Musings on the Place of a Space for an Archive Encounter

There is increasing interest in the materiality of archives in the archival, literary and historical fields, matching that of artists working with archives. For me, this project raises the complexities of space and place on experiences with archives. Alfred, Lord Tennyson is one of Lincolnshire's famous sons and the archive collections held within the Tennyson Research Centre (TRC) in this small cathedral city and county town are of international importance to literary scholars

Privilege and Practice—Challenges for Doctoral Education in Art and Design

Increasingly, doctoral education is being challenged to reflect and act on issues of access and equity. I argue that in art and design the expanding doctoral expectations and emphasis on doctoral community impact the multiple and intersectional concerns around diversity, equity and belonging that urgently need to be acknowledged and addressed. The benefits of community are widely acknowledged in the literature on doctoral education, and it is increasingly recognised that there are specific nuances to the needs of practice research doctoral communities. Prompted by insights from interviews with art and design doctoral researchers, I examine available data on participation in doctoral research in art and design in the United Kingdom in conjunction with literature on doctoral education and practice research. My aim is to highlight concerns relating to privilege and belonging in art and design doctorates that should make us increasingly uncomfortable. I believe that as a community art and design in higher education urgently needs to actively consider these issues. As well as indicating the necessity for further research, I argue that conversations are needed to devise and advocate for more inclusive and culturally responsive doctoral education specific to the needs of practice research in art and design

Clinical Heterogeneity in Patients With FOXP3 Mutations Presenting With Permanent Neonatal Diabetes

OBJECTIVE—Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by FOXP3 mutations. We aimed to determine the prevalence, genetics, and clinical phenotype of FOXP3 mutations in a large cohort with permanent neonatal diabetes (PNDM)

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.

Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs. We studied deceased-donor grafts allocated on the basis of preferential HLA matching, which provided some control for HLA genetic effects. No strong donor or recipient genetic effects contributing to long- or short-term allograft survival were found outside the HLA region. We discuss the implications for future research and clinical application

Comparative roles of upwelling and glacial iron sources in Ryder Bay, coastal western Antarctic Peninsula

Iron (Fe) is an essential micronutrient for phytoplankton, and is scarce in many regions including the open Southern Ocean. The western Antarctic Peninsula (WAP), an important source region of Fe to the wider Southern Ocean, is also the fastest warming region of the southern hemisphere. The relative importance of glacial versus marine Fe sources is currently poorly constrained, hindering projections of how changing oceanic circulation, productivity, and glacial dynamics may affect the balance of Fe sources in this region.Dissolved and total dissolvable Fe concentrations were measured throughout the summer bloom period at a coastal site on the WAP. Iron inputs to the surface mixed layer in early summer were strongly correlated with meteoric meltwater from glaciers and precipitation. A significant source of Fe from underlying waters was also identified, with dissolved Fe concentrations of up to 9.5 nM at 200 m depth. These two primary Fe sources act on different timescales, with glacial sources supplying Fe during the warm summer growing period, and deep water replenishing Fe over annual periods via deep winter mixing.Iron supply from deep water is sufficient to meet biological demand relative to macronutrient supply, making Fe limitation unlikely in this area even without additional summer Fe inputs from glacial sources. Both glacial and deep-water Fe sources may increase with continued climate warming, potentially enhancing the role of the WAP as an Fe source to offshore waters

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified