Learning Enhancement and Community Building Among Class Members Through Electronic Communications

This paper outlines the use of computer conferencing to enhance teaching and learning in an undergraduate college course, primarily as a supplement to lectures and class discussions, to implement homework assignments, to facilitate the writing process in writing-intensive courses, and to conduct informal course evaluations

El Payaso de Hospital como Agente de Salud

En los últimos años, en las instituciones clínicas se ha incrementado la presencia de organizaciones que, utilizando la figura del payaso para entrar en contacto con los pacientes pediátricos y su entorno (familiares y personal medico) realizan una labor artístico-terapéutica. Sin embargo, el rol de estos payasos de hospital aún no ha sido explorado ni difundido en profundidad. El presente trabajo explica la importancia de mantener y promover el espacio de juego en el contexto de la internación hospitalaria en la niñez y describe en profundidad el rol que el payaso de hospital desempeña en dicho ámbito como agente de salud, incluido en un equipo interdisciplinario, capaz de producir un cambio beneficioso para la salud integral del niño.Fil: Skrbec, Adriana Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; ArgentinaFil: Andrusiewicz, Valeria. No especifíca

Who's to Blame? Effects of Perpetrator Gender and Victim Confrontation on Perceptions of Blame

Color poster with text and graphs.The purpose of this study was to analyze participant's perception of blame and victimization based on the gender of the perpetrator and the presence of verbal conflict previous to the domestic abuse behavior.University of Wisconsin--Eau Claire Office of Research and Sponsored Programs

A Review of Error-Correction Strategies

Color poster with text and graphs.Teaching skills using effective procedures can sometimes still result in learner errors. How a teacher should respond when an error occurs is not always clear. Given the importance of teaching skills to persons with intellectual disabilities, and the lack of a cohesive research review, the purpose of this study was to review and evaluate research pertaining to correcting errors when teaching skills.University of Wisconsin--Eau Claire Office of Research and Sponsored Program

Solid double microemulsions for improved absorption of scarcely bioavailable drugs

Solid double microemulsions for improved absorption of scarcely bioavailable drug

Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic protease

We have extended a highly flexible method for rapidly assembling aspartic protease inhibitors to produce symmetric and asymmetric monohydroxyethylene peptidomimetics. This method is based on the prior synthesis of the central non-cleavable peptide- bond isostere [NH2\u2013P1cP10\u2013NH2; c=hydroxyethylene isostere, HNCH(Bz)CHOHCH2CH(Bz)NH], with the possibility of accurately controlling its stereochemistry (S,S,S or S,R,S), and subsequently adding appropriate flanking units, chosen from commercially available amino acids, aromatic carboxylic acids, or phenoxyacetic acid (Poa) derivatives. The method was used to make asymmetric inhibitors of general formula Kyn-Xaa-PhecPhe-dmPoa, (Kyn=kynurenic acid, Xaa=Val, Thr or d-thienylglycine, Mr=716\u2013754) and symmetric inhibitors of formula xPoa-PhecPhe-xPoa (xPoa=Poa or dimethyl-, hydroxy-, formyl- or acetyl- Poa, Mr=553\u2013609), with logPo/w values ranging from 4.1 to 7.6. Inhibition of HIV-PR did not depend on the stereochemistry of the hydroxyl group, while it depended markedly on the substituents present on the Poa residues, with dmPoa being preferred over Poa or its more hydrophilic derivatives. Conversely, inhibition of Candida albicans Sap2 was higher for the S,S,S epimers, and Poa or its hydrophilic derivatives were preferred over dmPoa

Cis-configured aziridines are new pseudo-irreversible dual-mode inhibitors of Candida albicans secreted aspartic protease 2

A series of cis-configured epoxides and aziridines containing hydrophobic moieties and amino acid esters,were synthesized as new potential inhibitors of the secreted aspartic protease 2 (SAP2) of Candida albicans. Enzyme assays revealed the N- benzyl-3-phenyl-substituted aziridines 11 and 17 as the most potent inhibitors, with second-order inhibition, rate constants (k(2)) between 56000 and 12-1000 M-1 min(-1). The compounds were shown to be pseudo-irreversible dual-mode, inhibitors: the interm ediate esterified enzyme resulting from nucleophilic ring opening was hydrolyzed and yielded amino alcohols as transition state-mimetic reversible inhibitors. The results of docking studies with the ring-closed aziridine forms of the inhibitors suggest binding modes mainly dominated by hydrophobic interactions with the S1, S1' S2, and S2' subsites of the protease, and docking studies with the processed amino alcohol forms predict additional hydrogen bonds of the new hydroxy group to the active site Asp residues. C. albicans growth assays showed the compounds to decrease SAP2-dependent growth while not affecting SAP2-independent growth