User-centered Evaluation of Metadata Schema for Murals: Preliminary Results from A Survey Study

There has not been a well-accepted metadata schema for murals as an important type of cultural heritage. This paper reports an ongoing study and preliminary results on evaluating a draft metadata schema of murals from the end-user perspective. Based on the results of an earlier interview-based evaluation, a questionnaire was designed and 185 effective responses were collected from potential users. “Work type”, “Title”, and “Creation date” were identified as the most important metadata elements, and the most useful elements for supporting the searching, browsing, and organizing information about murals. In summary, findings of this study contribute to polishing the design of the metadata schema for murals

Long-Term Dynamic of Land Reclamation and Its Impact on Coastal Flooding: A Case Study in Xiamen, China

While land reclaimed from the sea meets the land demand for coastal development, it simultaneously causes socio-economic systems to be prone to coastal flooding induced by storm surges and sea-level rise. Current studies have seldom linked reclamation with coastal flood impact assessment, hindering the provision of accurate information to support coastal flood risk management and adaptation. This study, using Xiamen, China as a case study, incorporates the spatiotemporal dynamics of reclamation into a coastal flood impact model, in order to investigate the long-term influence of reclamation activities on coastal flood inundation and the consequent exposure of the population to coastal flooding. We find that rapid population growth, continual economic development and urbanization drive a substantial logarithmic increase in coastal reclamation. Historical and future expansions of seaward land reclamation are found to cause dramatic surges in the expected annual inundation (EAI) and the expected annual population (EAP) exposed to coastal flooding. In Xiamen, EAI is estimated to increase by 440.2% from 1947 to 2035, owing to continuing land reclamation. Consequently, the population living in the flooded area has also increased sharply: the EAP of total population is estimated to rise from 0.8% in 1947 to 4.7% in 2035, where reclamation contributes over 80% of this increase. Moreover, a future 10 cm sea-level rise in 2035 will lead to extra 5.73% and 8.15% increases in EAI and EAP, respectively, and is expected to cause massive permanent submersion in the new reclamation zone. Our findings emphasize an integration of hard structures and nature-based solutions for building resilient coasts

Co-occurrence of pluvial and fluvial floods exacerbates inundation and economic losses: evidence from a scenario-based analysis in Longyan, China

AbstractHydrodynamics and socio-economic impacts of compound floods as the result of co-occurring pluvial and fluvial floods, have not been well studied, which challenges conventional urban flood risk management that treats different types of floods separately. This study generates a high-resolution land surface digital surface model based on images from unmanned aerial vehicles, and incorporates it into a combined flooding model that integrates the 1D river hydrodynamic model, 1D urban drainage hydrodynamic model and 2D overland flow model, in order to simulate the inundation characteristics of extreme floods when local pluvial floods coincide with upstream fluvial floods, and in a further step to quantify the direct economic losses on urban physical systems. As demonstrated by an empirical study of Longyan, China, the combination of pluvial and fluvial floods leads to substantial exacerbation in inundation extent and depth. Consequently, the joining of pluvial and fluvial floods greatly amplifies economic losses to urban physical systems, indicating that ignoring co-occurrence of different types of floods will potentially lead to underestimation of flood risk and insufficient adaptation. Our study emphasizes the need to account for the co-occurrence of multiple types of floods in flood risk assessment and management, to avoid the shortcomings of fragmented responses

Comparison of Two Algorithms for Multiline Bus Dynamic Dispatching

Dynamic bus scheduling refers to adjusting the departure time according to the latest time-varying information or adjusting bus speed in the process of operation. These control strategies can prevent bus bunching and alleviate traffic pressure. The paper studies the multiline bus dynamic scheduling with consideration of departure time and speed meanwhile. The hyperheuristic algorithm is proposed, and low-level heuristics (LLH) operators are designed. The simulation experiment is performed for the passenger flow distribution of different strengths and types of different scenarios. By comparing the experimental results of genetic algorithm (GA) and hyperheuristic algorithm in solving different scenarios, the results show that in smooth, increasing, decreasing, and multiconvex passenger flow mode, the performance of the hyperheuristic algorithm is higher than that of GA. The promotion rate reaches 18∼28%, and especially the average value of the hyperheuristic algorithm designed under multiconvex passenger flow is up to 28.62%, significantly reducing passengers’ waiting time. By comparing the stability of the three passenger flow modes, the results illustrate that the stability of the hyperheuristic algorithm is lower than that of GA. For the smooth passenger flow mode, the stability of medium and lower density of GA is higher than that of the hyperheuristic algorithm. In comparison, the high-density stability of the hyperheuristic algorithm is better than that of GA

Assessing Agricultural Livelihood Vulnerability to Climate Change in Coastal Bangladesh

The adverse impacts of climate change exert mounting pressure on agriculture-dependent livelihoods of many developing and developed nations. However, integrated and spatially specific vulnerability assessments in less-developed countries like Bangladesh are rare, and insufficient to support the decision-making needed for climate-change resilience. Here, we develop an agricultural livelihood vulnerability index (ALVI) and an integrated approach, allowing for (i) mapping out the hot spots of vulnerability distribution; (ii) identifying key factors of spatially heterogeneous vulnerability; and (iii) supporting intervention planning for adaptation. This study conceptualized vulnerability as a function of exposure, sensitivity, and adaptive capacity by developing a composite index from a reliable dataset of 64 indicators comprising biophysical, agro-ecological, and socioeconomic variables. The empirical studies of coastal Bangladesh revealed that Bhola, Patuakhali, and Lakshmipur districts, around the mouth of the deltaic Meghna estuaries, are the hot spot of vulnerability distribution. Furthermore, the spatially heterogeneous vulnerability was triggered by spatial variation of erosion, cyclones, drought, rain-fed agriculture, land degradation, soil phosphorus, crop productivity, sanitation and housing condition, infant mortality, emergency shelters, adoption of agro-technology. The integrated approach could be useful for monitoring and evaluating the effectiveness of adaptation intervention by substituting various hypothetical scenarios into the ALVI framework for baseline comparison

Retraction Note: miR-3928v is induced by HBx via NF-κB/ EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0681-y

miR-3928v is induced by HBx via NF-κB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3

Abstract Background Hepatitis B virus (HBV) plays a critical role in the tumorigenic behavior of human hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) have been reported to participate in HCC development via the regulation of their target genes. However, HBV-modulated miRNAs involved in tumorigenesis remain to be identified. Here, we found that a novel highly expressed miRNA, TLRC-m0008_3p (miR-3928v), may be an important factor that promotes the malignancy of HBV-related HCC. Methods Solexa sequencing was applied to profile miRNAs, and RT-qPCR was used to identify and quantitate miRNAs. We studied miR-3928v function in HCC cell lines by MTT, colony formation, migration/invasion, and vascular mimicry (VM) assays in vitro and by a xenograft tumor model in vivo. Finally, we predicted and verified the target gene of miR-3928v by a reporter assay, studied the function of this target gene, and cloned the promoter of miR-3928v and the transcription factor for use in dual-luciferase reporter assays and EMSAs. Results A variant of miR-3928 (miR-3928v) was identified and found to be highly expressed in HBV (+) HCC tissues. Voltage-dependent anion channel 3 (VDAC3) was validated as a target of miR-3928v and found to mediate the effects of miR-3928v in promoting HCC growth and migration/invasion. Furthermore, HBx protein increased early growth response 1 (EGR1) expression and facilitated its translocation into the nucleus to enhance miR-3928v promoter activity in an NF-κB signaling-dependent manner. Conclusions miR-3928v is induced by HBx through the NF-κB/EGR1 signaling pathway and down-regulates the tumor suppressor gene VDAC3 to accelerate the progression of HCC

OsExo70B1 Positively Regulates Disease Resistance to Magnaporthe oryzae in Rice

The exocyst, an evolutionarily conserved octameric protein complex, mediates tethering of vesicles to the plasma membrane in the early stage of exocytosis. Arabidopsis Exo70, a subunit of the exocyst complex, has been found to be involved in plant immunity. Here, we characterize the function of OsExo70B1 in rice. OsExo70B1 mainly expresses in leaf and shoot and its expression is induced by pathogen-associated molecular patterns (PAMPs) and rice blast fungus Magnaporthe oryzae (M. oryzae). Knocking out OsExo70B1 results in significantly decreased resistance and defense responses to M. oryzae compared to the wild type, including more disease lesions and enhanced fungal growth, downregulated expression of pathogenesis-related (PR) genes, and decreased reactive oxygen species accumulation. In contrast, the exo70B1 mutant does not show any defects in growth and development. Furthermore, OsExo70B1 can interact with the receptor-like kinase OsCERK1, an essential component for chitin reception in rice. Taken together, our data demonstrate that OsExo70B1 functions as an important regulator in rice immunity