85 research outputs found

    Thermal emission from WASP-24b at 3.6 and 4.5 {\mu}m

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    Aims. We observe occultations of WASP-24b to measure brightness temperatures and to determine whether or not its atmosphere exhibits a thermal inversion (stratosphere). Methods. We observed occultations of WASP-24b at 3.6 and 4.5 {\mu}m using the Spitzer Space Telescope. It has been suggested that there is a correlation between stellar activity and the presence of inversions, so we analysed existing HARPS spectra in order to calculate log R'HK for WASP-24 and thus determine whether or not the star is chromospherically active. We also observed a transit of WASP-24b in the Str\"{o}mgren u and y bands, with the CAHA 2.2-m telescope. Results. We measure occultation depths of 0.159 \pm 0.013 per cent at 3.6 {\mu}m and 0.202 \pm 0.018 per cent at 4.5 {\mu}m. The corresponding planetary brightness temperatures are 1974 \pm 71 K and 1944 \pm 85 K respectively. Atmosphere models with and without a thermal inversion fit the data equally well; we are unable to constrain the presence of an inversion without additional occultation measurements in the near-IR. We find log R'HK = -4.98 \pm 0.12, indicating that WASP-24 is not a chromospherically active star. Our global analysis of new and previously-published data has refined the system parameters, and we find no evidence that the orbit of WASP-24b is non-circular. Conclusions. These results emphasise the importance of complementing Spitzer measurements with observations at shorter wavelengths to gain a full understanding of hot Jupiter atmospheres.Comment: 7 pages, 4 figures, 3 tables. Accepted for publication in A&

    Thermal emission at 3.6-8 micron from WASP-19b: a hot Jupiter without a stratosphere orbiting an active star

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    We report detection of thermal emission from the exoplanet WASP-19b at 3.6, 4.5, 5.8 and 8.0 micron. We used the InfraRed Array Camera on the Spitzer Space Telescope to observe two occultations of WASP-19b by its host star. We combine our new detections with previous measurements of WASP-19b's emission at 1.6 and 2.09 micron to construct a spectral energy distribution of the planet's dayside atmosphere. By comparing this with model-atmosphere spectra, we find that the dayside atmosphere of WASP-19b lacks a strong temperature inversion. As WASP-19 is an active star (log RHK = -4.50 +/- 0.03), this finding supports the hypothesis of Knutson, Howard & Isaacson (2010) that inversions are suppressed in hot Jupiters orbiting active stars. The available data are unable to differentiate between a carbon-rich and an oxygen-rich atmosphere.Comment: As accepted for publication in MNRAS. 12 pages, 5 figures, 3 table

    Crowdfunding our health: economic risks and benefits

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    Crowdfunding is an expanding form of alternative financing that is gaining traction in the health sector. This article presents a typology for crowdfunded health projects and a review of the main economic benefits and risks of crowdfunding in the health market. We use evidence from a literature review, complimented by expert interviews, to extend the fundamental principles and established theories of crowdfunding to a health market context. Crowdfunded health projects can be classified into four types according to the venture's purpose and funding method. These are projects covering health expenses, fundraising health initiatives, supporting health research, or financing commercial health innovation. Crowdfunding could economically benefit the health sector by expanding market participation, drawing money and awareness to neglected health issues, improving access to funding, and fostering project accountability and social engagement. However, the economic risks of health-related crowdfunding include inefficient priority setting, heightened financial risk, inconsistent regulatory policies, intellectual property rights concerns, and fraud. Theorized crowdfunding behaviours such as signalling and herding can be observed in the market for health-related crowdfunding. Broader threats of market failure stemming from adverse selection and moral hazard also apply. Many of the discussed economic benefits and risks of crowdfunding health campaigns are shared more broadly with those of crowdfunding projects in other sectors. Where crowdfunding health care appears to diverge from theory is the negative externality inefficient priority setting may have towards achieving broader public health goals. Therefore, the market for crowdfunding health care must be economically stable, as well as designed to optimally and equitably improve public health

    Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium

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    While genome-wide association studies (GWAS) have primarily examined populations of European ancestry, more recent studies often involve additional populations, including admixed populations such as African Americans and Latinos. In admixed populations, linkage disequilibrium (LD) exists both at a fine scale in ancestral populations and at a coarse scale (admixture-LD) due to chromosomal segments of distinct ancestry. Disease association statistics in admixed populations have previously considered SNP association (LD mapping) or admixture association (mapping by admixture-LD), but not both. Here, we introduce a new statistical framework for combining SNP and admixture association in case-control studies, as well as methods for local ancestry-aware imputation. We illustrate the gain in statistical power achieved by these methods by analyzing data of 6,209 unrelated African Americans from the CARe project genotyped on the Affymetrix 6.0 chip, in conjunction with both simulated and real phenotypes, as well as by analyzing the FGFR2 locus using breast cancer GWAS data from 5,761 African-American women. We show that, at typed SNPs, our method yields an 8% increase in statistical power for finding disease risk loci compared to the power achieved by standard methods in case-control studies. At imputed SNPs, we observe an 11% increase in statistical power for mapping disease loci when our local ancestry-aware imputation framework and the new scoring statistic are jointly employed. Finally, we show that our method increases statistical power in regions harboring the causal SNP in the case when the causal SNP is untyped and cannot be imputed. Our methods and our publicly available software are broadly applicable to GWAS in admixed populations

    Dengue: a continuing global threat.

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    Dengue fever and dengue haemorrhagic fever are important arthropod-borne viral diseases. Each year, there are ∌50 million dengue infections and ∌500,000 individuals are hospitalized with dengue haemorrhagic fever, mainly in Southeast Asia, the Pacific and the Americas. Illness is produced by any of the four dengue virus serotypes. A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated. Antiviral drugs and vaccines that are currently under development could also make an important contribution to dengue control in the future

    Change & Maintaining Change in School Cafeterias: Economic and Behavioral-Economic Approaches to Increasing Fruit and Vegetable Consumption

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    Developing a daily habit of consuming fruits and vegetables (FV) in children is an important public-health goal. Eating habits acquired in childhood are predictive of adolescent and adult dietary patterns. Thus, healthy eating patterns developed early in life can protect the individual against a number of costly health deficits and may reduce the prevalence of obesity. At present, children in the United States (US) under-consume FV despite having access to them through the National School Lunch Program. Because access is an obstacle to developing healthy eating habits, particularly in low-income households, targeting children’s FV consumption in schools has the advantage of near-universal FV availability among more than 30 million US children. This chapter reviews economic and behavioral-economic approaches to increasing FV consumption in schools. Inclusion criteria include objective measurement of FV consumption (e.g., plate waste measures) and minimal demand characteristics. Simple but effective interventions include (a) increasing the variety of vegetables served, (b) serving sliced instead of whole fruits, (c) scheduling lunch after recess, and (d) giving children at least 25 minutes to eat. Improving the taste of FV and short-term incentivizing consumption of gradually increasing amounts can produce large increases in consumption of these foods. Low-cost game-based incentive program may increase the practicality of the latter strategy

    Synthesis of the elements in stars: forty years of progress

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