132 research outputs found
Seismic shothole drillers’ lithostratigraphic logs: Unearthing a wealth of regional geoscience information in northwestern Canada
AbstractSeismic shothole drillers’ logs, record the near-surface (avg. 18.6m deep) lithostratigraphy encountered when drilling holes to place explosive charges. These records offer a largely unrecognized wealth of geoscience information in areas for which little may be otherwise known. Stored in the Basic Files archives of petroleum exploration and seismic acquisition companies, this study first convinced companies of the potential utility of this data, then recovered the hard copy and digitally scanned records (paper, fiche, microfilm) and rendered these into a digital database and GIS. The final database of 343,989 records provides the largest source of geoscience information of its kind in northwestern Canada, and in many cases contains unique and original records on a host of subjects including surficial-, bedrock-, and hydro-geology, permafrost, and geohazards. The drillers’ log records have further been used to create geospatial models of drift, till, muskeg, massive ice and ground ice thicknesses, and continue to be applied to new avenues of research such as temporal variations of bottomfast ice extents in offshore shallow marine environments. Published in freely downloadable Geological Survey of Canada Open File reports and providing commonly used database and GIS file formats, this data rescue exercise preserves and greatly enhances what was becoming an increasingly discarded corporate data set of unrecognized potential
Postglacial Sea-Level History and Coastline Change at Port au Choix, Great Northern Peninsula, Newfoundland
Late Quaternary Relative Sea-Level Change on the West Coast of Newfoundland
Two revised relative sea-level (RSL) curves are presented for the Port au Choix to Daniel’s Harbour area of the Great Northern Peninsula, northwestern Newfoundland. Both curves are similar, showing continuous emergence of 120-140 m between 14 700 cal BP and present. The half-life of exponential curves fit to the RSL data is 1400 years and the rate of emergence varies from ~2.3 m per century prior to 10 000 cal BP to ~0.13 m per century since 5000 cal BP. The curves fit a general pattern of RSL history along the west coast of Newfoundland, where there is a southward transition from solely emergence to emergence followed by submergence. Isostatic depression curves are generated for four RSL records spanning the west coast. Almost double the crustal depression is recorded to the northwest, reflecting the greater glacioisostatic loading by the Laurentide Ice Sheet over southern Labrador and Québec compared to a smaller loading centre by a regional ice complex over Newfoundland. Only the St. George’s Bay RSL record in the southwest appears to show evidence for a proglacial forebulge, when at 6000 cal BP an isostatic ridge of 4 m amplitude begins to collapse.Deux courbes du niveau marin relatif (NMR) sont présentées pour la région allant de Port-au-Choix à Daniel’s Harbour sur la Grande Péninsule Nord, au nord-ouest de Terre-Neuve. Les deux courbes sont semblables, montrant une émergence continue de 120 à 140 m entre 14 700 cal BP et l’actuel. La demi-vie des courbes exponentielles ajustées au NMR est de 1400 ans, et le taux d’émergence varie de ~2.3 m par siècle avant 10 000 cal BP à ~0.13 m par siècle depuis 5000 cal BP. Les courbes s’ajustent au modèle général de l’histoire du NMR de la côte ouest de Terre-Neuve, où il existe une transition d’émergence seule à une émergence suivie d’une submergence, en allant vers le sud. Des courbes de dépressions isostatiques préliminaires sont générées pour quatre chronologies du NMR couvrant la côte ouest. Presque le double de la dépression de la croûte est enregistré au nord-ouest, reflétant la charge glacio-isostatique plus grande de l’Inlandsis Laurentidien sur le sud du Labrador et du Québec comparée à la charge plus faible du complexe glaciaire régional localisé sur Terre-Neuve. Seules les données du NMR de St. George’s Bay, au sud-ouest, semble démontrer l’affaissement du bourrelet périphérique lorsqu’une vague isostatique de 4 m d’amplitude commence à s’effondrer vers 6000 cal BP
Highly disturbed populations of seagrass show increased resilience but lower genotypic diversity
The response of seagrass systems to a severe disturbance provides an opportunity to quantify the degree of resilience in different meadows, and subsequently to test whether there is a genetic basis to resilience. We used existing data on levels of long-standing disturbance from poor water quality, and the responses of seagrass (Zostera muelleri) after an extreme flood event in Moreton Bay, Queensland, Australia. Sites were grouped into high and low disturbance categories, in which seagrass showed high and low resilience, respectively, as determined by measuring rates of key feedback processes (nutrient removal, suppression of sediment resuspension, and algal grazing), and physiological and morphological traits. Theoretically, meadows with higher genotypic diversity would be expected to have greater resilience. However, because the more resilient meadows occur in areas historically exposed to high disturbance, the alternative is also possible, that selection will have resulted in a narrower, less diverse subset of genotypes than in less disturbed meadows. Levels of genotypic and genetic diversity (allelic richness) based on 11 microsatellite loci, were positively related (R2 = 0.58). Genotypic diversity was significantly lower at highly disturbed sites (R = 0.49) than at less disturbed sites (R = 0.61). Genotypic diversity also showed a negative trend with two morphological characteristics known to confer resilience on seagrass in Moreton Bay, leaf chlorophyll concentrations and seagrass biomass. Genetic diversity did not differ between disturbed and undisturbed sites. We postulate that the explanation for these results is historical selection for genotypes that confer protection against disturbance, reducing diversity in meadows that contemporarily show greater resilience
Share and enjoy: anatomical models database-generating and sharing cardiovascular model data using web services
Sharing data between scientists and with clinicians in cardiac research has been facilitated significantly by the use of web technologies. The potential of this technology has meant that information sharing has been routinely promoted through databases that have encouraged stakeholder participation in communities around these services. In this paper we discuss the Anatomical Model Database (AMDB) (Gianni et al. Functional imaging and modeling of the heart. Springer, Heidelberg, 2009; Gianni et al. Phil Trans Ser A Math Phys Eng Sci 368:3039–3056, 2010) which both facilitate a database-centric approach to collaboration, and also extends this framework with new capabilities for creating new mesh data. AMDB currently stores cardiac
geometric models described in Gianni et al. (Functional imaging and modelling of the heart. Springer, Heidelberg, 2009), a number of additional cardiac models describing geometry and functional properties, and most recently models generated using a web service. The functional models represent data from simulations in geometric form, such as electrophysiology or mechanics, many of which are present in AMDB as part of a benchmark study. Finally, the heartgen service has been added for producing left or bi-ventricle models derived from binary image data using the methods described in Lamata et al. (Med Image Anal 15:801–813, 2011).
The results can optionally be hosted on AMDB alongside other community-provided anatomical models. AMDB is, therefore, a unique database storing geometric data (rather than abstract models or image data) combined with a powerful web service for generating new geometric models
Playing Games with Tito:Designing Hybrid Museum Experiences for Critical Play
This article brings together two distinct, but related perspectives on playful museum experiences: Critical play and hybrid design. The article explores the challenges involved in combining these two perspectives, through the design of two hybrid museum experiences that aimed to facilitate critical play with/in the collections of the Museum of Yugoslavia and the highly contested heritage they represent. Based on reflections from the design process as well as feedback from test users, we describe a series of challenges: Challenging the norms of visitor behaviour, challenging the role of the artefact, and challenging the curatorial authority. In conclusion, we outline some possible design strategies to address these challenges
MicroRNA regulation in human CD8+ T cell subsets – cytokine exposure alone drives miR-146a expression
Dear British criminology: Where has all the race and racism gone?
In this article we use Emirbayer and Desmond’s institutional reflexivity framework to critically examine the production of racial knowledge in British criminology. Identifying weakness, neglect and marginalization in theorizing race and racism, we focus principally on the disciplinary unconscious element of their three-tier framework, identifying and interrogating aspects of criminology’s ‘obligatory problematics’, ‘habits of thought’ and ‘position-taking’ as well as its institutional structure and social relations that combine to render the discipline ‘institutionally white’. We also consider, briefly, aspects of criminology’s relationship to race, racism and whiteness in the USA. The final part of the article makes the case for British criminology to engage in telling and narrating racisms, urging it to understand the complexities of race in our subject matter, avoid its reduction to class and inequality, and to pay particular attention to reflexivity, history, sociology and language, turning to face race with postcolonial tools and resolve
Assessing the effectiveness of Enhanced Psychological Care for patients with depressive symptoms attending cardiac rehabilitation compared with treatment as usual (CADENCE): A pilot cluster randomised controlled trial
© 2018 The Author(s). Background: Around 17% of people attending UK cardiac rehabilitation programmes have depression. Optimising psychological wellbeing is a rehabilitation goal, but provision of psychological care is limited. We developed and piloted an Enhanced Psychological Care (EPC) intervention embedded within cardiac rehabilitation, aiming to test key areas of uncertainty to inform the design of a definitive randomised controlled trial (RCT) and economic evaluation. Methods: An external pilot randomised controlled trial (RCT) randomised eight cardiac rehabilitation teams (clusters) to either usual care of cardiac rehabilitation provision (UC), or EPC in addition to UC. EPC comprised mental health care coordination and patient-led behavioural activation with nurse support. Adults eligible for cardiac rehabilitation following an acute coronary syndrome and identified with new-onset depressive symptoms during an initial nurse assessment were eligible. Measures were performed at baseline and 5- and 8-month follow-ups and compared between EPC and UC. Team and participant recruitment and retention rates, and participant outcomes (clinical events, depression, anxiety, health-related quality of life, patient experiences, and resource use) were assessed. Results: Eight out of twenty teams were recruited and randomised. Of 614 patients screened, 55 were eligible and 29 took part (5%, 95% CI 3 to 7% of those screened), with 15 patient participants cluster randomised to EPC and 14 to UC. Nurse records revealed that 8/15 participants received the maximum number of EPC sessions offered; and 4/15 received no sessions. Seven out of fifteen EPC participants were referred to another NHS psychological service compared to none in UC. We followed up 27/29 participants at 5 months and 17/21 at 8 months. The mean difference (EPC minus UC) in depressive symptoms (Beck Depression Inventory) at follow-up (adjusting for baseline score) was 1.7 (95% CI - 3.8 to 7.3; N = 26) at 5 months and 4.4 (95% CI - 1.4 to 10.2; N = 17) at 8 months. Discussion: While valued by patients and nurses, organisational and workload constraints are significant barriers to EPC implementation. There remains a need to develop and test new models of psychological care within cardiac rehabilitation. Our study offers important data to inform the design of future trials of similar interventions
Mortality Risk of Hypnotics: Strengths and Limits of Evidence
Sleeping pills, more formally defined as hypnotics, are sedatives used to induce and maintain sleep. In a review of publications for the past 30 years, descriptive epidemiologic studies were identified that examined the mortality risk of hypnotics and related sedative-anxiolytics. Of the 34 studies estimating risk ratios, odds ratios, or hazard ratios, excess mortality associated with hypnotics was significant (p < 0.05) in 24 studies including all 14 of the largest, contrasted with no studies at all suggesting that hypnotics ever prolong life. The studies had many limitations: possibly tending to overestimate risk, such as possible confounding by indication with other risk factors; confusing hypnotics with drugs having other indications; possible genetic confounders; and too much heterogeneity of studies for meta-analyses. There were balancing limitations possibly tending towards underestimates of risk such as limited power, excessive follow-up intervals with possible follow-up mixing of participants taking hypnotics with controls, missing dosage data for most studies, and over-adjustment of confounders. Epidemiologic association in itself is not adequate proof of causality, but there is proof that hypnotics cause death in overdoses; there is thorough understanding of how hypnotics euthanize animals and execute humans; and there is proof that hypnotics cause potentially lethal morbidities such as depression, infection, poor driving, suppressed respiration, and possibly cancer. Combining these proofs with consistent evidence of association, the great weight of evidence is that hypnotics cause huge risks of decreasing a patient's duration of survival
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