El juego como herramienta pedag?gica para fortalecer el nivel literal de lectura en los estudiantes de grado tercero de primaria del Colegio Montebello

151 p. Recurso Electr?nicoEste proyecto de intervenci?n pedag?gica (PIP), tiene como eje fundamental brindar a los estudiantes del grado tercero de b?sica primaria del colegio Montebello diferentes actividades orientadas a encaminar el juego como una herramienta para fortalecer el nivel descriptivo o literal de lectura, con el fin de que los ni?os y ni?as desarrollen de sus capacidades de lenguaje. Por lo tanto es necesario generar espacios de juego como medio de respeto, aprendizaje y diversi?n con la expectativa de generar un desarrollo lingu??stico orient?ndolos hacia un alto nivel cr?tico en cuanto a la lectura, sin embargo para llegar a ello se hace necesario reforzar los niveles desde su partida literal, inferencial hasta llegar a un nivel cr?tico, en los grados superiores. Desde la investigaci?n acci?n e investigaci?n formativa se pudo mejorar el proyecto ya que este nos brinda la oportunidad de tener contacto y comunicaci?n directo con los estudiantes, colegio y comunidad educativa. Por lo anterior se realizaron varias propuestas pedag?gicas entre ellas, entrevistas, talleres, videos entre otros, dise?ados para fortalecer el nivel literal de lectura. Es por ello que se tom? como herramienta el juego, por medio del cual reforzamos las tem?ticas de lectura, ya que como se conoce el juego transforma en activo lo pasivo. Este proyecto de intervenci?n se desarroll? en tres fases: la sensibilizaci?n donde se realiz? el diagn?stico inicial de los estudiantes; se evidencio la problem?tica y se encuentro una propuesta para implementar con los estudiantes del grado cuarto b?sica primaria del colegio Montebello, dando continuidad a ello realizamos la fase de intervenci?n en la cual se aplicaron los talleres que dieron respuesta a la problem?tica encontrada, la cual se bas? en fortalecer el nivel literal de lectura; para finalizar se pasa a una tercera fase: la evaluaci?n, donde se pudo evidenciar cuales fueron los alcances y la soluci?n a la problem?tica que se dio luego de haber aplicado el proyecto.This project of pedagogic intervention had as main axis to bring the students of third grade of Montebello school many activities orientated to take the game as a tool that reinforce the descriptive level of the lecture, with the purpose that the children developed their language capacities. Therefore, it?s necessary to create game spaces as a way of respect, learn and joy with the expectation to generate a linguistic development, guiding to a high level of criticism about the lecture. However, it?s required reinforce the levels since the literal definition, to an inferential and finally reach the critical standard in the major grades. With the investigation of action as well as the formative investigation were the way to improve the project that brought the opportunity to have a contact and a direct communication with the students, the school and the educative community. They were made many pedagogic approaches like interviews, videos, workshops and more, developed to strength the literal meaning of the lecture. According to this, the game was taken as a tool by which bolster the lecture thematic, the game turn around the passive to the active. This project was develop in three phases, the first one with the sensibilization and an initial diagnostic of the children, where the problematic was shown and the research and development of an approach to implement with the students of fourth grade in Montebello School. The second phase was about the intervention of the workshops that brings answers to the initial problem, making stronger the literal level of lecture. Finally the project ended with the evaluation, which displayed the scope and solutions of the problematic. Keywords. Game, reading comprehension, lecture, literal level

Plan de negocios para la implementaci?n de un outsourcing de almacenamiento para productos farmac?uticos, cosm?ticos y afines en el Sur de Lima

Considerando que las empresas del sector farmac?utico, cosm?tico y af?n requieren por normativa contar con un almac?n que cumpla con las buenas pr?cticas de almacenamiento (BPA) , lo cual implica invertir en infraestructura, capacitaci?n del personal, tecnolog?a de informaci?n y certificaciones; que empresas como las MIPYME no est?n en la capacidad de realizar, raz?n por la cual tercerizar el almacenamiento de sus productos es una excelente opci?n que les va permitir cumplir con las BPA, mejorar sus eficiencias operativas y enfocarse en su core de negocio. Ante este escenario, el presente plan de negocios propone la implementaci?n de un almac?n que brinde servicios de outsourcing de almacenamiento para la micro, peque?a y mediana empresa (MIPYME) de este sector a precios competitivos en el mercado, con alta calidad y flexibilidad del servicio. Este almac?n se va a ubicar al sur de Lima (Lur?n) aprovechando su bajo costo de metro cuadrado del terreno, su r?pida conexi?n a v?as principales (Av. Panamericana Sur) y disponibilidad de terrenos para futuras expansiones. Este outsourcing de almacenamiento va a manejar tarifas diferenciadas por pallet o ubicaci?n seg?n el tipo de producto y va ofrecer adem?s del almacenamiento otros servicios complementarios como la recepci?n, preparaci?n de pedidos y acondicionado

Antihyperthermic treatment decreases perihematomal hypodensity

OBJECTIVE: To investigate the effect on perihematomal hypodensity and outcome of a decrease in body temperature in the first 24 hours in patients with intracerebral hemorrhage (ICH). METHODS: In this retrospective study on a prospectively registered database, among the 1,100 patients, 795 met all the inclusion criteria. Temperature variations in the first 24 hours and perihematomal hypodensity (PHHD) were recorded. Patients >/=37.5 degrees C were treated with antihyperthermic drugs for at least 48 hours. The main objective was to determine the association among temperature variation, PHHD, and outcome at 3 months. RESULTS: The decrease in temperature in the first 24 hours increased the possibility of good outcome 11-fold. Temperature decrease, lower PHHD volume, and a good outcome were observed in 31.8% of the patients who received antihyperthermic treatment. CONCLUSION: The administration of early antihyperthermic treatment in patients with spontaneous ICH with a basal axillary temperature >/=37.5 degrees C resulted in good outcome in a third of the treated patients

Liver-related events and mortality among elderly patients with advanced chronic hepatitis C treated with direct-acting antivirals

BACKGROUND: Direct-acting antivirals (DAAs) are effective in patients aged >/=65 years. However, little is known about the effects of DAAs on survival, liver decompensation and development of hepatocellular carcinoma (HCC). OBJECTIVE: To compare the incidence of liver-related events and mortality between patients aged >/=65 and /=65 and /=65 and 380 aged /=65 years treated with DAAs seems to be secondary to non-liver-related causes. These results support the utilization of DAAs in patients aged >/=65 years

Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function

The ribosomal protein L11 (RPL11) integrates different types of stress into a p53-mediated response. Here, we analyzed the impact of the ubiquitin-like protein SUMO on the RPL11-mouse double-minute 2 homolog-p53 signaling. We show that small ubiquitin-related modifier (SUMO)1 and SUMO2 covalently modify RPL11. We find that SUMO negatively modulates the conjugation of the ubiquitin-like protein neural precursor cell-expressed developmentally downregulated 8 (NEDD8) to RPL11 and promotes the translocation of the RP outside of the nucleoli. Moreover, the SUMO-conjugating enzyme, Ubc9, is required for RPL11-mediated activation of p53. SUMOylation of RPL11 is triggered by ribosomal stress, as well as by alternate reading frame protein upregulation. Collectively, our data identify SUMO protein conjugation to RPL11 as a new regulator of the p53-mediated cellular response to different types of stress and reveal a previously unknown SUMO-NEDD8 interplay.-El Motiam, A., Vidal, S., de la Cruz-Herrera, C. F., Da Silva-Alvarez, S., Baz-Martinez, M., Seoane, R., Vidal, A., Rodriguez, M. S., Xirodimas, D. P., Carvalho, A. S., Beck, H. C., Matthiesen, R., Collado, M., Rivas, C. Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function

Inclusive and multiplicity dependent production of electrons from heavy-flavour hadron decays in pp and p-Pb collisions

Measurements of the production of electrons from heavy-flavour hadron decays in pp collisions at root s = 13 TeV at midrapidity with the ALICE detector are presented down to a transverse momentum (p(T)) of 0.2 GeV/c and up to p(T) = 35 GeV/c, which is the largest momentum range probed for inclusive electron measurements in ALICE. In p-Pb collisions, the production cross section and the nuclear modification factor of electrons from heavy-flavour hadron decays are measured in the p(T) range 0.5 < p(T) < 26 GeV/c at root s(NN) = 8.16 TeV. The nuclear modification factor is found to be consistent with unity within the statistical and systematic uncertainties. In both collision systems, first measurements of the yields of electrons from heavy-flavour hadron decays in different multiplicity intervals normalised to the multiplicity-integrated yield (self-normalised yield) at midrapidity are reported as a function of the self-normalised charged-particle multiplicity estimated at midrapidity. The self-normalised yields in pp and p-Pb collisions grow faster than linear with the self-normalised multiplicity. A strong p(T) dependence is observed in pp collisions, where the yield of high-p(T) electrons increases faster as a function of multiplicity than the one of low-p(T) electrons. The measurement in p-Pb collisions shows no p(T) dependence within uncertainties. The self-normalised yields in pp and p-Pb collisions are compared with measurements of other heavy-flavour, light-flavour, and strange particles, and with Monte Carlo simulations

Hypertriton Production in p-Pb Collisions at √sNN = 5.02 TeV

The study of nuclei and antinuclei production has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high-energy hadronic collisions. The first measurement of the production of ${\rm ^{3}_{\Lambda}\rm H}$ in p-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 5.02 TeV is presented in this Letter. Its production yield measured in the rapidity interval -1 < y < 0 for the 40% highest multiplicity p-Pb collisions is ${\rm d} N /{\rm d} y =[\mathrm{6.3 \pm 1.8 (stat.) \pm 1.2 (syst.) ] \times 10^{-7}}$. The measurement is compared with the expectations of statistical hadronisation and coalescence models, which describe the nucleosynthesis in hadronic collisions. These two models predict very different yields of the hypertriton in small collision systems such as p-Pb and therefore the measurement of ${\rm d} N /{\rm d} y$ is crucial to distinguish between them. The precision of this measurement leads to the exclusion with a significance larger than 6$\sigma$ of some configurations of the statistical hadronisation, thus constraining the production mechanism of loosely bound states

Measurement of the non-prompt D-meson fraction as a function of multiplicity in proton-proton collisions at s \sqrt{s} = 13 TeV

The fractions of non-prompt (i.e. originating from beauty-hadron decays) D0 and D+ mesons with respect to the inclusive yield are measured as a function of the charged-particle multiplicity in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV with the ALICE detector at the LHC. The results are reported in intervals of transverse momentum (pT) and integrated in the range 1 < pT < 24 GeV/c. The fraction of non-prompt D0 and D+ mesons is found to increase slightly as a function of pT in all the measured multiplicity intervals, while no significant dependence on the charged- particle multiplicity is observed. In order to investigate the production and hadronisation mechanisms of charm and beauty quarks, the results are compared to PYTHIA 8 as well as EPOS 3 and EPOS 4 Monte Carlo simulations, and to calculations based on the colour glass condensate including three-pomeron fusion

K∗(892)0 and φ(1020) production in p-Pb collisions at √s NN = 8.16 TeV

The production of K*(892)(0) and phi(1020) resonances has been measured in p-Pb collisions at root s(NN) = 8.16 TeV using the ALICE detector. Resonances are reconstructed via their hadronic decay channels in the rapidity interval -0.5 8 GeV/c), the R-pPb values of all hadrons are consistent with unity within uncertainties. The R-pPb of K*(892)(0) and phi(1020) at root s(NN) = 8.16 and 5.02 TeV show no significant energy dependence