Med pædagogen på tidsrejse

Hvad skal der til for at gøre børn nysgerrige på lokalhistorien og give dem mod på at høre historier fra fortiden? Hvordan skabes god kulturformidling for børn i alderen 3-6 år? Hvordan kan pædagogiske dagtilbud og museer sammen skabe en ramme, som optimerer børns møde med kulturhistorie? Det kan du læse mere om her. Artiklen giver et bud på metoder til inddragelse af kulturhistorie i det pædagogiske arbejde, hvor metoderne er afprøvet i et samarbejde mellem pædagoger og museumsformidlere. Pædagogernes ekspertise om børnegrupper og børns udvikling sammen med museumsformidlernes viden om kulturhistorie forenes i et kulturhistorisk tilbud målrettet børn i alderen 3-6 år

Hot gas halos around disk galaxies: Confronting cosmological simulations with observations

Models of disk galaxy formation commonly predict the existence of an extended reservoir of accreted hot gas surrounding massive spirals at low redshift. As a test of these models, we use X-ray and H-alpha data of the two massive, quiescent edge-on spirals NGC 5746 and NGC 5170 to investigate the amount and origin of any hot gas in their halos. Contrary to our earlier claim, the Chandra analysis of NGC 5746, employing more recent calibration data, does not reveal any significant evidence for diffuse X-ray emission outside the optical disk, with a 3-sigma upper limit to the halo X-ray luminosity of 4e39 erg/s. An identical study of the less massive NGC 5170 also fails to detect any extraplanar X-ray emission. By extracting hot halo properties of disk galaxies formed in cosmological hydrodynamical simulations, we compare these results to expectations for cosmological accretion of hot gas by spirals. For Milky Way-sized galaxies, these high-resolution simulations predict hot halo X-ray luminosities which are lower by a factor of ~2 compared to our earlier results reported by Toft et al. (2002). We find the new simulation predictions to be consistent with our observational constraints for both NGC 5746 and NGC 5170, while also confirming that the hot gas detected so far around more actively star-forming spirals is in general probably associated with stellar activity in the disk. Observational results on quiescent disk galaxies at the high-mass end are nevertheless providing powerful constraints on theoretical predictions, and hence on the assumed input physics in numerical studies of disk galaxy formation and evolution.Comment: 16 pages, 8 figures, ApJ accepted. Supersedes arXiv:astro-ph/061089

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362