ESTUDO DE MAPEAMENTO SISTEMÁTICO SOBRE AS TENDÊNCIAS E DESAFIOS DO CLOUD GAMING

Os jogos digitais constituem hoje um dos principais mercados na área do entretenimento. Como fatores para o contínuo crescimento da indústria têm-se as diversas transformações apoiadas pelas inovações tecnológicas. Entre essas inovações está a computação em nuvem, que trouxe uma extensa gama de possibilidades e permitiu a concepção de uma nova forma de jogar: o Cloud Gaming. A fim de apresentar um panorama sobre as dificuldades e possíveis caminhos em direção ao aumento da adoção do Cloud Gaming, este trabalho analisou, através de um mapeamento sistemático, as tendências e desafios na utilização da computação em nuvem para jogos digitais. Após a definição e execução do protocolo de mapeamento, diversos critérios de seleção e exclusão foram aplicados aos estudos encontrados. Em seguida, uma análise geral e, posteriormente, das respostas das questões de pesquisa foram realizadas e tiveram seus dados apresentados e interpretados através de gráficos, tabelas, além de descrição textual. Foram identificados como problemas e desafios a limitação de banda e compressão dos vídeos, alocação de recursos de rede para servidores com máquinas virtuais, entre outros. Como possíveis tendências, os estudos evidenciaram o foco no streaming baseado em gráficos, ao invés do streaming baseado em vídeo e virtualização de GPU

Brain and lung cryptococcoma and concurrent corynebacterium pseudotuberculosis infection in a goat: a case report

A four-year-old male goat with a history of neurological disorder was euthanized. It presented uncommon nodules in the brain and lungs associated with multiple abscesses, predominantly in the spleen and liver. Histological examination of brain and lung sections revealed yeast forms confirmed to be Cryptococcus gattii after a combination of isolation and polymerase chain reaction (PCR) procedures. Moreover, Corynebacterium pseudotuberculosis infection was diagnosed by PCR of samples from the lung, spleen and liver. The present report highlights the rare concurrent infection of C. gatti and C. pseudotuberculosis in an adult goat from São Paulo state, Brazil, and indicates the necessity of surveillance in the treatment of goats with atypical pulmonary infections associated with neurological disorders.São Paulo State University School of Veterinary Medicine Laboratory of Animal Pathology and MicrobiologyFederal University of Minas Gerais Laboratory of Cellular and Molecular GeneticsFederal University of São Paulo Department of MicrobiologyUNIFESP, Department of MicrobiologySciEL

Influence of strains and environmental cultivation conditions on the bioconversion of ergosterol and vitamin D 2 in the sun mushroom

The fungus Agaricus subrufescens is grown commercially in China, the USA, Brazil, Taiwan and Japan, among others. However, each country adopts a cultivation system that significantly influences the agronomical parameters and chemical composition of the harvested mushrooms. In this study, the influence of the cultivation process on the content of ergosterol and vitamin D2 was evaluated. RESULTS: Four commercial strains of A. subrufescens (ABL 04/49, ABL CS7, ABL 18/01 and ABL 19/01) and two environmental cultivation conditions (in the field and a controlled chamber with the absence of sunlight) were used. Infield cultivation, ABL CS7 and ABL 19/01 strains presented better agronomic parameters, whereas in a protected environment ABL 19/01, ABL 04/49 and ABL 18/01 demonstrated better performance, respectively. The highest biological efficiency value (64%) was provided by ABL 19/01 strain in a controlled environment. CONCLUSION: The highest content in ergosterol (990 mg kg−1) and vitamin D2 (36.8 mg kg−1) were observed in mushrooms obtained in the field from strain ABL 04/49, which presents reasonable agronomic parameters for cultivation.This research was funded by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP No. 2017/22501-2 for CVS, 2019/12605-0 for DMMS and 2018/21492-2 for DCZ, 19/00419-8 for WGVJ). The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); national funding by FCT, PI, through the institutional scientific employment program contracts for A Fernandes and L Barros. This work is funded by the European Structural and Investment Funds (FEEI) through the Regional Operational Program North 2020, within the scope of Project Mobilizador ValorNatural®.info:eu-repo/semantics/publishedVersio

Uso dos solos em assentamentos rurais no Sudoeste Goiano / Use of soils of rural settlements in Southwest Goiano

Os assentamentos da Reforma Agrária em Goiás possuem realidades muito distintas, sejam pela localização geográfica ou por condições das famílias assentadas. No Território Rural do Sudoeste Goiano há uma grande extensão de área e à forte presença da agroindústria nessa região, aumentando assim a pressão de uso do solo em condições de mono cultivos, diminuindo as opções produtivas e diversificação de usos do solo. Nesse sentido, este trabalho utiliza a aplicação dos conceitos e técnicas de sensoriamento remoto para a identificação e caracterização do uso e cobertura do solo nos assentamentos localizados no Território Rural do Sudoeste Goiano. Foram utilizados dados geográficos dos limites das áreas dos assentamentos, imagens do satélite Landsat 8 (ano 2017) e consultas no Google Earth e visitas in loco. Foram identificados 13 assentamentos, e destes o município de Rio Verde é o que possui 75% das áreas destinadas à reforma agrária e 78% das famílias assentadas. As principais atividades produtivas dos assentamentos encontram-se, atualmente, baseadas nos mono cultivos de soja, milho e sorgo, seguido em menor escala da pecuária. Percebe-se nos assentamentos que a conservação ambiental, (mata nativa) encontra-se em seus percentuais mínimos.  

Benefits of Assistive Technology for Children with Monoplegic Motor Disabilities

The benefits of Assistive technology involve assistance techniques where it presents resources to help people with disabilities, so our target audience are children with monoplegia motor disabilities, that is, the individual cannot move a limb, it was hand chosen as the focus of the problem to solve the handicapped condition.  The objective is to point out techniques in assistive technology to improve the lives of children with monoplegic motor disabilities, through a procedure of a tool called Neomano Glove, demonstrating its benefits, and a comparison of another hand rehabilitation glove is also made, showing the superiority and motivation of using the Neomano Glove capable of solving and facilitating children\u27s lives.  However, the methodology used was the bibliographic research accompanied by two types of research, quantitative and qualitative, so the neomano glove is very effective, as several users have already tested and approved its use, but the equipment can still be improved, as the accessory can evolve to help the hearing impaired communicate Libras

Diálogos sobre acessibilidade em transporte e mobilidade humana / Dialogues on accessibility in transport and human mobility

O presente trabalho propõe um outro olhar possível sobre a questão da deficiência, a partir de um afastamento do referencial estritamente biomédico e normativo sobre o corpo - que enxerga o corpo deficiente a partir de uma concepção de falta. Uma outra forma de pensar a deficiência emerge tendo em vista uma dimensão sensível do campo da reabilitação. Trata-se também de uma dimensão sócio-política, na medida em que o conceito de deficiência é então conjeturado a partir de uma articulação com o campo social que o enreda, através de uma perspectiva cartográfica.Quais são as barreiras visíveis e invisíveis que atravessam a mobilidade humana? É a pergunta que indaga o trabalho que se desenvolve a partir da problematização de questões relativas à mobilidade no cotidiano, tendo como matéria-prima de transversalização falas suscitadas em rodas de conversa sobre o tema

Fosfatagem corretiva e adubação em cobertura na produção de mudas de Tamarindus indica L/Correct phosphating and top dressing fertilization in the production of Tamarindus indica L. seedlings

A nutrição adequada de mudas durante a fase de viveiro promove melhor adaptação no local de plantio, tornando-se necessário o conhecimento das exigências de cada espécie. O objetivo deste trabalho foi avaliar o efeito da fosfatagem corretiva e da adubação nitrogenada e potássica em cobertura na produção de mudas de tamarindo. A fosfatagem corretiva promoveu maior incremento em diâmetro de colo das mudas quando associada à adubação nitrogenada em cobertura

Temporal patterns of cytokine and injury biomarkers in hospitalized COVID-19 patients treated with methylprednisolone

BackgroundThe novel coronavirus disease 2019 (COVID-19) presents with complex pathophysiological effects in various organ systems. Following the COVID-19, there are shifts in biomarker and cytokine equilibrium associated with altered physiological processes arising from viral damage or aggressive immunological response. We hypothesized that high daily dose methylprednisolone improved the injury biomarkers and serum cytokine profiles in COVID-19 patients.MethodsInjury biomarker and cytokine analysis was performed on 50 SARS-Cov-2 negative controls and 101 hospitalized severe COVID-19 patients: 49 methylprednisolone-treated (MP group) and 52 placebo-treated serum samples. Samples from the treated groups collected on days D1 (pre-treatment) all the groups, D7 (2 days after ending therapy) and D14 were analyzed. Luminex assay quantified the biomarkers HMGB1, FABP3, myoglobin, troponin I and NTproBNP. Immune mediators (CXCL8, CCL2, CXCL9, CXCL10, TNF, IFN-γ, IL-17A, IL-12p70, IL-10, IL-6, IL-4, IL-2, and IL-1β) were quantified using cytometric bead array.ResultsAt pretreatment, the two treatment groups were comparable demographically. At pre-treatment (D1), injury biomarkers (HMGB1, TnI, myoglobin and FABP3) were distinctly elevated. At D7, HMGB1 was significantly higher in the MP group (p=0.0448) compared to the placebo group, while HMGB1 in the placebo group diminished significantly by D14 (p=0.0115). Compared to healthy control samples, several immune mediators (IL-17A, IL-6, IL-10, MIG, MCP-1, and IP-10) were considerably elevated at baseline (all p≤0.05). At D7, MIG and IP-10 of the MP-group were significantly lower than in the placebo-group (p=0.0431, p=0.0069, respectively). Longitudinally, IL-2 (MP-group) and IL-17A (placebo-group) had increased significantly by D14. In placebo group, IL-2 and IL-17A continuously increased, as IL-12p70, IL-10 and IP-10 steadily decreased during follow-up. The MP treated group had IL-2, IFN-γ, IL-17A and IL-12p70 progressively increase while IL-1β and IL-10 gradually decreased towards D14. Moderate to strong positive correlations between chemokines and cytokines were observed on D7 and D14.ConclusionThese findings suggest MP treatment could ameliorate levels of myoglobin and FABP3, but appeared to have no impact on HMGB1, TnI and NTproBNP. In addition, methylprednisolone relieves the COVID-19 induced inflammatory response by diminishing MIG and IP-10 levels. Overall, corticosteroid (methylprednisolone) use in COVID-19 management influences the immunological molecule and injury biomarker profile in COVID-19 patients

A list of land plants of Parque Nacional do Caparaó, Brazil, highlights the presence of sampling gaps within this protected area

Brazilian protected areas are essential for plant conservation in the Atlantic Forest domain, one of the 36 global biodiversity hotspots. A major challenge for improving conservation actions is to know the plant richness, protected by these areas. Online databases offer an accessible way to build plant species lists and to provide relevant information about biodiversity. A list of land plants of “Parque Nacional do Caparaó” (PNC) was previously built using online databases and published on the website "Catálogo de Plantas das Unidades de Conservação do Brasil." Here, we provide and discuss additional information about plant species richness, endemism and conservation in the PNC that could not be included in the List. We documented 1,791 species of land plants as occurring in PNC, of which 63 are cited as threatened (CR, EN or VU) by the Brazilian National Red List, seven as data deficient (DD) and five as priorities for conservation. Fifity-one species were possible new ocurrences for ES and MG states

High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort

Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded from the analyses. Among the remaining 1638 participants who were seronegative at baseline, 214 showed seroconversion at visit 2. The seroconversion incidence was 13·06% (95% CI 11·52–14·79) overall and 6·78% (5·61–8·10) for symptomatic seroconversion, over a median follow-up period of 57 days (IQR 54–61). 48·1% of seroconversion events were estimated to be asymptomatic. The sample had higher proportions of affluent and higher-educated people than those reported for the Manaus city population. In the fully adjusted and corrected model, risk factors for seroconversion before visit 2 were having a COVID-19 case in the household (IRR 1·49 [95% CI 1·21–1·83]), not wearing a mask during contact with a person with COVID-19 (1·25 [1·09–1·45]), relaxation of physical distancing (1·31 [1·05–1·64]), and having flu-like symptoms (1·79 [1·23–2·59]) or a COVID-19 diagnosis (3·57 [2·27–5·63]) between the first and second visits, whereas working remotely was associated with lower incidence (0·74 [0·56–0·97]). Interpretation: An intense infection transmission period preceded the second wave of COVID-19 in Manaus. Several modifiable behaviours increased the risk of seroconversion, including non-compliance with non-pharmaceutical interventions measures such as not wearing a mask during contact, relaxation of protective measures, and non-remote working. Increased testing in high-transmission areas is needed to provide timely information about ongoing transmission and aid appropriate implementation of transmission mitigation measures. Funding: Ministry of Education, Brazil; Fundação de Amparo à Pesquisa do Estado do Amazonas; Pan American Health Organization (PAHO)/WHO.World Health OrganizationRevisión por pare