9 research outputs found
Cancer treating nanothread
Medicine doesn't stand still; scientists from all over the world
are working to create new medicines and ways of treatment of
different diseases. New openings and technologies give them a
chance to combat those illnesses which earlier seemed to be
incurable
Diphenoxo-Bridged Ni<sup>II</sup>Ln<sup>III</sup> Dinuclear Complexes as Platforms for Heterotrimetallic (Ln<sup>III</sup>Ni<sup>II</sup>)<sub>2</sub>Ru<sup>III</sup> Systems with a High-Magnetic-Moment Ground State: Synthesis, Structure, and Magnetic Properties
The first examples of pentanuclear heterotrimetallic
[(LnNi)<sub>2</sub>Ru] [Ln<sup>3+</sup> = Gd (<b>1</b>) and
Dy (<b>2</b>)] complexes were prepared and magnetostructurally
characterized.
They exhibit ferromagnetic interactions, leading to a high-magnetic-moment
ground state
Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?
Contains fulltext :
88536.pdf (publisher's version ) (Open Access)CONTEXT: Hypospadias is a common congenital malformation of the male external genitalia with a multifactorial etiology. Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in studies of small sample size. Most of these associations have not been replicated. OBJECTIVE: The aim of this study was to investigate whether previously reported associations for four single-nucleotide polymorphisms (SNPs) in genes involved in hormonal pathways could be replicated in a large Dutch hypospadias sample. The SNPs investigated are rs523349 in steroid-5 alpha-reductase (SRD5A2), rs6932902 in estrogen receptor 1 (ESR1), rs2987983 in ESR2, and rs11119982 in activating transcription factor 3 (ATF3). DESIGN, PARTICIPANTS, AND METHODS: We genotyped 620 Caucasian hypospadias cases and 596 controls for these SNPs using TaqMan-based genotyping. RESULTS: We did not replicate the associations of the SNPs in SRD5A2 and ESR1 with hypospadias. The SNPs in ESR2 and ATF3 were borderline associated with hypospadias [odds ratios 0.9 (95% confidence interval 0.7-1.0) and 1.2 (95% confidence interval 1.0-1.4), respectively] but in the opposite direction compared with earlier publications. Stratification according to localization of the urethral opening produced comparable results in the subgroups. CONCLUSIONS: The lack of consistency between our and previously performed studies might represent spurious results or chance findings in our or the earlier studies, differences in criteria used to select the study populations, or a real difference between populations, i.e. different genes contributing to disease risk. These results once again confirm the importance of replication in genetic association approaches.1 mei 201
Science with the Cherenkov Telescope Array
The Cherenkov Telescope Array, CTA, will be the major global observatory for
very high energy gamma-ray astronomy over the next decade and beyond. The
scientific potential of CTA is extremely broad: from understanding the role of
relativistic cosmic particles to the search for dark matter. CTA is an explorer
of the extreme universe, probing environments from the immediate neighbourhood
of black holes to cosmic voids on the largest scales. Covering a huge range in
photon energy from 20 GeV to 300 TeV, CTA will improve on all aspects of
performance with respect to current instruments.
The observatory will operate arrays on sites in both hemispheres to provide
full sky coverage and will hence maximize the potential for the rarest
phenomena such as very nearby supernovae, gamma-ray bursts or gravitational
wave transients. With 99 telescopes on the southern site and 19 telescopes on
the northern site, flexible operation will be possible, with sub-arrays
available for specific tasks. CTA will have important synergies with many of
the new generation of major astronomical and astroparticle observatories.
Multi-wavelength and multi-messenger approaches combining CTA data with those
from other instruments will lead to a deeper understanding of the broad-band
non-thermal properties of target sources.
The CTA Observatory will be operated as an open, proposal-driven observatory,
with all data available on a public archive after a pre-defined proprietary
period. Scientists from institutions worldwide have combined together to form
the CTA Consortium. This Consortium has prepared a proposal for a Core
Programme of highly motivated observations. The programme, encompassing
approximately 40% of the available observing time over the first ten years of
CTA operation, is made up of individual Key Science Projects (KSPs), which are
presented in this document
Science with the Cherenkov Telescope Array
The Cherenkov Telescope Array, CTA, will be the major global observatory for very high energy gamma-ray astronomy over the next decade and beyond. The scientific potential of CTA is extremely broad: from understanding the role of relativistic cosmic particles to the search for dark matter. CTA is an explorer of the extreme universe, probing environments from the immediate neighbourhood of black holes to cosmic voids on the largest scales. Covering a huge range in photon energy from 20 GeV to 300 TeV, CTA will improve on all aspects of performance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to provide full sky coverage and will hence maximize the potential for the rarest phenomena such as very nearby supernovae, gamma-ray bursts or gravitational wave transients. With 99 telescopes on the southern site and 19 telescopes on the northern site, flexible operation will be possible, with sub-arrays available for specific tasks. CTA will have important synergies with many of the new generation of major astronomical and astroparticle observatories. Multi-wavelength and multi-messenger approaches combining CTA data with those from other instruments will lead to a deeper understanding of the broad-band non-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory, with all data available on a public archive after a pre-defined proprietary period. Scientists from institutions worldwide have combined together to form the CTA Consortium. This Consortium has prepared a proposal for a Core Programme of highly motivated observations. The programme, encompassing approximately 40% of the available observing time over the first ten years of CTA operation, is made up of individual Key Science Projects (KSPs), which are presented in this document