Cutting down on the grog: the crystallisation of Neolithic ceramic traditions at Cova d’En Pardo (Alicante, Spain) and cultural change in the western Mediterranean basin (mid-6th and 5th millennia cal. BC)

This paper presents the characterisation of 48 ceramic samples from Cova d’En Pardo (Alicante, Spain). Provenance and technology analysis are carried out on materials dated back to different Early and Middle Neolithic cultural phases, including pioneer and Epicardial levels, poorly known in the area. The techniques employed are optical petrography and scanning electron microscope. Two main fabrics were identified, characterised by the heavy presence of temper (grog and calcite), along with five minor petrographic classes, including two imports, one of them probably from southern Iberia. The comparison among occupational phases within the site reveals changes along the stratigraphic series, especially during the transition from the 6th to 5th millennia cal. BC, which is reflected in temper choice. Evidence from the earliest occupation of the site also agrees with the picture of discontinuity previously observed on nearby contexts between pioneer and traditional Cardial ceramic technology, which might be connected to neolithization routes. Firing technology is characterised by the occurrence of microstructure gradients and signs of fast heating rates.Sample preparation and analyses were funded by the projects NEOMEDPOT (Marie Skłodowska-Curie program, European Commission, grant number 659466) and Espacios sociales y espacios de frontera durante el calcolítico y la Edad del Bronce en el Levante de la península Ibérica (HAR2016-76586-P, Ministerio de Economía y Competitividad and FEDER). Miguel del Pino is a postdoctoral researcher within the Viera y Clavijo program, funded by the Universidad de Las Palmas de Gran Canaria (Spain). The initial draft of the paper was finished while a postdoctoral researcher within the APOSTD program funded by the Generalitat Valenciana and FEDER funds (Spain)

Cova d’En Pardo (Planes, Alicante). Un avance sobre la secuencia cultural

La valoración general de las recientes excavaciones en la Cova d’En Pardo (1993 –2006) permiten presentar la secuencia de ocupación de la cavidad, en lo que la Prehistoria reciente se refiere, desde un Neolítico caracterizado por la presencia de cerámicas impresas hasta el Bronce Final. Se adelanta ahora la revisión de la sedimentología, nuevas dataciones de radiocarbono y la valoración cultural de los distintos niveles a partir de la valoración de la cerámica localizada en las intervenciones de la denominada sala de la derecha.The valuation in general of the recent excavations at the En Pardo’s Cave (1993-2006) presents the sequence of the cavity occupation, as it recent Prehistory refers to, from a Neolithic which characterizes for the presence of printed ceramics to the Final Bronze. It implies to go further with the review of the sedimentology, new radiocarbon data and the cultural evaluation of the different levels obtained from the valuation of the ceramic found during the interventions done at the so-called gallery of the right

Understanding the first Neolithic occupation of Cova d’En Pardo (Planes, Alicante): preliminary results of the multidisciplinary analysis of levels VIII and VIIIb

Se presentan los resultados de las excavaciones llevadas a cabo en la Cova d’En Pardo (Planes, Alicante), concretamente los niveles VIII y VIIIb. El desarrollo de un proyecto multidisciplinar ha permitido caracterizar la ocupación de una pequeña cavidad por parte de las primeras comunidades campesinas asociadas al inicio del proceso de neolitización del levante de la península Ibérica.We present the results of excavations carried out in the Cova d’En Pardo (Planes, Alicante), specifically the levels VIII and VIIIb. The development of a multidisciplinary project has allowed characterize the occupation of a small cavity by the first farming communities associated with the Neolithization process of the Levant of Iberian Peninsula.Este trabajo se ha realizado en el marco del proyecto Origins and Spread of Agriculture in the western Mediterranean región (ERC-2008-AdG 230561)

Red en cultura material prehistórica: talleres de experimentación lítica en titulaciones de la UA

Una parte muy importante de las herramientas que fueron elaborando los seres humanos a lo largo de más de 2,5 millones de años se fabricaron durante la Prehistoria usando diferentes tipos de rocas. Entre los contenidos curriculares de los grados en Historia en España y en másteres afines, destacan diversas nociones sobre tecnología e instrumental lítico prehistórico, para que el alumnado conozca los procesos de producción lítica tallada, su evolución tecnológica y tipológica, y los procesos de clasificación y análisis. A pesar del creciente empleo de material gráfico como recurso docente, la metodología de clase teórica/participativa se muestra insuficiente a la hora de conseguir buenos resultados de aprendizaje. El desarrollo de talleres de experimentación lítica tallada sobre instrumental prehistórico permite el aprendizaje mediante la interacción y una mejor asimilación por parte de los estudiantes. La experiencia de las asignaturas del Grado en Historia y del Máster en Arqueología Profesional y Gestión del Patrimonio de la UA es un ejemplo de evaluación de las fortalezas y debilidades del desarrollo de dichos talleres

History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico

Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary by geographic regions ranging from countries to neighborhoods. We examined the geographic variation of admixture across the island of Puerto Rico and the degree to which it could be explained by historic and social events. We analyzed a census-based sample of 642 Puerto Rican individuals that were genotyped for 93 ancestry informative markers (AIMs) to estimate African, European and Native American ancestry. Socioeconomic status (SES) data and geographic location were obtained for each individual. There was significant geographic variation of ancestry across the island. In particular, African ancestry demonstrated a decreasing East to West gradient that was partially explained by historical factors linked to the colonial sugar plantation system. SES also demonstrated a parallel decreasing cline from East to West. However, at a local level, SES and African ancestry were negatively correlated. European ancestry was strongly negatively correlated with African ancestry and therefore showed patterns complementary to African ancestry. By contrast, Native American ancestry showed little variation across the island and across individuals and appears to have played little social role historically. The observed geographic distributions of SES and genetic variation relate to historical social events and mating patterns, and have substantial implications for the design of studies in the recently admixed Puerto Rican population. More generally, our results demonstrate the importance of incorporating social and geographic data with genetics when studying contemporary admixed populations

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe