ARE EMOTIONAL DISPLAYS AN EVOLUTIONARY PRECURSOR TO COMPOSITIONALITY IN LANGUAGE?

Compositionality is a basic property of language, spoken and signed, according to which the meaning of a complex structure is determined by the meanings of its constituents and the way they combine (e.g., Jackendoff, 2011 for spoken language; Sandler 2012 for constituents conveyed by face and body signals in sign language; Kirby & Smith, 2012 for emergence of compositionality). Here we seek the foundations of this property in a more basic, and presumably prior, form of communication: the spontaneous expression of emotion. To this end, we ask whether features of facial expressions and body postures are combined and recombined to convey different complex meanings in extreme displays of emotions. There is evidence that facial expressions are processed in a compositional fashion (Chen & Chen, 2010). In addition, facial components such as nose wrinkles or eye opening elicit systematic confusion while decoding facial expressions of disgust and anger and fear and surprise, respectively (Jack et al., 2014), suggesting that other co-occurring signals contribute to their interpretation. In spontaneous emotional displays of athletes, the body – and not the face – better predicts participants’ correct assessments of victory and loss pictures, as conveying positive or negative emotions (Aviezer et al., 2012), suggesting at least that face and body make different contributions to interpretations of the displays. Taken together, such studies lead to the hypothesis that emotional displays are compositional - that each signal component, or possibly specific clusters of components (Du et al., 2014), may have their own interpretations, and make a contribution to the complex meaning of the whole. On the assumption that emotional displays are older than language in evolution, our research program aims to determine whether the crucial property of compositionality is indeed present in communicative displays of emotion

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

The immune response in the brain has been widely investigated and while many studies have focused on the proinflammatory cytotoxic response, the brain’s innate immune system demonstrates significant heterogeneity. Microglia, like other tissue macrophages, participate in repair and resolution processes after infection or injury to restore normal tissue homeostasis. This review examines the mechanisms that lead to reduction of self-toxicity and to repair and restructuring of the damaged extracellular matrix in the brain. Part of the resolution process involves switching macrophage functional activation to include reduction of proinflammatory mediators, increased production and release of anti-inflammatory cytokines, and production of cytoactive factors involved in repair and reconstruction of the damaged brain. Two partially overlapping and complimentary functional macrophage states have been identified and are called alternative activation and acquired deactivation. The immunosuppressive and repair processes of each of these states and how alternative activation and acquired deactivation participate in chronic neuroinflammation in the brain are discussed

Use of Telemedicine for Postdischarge Assessment of the Surgical Wound: International Cohort Study, and Systematic Review With Meta-analysis

Objective: This study aimed to determine whether remote wound reviews using telemedicine can be safely upscaled, and if standardized assessment tools are needed. // Background: Surgical site infection (SSI) is the most common complication of surgery worldwide, and frequently occurs after hospital discharge. Evidence to support implementation of telemedicine during postoperative recovery will be an essential component of pandemic recovery. // Methods: The primary outcome of this study was SSI reported up to 30 days after surgery (SSI), comparing rates reported using telemedicine (telephone and/or video assessment) to those with in-person review. The first part of this study analyzed primary data from an international cohort study of adult patients undergoing abdominal surgery who were discharged from hospital before 30 days after surgery. The second part combined this data with the results of a systematic review to perform a meta-analysis of all available data conducted in accordance with PRIMSA guidelines (PROSPERO:192596). // Results: The cohort study included 15,358 patients from 66 countries (8069 high, 4448 middle, 1744 low income). Of these, 6907 (45.0%) were followed up using telemedicine. The SSI rate reported using telemedicine was slightly lower than with in-person follow-up (13.4% vs 11.1%, P<0.001), which persisted after risk adjustment in a mixed-effects model (adjusted odds ratio: 0.73, 95% confidence interval: 0.63–0.84, P<0.001). This association was consistent across sensitivity and subgroup analyses, including a propensity-score matched model. In 9 eligible nonrandomized studies identified, a pooled mean of 64% of patients underwent telemedicine follow-up. Upon meta-analysis, the SSI rate reported was lower with telemedicine (odds ratio: 0.67, 0.47–0.94) than in-person (reference) follow-up (I2=0.45, P=0.12), although there a high risk of bias in included studies. // Conclusions: Use of telemedicine to assess the surgical wound postdischarge is feasible, but risks underreporting of SSI. Standardized tools for remote assessment of SSI must be evaluated and adopted as telemedicine is upscaled globally

Motivate To Communicate 300 Permainan dan Aktivitas untuk Anak Autis

Buku praktis ini berisi beragam ide menarik dan panduan untuk memotivasi anak-anak yang mengalami gangguan spektrum autisme dan masalah-masalah komunikasi lainnya. Formatnya yang praktis memudahkan anda untuk mengakses lebih dari 300 permainan dan aktivitas seru untuk mengembangkan keterampilan komunikasi anak anda. Gagasan-gagasan Innovatif dalam buku ini telah dikembangkan dari pengalaman klinis dan edukatif selama lebih dari 40 tahun dan didesain sedemikian rupa sehingga menyenangkan baik untuk anak-anak maupun orang dewasa.xi+160 hlm; 15x23 c

Compositionality of empathy: a framework for decoding emotion expression and human communication

Empathy, language, and language’s principle of compositionality are foundational cognitive elements for human interaction, enabling us to communicate, express, and understand one another. Empathy helps interpret the emotions of others, language is the instrument to communicate them, while compositionality, a fundamental principle in language, refers to the way complex meanings arise from the combination of simpler elements, such as phonemes and their arrangements in words. Recent research shows that compositionality extends beyond linguistic structures to emotional displays – that is, facial and bodily features without a specific meaning combine to create specific emotions or emotion dimensions with complex meanings. This paper explores how empathy decodes compositional emotional expressions, offering a framework for understanding human communication. Using a feature-based approach, we investigate the relationship between emotional displays and empathetic responses. Results show face and body features conveying dominance (e.g., raised heads, smiling mouths) elicit empathy for positive emotions, while features expressive submissiveness (e.g., bowed heads, hands on the face) predict empathy for sadness. Additionally, combinations of dominant and submissive cues yield nuanced empathetic reactions, emphasizing the role of compositional signals in communication. Our findings reveal empathy’s role in decoding compositional emotional displays. Keywords: Empathy, Compositionality, Emotion expression, Emotion dimensions, Human communication