An analysis of the Photographs in Digital Archive of UNESCO

The present study discussed the digitally archived photographs available in the digital archive section of the website of UNESCO. A total of 5048 photographs have been analyzed based on the topic, country, year, photographer\u27s name, and the name of the person. It is found that digital archives are playing an important role to know about one’s culture, past events, and initiatives. Digital archives are advantageous over traditional archives as they can be preserved for a longer period whereas traditional archives have many drawbacks such as getting damaged by rain, moisture, fire, and natural disasters. Every event that is useful from a future point of view should be digitized

The mRNA cap-binding complex stimulates the formation of pre-initiation complex at the promoter via its interaction with Mot1p in vivo

The cap-binding complex (CBC) binds to the cap structure of mRNA to protect it from exonucleases as well as to regulate downstream post-transcriptional events, translational initiation and nonsense-mediated mRNA decay. However, its role in regulation of the upstream transcriptional events such as initiation or elongation remains unknown. Here, using a formaldehyde-based in vivo cross-linking and chromatin immunoprecipitation assay in conjunction with transcriptional, mutational and co-immunoprecipitational analyses, we show that CBC is recruited to the body of yeast gene, and then stimulates the formation of pre-initiation complex (PIC) at several yeast promoters through its interaction with Mot1p (modifier of transcription). Mot1p is recruited to these promoters, and enhances the PIC formation. We find that CBC promotes the recruitment of Mot1p which subsequently stimulates PIC formation at these promoters. Furthermore, the formation of PIC is essential for recruitment of CBC. Thus, our study presents an interesting observation that an mRNA binding factor exhibits a reciprocal synergistic effect on formation of PIC (and hence transcriptional initiation) at the promoter, revealing a new pathway of eukaryotic gene regulation in vivo

Role of Yoni Dhadhyakara Lepa in First Degree Uterine Prolapse

According to WHO estimation the global occurrence of uterine prolapse is increasing and is assumed to be two to twenty percent. In Ayureda Doshas involved in Prasramsini Yonivyapa is Pitta Pradhan Vata Dosha. So, for the Samprapti Vighatana of Prasramsini Yonivyapada treatment should emphasize mainly on Pitta and Vata Shamana. Acharaya Sushruta has described Prasramsini Yonivyapada in Pittaja Yonivyapada which can be correlated with and first and second degree uterine prolapse. This condition is usually encountered in perimenopausal or postmenopausal period although young age group with distress during labor is not an exemption. A 42 years old female presented with first degree uterine prolapse was treated with Yoni Dhadhyakara Lepa (Madanphala, Madhuyasti, Karpura) followed by Yoniprakshalana with Triphala Kwatha. This treatment was continued for seven days twice daily for three consecutive months with positive outcome and good symptomatic relief in the patient

Managing endometrial calcifications using Kshara Taila and Phalaghrita Uttara Basti: A case report

Endometrial calcification is an uncommon clinical entity. They can be detected during pelvic ultrasonography or as incidental pathologic findings. Most of the cases are asymptomatic or present with secondary infertility and menstrual anomalies. Its definite etiology is still not known and the pathogenesis is uncertain; its clinical importance is not yet fully validated. Since there is no exact simulating disease to compare this condition in Ayurveda; according to the features involved in its pathophysiology; involvement of Tridosha has been contemplated. Therefore, the management of endometrial calcifications is conducted by considering the specific Dosha involved. Uttara Basti is a minimally invasive procedure that can be easily performed as an outpatient procedure, offering a more convenient and cost-effective approach to enhance the treatment of endometrial calcifications. Here in this case study, the patient had been diagnosed with endometrial calcifications and was subsequently scheduled for an Ayurvedic management protocol. The procedure of Uttara Basti with Kshara Oil and Phala ghrita, was undertaken for a duration of 3 consecutive months, following the cessation of menstrual flow. The patient experienced improvment in scanty menses, her USG showed a reduction in endometrial calcification. Furthermore, she was conceived

Current updates on Anguli Pramana, an ancient tool of measurements

Introduction: Anguli Pramana is an ancient form of anthropometry. Though it is an age old technique of measurement, it is one of the unique hypothetical concepts put forth by acharyas. It is included in the syllabus of Rachana Sharir and students are studying over years. There is a need of updating the existing knowledge. Hence, the present study was a small step in this direction. Materials and Methods: Along with ethical clearance, the study was conducted on 770 healthy participants of age group 18-50 years in Ahmednagar and Nashik Region. Considering middle finger width of the right hand at proximal interphalangeal joint as Swa-anguli Pramana, measurements were taken for selected body parts related to the lower limb. Data obtained was analysed applying Z score test. Results: In the present study, measured values for selected parameters when compared with the standard values stated by acharya found statistically different. Discussion: Result of the present study reveal that the anthropometric values stated in ancient time are not valid in the present era. This may be due to evolutionary changes and changes in life style. The present study gives tentative information regarding the same. The result obtained is confined to the selected sample size and for selected parameters. The research can be extended further to arrive at a proper conclusion

Study of Anguli Pramana in individuals with different nutritional status with respect to its validity in the present era

Introduction: Anguli Pramana is an ancient form of Anthropometry put forth by sages. It mainly deals with the measurements of the human body. Literature search revealed that, not a single study was being carried out for assessing the validity of Anguli Pramana in the present era. Therefore, the present study was planned. Method: After ethical clearance, 770 participants between 18-50 years were selected from Ahmednagar and Nashik region. Measurements were taken for selected parameters and converted into Swa-Anguli Pramana. Body Mass Index of each participant was calculated and categorized according to the nutritional status. The data analyzed with Student’s t-test using Systat 13.0 version software. Result: Comparative data of standard and measured value was found statistically different in all nutritional status groups. Discussion: Anguli Pramana may not be considered valid in the present era may be due to evolutionary changes and lifestyle changes in the human being

A Systematic Review: Standard Measurement method of Anguli pramana

Introduction:  Anguli pramana is an ancient form of anthropometric measurements where individual’s own finger width is used as a unit of measurement. Different researchers had attempted to standardize the Anguli pramana.  This systematic review aims to review all the available published literature and to provide the narrative summary on Anguli pramana. Methods: References were sought in Google scholar, AYUSH Research portal, DHARA online, Pub med, Shodhganga, eShodhSindhu datasets and other sources like Grey literature by utilizing all the keywords and MeSH terminologies. Following PRISMA guidelines, 32 full-text eligible papers were assessed and 9 articles extracted for study design, population parameters, methodology, evaluation system, outcome and other relevant findings. Result: 5 out of 9 studies have reconfirmed that breadth of middle finger (BM) of right hand proved as more accurate method of measurement in Anguli pramana while in 3 studies average of right and left middle finger at proximal interphalangeal joint is used as a method of measurement. Only 1 study shows use of average of breadth of four fingers at metacarpophalangeal joints of right and left hand as a method of measurement. Discussion: Present systematic review concludes that breadth of middle finger of the right hand at proximal interphalangeal joint (BM) is the standard method of measurement for Anguli pramana

Gender wise consideration of Anguli Pramana in the present era

Introduction: Anguli pramana is a unique concept in Ayurved. It was stated by acharyas at times when there was no any sort of standardised unit of measurements. Acharyas have mentioned Anguli pramana for various parts of the body. In respect of male and female gender, no separate anthropometric values found to be mentioned. Hence, the present study aimed at gender wise consideration of Anguli pramana. Method: After seeking ethical permission, 770 healthy participants of both gender between age group 18-50 years in Ahmednagar and Nashik region were selected for the study. Measurements were taken for selected body parts. The middle finger width of the right hand at proximal interphalangeal joint was used as a unit for Anguli pramana. Collected data treated with the Student’s t test for inference. Result: Measured values for selected parameters when compared with the standard values stated by acharya in both genders found statistically different except for a few i.e., Pad parinah and Pad vistar. Discussion: Variations in Anguli pramana may be due to evolutionary changes and lifestyle in the present era. The present study concluded that Anguli pramana is not valid in the present era. Its validity was checked according to gender separately. Though the findings are confined to the selected sample size and selected parameters, it could further be extended to arrive at generalization

An Observational Study to Assess the Validity of Anguli Pramana in the Present Era

Introduction: The concept of Anguli pramana is one of the hypothetical concepts in Ayurved put forth by acharyas. It mainly deals with the measurements of various parts of the human body. After reviewing the previous research done, it was noticed that, not a single study was being carried out by anyone of the researchers for assessing the validity of Anguli pramana in the present era. Therefore, the present study was planned. Method: After ethical clearance, the study was conducted. In total 770 participants of age group 18-50 years from Ahmednagar and Nashik region were selected. Measurements were taken for selected parameters, recorded and converted into Swa-anguli pramana.  Swa-anguli pramana was measured by taking width of the middle finger at the proximal interphalangeal joint of right hand. All the measurements were taken following Standard Operating Procedure. The data was analyzed with the test of Normality, Z score using Systat 13.0 version software. Result: In the present study, obtained value and standard value stated by Acharya Charaka for the selected parameters were compared and found statistically different. Similarly, obtained value and standard value stated by Acharya Sushruta for the selected parameters were compared and found statistically different. Discussion: The results were negative i.e., non comparable with the standard values stated by acharas for the selected parameters. It was observed that the Anguli pramana mentioned in ancient literature may not be considered valid in the present era. It may be because of evolutionary changes and lifestyle changes of the human being

PHYTOCHEMICAL EVALUATION AND ANTIHYPERGLYCEMIC EFFECTS OF ELAEOCARPUS GANITRUS ROXB (RUDRAKSHA) IN STREPTOZOTOCIN INDUCED DIABETES

Objective: Present study was aimed at examining the constituents of essential oil of leaves and evaluation of phytochemical and antihyperglycemic effect of methanolic seed extracts of Elaeocarpus ganitrus Roxb. in Streptozotocin induced diabetes.Methods: Essential oil was extracted from E. ganitrus leaves by hydrodistillation and purified oil was subjected to GC-FID analysis Preliminary phytochemical screening of various extracts of E. ganitrus seeds was carried out and antidiabetic activity of methanolic extract was evaluated in streptozotocin induced diabetic rats. Results: The results revealed which showed the presence of altogether sixteen constituents. The methanolic seed extract of E. ganitrus exhibit potent antidiabetic activity comparable to the standard drug glybenclamide.Conclusion: It can be concluded from the study that methanolic extract of E. ganitrus seeds possess potent hypoglycemic activity