancam jiwa yang diakibatkan oleh disregulasi respon imun host terhadap infeksi dan masih menjadi salah satu masalah kesehatan utama di dunia, sebanyak 20% kematian di dunia diakibatkan karena sepsis. Dari tingginya tingkat kematian karena sepsis, penentuan prognosis pada penderita sepsis penting dilakukan untuk menentukan pengelolaan pasien selanjutnya. Oleh karena itu dikembangkan biomarker yang dapat digunakan sebagai prediktor mortalitas pada pasien sepsis. Monocyte Chemoattractant Protein-1 (MCP-1) adalah sitokin proinflamasi yang sering ditemui pada fase awal terjadinya infeksi dan merupakan salah satu sitokin yang penting dalam respons pertahanan terhadap infeksi, sehingga dapat diandalkan dalam memperkirakan prognosis pada pasien sepsis. Pada kondisi sepsis juga sering terjadi koagulopati karena disfungsi mikrovaskular berakibat aktivasi endotel dapat diinduksi secara lokal. Berbagai macam senyawa fibrin dapat dideteksi dalam plasma dari pasien dengan aktivasi koagulasi intravaskular. Salah satu cara untuk mengetahui disfungsi mikrovaskular yaitu menggunakan Uji D-dimer. D-dimer dapat digunakan sebagai penanda kegagalan mikrosirkulasi. Hampir semua pasien yang dirawat dengan sepsis mengalami peningkatan kadar D-dimer yang sangat erat kaitannya dengan disfungsi organ. Baik MCP-1 maupun D-dimer merupakan parameter yang secara independen dapat memprediksi mortalitas pada pasien sepsis. Kombinasi keduanya diharapkan dapat meningkatkan nilai prediktor mortalitas pada penderita sepsis. Tujuan. Menentukan perbedaan kadar MCP-1 dan D-dimer pada penderita sepsis survivor dan non survivor. Mengetahui performa kombinasi MCP-1 dan D-dimer sebagai prediktor mortalitas pada penderita sepsis. Metode. Penelitian kohort prospektif ini melibatkan 83 penderita sepsis yang ditegakkan dengan kriteria SEPSIS-3 yang di rawat di RSUD Dr. Saiful Anwar Malang sejak Oktober 2019 sampai Nopember 2020. Sisa serum pasien suspek sepsis dikumpulkan. Kemudian, dilakukan pemilahan serum pasien berdasarkan rekam medis pasien apakah pasien memenuhi kriteria inklusi dan tidak tereksklusi. Lama rawat dan luaran pasien dicatat. Lalu, dilakukan pemeriksaan serologis MCP-1 menggunakan ELISA kit (LEGENDMAX) dan D-dimer menggunakan metode imunoturbodimetri (Sysmex). Data yang terkumpul dianalisis dengan uji normalitas distribusi, uji beda, analisis kurva ROC, analisis kesintasan menggunakan Kurva Kaplan Meier, Hazard Ratio menggunakan Cox regression. Hasil. Kadar MCP-1 dan D-dimer pada penderita sepsis non survivor lebih tinggi secara signifikan dibandingkan kadar MCP-1 dan D-dimer penderita sepsis survivor (p 123,03 pg/mL adalah 81% dan 80% dengan AUC 89,2% (95% CI 81,1%-97,3%) p=0,000, ix sedangkan sensitivitas dan spesifisitas D-dimer pada cut-off > 43,5 mg/L FEU sebesar 67,2% dan 60% dengan AUC 67,4% (95% CI 55-8%-79,1%) p=0,012. Kesimpulan. Kombinasi MCP-1 dan D-dimer dapat dipertimbangkan sebagai biomarker prediktor mortalitas pada pasien sepsis

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain

A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important regulators of neural stem/precursor cells (NSPC) proliferation. GC are released from the adrenal glands in ultradian secretory pulses that generate characteristic circadian oscillations. Here, we investigated the hypothesis that GC oscillations prevent NSPC activation and preserve a quiescent NSPC pool in the aging hippocampus. We found that hippocampal NSPC populations lacking expression of the glucocorticoid receptor (GR) decayed exponentially with age, while GR-positive populations decayed linearly and predominated in the hippocampus from middle age onwards. Importantly, GC oscillations controlled NSPC activation and GR knockdown reactivated NSPC proliferation in aged mice. When modeled in primary hippocampal NSPC cultures, GC oscillations control cell cycle progression and induce specific genome-wide DNA methylation profiles. GC oscillations induced lasting changes in the methylation state of a group of gene promoters associated with cell cycle regulation and the canonical Wnt signaling pathway. Finally, in a mouse model of accelerated aging, we show that disruption of GC oscillations induces lasting changes in dendritic complexity, spine numbers and morphology of newborn granule neurons. Together, these results indicate that GC oscillations preserve a population of GR-expressing NSPC during aging, preventing their activation possibly by epigenetic programming through methylation of specific gene promoters. Our observations suggest a novel mechanism mediated by GC that controls NSPC proliferation and preserves a dormant NSPC pool, possibly contributing to a neuroplasticity reserve in the aging brain.The experimental work was financed by grants from the Innovational Research Incentives Scheme VIDI 864.09.016 from the Netherlands organization for Scientific Research (NWO); the International Foundation for Alzheimer’s Research (ISAO), and Alzheimer Nederland to CPF. HM and LG-C were supported by the Spanish Ministry of Economy and Competitiveness, grant SAF2015- 70433-R to HM and Juan de la Cierva Program to LG-C. EG and NT were financed by the Swiss National Science Foundation. PJL was supported by Alzheimer Nederland. SM-S was financed by the Jesus de Gangoiti Foundation. We acknowledge the assistance of Rafael Hortigüela and Tijana Radic during the paper preparation and Ronald Breedijk and Mark Hink at the Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam for providing technical assistance with the confocal microscop

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR

Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls. Although AHRR methylation is known to associate with smoking, the AHRR association with PTSD is most pronounced in non-smokers, suggesting the result was independent of smoking status. Evaluation of metabolomics data reveals that AHRR methylation associated with kynurenine levels, which are lower among subjects with PTSD. This study supports epigenetic differences in those with PTSD and suggests a role for decreased kynurenine as a contributor to immune dysregulation in PTSD

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes