Performance Benchmarking of Infrastructure-as-a-Service (IaaS) Clouds with CloudWorkBench

The continuing growth of the cloud computing market has led to an unprecedented diversity of cloud services with different performance characteristics. To support service selection, researchers and practitioners conduct cloud performance benchmarking by measuring and objectively comparing the performance of different providers and configurations (e.g., instance types in different data center regions). In this tutorial, we demonstrate how to write performance tests for IaaS clouds using the Web-based benchmarking tool Cloud WorkBench (CWB). We will motivate and introduce benchmarking of IaaS cloud in general, demonstrate the execution of a simple benchmark in a public cloud environment, summarize the CWB tool architecture, and interactively develop and deploy a more advanced benchmark together with the participants

Hierarchical strategies for efficient fault recovery on the reconfigurable PAnDA device

A novel hierarchical fault-tolerance methodology for reconfigurable devices is presented. A bespoke multi-reconfigurable FPGA architecture, the programmable analogue and digital array (PAnDA), is introduced allowing fine-grained reconfiguration beyond any other FPGA architecture currently in existence. Fault blind circuit repair strategies, which require no specific information of the nature or location of faults, are developed, exploiting architectural features of PAnDA. Two fault recovery techniques, stochastic and deterministic strategies, are proposed and results of each, as well as a comparison of the two, are presented. Both approaches are based on creating algorithms performing fine-grained hierarchical partial reconfiguration on faulty circuits in order to repair them. While the stochastic approach provides insights into feasibility of the method, the deterministic approach aims to generate optimal repair strategies for generic faults induced into a specific circuit. It is shown that both techniques successfully repair the benchmark circuits used after random faults are induced in random circuit locations, and the deterministic strategies are shown to operate efficiently and effectively after optimisation for a specific use case. The methods are shown to be generally applicable to any circuit on PAnDA, and to be straightforwardly customisable for any FPGA fabric providing some regularity and symmetry in its structure

Supramolecular structure in the membrane of Staphylococcus aureus

The fundamental processes of life are organized and based on common basic principles. Molecular organizers, often interacting with the membrane, capitalize on cellular polarity to precisely orientate essential processes. The study of organisms lacking apparent polarity or known cellular organizers (e.g., the bacterium Staphylococcus aureus) may enable the elucidation of the primal organizational drive in biology. How does a cell choose from infinite locations in its membrane? We have discovered a structure in the S. aureus membrane that organizes processes indispensable for life and can arise spontaneously from the geometric constraints of protein complexes on membranes. Building on this finding, the most basic cellular positioning system to optimize biological processes, known molecular coordinators could introduce further levels of complexity. All life demands the temporal and spatial control of essential biological functions. In bacteria, the recent discovery of coordinating elements provides a framework to begin to explain cell growth and division. Here we present the discovery of a supramolecular structure in the membrane of the coccal bacterium Staphylococcus aureus, which leads to the formation of a large-scale pattern across the entire cell body; this has been unveiled by studying the distribution of essential proteins involved in lipid metabolism (PlsY and CdsA). The organization is found to require MreD, which determines morphology in rod-shaped cells. The distribution of protein complexes can be explained as a spontaneous pattern formation arising from the competition between the energy cost of bending that they impose on the membrane, their entropy of mixing, and the geometric constraints in the system. Our results provide evidence for the existence of a self-organized and nonpercolating molecular scaffold involving MreD as an organizer for optimal cell function and growth based on the intrinsic self-assembling properties of biological molecules

The Baryon Content of Cosmic Structures

We make an inventory of the baryonic and gravitating mass in structures ranging from the smallest galaxies to rich clusters of galaxies. We find that the fraction of baryons converted to stars reaches a maximum between M500 = 1E12 and 1E13 Msun, suggesting that star formation is most efficient in bright galaxies in groups. The fraction of baryons detected in all forms deviates monotonically from the cosmic baryon fraction as a function of mass. On the largest scales of clusters, most of the expected baryons are detected, while in the smallest dwarf galaxies, fewer than 1% are detected. Where these missing baryons reside is unclear.Comment: ApJ Letters, in pres

Oculomotor and linguistic processing effects in reading dynamic horizontally scrolling text.

Two experiments are reported investigating oculomotor behavior and linguistic processing when reading dynamic horizontally scrolling text (compared to reading normal static text). Three factors known to modulate processing time in normal reading were investigated: Word length and word frequency were examined in Experiment 1, and target word predictability in Experiment 2. An analysis of global oculomotor behavior across the 2 experiments showed that participants made fewer and longer fixations when reading scrolling text, with shorter progressive and regressive saccades between these fixations. Comparisons of the linguistic manipulations showed evidence of a dissociation between word-level and sentence-level processing. Word-level processing (Experiment 1) was preserved for the dynamic scrolling text condition with no difference in length and frequency effects between scrolling and static text formats. However, sentence-level integration (Experiment 2) was reduced for scrolling compared to static text in that we obtained no early facilitation effect for predictable words under scrolling text conditions

Cluster AgeS Experiment (CASE): RR Lyrae stars from the globular cluster Omega Centauri as standard candles

New photometry of RRab and RRc stars in Omega Cen is used to calibrate their absolute magnitudes M_V as a function of: a) metallicity; and b) the Fourier parameters of light curves in the V band. The zero point of both calibrations relies on the distance modulus to the cluster derived earlier by the CASE project based on observations of the detached eclipsing binary OGLE GC17. For RRab variables we obtained a relation of M_V=(0.26\pm 0.08)[Fe/H]+(0.91\pm 0.13). A dereddened distance modulus to the LMC based on that formula is $\mu_{0}=18.56\pm 0.14$ mag. The second calibration of M_V, which is based on Fourier coefficients of decomposed light curves, results in the LMC distance of $\mu_{0}=18.51\pm 0.07$ mag.Comment: accepted for publication in MNRAS, 13 pages, 8 figure

Greater strength gains after training with accentuated eccentric than traditional isoinertial loads in already strength-trained men

As training experience increases it becomes more challenging to induce further neuromuscular adaptation. Consequently, strength trainers seek alternative training methods in order to further increase strength and muscle mass. One method is to utilize accentuated eccentric loading, which applies a greater external load during the eccentric phase of the lift as compared to the concentric phase. Based upon this practice, the purpose of this study was to determine the effects of 10 weeks of accentuated eccentric loading vs. traditional isoinertial resistance training in strength-trained men. Young (22 ± 3 years, 177 ± 6 cm, 76 ± 10 kg, n = 28) strength-trained men (2.6 ± 2.2 years experience) were allocated to concentric-eccentric resistance training in the form of accentuated eccentric load (eccentric load = concentric load + 40%) or traditional resistance training, while the control group continued their normal unsupervised training program. Both intervention groups performed three sets of 6-RM (session 1) and three sets of 10-RM (session 2) bilateral leg press and unilateral knee extension exercises per week. Maximum force production was measured by unilateral isometric (110° knee angle) and isokinetic (concentric and eccentric 30°.s-1) knee extension tests, and work capacity was measured by a knee extension repetition-to-failure test. Muscle mass was assessed using panoramic ultrasonography and dual-energy x-ray absorptiometry. Surface electromyogram amplitude normalized to maximum M-wave and the twitch interpolation technique were used to examine maximal muscle activation. After training, maximum isometric torque increased significantly more in the accentuated eccentric load group than control (18 ± 10 vs. 1 ± 5%, p \u3c 0.01), which was accompanied by an increase in voluntary activation (3.5 ± 5%, p \u3c 0.05). Isokinetic eccentric torque increased significantly after accentuated eccentric load training only (10 ± 9%, p \u3c 0.05), whereas concentric torque increased equally in both the accentuated eccentric load (10 ± 9%, p \u3c 0.01) and traditional (9 ± 6%, p \u3c 0.01) resistance training groups; however, the increase in the accentuated eccentric load group was significantly greater (p \u3c 0.05) than control (1 ± 7%). Knee extension repetition-to-failure improved in the accentuated eccentric load group only (28%, p \u3c 0.05). Similar increases in muscle mass occurred in both intervention groups. In summary, accentuated eccentric load training led to greater increases in maximum force production, work capacity and muscle activation, but not muscle hypertrophy, in strength-trained individuals

Segue 2: A Prototype of the Population of Satellites of Satellites

We announce the discovery of a new Milky Way satellite Segue 2 found in the data of the Sloan Extension for Galactic Understanding and Exploration (SEGUE). We followed this up with deeper imaging and spectroscopy on the Multiple Mirror Telescope. From this, we derive a luminosity of M_v = -2.5, a half-light radius of 34 pc and a systemic velocity of -40$ km/s. Our MMT data also provides evidence for a stream around Segue 2 at a similar heliocentric velocity, and the SEGUE data show that it is also present in neighboring fields. We resolve the velocity dispersion of Segue 2 as 3.4 km/s and the possible stream as about 7 km/s. This object shows points of comparison with other recent discoveries, Segue 1, Boo II and Coma. We speculate that all four objects may be representatives of a population of satellites of satellites -- survivors of accretion events that destroyed their larger but less dense parents. They are likely to have formed at redshifts z > 10 and are good candidates for fossils of the reionization epoch.Comment: MNRAS, Submitte

Time asymmetric spacetimes near null and spatial infinity. I. Expansions of developments of conformally flat data

The Conformal Einstein equations and the representation of spatial infinity as a cylinder introduced by Friedrich are used to analyse the behaviour of the gravitational field near null and spatial infinity for the development of data which are asymptotically Euclidean, conformally flat and time asymmetric. Our analysis allows for initial data whose second fundamental form is more general than the one given by the standard Bowen-York Ansatz. The Conformal Einstein equations imply upon evaluation on the cylinder at spatial infinity a hierarchy of transport equations which can be used to calculate in a recursive way asymptotic expansions for the gravitational field. It is found that the the solutions to these transport equations develop logarithmic divergences at certain critical sets where null infinity meets spatial infinity. Associated to these, there is a series of quantities expressible in terms of the initial data (obstructions), which if zero, preclude the appearance of some of the logarithmic divergences. The obstructions are, in general, time asymmetric. That is, the obstructions at the intersection of future null infinity with spatial infinity are different, and do not generically imply those obtained at the intersection of past null infinity with spatial infinity. The latter allows for the possibility of having spacetimes where future and past null infinity have different degrees of smoothness. Finally, it is shown that if both sets of obstructions vanish up to a certain order, then the initial data has to be asymptotically Schwarzschildean to some degree.Comment: 32 pages. First part of a series of 2 papers. Typos correcte

Periostin as a Multifunctional Modulator of the Wound Healing Response

During tissue healing, dynamic and temporal alterations occur in the structure and composition of the extracellular matrix (ECM) that are required for effective repair to occur. Matricellular proteins (MPs) are a group of diverse non-structural ECM components, which bind cell surface receptors mediating interactions between the cell and its microenviroment, effectively regulating adhesion, migration, proliferation, signaling and cell phenotype. Periostin (Postn), a pro-fibrogenic secreted glycoprotein, was defined as a MP based on its expression pattern and regulatory roles during development, healing and in disease processes. Postn consists of a typical signal sequence, an EMI domain responsible for binding to fibronectin, four tandem fasciclin-like domains that are responsible for integrin binding and a C-terminal region where multiple splice variants originate. This review will focus specifically on the role of Postn in wound healing and remodeling, an area of intense research in the last 10 years particularly related to skin healing as well as in myocardium post infarction. Postn interacts with cells through various integrin pairs and is an essential downstream effector of TGF-β superfamily signaling. As will be discussed, across different tissues, Postn is associated with pro-fibrogenic process, specifically, the transition of fibroblasts to myofibroblasts, collagen fibrillogenesis and ECM synthesis. Although the complexity of Postn as a modulator of cell behavior in tissue healing is only beginning to be elucidated, its expression is clearly a defining event in moving wound healing through the proliferative and remodeling phases