Cumberland Helpers in Partnerships: A Program of Intervention at Cumberland Elementary and Junior High School

Low- or non-achievement by students has historically been a problem for teachers and administrators, as well as for parents and students. Same grade retention has been proven by many researchers to be non-productive and in many cases, punitive. The Cumberland Helpers in Partnerships (CHIPs) program was begun at Cumberland Elementary and Junior High School as an interventive measure to combat this problem of low achievement. Sixth, seventh, and eighth grade students who were considered academically at risk at the end of the first semester of the 1995-1996 school year (N=78) were asked to voluntarily attend tutoring sessions to help improve their grades. Academically proficient junior high students were selected as tutors and they took part in ten training sessions throughout the 18 week tutoring period. Training sessions were conducted by a certified staff member. Tutors were in the tutoring lab four days per week for the 18 week period. At risk students voluntarily self-selected whether they were a member of the experimental group or the control group, depending on whether they attended the tutoring sessions a pre-determined number of times. The experimental group of students (N=29) were those who attended at least 36 of the 72 sessions. The control group {N=49) were those who attended less than 36 of the 72 sessions. Three t-tests were conducted on these at risk students. A pre-program grade point average (GPA) was taken from official school records for each student. At the end of the 18 week period, a post-program GPA was taken for each student. It was found by this researcher that after examination of the mean scores for both pre- and post-program on both the experimental as well as the control group, more academic progress was made by the control group than the experimental group. A suggestion for further research is recommended in the areas of grades as they impact self-esteem and self-image, and the correlation, if any, between students\u27 grades and parent involvement in the education process

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

Cumberland Helpers in Partnerships: A Program of Intervention at Cumberland Elementary and Junior High School

Low- or non-achievement by students has historically been a problem for teachers and administrators, as well as for parents and students. Same grade retention has been proven by many researchers to be non-productive and in many cases, punitive. The Cumberland Helpers in Partnerships (CHIPs) program was begun at Cumberland Elementary and Junior High School as an interventive measure to combat this problem of low achievement. Sixth, seventh, and eighth grade students who were considered academically at risk at the end of the first semester of the 1995-1996 school year (N=78) were asked to voluntarily attend tutoring sessions to help improve their grades. Academically proficient junior high students were selected as tutors and they took part in ten training sessions throughout the 18 week tutoring period. Training sessions were conducted by a certified staff member. Tutors were in the tutoring lab four days per week for the 18 week period. At risk students voluntarily self-selected whether they were a member of the experimental group or the control group, depending on whether they attended the tutoring sessions a pre-determined number of times. The experimental group of students (N=29) were those who attended at least 36 of the 72 sessions. The control group {N=49) were those who attended less than 36 of the 72 sessions. Three t-tests were conducted on these at risk students. A pre-program grade point average (GPA) was taken from official school records for each student. At the end of the 18 week period, a post-program GPA was taken for each student. It was found by this researcher that after examination of the mean scores for both pre- and post-program on both the experimental as well as the control group, more academic progress was made by the control group than the experimental group. A suggestion for further research is recommended in the areas of grades as they impact self-esteem and self-image, and the correlation, if any, between students\u27 grades and parent involvement in the education process

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.

Importance Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness and safety of these noninvasive respiratory strategies. Objective To determine whether either CPAP or HFNO, compared with conventional oxygen therapy, improves clinical outcomes in hospitalized patients with COVID-19-related acute hypoxemic respiratory failure. Design, Setting, and Participants A parallel group, adaptive, randomized clinical trial of 1273 hospitalized adults with COVID-19-related acute hypoxemic respiratory failure. The trial was conducted between April 6, 2020, and May 3, 2021, across 48 acute care hospitals in the UK and Jersey. Final follow-up occurred on June 20, 2021. Interventions Adult patients were randomized to receive CPAP (n = 380), HFNO (n = 418), or conventional oxygen therapy (n = 475). Main Outcomes and Measures The primary outcome was a composite of tracheal intubation or mortality within 30 days. Results The trial was stopped prematurely due to declining COVID-19 case numbers in the UK and the end of the funded recruitment period. Of the 1273 randomized patients (mean age, 57.4 [95% CI, 56.7 to 58.1] years; 66% male; 65% White race), primary outcome data were available for 1260. Crossover between interventions occurred in 17.1% of participants (15.3% in the CPAP group, 11.5% in the HFNO group, and 23.6% in the conventional oxygen therapy group). The requirement for tracheal intubation or mortality within 30 days was significantly lower with CPAP (36.3%; 137 of 377 participants) vs conventional oxygen therapy (44.4%; 158 of 356 participants) (absolute difference, -8% [95% CI, -15% to -1%], P = .03), but was not significantly different with HFNO (44.3%; 184 of 415 participants) vs conventional oxygen therapy (45.1%; 166 of 368 participants) (absolute difference, -1% [95% CI, -8% to 6%], P = .83). Adverse events occurred in 34.2% (130/380) of participants in the CPAP group, 20.6% (86/418) in the HFNO group, and 13.9% (66/475) in the conventional oxygen therapy group. Conclusions and Relevance Among patients with acute hypoxemic respiratory failure due to COVID-19, an initial strategy of CPAP significantly reduced the risk of tracheal intubation or mortality compared with conventional oxygen therapy, but there was no significant difference between an initial strategy of HFNO compared with conventional oxygen therapy. The study may have been underpowered for the comparison of HFNO vs conventional oxygen therapy, and early study termination and crossover among the groups should be considered when interpreting the findings. Trial Registration isrctn.org Identifier: ISRCTN16912075