Viscoelastic and Dynamic Properties of Soft Liners and Tissue Conditioners

The creep compliance and dynamic modulus of two tissue conditioners and five soft liners were determined after storage in water at 37 C. Under static conditions the tissue conditioners functioned like viscous liquids, whereas the soft liners were more elastic. In general, linear viscoelasticity was not observed. Under dynamic conditions, the materials were stiffer.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67015/2/10.1177_00220345790580080601.pd

Universality class of S=1/2 quantum spin ladder system with the four spin exchange

We study s=1/2 Heisenberg spin ladder with the four spin exchange. Combining numerical results with the conformal field theory(CFT), we find a phase transition with central charge c=3/2. Since this system has an SU(2) symmetry, we can conclude that this critical theory is described by k=2 SU(2) Wess-Zumino-Witten model with Z$_2$ symmetry breaking

On the 3-particle scattering continuum in quasi one dimensional integer spin Heisenberg magnets

We analyse the three-particle scattering continuum in quasi one dimensional integer spin Heisenberg antiferromagnets within a low-energy effective field theory framework. We exactly determine the zero temperature dynamical structure factor in the O(3) nonlinear sigma model and in Tsvelik's Majorana fermion theory. We study the effects of interchain coupling in a Random Phase Approximation. We discuss the application of our results to recent neutron-scattering experiments on the Haldane-gap material ${\rm CsNiCl_3}$.Comment: 8 pages of revtex, 5 figures, small changes, to appear in PR

Rolling tachyon in anti-de Sitter space-time

We study the decay of the unstable D-particle in three-dimensional anti-de Sitter space-time using worldsheet boundary conformal field theory methods. We test the open string completeness conjecture in a background for which the phase space available is only field-theoretic. This could present a serious challenge to the claim. We compute the emission of closed strings in the AdS(3) x S^3 x T^4 background from the knowledge of the exact corresponding boundary state we construct. We show that the energy stored in the brane is mainly converted into very excited long strings. The energy stored in short strings and in open string pair production is much smaller and finite for any value of the string coupling. We find no "missing energy" problem. We compare our results to those obtained for a decay in flat space-time and to a background in the presence of a linear dilaton. Some remarks on holographic aspects of the problem are made.Comment: JHEP style, 45 pages, one figure; v2: typos corrected, references added, version to appear in JHE

Configuration of anchorage holes affects fixation of the acetabular component in cemented total hip replacement - a finite element study

Our survey of current practice among UK orthopaedic surgeons shows wide variations in fixation techniques. The aim of this study is to investigate the effect of drilling different configurations of anchorage holes in the acetabulum on implant stability. To avoid variables that could incur during in-vitro testing, we used commercially-available COSMOS finite element analysis package to investigate the stress distributions, deformations, and strains on the cement mantle when drilling three large anchorage holes and six smaller ones, with straight and rounded cement pegs. The results, which are in line with our in-vitro studies on simulated reconstructed acetabulae, indicate better stability of the acetabular component when three larger holes than six smaller holes are drilled and when the necks of the anchorage holes are rounded. The longevity of total hip replacements could be improved by drilling three large anchorage holes, rather than many smaller ones, as initially proposed by Charnley

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Testing the applicability of morphometric characterisation in discordant catchments to ancient landscapes: A case study from southern Africa

The ancient landscapes south of the Great Escarpment in southern Africa preserve large-scale geomorphological features despite their antiquity. This study applies and evaluates morphometric indices (such as hypsometry, long profile analysis, stream gradient index, and linear/areal catchment characteristics) to the Gouritz catchment, a large discordant catchment in the Western Cape. Spatial variation of morphometric indices were assessed across catchment (trunk rivers) and subcatchment scales. The hypsometric curve of the catchment is sinusoidal, and a range of curve profiles are evident at subcatchment scale. Hypsometric integrals do not correlate to catchment properties such as area, circularity, relief, and dissection; and stream length gradients do not follow expected patterns, with the highest values seen in the mid-catchment areas. Rock type variation is interpreted to be the key control on morphometric indices within the Gouritz catchment, especially hypsometry and stream length gradient. External controls, such as tectonics and climate, were likely diminished because of the long duration of catchment development in this location. While morphometric indices can be a useful procedure in the evaluation of landscape evolution, this study shows that care must be taken in the application of morphometric indices to constrain tectonic or climatic variation in ancient landscapes because of inherited tectonic structures and signal shredding. More widely, we consider that ancient landscapes offer a valuable insight into long-term environmental change, but refinements to geomorphometric approaches are needed

Magnetization and dimerization profiles of the cut two-leg spin ladder and spin-1 chain

The physical properties of the edge states of the cut two-leg spin ladder are investigated by means of the bosonization approach. By carefully treating boundary conditions, we derive the existence of spin-1/2 edge states in the spin ladder with a ferromagnetic rung exchange and for the open spin-1 Heisenberg chain. In contrast, such states are absent in the antiferromagnetic rung coupling case. The approach, based on a mapping onto decoupled semi-infinite off-critical Ising models, allows us to compute several physical quantities of interest. In particular, we determine the magnetization and dimerization profiles of the cut two-leg spin ladder and of the open biquadratic spin-1 chain in the vicinity of the SU(2)$_2$ WZNW critical point.Comment: RevTeX 4, no figure, 26 page