Shear-strain-induced Spatially Varying Super-lattice Structures on Graphite studied by STM

We report on the Scanning Tunneling Microscope (STM) observation of linear fringes together with spatially varying super-lattice structures on (0001) graphite (HOPG) surface. The structure, present in a region of a layer bounded by two straight carbon fibers, varies from a hexagonal lattice of 6nm periodicity to nearly a square lattice of 13nm periodicity. It then changes into a one-dimensional (1-D) fringe-like pattern before relaxing into a pattern-free region. We attribute this surface structure to a shear strain giving rise to a spatially varying rotation of the affected graphite layer relative to the bulk substrate. We propose a simple method to understand these moire patterns by looking at the fixed and rotated lattices in the Fourier transformed k-space. Using this approach we can reproduce the spatially varying 2-D lattice as well as the 1-D fringes by simulation. The 1-D fringes are found to result from a particular spatial dependence of the rotation angle.Comment: 14 pages, 6 figure

Tunneling Study of the Charge-Ordering Gap on the Surface of La0.350_{0.350}Pr0.275_{0.275}Ca0.375_{0.375}MnO3_3 Thin Films

Variable temperature scanning tunneling microscopy/spectroscopy studies on (110) oriented epitaxial thin films of La$_{0.350}$Pr$_{0.275}$Ca$_{0.375}$MnO$_3$ are reported in the temperature range of 77 to 340 K. The films, grown on lattice matched NdGaO$_3$ substrates, show a hysteretic metal-insulator transition in resistivity at 170 K. The topographic STM images show step-terrace morphology while the conductance images display a nearly homogeneous surface. The normalized conductance spectra at low temperatures (T$<$150 K) show an energy gap of 0.5 eV while for T$\geq$180 K a gap of 0.16 eV is found from the activated behavior of the zero bias conductance. The presence of energy gap and the absence of phase separation on the surface over more than 2 $\mu$m$\times$2 $\mu$m area contradicts the metallic behavior seen in resistivity measurements at low temperatures. We discuss the measured energy gap in terms of the stabilization of the insulating CO phase at the film surface.Comment: 5 pages, 5 figures To appear in Phys. Rev.

Boiling Study of Nanofluid on Graphene Coated Substrate

A comparative study is done to understand the effect of variation in surface energy of substrates on boiling and dry-out characteristics of nanofluid. Droplet of TiO2 nanofluid on glass substrate shows strong pinning along the droplet perimeter. As the droplet evaporates, boundary of nanofluid droplet recedes slowly towards the center leaving a ring-shaped stain of concentrated nanoparticles. Surface energy of glass substrate is modified by graphene coating, confirmed by increase in contact angle. While boiling of nanofluid on graphene coated glass substrate shows an almost uniform dry-out pattern. Reduced wettability of nanofluid droplet on graphene coated glass substrate is responsible for this behavior

Non-methane volatile organic compounds emitted from domestic fuels in Delhi: Emission factors and total city-wide emissions

In controlled laboratory conditions, 62 samples of domestic fuels collected from 56 grids of Delhi were burnt to quantify the emissions of 23 non-methane volatile organic compounds (NMVOCs), i.e., alkanes (11), alkenes (6), alkynes (1) and aromatic compounds (5). The domestic fuels used for residential activities were comprised of 20 unique types of fuel woods, 3 species of crop residue, dung cakes and coal. These fuels are primarily used for cooking and water/space heating during winters. The current study reports the total emission budget of NMVOCs from domestic burning over Delhi. Furthermore, this study also compares the differences in EFs of NMVOCs which are calculated for different burning cycles and sample collection methods. The EFs of NMVOCs calculated from the samples collected during the flaming stage using canisters were analysed for 23 NMVOCs and then compared with same species emitted from complete burning cycle. In addition to this, 10 consumption and emission hotspot grids were also identified in Delhi; based on the ground survey and laboratory simulated results. The total annual usage of domestic fuels for the year 2019 was found to be 0.415 Mt/yr (million tonnes) in Delhi. 12.01 Gg/yr of annual NMVOC emissions was calculated from domestic fuel burning in which the emissions from dung cake and fuel wood dominated with 6.6 Gg/yr and 5.4 Gg/yr, respectively. The EFs of NMVOCs calculated using canister and online collection method differ significantly from each other. The flaming stage presented enhanced emissions compared to the complete burning cycle by ~7 times which suggests that the method of data analysis and the period of sample collection play a pivotal role in the preparation of an emission inventory and estimating the budget

OPTIMADE, an API for exchanging materials data.

The Open Databases Integration for Materials Design (OPTIMADE) consortium has designed a universal application programming interface (API) to make materials databases accessible and interoperable. We outline the first stable release of the specification, v1.0, which is already supported by many leading databases and several software packages. We illustrate the advantages of the OPTIMADE API through worked examples on each of the public materials databases that support the full API specification

Overexpression of Prothymosin Alpha Predicts Poor Disease Outcome in Head and Neck Cancer

In our recent study, tissue proteomic analysis of oral pre-malignant lesions (OPLs) and normal oral mucosa led to the identification of a panel of biomarkers, including prothymosin alpha (PTMA), to distinguish OPLs from histologically normal oral tissues. This study aimed to determine the clinical significance of PTMA overexpression in oral squamous cell hyperplasia, dysplasia and head and neck squamous cell carcinoma (HNSCC).Immunohistochemistry of PTMA protein was performed in HNSCCs (n = 100), squamous cell hyperplasia (n = 116), dysplasia (n = 50) and histologically normal oral tissues (n = 100). Statistical analysis was carried out to determine the association of PTMA overexpression with clinicopathological parameters and disease prognosis over 7 years for HNSCC patients.<0.001). Chi-square analysis showed significant association of nuclear PTMA with advanced tumor stages (III+IV). Kaplan Meier survival analysis indicated reduced disease free survival (DFS) in HNSCC patients (p<0.001; median survival 11 months). Notably, Cox-multivariate analysis revealed nuclear PTMA as an independent predictor of poor prognosis of HNSCC patients (p<0.001, Hazard's ratio, HR = 5.2, 95% CI = 2.3–11.8) in comparison with the histological grade, T-stage, nodal status and tumor stage.Nuclear PTMA may serve as prognostic marker in HNSCC to determine the subset of patients that are likely to show recurrence of the disease

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies

Development of environment-friendly reduced graphene oxide coating and corrosion behavior on cold-rolled interstitial-free (IF) steel

Many different processes have been developed to grow graphene film to protect metals. These processes are primarily based on chemical vapour deposition and are challenging to scale. In this paper, we have attempted to grow the reduced graphene oxide (rGO)-like film using the natural resin 'shellac' as a precursor through the simple process of dip coating of shellac varnish and annealing of coated substrates in a reducing atmosphere. X-ray diffraction (XRD) analysis and Raman spectroscopy were used to establish the rGO phases grown in the coating. The corrosion studies of rGO films grown on cold-rolled interstitial-free steel are investigated with different loadings of shellac in the varnish solution and subsequent heat treatments. Scanning electron probe micro-analysis was done to do elemental analysis, and potentiometric studies were done to investigate the corrosion behavior of the coatings. The structure-property correlation of the film has established the corrosion mechanism using different microscopy techniques