52 research outputs found
Artificial intelligence to detect and forecast earthquakes
- Author
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Precursors to large earthquakes have been widely but not systematically identified. The ability of deep neural networks to solve complex tasks that involve generalisations makes them highly suited to earthquake and precursor detection. Large moment magnitude (Mw) earthquakes and associated tsunamis can have a huge economic and social impact. Detecting precursors could significantly improve seismic hazard preparedness, particularly if precursors can assist, within a more general probabilistic forecasting framework, in reducing the uncertainty interval on expected earthquakes’ timing, location and Mw. Additionally, artificial intelligence has recently been used to improve the detection and location of smaller earthquakes, assisting in the completion and automation of seismic catalogues.
This paper is the first to present a deep learning-based solution for detecting and identifying short-term changes in the raw seismic signal, correlated to earthquake occurrence. Deep neural networks (DNNs) were employed to investigate the background seismic signal prior to 31 Mw >= 6 earthquakes in the Japan region. Instantaneous, precursor-related features (features correlated to the investigated earthquakes) were detected as opposed to predicting future values based on previously observed values in the case of time series forecasting. The network achieved a 98% train accuracy and a 96% test accuracy classifying noise unrelated to Mw >= 6 earthquakes from signal immediately prior to the investigated earthquakes. Additionally, the precursor-related features became increasingly systematic (more frequently detected prior to the investigated earthquakes) with earthquake proximity. Discriminative features appeared most dominant over a frequency range of ~ 0.1-0.9 Hz, coinciding with microseismic noise and recent observations of broadband slow earthquake signal (Masuda et al. 2020). In particular, frequencies of ~ 0.16 and ~ 0.21 Hz provided significant precursor-related information.
Deep learning successfully detected features of the seismic data correlated to earthquake occurrence. Developing a better understanding of the origin of the precursor-related features and their reliability is the next step towards establishing an earthquake forecasting system
Funding challenges of voluntary welfare organizations in Singapore's disability sector
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2017
- Field of study
Predictors of recurrence of major depressive disorder
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2020
- Field of study
A total of 201 patients with major depressive disorder from four hospitals in Malaysia were followed up for 5 years to determine the prognostic factors of recurrent major depressive disorder that could potentially contribute to improving the management of MDD patients. For each individual patient, at the time of recruitment as part of a case-control study, information was collected on recent threatening life events, personality and social and occupational functioning, while blood samples were collected to genotype single nucleotide polymorphisms of vitamin D receptor (VDR), zinc transporter-3 (ZnT3), dopamine transporter-1 (DAT1), brain-derived neurotropic factor (BDNF), serotonin receptor 1A (HT1A) and 2A (HT2A) genes. Kaplan-Meier and Cox-regression were used to estimate hazard functions for recurrence of major depressive disorder. Individuals with severe MDD in previous major depressive episodes had five and a half times higher hazard of developing recurrence compared to mild and moderate MDD (HR = 5.565, 95% CI = 1.631–18.994, p = 0.006). Individuals who scored higher on social avoidance had three and a half times higher hazard of recurrence of MDD (HR = 3.525, 95% CI = 1.349–9.209; p = 0.010). There was significant interaction between ApaI +64978C>A single nucleotide polymorphism and severity. The hazard ratio increased by 6.4 times from mild and moderate to severe MDD for A/A genotype while that for C/A genotype increased by 11.3 times. Social avoidance and severity of depression at first episode were prognostic of recurrence. Screening for personality factors at first encounter with MDD patients needs to be considered as part of the clinical practice. For those at risk of recurrence in relation to social avoidance, the psychological intervention prescribed should be customized to focus on this modifiable factor. Prompt and appropriate management of severe MDD is recommended to reduce risk of recurrence
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Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/08/2021
- Field of study
Data availability:
The data supporting the conclusions of this paper are provided in the article and the Supplementary Information. Any remaining raw data will be available from the corresponding author upon reasonable request. Source Data are provided with this paper.Supplementary information is available online at https://www.nature.com/articles/s41467-021-24849-4#Sec23 .Source data are available online at https://www.nature.com/articles/s41467-021-24849-4#Sec24 .Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy. Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure and die within 3–4 weeks after inducing the mutation. When the same Lmna mutations are induced in mice genetically deficient in the LINC complex protein SUN1, life is extended to more than one year. Disruption of SUN1’s function is also accomplished by transducing and expressing a dominant-negative SUN1 miniprotein in Lmna deficient cardiomyocytes, using the cardiotrophic Adeno Associated Viral Vector 9. The SUN1 miniprotein disrupts binding between the endogenous LINC complex SUN and KASH domains, displacing the cardiomyocyte KASH complexes from the nuclear periphery, resulting in at least a fivefold extension in lifespan. Cardiomyocyte-specific expression of the SUN1 miniprotein prevents cardiomyopathy progression, potentially avoiding the necessity of developing a specific therapeutic tailored to treating each different LMNA cardiomyopathy-inducing mutation of which there are more than 450.This research was funded in part by the Singapore Biomedical Research Council Translational Clinical Research grant NMRC/TCR/006-NUHS/2013 to C.L.S. and R.S.Y.F., and the Singapore Agency for Science, Technology, and Research (A*STAR) to C.L.S
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
A saturated map of common genetic variants associated with human height
- Author
- Abecasis GR
- Adair LS
- Adams HHH
- Aguilar-Salinas CA
- Ahluwalia TS
- Akiyama M
- Al-Mulla F
- Allison MA
- Alvarez M
- Andersen MK
- Ani A
- Appadurai V
- Arbeeva L
- Arias JD
- Arnett DK
- Asselbergs FW
- Assimes TL
- Asvold BO
- Attia J
- Auton A
- Banas B
- Bandinelli S
- Bartell E
- Bennett DA
- Bergler T
- Berndt SI
- Bharadwaj D
- Bhaskar S
- Bielak LF
- Biino G
- Bisgaard H
- Boehnke M
- Boerwinkle E
- Boger CA
- Bollepalli S
- Bonnelykke K
- Bonnycastle LL
- Boomsma DI
- Borglum AD
- Borja JB
- Bork-Jensen J
- Bouchard C
- Bowden DW
- Bradfield JP
- Bradford Y
- Brandslund I
- Braund PS
- Brody JA
- Brumpton B
- Burgdorf KS
- Buring JE
- Cade BE
- Cai H
- Cai QY
- Campbell A
- Canadas-Garre M
- Catamo E
- Caulfield MJ
- Chai JF
- Chai XR
- Chambers JC
- Chandak GR
- Chang LC
- Chang YC
- Chanock SJ
- Chasman DI
- Chaturvedi N
- Chen CH
- Chen SH
- Chen YDI
- Chen ZM
- Cheng CY
- Chesi A
- Cho YS
- Choi SH
- Christofidou P
- Christophersen IE
- Chung RH
- Ciullo M
- Cocca M
- Cole JW
- Collins FS
- Concas MP
- Cooper RS
- Couture C
- Cruz M
- Cucca F
- Cuellar-Partida G
- Cupples LA
- Cutler MJ
- Damrauer SM
- Danning R
- Dantoft TM
- Daw EW
- de Borst GJ
- de Groot LCPGM
- De Jager PL
- de Kleijn DPV
- de Silva HJ
- Dedoussis GV
- Degenhard F
- Delgado GE
- Delitala A
- Deloukas P
- Demirkan A
- den Hollander AI
- Deng X
- Devineni P
- Dietl A
- Dimitriou M
- Dimitrov L
- Dorajoo R
- Du SF
- Easton DF
- Ekici AB
- Elders PJM
- Eliasen AU
- Eliassen AH
- Ellinor PT
- Elmstahl S
- Engmann JE
- Erdmann J
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Farmaki AE
- Fatkin D
- Faul JD
- Feenstra B
- Feitosa MF
- Fernandez-Lopez JC
- Ferreira T
- Ferrucci L
- Ford I
- Forer L
- Fornage M
- Francescatto M
- Franke A
- Franks PW
- Frayling TM
- Freedman BI
- Freitag-Wolf S
- Fuchsberger C
- Galesloot TE
- Gao Y
- Gao ZS
- Gasparini P
- Geller F
- Giannakopoulou O
- Gieger C
- Girotto G
- Giulianini F
- Gjesing AP
- Goddard ME
- Goel A
- Golightly YM
- Gonzalez-Villalpando C
- Gordon SD
- Gordon-Larsen P
- Gorski M
- Graff M
- Graham SE
- Grallert H
- Grant SFA
- Grarup N
- Griffiths L
- Grove J
- Gudnason V
- Guo XQ
- Gustafsson S
- Haessler J
- Haiman C
- Hakonarson H
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- Hansen TF
- Hart LMT
- Hartman CA
- Hattersley AT
- Havulinna AS
- Haworth SJ
- Hayward C
- He J
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- Hebbar P
- Heckbert SR
- Heid IM
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- Hengstenberg C
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- Hishigaki H
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- Hottenga JJ
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- Hung YJ
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- Hypponen E
- Iacono WG
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- Iha H
- Ikeda DD
- Ikram MA
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- Jarvelin MR
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- Jiang YX
- Jin ZB
- Jockel KH
- Johansson I
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- Justice AE
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- Kessler T
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- Kiemeney LALM
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- Kim EK
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- Kim YJ
- Kirchhof P
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- Kleber ME
- Knol MJ
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- Koistinen HA
- Kolovou GD
- Kooner JS
- Kooperberg C
- Kottgen A
- Kovacs P
- Kraaijeveld A
- Kraft P
- Krauss RM
- Kumari M
- Kurbasic A
- Kutalik Z
- Laakso M
- Lange LA
- Langenberg C
- Launer LJ
- Lauzon M
- Le Marchand L
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- Lea R
- Lee H
- Lee JY
- Lee NR
- Lehtimaki T
- Leonard HL
- Lettre G
- Li HX
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- Lin HH
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- Lindgren CM
- Linneberg A
- Liu CT
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- Liu XP
- Lo KS
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- Loeffler M
- Loh PR
- London B
- Long JR
- Loos RJF
- Lores-Motta L
- Luan JA
- Lubitz SA
- Lull K
- Lye SJ
- Lyssenko V
- Lyytikainen LP
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- Magi R
- Magnusson PKE
- Mahajan A
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- Mamakou V
- Mangino M
- Manichaikul A
- Marcus GM
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- Melendez TL
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- Metspalu A
- Miao JK
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- Millwood IY
- Mishra PP
- Mitchell BD
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- Mitchell RE
- Mohlke KL
- Mollehave LT
- Mook-Kanamori DO
- Moore A
- Morgan A
- Morris AD
- Mucci LA
- Mucha S
- Mukamel RE
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- Munz M
- Nakatochi M
- Nalls MA
- Nazarian S
- Nelson AE
- Nelson CP
- Nethander M
- Neville MJ
- Newton-Cheh C
- Ng MCY
- Nho CW
- Nielsen AA
- Nielsen CS
- Nolte IM
- Nongmaithem SS
- Noordam R
- North KE
- Nothen MM
- Ntalla I
- Nutile T
- O'Donnell CJ
- Ohlsson C
- Okada Y
- Oldehinkel AJ
- Orozco L
- Pahkala K
- Pajukanta P
- Palmer CNA
- Pandit A
- Parna K
- Parra EJ
- Pattaro C
- Pauper M
- Pedersen O
- Pennell CE
- Penninx BWJH
- Perusse L
- Peters A
- Petersen ERB
- Petersen LV
- Peyser PA
- Pitkanen N
- Polasek O
- Porteous DJ
- Posthuma D
- Poveda A
- Power C
- Pramstaller PP
- Preuss MH
- Province MA
- Pyarajan S
- Qi QB
- Qu J
- Rader DJ
- Raffield LM
- Raghavan S
- Raitakari OT
- Rakugi H
- Ralhan S
- Rallidis LS
- Ramirez J
- Rao DC
- Rasheed A
- Raven D
- Rayner NW
- Redline S
- Reilly DF
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- Riveros C
- Roden DM
- Rohde R
- Rosendaal FR
- Rotter JI
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- Sanghera DK
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- Schulze MB
- Schunkert H
- Scott LJ
- Scott RJ
- Sendamarai A
- Sever P
- Shen BT
- Shi JCZ
- Shin JH
- Shiroma EJ
- Shoemaker MB
- Shu XO
- Sidore C
- Sidorenko J
- Sim X
- Simonsick EM
- Sims M
- Singh JR
- Singleton AB
- Sinner MF
- Sitlani CM
- Slieker RKC
- Smit RAJ
- Smith AV
- Smith JA
- Smith JG
- Smyth LJ
- Snieder H
- Southam LE
- Spector TD
- Spracklen CN
- Stampfer MJ
- Stark KJ
- Stefansson K
- Steinthorsdottir V
- Strachan DP
- Sun L
- Sun YV
- Tabara Y
- Tai ES
- Takeuchi F
- Tallapragada D
- Tang H
- Tardif JC
- Taylor KD
- Tayo BO
- Tcheandjieu C
- Terzikhan N
- Tesolin P
- Teumer A
- Thanaraj TA
- Theusch E
- Thompson DJ
- Thorleifsson G
- Thorsteinsdottir U
- Timmers PRHJ
- Timpson NJ
- Tonjes A
- Tremblay A
- Trompet S
- Tuomi T
- Tuomilehto J
- Turman C
- Tusie-Luna MT
- Uitterlinden AG
- Vaccargiu S
- van Dam RM
- van der Harst P
- van der Laan SW
- van der Most PJ
- Van der Velde N
- van Duijn CM
- van Klinken JB
- van Schoor NM
- van Setten J
- Vedantam S
- Verma SS
- Verweij N
- Veturi Y
- Vidal PM
- Visscher PM
- Vitart V
- Volker U
- Vollenweider P
- Volzke H
- Vrieze S
- Wacher-Rodarte NH
- Walker M
- Walters RG
- Wang CA
- Wang CL
- Wang LH
- Wang YX
- Wang Z
- Wareham NJ
- Warren HR
- Watanabe RM
- Watkins H
- Wei WB
- Weir DR
- Werge TM
- Wickremasinghe AR
- Widen E
- Wielscher M
- Wiggins KL
- Wilkens LR
- Willemsen G
- Willer CJ
- Willett WC
- Wilson JF
- Winkler TW
- Winsvold BS
- Wong A
- Wong TY
- Woo JT
- Wood AR
- Wright AF
- Wu JY
- Wu Y
- Wuttke M
- Xia R
- Xie T
- Xu HC
- Yajnik CS
- Yamamoto K
- Yang J
- Yang JY
- Yao J
- Yengo L
- Yin XY
- Yokota M
- Young H
- Young KL
- Yousri NA
- Yu L
- Yuan JM
- Zeggini E
- Zemel BS
- Zeng LY
- Zhang WH
- Zhang XY
- Zhao JH
- Zhao W
- Zheng W
- Zhou W
- Zhu XF
- Zimmermann ME
- Zmuda JM
- Zoledziewska M
- Zonderman AB
- Zwart JA
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/11/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants
A saturated map of common genetic variants associated with human height.
- Author
- 't Hart LM
- 23andMe Research Team
- Abecasis GR
- Adair LS
- Adams HHH
- Aguilar-Salinas CA
- Ahluwalia TS
- Akiyama M
- Al-Mulla F
- Allison MA
- Alvarez M
- Andersen MK
- Ani A
- Appadurai V
- Arbeeva L
- Arias JD
- Arnett DK
- Asselbergs FW
- Assimes TL
- Attia J
- Auton A
- Banas B
- Bandinelli S
- Bartell E
- Bennett DA
- Bergler T
- Berndt SI
- Bharadwaj D
- Bhaskar S
- Bielak LF
- Biino G
- Bin Wei W
- Bisgaard H
- Boehnke M
- Boerwinkle E
- Bollepalli S
- Bonnycastle LL
- Boomsma DI
- Borja JB
- Bork-Jensen J
- Bouchard C
- Bowden DW
- Bradfield JP
- Bradford Y
- Brandslund I
- Braund PS
- Brody JA
- Brumpton B
- Burgdorf KS
- Buring JE
- Böger CA
- Bønnelykke K
- Børglum AD
- Cade BE
- Cai H
- Cai Q
- Campbell A
- Catamo E
- Caulfield MJ
- Cañadas-Garre M
- Chai J-F
- Chai X
- Chambers JC
- Chandak GR
- Chang L-C
- Chang Y-C
- Chanock SJ
- Chasman DI
- Chaturvedi N
- Chen C-H
- Chen S-H
- Chen Y-DI
- Chen Z
- Cheng C-Y
- Chesi A
- Cho YS
- Choi SH
- Christofidou P
- Christophersen IE
- Chung R-H
- Ciullo M
- Cocca M
- Cole JW
- Collins FS
- Concas MP
- Cooper RS
- Couture C
- Cruz M
- Cucca F
- Cuellar-Partida G
- Cupples LA
- Cutler MJ
- Damrauer SM
- Danning R
- Dantoft TM
- Daw EW
- de Borst GJ
- de Groot LCPGM
- De Jager PL
- de Kleijn DPV
- Dedoussis GV
- Degenhard F
- Delgado GE
- Delitala A
- Deloukas P
- Demirkan A
- den Hollander AI
- Deng X
- Devineni P
- Dietl A
- Dimitriou M
- Dimitrov L
- DiscovEHR (DiscovEHR and MyCode Community Health Initiative)
- Dorajoo R
- Du S
- Easton DF
- Ekici AB
- Elders PJM
- Eliasen AU
- Eliassen AH
- Ellinor PT
- Elmståhl S
- eMERGE (Electronic Medical Records and Genomics Network)
- Engmann JE
- Erdmann J
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Farmaki A-E
- Fatkin D
- Faul JD
- Feenstra B
- Feitosa MF
- Fernandez-Lopez J-C
- Ferreira T
- Ferrucci L
- Ford I
- Forer L
- Fornage M
- Francescatto M
- Franke A
- Franks PW
- Frayling TM
- Freedman BI
- Freitag-Wolf S
- Fuchsberger C
- Galesloot TE
- Gao Y
- Gao Z
- Gasparini P
- Geller F
- Giannakopoulou O
- Gieger C
- Girotto G
- Giulianini F
- Gjesing AP
- Goddard ME
- Goel A
- Golightly YM
- Gonzalez-Villalpando C
- Gordon SD
- Gordon-Larsen P
- Gorski M
- Graff M
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- Gudnason V
- Guo X
- Gustafsson S
- Haessler J
- Haiman C
- Hakonarson H
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- Hansen TF
- Hartman CA
- Hattersley AT
- Havulinna AS
- Haworth SJ
- Hayward C
- He J
- Heard-Costa N
- Hebbar P
- Heckbert SR
- Heid IM
- Heng C-K
- Hengstenberg C
- Hewitt AW
- Highland HH
- Hindy G
- Hirschhorn JN
- Hishigaki H
- Ho Y-LA
- Hofer E
- Holliday E
- Horn K
- Hornsby WE
- Hottenga J-J
- Hoyng CB
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- Huang PL
- Huang W
- Huerta-Chagoya A
- Huffman JE
- Hung Y-J
- Hunt SC
- Huo S
- Hveem K
- Hwang MY
- Hyppönen E
- Iacono WG
- Ichihara S
- Iha H
- Ikeda DD
- Ikram MA
- Isasi CR
- Isono M
- Jackson AU
- Jackson RD
- Janaka de Silva H
- Jansen IE
- Jarvelin M-R
- Ji Y
- Jiang Y
- Jin Z-B
- Johansson I
- Jonas JB
- Jonsson A
- Joshi PK
- Jousilahti P
- Jukema JW
- Justice AE
- Jäger S
- Jöckel K-H
- Jørgensen T
- Kalafati I-P
- Kamatani Y
- Kanai M
- Kang KD
- Kanoni S
- Kaprio J
- Karaderi T
- Kardia SLR
- Karpe F
- Kasturiratne A
- Kato N
- Katsuya T
- Kawaguchi T
- Kee F
- Kember RL
- Kentistou KA
- Kessler T
- Khera AV
- Khor CC
- Kiemeney LALM
- Kim B-J
- Kim EK
- Kim H-L
- Kim H-N
- Kim YJ
- Kirchhof P
- Kivimaki M
- Kleber ME
- Knol MJ
- Koh W-P
- Koistinen HA
- Kolovou GD
- Kooner JS
- Kooperberg C
- Kovacs P
- Kraaijeveld A
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- Krauss RM
- Kumari M
- Kurbasic A
- Kutalik Z
- Kähönen M
- Kårhus LL
- Köttgen A
- Laakso M
- Lange LA
- Langenberg C
- Launer LJ
- Lauzon M
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- Lea R
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- Lee NR
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- Leonard HL
- Lettre G
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- Li SA
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- Li X
- Liang J
- Lieb W
- Lifelines Cohort Study
- Lin H
- Lin K
- Lin S-Y
- Lin X
- Lind L
- Lindgren CM
- Linneberg A
- Liu C-T
- Liu J
- Liu J
- Liu X
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- Loos RJF
- Lores-Motta L
- Luan J
- Lubitz SA
- Lye SJ
- Lyssenko V
- Lyytikäinen L-P
- Lüll K
- Machado M
- Mackey DA
- Magnusson PKE
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- Malden DE
- Mamakou V
- Mangino M
- Manichaikul A
- Marcus GM
- Marouli E
- Marten J
- Martin NG
- Matsuda F
- Mattheisen M
- Mavarani L
- McCarthy MI
- McDaid AF
- McGarrah RW
- McGue M
- McKnight AJ
- Medina-Gomez C
- Medland SE
- Meidtner K
- Melendez TL
- Mellström D
- Mercader JM
- Metspalu A
- Miao J
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- Noordam R
- North KE
- Ntalla I
- Nutile T
- Nöthen MM
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- Ohlsson C
- Okada Y
- Oldehinkel AJ
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- Pahkala K
- Pajukanta P
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- Pandit A
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- Pattaro C
- Pauper M
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- Peters A
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- Petersen LV
- Peyser PA
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- Polašek O
- Porteous DJ
- Posthuma D
- Poveda A
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- PRACTICAL Consortium
- Pramstaller PP
- Preuss MH
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- Pärna K
- Qi Q
- Qu J
- Rader DJ
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- Raghavan S
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- Ruggiero D
- Ruotsalainen SE
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- Ryan KA
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- Sabater-Lleal M
- Sakaue S
- Saleheen D
- Salomaa V
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- Steinthorsdottir V
- Strachan DP
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- Thorleifsson G
- Thorsteinsdottir U
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- Tremblay A
- Trompet S
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- Tuomilehto J
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- Tönjes A
- Uitterlinden AG
- Understanding Society Scientific Group
- VA Million Veteran Program
- Vaccargiu S
- van Dam RM
- van der Harst P
- van der Laan SW
- van der Most PJ
- Van der Velde N
- van Duijn CM
- van Klinken JB
- van Schoor NM
- van Setten J
- Vedantam S
- Verma SS
- Verweij N
- Veturi Y
- Vidal PM
- Visscher PM
- Vitart V
- Vollenweider P
- Vrieze S
- Völker U
- Völzke H
- Wacher-Rodarte NH
- Walker M
- Walters RG
- Wang C
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- Wang L
- Wang YX
- Wang Z
- Wareham NJ
- Warren HR
- Watanabe RM
- Watkins H
- Weir DR
- Werge TM
- Wickremasinghe AR
- Widen E
- Wielscher M
- Wiggins KL
- Wilkens LR
- Willemsen G
- Willer CJ
- Willett WC
- Wilson JF
- Winkler TW
- Winsvold BS
- Wong A
- Wong T-Y
- Woo J-T
- Wood AR
- Wright AF
- Wu J-Y
- Wu Y
- Wuttke M
- Xia R
- Xie T
- Xu H
- Yajnik CS
- Yamamoto K
- Yang J
- Yang J
- Yao J
- Yengo L
- Yin X
- Yokota M
- Young H
- Young KL
- Yousri NA
- Yu L
- Yuan J-M
- Zeggini E
- Zemel BS
- Zeng L
- Zhang W
- Zhang X
- Zhao J-H
- Zhao W
- Zheng W
- Zhou W
- Zhu X
- Zimmermann ME
- Zmuda JM
- Zoledziewska M
- Zonderman AB
- Zwart J-A
- Åsvold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
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- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
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- Balbay Abidin Oner
- Balon Sandrine
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- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
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- Becker Delmiro
- Behan Helena
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- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
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- Bowes Bonnie
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- Bratsberg Bjorn
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- Brizio Elisabetta
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- Broadhurst Phil
- Brown Wendy
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- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
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- Byers Heather
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- Clement Ana Isabel
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- Corso Amalia
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- Dawn Frances
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- de Almeida Angelica Olivetto
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- De Bels David
- de Ceballos José Peral Gutierrez
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- de Jesús Ortiz Alberto
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- De lange Dylan
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- De Pablo Ana María
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- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
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- Di Yanhong
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- Dieperink Willem
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- Ding Min
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- Dong Jingwen
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- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
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- Dugernier Thierry
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- Dullenkopf Alexander
- Dungca Adonis
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- Déserts Marc Danguy des
- D’Ambrosio Francesco
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- Egi Moritoki
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- Ei Poe Poe
- Elatrous Souheil
- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
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- Eng Timothy
- Erdivanli Başar
- Erdogan Elif
- Eroglu Ahmet
- Ershova Olga
- Escalante Rosana Gabriela
- Espinosa Cristina Paños
- Esposito Romina
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- Etourneau Fabienne
- Evers Mirjam
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- Fernandez Maria Cristina Iglesias
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- Fernández Ana Wensell
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- Ferretti Christian
- Ffarcsi Madiha Hashmi
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- Fielding Mark
- Figaro-Barclay Dianne
- Figueiredo Margarida Ferreira
- Fijen Jan-Willem
- Filipescu Daniela Carmen
- Filipović-Grčić Ina
- Finn Damien O’Connell Rosemary
- Finnstrom Inger Johanne
- Fioretti Audrey
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- Fivecoat Pauline
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- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
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- Avogadro Prune
- Avramopoulou Lamprini
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- Aydemir Semih
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- Azencot Mazal
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- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
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- Balbay Abidin Oner
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- Banwarie Preveen
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- Barakat-Johnson Michelle
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- Barros Elaine
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- Barrueco-Francioni Jesus Emilio
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- Baruah Rosaleen
- Bascary Carlos Alejandro
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- Ei Poe Poe
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- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
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- Erdogan Elif
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- Kartalov Andrijan
- Kataoka Jun
- Katerina Kounougeri
- Katsenos Chrysostomos
- Kauppi Outi
- Kaushik Shuchi
- Kazakos Nikolaos
- Kağnıcı Ali
- Kehoe Jennifer
- Kerslake Ian
- Kesti Ulla
- Khaled Ala
- Khaled Taha
- Khanna Ashish
- Khanna Ashish K.
- Khoo Tien Meng
- Khoronenko Victoria
- Khwannimit Bodin
- Kilapong Bram
- Kim Je Hyeong
- Kim Junghyun
- Kim Kyung Chan
- Kim Seok Chan
- Kindgen-Milles Detlef
- Kiselev Alexander
- Kjærgård Inger Ebbesen
- Kleanthous Pavlina
- Knafelj Rihard
- Kodal Anne Marie
- Kolbe Nina
- Kolussi Uta
- Kondili Eumorfia
- Koopmans Matty
- Kotanidi Veronika
- Kotze Michelle
- Koulouras Vasilios
- Kourelea Styliani
- Koutsodimitropoulos Ioannis
- Kovaleva Julia
- Krastins Ivasr
- Kristoffersen Elin
- Kubisz-Pudelko Agnieszka
- Kuijpers Paul
- Kulakov Vladimir
- Kuscu Ozlem Ozkan
- Kushare Vilas
- Kusi-Appiah Anita-Chrysolyte
- Kuzmanovska Biljana
- Kyriakoudi Anna
- Kütimets Martin
- Labeau Sonia O.
- Lacaden Grace
- Lafuente Estevão
- Lagerhäll Caroline
- Laizner Andréa Maria
- Lajara Miguel Angel Gimenez
- Lajeunesse Jennifer
- Lakshmanan Ramanathan
- Lalor Jennifer
- Landaverde Antonio
- Lang Martin
- Langvad Anne
- Lančaričová Danca
- Larina Eugeniya
- Larsson Ing-Marie
- Lausch Martina
- Lavrentieva Athena
- Lavy Alinoy
- Le Guen Yann
- Lebon Richard
- Ledochowski Stanislas
- Lee Heung Bum
- Lee Jarone
- Lee Jongmin
- Lee Sang-Miin
- Lee Sang-Min
- Lee Seok Jeong
- Lee Won-Yeon
- Legorburo Maria Schofield
- Lei DeHong
- Lei Lei
- Lei Yang
- Leong Thomas
- Leonova Anna
- Lepida Dimitra
- Leslie Gavin D.
- Lestari Mayang Indah
- Levy Dassy
- Lewis Abby
- Li Biyan
- Li Chunxia
- Li Ji
- Li Jing
- Li Jinhua
- Li Li Chuntang
- Li Ling
- Li Miao
- Li Ning
- Li Qi
- Li Qing
- Li Tingting
- Li Weiwei
- Li Xiaohan
- Li Xingguo
- Li Xinjian
- Li Xinxia
- Li Xue Qin
- Li Yan
- Li Ying
- Li ZhangShuangzi
- Li Zhuqing
- Liang Jinxian
- Liang Qiong
- Liang Xuejuan
- Liarmakopoulou Antonia
- Lijuan Sun
- Lima Ângela
- Lin Dongliang
- Lin Frances
- Lin Qiang
- Lin Xue
- Lind Ranveig
- Lipovestky Fernando
- Lipovesty Fernando
- Liu Congcong
- Liu Guangyan
- Liu Hongmei
- Liu Jin
- Liu Jingyu
- Liu Kewei
- Liu Lihong
- Liu Ling
- Liu Lu
- Liu Man
- Liu Miao
- Liu Sophie
- Liu Xiaodi
- Liu XiaoZhe
- Liu XiuMei
- Liu XueLian
- Liu Yan
- Liu Yang
- Liu Ying
- Liu Yu
- Liu Yupeng
- Llaurado-Serra M.
- Llaurado-Serra Mireia
- Llewellym Thomas
- Llinas Ana Alabart
- Loef Bert
- Lois Manuel
- Long Yan
- Long Yanfei
- Lord Jenny
- Lorenzo Javier
- Losilla Monica Recio
- Lospitao Sara
- Loudet Cecilia
- Loudet Cecilia Inés
- Luan Linlin
- Luchian Mihail
- Luis Eulália
- Lukic Milica
- Lund Mette
- Lunde Gro Anne
- Luo Feifei
- Luo Xianping
- Luo Xiaofang
- Luque Carmen Partera
- Lusenius Virpi
- Lv Mengmeng
- Lv Shanshan
- Lye India
- Lynch Ceri
- Löf Gun
- Löfqvist Carita
- Ma Chaoqun
- Ma Fuying
- Maddison Liivi
- Maggiore Salvatore Maurizio
- Magomedov Marat
- Maguire Teena
- Mahanes Dea
- Mahmood Saeed
- Mahmoodpoor Ata
- Maidana Elizabeth
- Maiyalagan Sundaresan
- Malmin Siv Karin
- Maltby Louise
- Malvemyr Ann-Sofie
- Manandhar Meena
- Manap Nurulhuda Binti A.
- Mancini Federica
- Mandaroux Simon
- Mandis Konstantinos
- Mandourah Yasser
- Mangal Kishore
- Manosa Silvia Call
- Manzo Antonio
- Marconi Romina
- Marin Jorge
- Markham Amber
- Marko Peter
- Markota Andrej
- Markoulias Chrysanthos
- Marriott Victoria
- Marsh Brian
- Martin Gilles
- Martin Kerrie
- Martin Marina Alessandra
- Martin-Loeches Ignacio
- Martinez Pilar
- Martinez Regina
- Martinez-Gonzalez Mayra
- Martinez-Hurtado Eugenio
- Martinos Charalampos
- Martins Claudia
- Martonova Andrea
- Maruyama Kumi
- Maseda Emilio
- Massard Audrey
- Mastantuono Marcela
- Masters Kristy
- Matas Marijana
- Mathaios Mina
- Matiushkov Nikita
- Matrona Oliva
- Matthews Kelly
- Mattsson Gunilla
- Maulicino Laura
- Maus Marianne
- Mazlan Mohd Zulfakar
- Mazocoli Eliane
- McCann Nicola
- McDonnell Andrea
- McDowell-Skaines Sharon
- McLucas Andrea
- McMullen Jane
- McPherson Sandra
- McQuirter Megan
- Mebazaa Mhamed Sami
- Megna Chiara
- Mehay Daisy
- Meland Barbro
- Mendes Luis
- Mendez Gabriela
- Mendiara Yolanda
- Meng Gen
- Mentec Hervé
- Mer Mervyn
- Mergeay Matthia
- Merhabene Takoua
- Merheb Marie
- Merilainen Merja
- Merritt-Charles Lorna
- Meybohm Patrick
- Miao Limei
- Michailidou Evangelia
- Mickelsson Ulrica
- Microys Sherissa
- Migliorino Pina
- Mihaljevic Slobodan
- Mikaszewska-Sokolewicz Malgorzata
- Mikkelsen Sanne
- Milic Morena
- Milioto Esteban
- Miller Mia Thorning
- Milner Wendy
- Minope John Thomas Sanchez
- Mirabella Lucia
- Mirkovic Tomislav
- Misic Vanja
- Mitchell Marion
- Mo Antonella
- Moghal Arif
- Mogrovejo Pedro
- Moise Alida
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- Monges Natalia
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- Monstad Kristina Reinertsen
- Montaldi Gloria
- Montravers Philippe
- Morakul Sunthiti
- Moreira Maria Liz
- Morren Faye
- Morrison Lynette
- Mostafa Nafseen
- Motherway Catherine
- Mousafiri Ourania
- Mouton Lucie
- Mpouzika Meropi
- Mu Chenghau
- Mueller Dorothee
- Muhizi Jerome
- Mulvey Regina
- Muriel Daniel Sancho
- Muzha Dritan
- Mylordou Maria
- Nafees Khalid Mahmood Khan
- Nahar Dick
- Naija Walid
- Nakayama Izumi
- Nananmori Masakatsu
- Nandyelly San Juan Roman
- Napolitano Lena
- Naranpurev Mendsaikhan
- Nardai Gabor
- Naumovski Filip
- Nava Claudia Lizbeth Lopez
- Nava Luis Pedro Ambriz
- Navarro Berenice
- Navarro José Alejandro
- Negro Alessandra
- Nestora Konstantina
- Newby Lynette
- Ngo Delphine
- Ni Dongshu
- Nieto Montserrat Venturas
- Nikolaou Charikleia
- Nishime Yoshimasa
- Noblezada-Uy Debbie
- Nocheretti Mariangeles Gabriela
- Noguchi Ayako
- Nogueira Paula Cristina
- Nor Basri Mat
- Nor Mohd Basri Mat
- North Samantha
- Nshimyumuremyi Isaac
- Nunes Catarina
- Nuñez Cesar Rodriguez
- Nyhus Marit
- Nzarora Josue
- Ochoa Maria-Elena
- Odenthal Tobias
- Ogbeide Vongayi
- Ohuchi Akira
- Oikonomou Mrina
- Oiting Oscar
- Olanipekun Simeon
- Olivares Pablo Garcia
- Oliveira Evellyn
- Olsen Brita Fosser
- Onelli Adriana
- Onrust Marisa
- Onyeka Tonia
- Orozco Estefania
- Orvelius Lotti
- Ory Solenne
- Osei Irene Pearl
- Ostenjo Hege
- Ouyang Fei
- Owens Daniel
- Owojuyigbe Afolabi
- Ozgultekin Asu
- O’Brien Catherine
- O’Donnell Caroline
- O’Nuallain Siobhan
- O’Shea Aidan
- O’Shea Fiona
- Pacturanan Michelle
- Paddle Jonathan
- Padilla Nayeli Rocio Cañas
- Pagella Gonzalo
- Pagioulas Konstantinos
- Paillet Caroline
- Palaez Carolina
- Palfreeman Christopher
- Palfrey Ruth
- Palmu Auli
- Palo Jose Emmanuel
- Pan Fuqun
- Pang Xuelian
- Panka Bernardo
- Pantaleao Taís
- Pantelas Nikolaos
- Pantiora Eirini
- Papadopoulos Dimitrios
- Papageorgiou Eirini
- Papanikolaou Metaxia
- Papathanakos Georgios
- Papavasilopoulou Theonymfi
- Parag Nivisha
- Parente Isabel
- Park Jisoo
- Park Seung Yong
- Park So Young
- Park Sunghoon
- Park Tai Sun
- Parke Rachael
- Parkin Emma
- Parsons Leanne
- Parsons Penny
- Pascual-Bielsa Ana
- Pastore Beatrice
- Pastores Stephen M.
- Pathak Sabina Dhakal
- Patrichi Tatiana
- Patsalos Artemis
- Patsiou Eirini-Chysovalanto
- Pavlisa Gordana
- Pedersen Anne Sofie Bomholt
- Pedersen Karin Rehnholt
- Pederzani Marcelo
- Pedro Laura
- Peipei Xu
- Peker Nebia
- Peltomaa Minna
- Pelz Sabrina
- Pena José Manuel Garcia
- Peratoner Alberto
- Pereira Jorge
- Perez Hugo
- Perez-Torres David
- Perez-Vacas Jonathan
- Perme Janja
- Peterson Jessica
- Petosic Antonija
- Petrisor Cristina
- Petrushin Maxim
- Pečenković Suzana
- Philippart François
- Piergentili Federica
- Pili-Floury Sébastien
- Pillard Cindy
- Pineda Ana Alícia Velarde
- Pinheiro Cristiana Mota
- Pinto Susana
- Pinto Vitor Manuel Vaz
- Piradov Michael
- Pires Filpe
- Pivkina Alexandra
- Piza Petr
- Piñan Isabel Santín
- Plantefève Gaëtan
- Pleitinckx Vincianne
- Polgarova Petra
- Polo Ana Belén Curto
- Popescu Mihai
- Popescu Monica
- Potestio Christopher
- Powell Madeleine
- Preda Gabriel
- Prol-Silva Estefanía
- Prowle John
- Psarulis Konstantinos
- Pulak Paul
- Pulletz Mark
- Putruele Sofia
- Qawasmeh Khaled Al
- Qiao Hongmei
- Quagliotto Catia
- Quaini Attilio
- Quintard Hervé
- Quiroga Cristian
- Rabarova Daria
- Radavidson Anthony
- Radivojevic Renata Curic
- Rahim Azmin Huda Abdul
- Raimondo Arena
- Raitsiou Bogdan
- Raizman Rose
- Raj Ashok Sundai
- Rajendran Ajitha
- Rajković Marija
- Ramaker Bart
- Ramalho Aline
- Ramirez Mario
- Ramiro Charalice
- Ran Qiong
- Ranalli Flavia
- Randell Claire
- Rapley Jackie
- Rastegar Touraj
- Ratnam Shanthi
- Ratnam Shanti
- Ravani Ifigenia
- Reece-Anthony Rosie
- Reidinga Auke
- Reijntjens Jennifer
- Remor Natalie
- Ren Aiua
- Reyes Amylkar Garay
- Reyes Amylkar José Garay
- Reyes Laura Martinez
- Reyes Paul Eric
- Reynolds Claire
- Ribas Antoni Margarit
- Ribas Antonio Margarit
- Riera Alba
- Riessen Reimer
- Ringdal Mona
- Rinket Martin
- Ripolles-Melchor Javier
- Rita Clara Santa
- Rivas Juan Carlos
- Rivas Noelia
- Riveiro Marilyn
- Rizzo Antonino
- Rocco Monica
- Rocha Pamela
- Rodriguez Gabriel Enrique
- Rojas-Suarez José
- Rokosh Ella
- Roller Martin
- Roman-Pognuz Erik
- Romero-Gonzalez Juan P.
- Ronchini Ana Lucia Vitti
- Rooney Glenda
- Rosado Ines
- Rosalia Rodney
- Rosati Moris
- Rose Bernd Oliver
- Rose Louise
- Rostello Oscar Fernández
- Rothenfusser Monika
- Rubulotta Francesca
- Rubulotta Giorgia
- Rygvadottir Brynja
- Saager Leif
- Sabbag Ignacio
- Saha Rajnish
- Sakki Jenni-Katarina
- Sakuramoto Hideaki
- Salazar Janel
- Salberg Armorel
- Salman Fatema
- Salo Swagotika
- Salvà-Costa Vicent
- Samat Noryani Mohd
- Sanchez Losune Cano
- Sanchez Maria Angeles Hurtado
- Sanchez-Hurtado Luis Alejandro
- Sandberg Ulla
- Sandesc Dorel
- Sankar-Maharaj Sasha
- Sankey Babangida John
- Santiago Eleanor
- Santos Jacinta
- Santos Rayanne
- Sanz Luz Coronado
- Sanz Miquel
- Sarkar Nikki
- Saul Pablo
- Sawawiboon Chaiwut
- Schaller Stefan
- Schallom Marilyn
- Schefold Joerg C.
- Schmidt Raysa Cristina
- Schmollgruber Shelley
- Schmukler Armando
- Schmutz René
- Schulze Tobias
- Schüppel Sebastian
- Scire Giovanni
- Scutariu Monica Adriana
- Sellami Walid
- Sepulveda Maria Idalia
- Sergeev Dmitry
- Serin Sibel Ocak
- Seromenho Vanda
- Serpa Leticia
- Sertznig Claude
- Setten Mariano
- Shah Bhagyesh
- Shao Hongyan
- Shaw David
- Shawish Sabah Abu
- Shayamano Rosina
- Sheehan Christine
- Shen Yanling
- Sherwin James
- Shi Guanxiu
- Shi Zeya
- Shime Nobuaki
- Shimizu Masako
- Short Jack
- Shosholcheva Mirjana
- Shosolcheva Mirjana
- Sierra Rafael
- Sills Martin
- Silva Pedro
- Sim Yun Su
- Simi Marcelo
- Simon Philipp
- Singh Keevan
- Singh Mukta
- Sjobo Britt
- Skorstad Elin Mari
- Slobodianiuk Gari
- Slobodianiuk Garri
- Smajic Jasmina
- Smiley Kathleen Ann
- Smith Catherine
- Smith Chris
- Smith Julie
- Smith Neil
- Smith Orla
- Smith Samantha
- Soledad Javiera
- Somerville Justine
- Sona Carrie
- Song Bing
- Song Caiju
- Song JinHui
- Song Min
- Song Rima
- Sosa Miguel Ángel
- Sosnowski Kellie
- Sostaric Maja
- Soula Enas
- Soulisse Léa
- Soundoulounaki Stella
- Souppart Virginie
- Sourla Evdokia
- Sousa Bruno
- Spadaro Savino
- Spina Rosario
- Spyropoulou Anastasia
- Spångfors Martin
- Stafylaraki Maria
- Staikos Ioannis
- Stalika Kristina Mariana Matei
- Stanojević Maja
- Starchenko Irina
- Stefanovic Branislava
- Steffenak Elin
- Stehr Sebastian
- Stenset Ane
- Stiban Sonia
- Stivanello Lucia
- Stojanovic Milena
- Stones Elizabeth
- Straede Esben
- Stübner Andeas
- Subedi Nisha Bhandari
- Suen Gabriel
- Sulaiman Siti Rohayah
- Sun Chengxia
- Sun Wei
- Sun Yue
- Susanti Ade
- Sustic Alan
- Swinnen Walter
- Syed Muhommed Ridwaan
- Sykehus Drammen
- Szakmany Tamas
- Sánchez-Hurtado Luis
- Tababa Osama Wanees Emhemid
- Tabah Alexis
- Tabib Majd
- Taghavi Noushin
- Taibi Maria Rosa
- Taito Shunsuke
- Tak Poon Shing
- Takahashi Kenji
- Talik Imen
- Tallot Mandy
- Tamayo Luis Mario
- Tamme Kadri
- Tan Lei
- Tao Jing
- Tapia Fernando
- Tavares Ana
- Taşdemir Banu
- Teig Magnus
- Tejeda-Huezo Brigitte
- Telleria Vanesa Mercado
- Templeton Mae
- Terry Dorothy
- Tervo-Heikkinen Tarja
- Thankamma Bindu
- Theisen Christian
- Thix Cyril
- Tholioti Thomai
- Thoma Giannoula
- Thomas Beverley
- Thompson Amy
- Thompson Lorraine
- Thomsen Tina Damgaar
- Thorpe Elaine
- Tian Eryun
- Tian Xiao Fang
- Tian Yani
- Tian Zhixia
- Timsit Jean-Francois
- Tingsvik Catarina
- Tirado Celia
- Toellefsen Annette
- Tokareva Ekaterina
- Tokur Murat Emre
- Tole Eunice
- Tomescu Dana
- Tong Jenny May Geok
- Tonkovic Dinko
- Toppin Patrick
- Torlinski Tomasz
- Traina Lidia
- Tranello Francesca Paola
- Tribulev Maksim
- Tridente Ascanio
- Triki Ahmed Ramadan
- Tripathy Swagata
- Trongtrakul Konlawij
- Trongtratul Konlawij
- Trposak Angela
- Trudvang Siw
- Trueman-Dawkins Treiza
- Tsarev Alexander
- Tsikriki Syragoula
- Tsikritsaki Kyriaki
- Tsujimoto Mayumi
- Tubacka Marta
- Tuinstra Binny
- Tuo Lili
- Turan Can
- Turan Sema
- Turc Jean
- Turner Sarah Jane
- Turčan Anton
- Tutillo Diego Rolando Morocho
- Twagirumugabe Theogene
- Twiggs Hilary
- Uba Stella
- Uccelli Francesco
- Udiljak Nikolina
- Ugwu Innocent
- Umek Nejc
- Undar Hasan Nabi
- Vakalos Aristeidis
- Valerio Idália
- Valgolio Emanuel
- Valta Maija
- Valta Maija Anniina
- van Axel Alisha
- Van Cotthem Ilse
- Van de Velde Stijn
- Van Den Berg Lettie
- Van Den Brink Mark
- Van Den Elst Arlette
- van der Kuil Mark
- Van Gulik Laura
- Van Regenmortel Niels
- Van Vliet Peter
- Vanroest Margijske
- Varela Maria
- Vaschetto Rosanna
- Vasquez Alexandra
- Vaughan-Jones Nicola
- Velickovic Jelena
- Veličković Dejan
- Ventour Dale
- Vermeijden Jan Wytze
- Vieira João
- Villa Robert
- Villafuerte Missael Vladimir Espinoza
- Villanueva Ximena
- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
- Wang Fanglan
- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de Jesús Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Šuput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali Kağnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
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- Xianping Luo
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- Xiao Xu
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- Xiaodi Liu
- Xiaofang Luo
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- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
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- Xiaowu Bai
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- Xiaoyan Chen
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- Xingguo Li
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- Xinxia Li
- Xinxia Li
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- Xiuhua Fang
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- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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