1,468 research outputs found
Interview with Shannon Simpson
In her June 12, 2013 interview with Martha Manning, Shannon Simpson detailed her time as an undergraduate student at Winthrop from 1995-1999. Discussed are details of Simpsonâs life as a student â residence halls, classes, meals â rules and regulations on campus, and her desire to go back to Winthrop as a graduate student in 2013. Included are Simpsonâs thoughts on professors, traditions, and cultural events on campus. Simpson also shares details of her career as a police officer after attending Winthrop to a transition as an employee in Human Resources. This interview was conducted for inclusion into the Louise Pettus Archives and Special Collections Oral History Program.https://digitalcommons.winthrop.edu/oralhistoryprogram/1009/thumbnail.jp
Prospectus, October 12, 1994
https://spark.parkland.edu/prospectus_1994/1016/thumbnail.jp
Prospectus, October 19, 1994
https://spark.parkland.edu/prospectus_1994/1017/thumbnail.jp
Electronic Structure of Iron Porphyrin Adsorbed to the Pt(111) Surface
Systematic density functional theory calculations that treat the strong on-site 3d electronâelectron interactions on iron via a Hubbard Ueff = 3.0 eV and the van der Waals (vdW) interactions between the substrate and adsorbate within the vdW-DF framework are employed to study the adsorption of the iron porphyrin (FeP) molecule to the Pt(111) surface. The more accurate vdW-DF-optPBE and vdW-DF-optB88 functionals found the same binding site to be the most stable and yielded binding energies that were within âŒ20% of each other, whereas the binding energies computed with the vdW-DF-revPBE functional were substantially weaker. This work highlights the importance of vdW interactions for organometallic molecules chemisorbed to transition metal surfaces. The stability of the binding sites was found to depend upon the number of FeâPt and CâPt bonds that were formed. Whereas in the gas phase the most stable spin state of FeP is the intermediate spin S = 1 state, the high spin S = 2 state is preferred for the FePâPt(111) system on the binding sites considered herein. The spin switch results from the elongation of the FeâN bonds that occur upon adsorption
Tuning of Human Modulation Filters Is Carrier-Frequency Dependent
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Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab.
The Epidermal Growth Factor Receptor (EGFR) is selectively expressed on the surface of numerous tumours, such as non-small cell lung, ovarian, colorectal and head and neck carcinomas. EGFR has therefore become a target for cancer therapy. Cetuximab is a chimeric human/mouse monoclonal antibody (mAb) that binds to EGFR, where it both inhibits signaling and induces cell death by antibody-dependent cell mediated cytotoxicity (ADCC). Cetuximab has been approved for clinical use in patients with head and neck squamous cell carcinoma (HNSCC) and colorectal cancer. However, only 15-20% patients benefit from this drug, thus new strategies to improve cetuximab efficiency are required. We aimed to develop a reliable and easy preclinical mouse model to evaluate the efficacy of EGFR-targeted antibodies and examine the immune mechanisms involved in tumour regression. We selected an anti-mouse EGFR mAb, 7A7, which has been reported to be "mouse cetuximab" and to exhibit similar properties to its human counterpart. Unfortunately, we were unable to reproduce previous results obtained with the 7A7 mAb. In our hands, 7A7 failed to recognize mouse EGFR, both in native and reducing conditions. Moreover, in vivo administration of 7A7 in an EGFR-expressing HPV38 tumour model did not have any impact on tumour regression or animal survival. We conclude that 7A7 does not recognize mouse EGFR and therefore cannot be used as the mouse equivalent of cetuximab use in humans. As a number of groups have spent effort and resources with similar issues we feel that publication is a responsible approach
Repeated exposure reduces the response to impulsive noise in European seabass
This is the final version of the article. Available from the publisher via the DOI in this record.Human activities have changed the acoustic environment of many terrestrial and aquatic ecosystems around the globe. Mounting evidence indicates that the resulting anthropogenic noise can impact the behaviour and physiology of at least some species in a range of taxa. However, the majority of experimental studies have considered only immediate responses to single, relatively short-term noise events. Repeated exposure to noise could lead to a heightened or lessened response. Here, we conduct two long-term (12Â week), laboratory-based exposure experiments with European seabass (Dicentrarchus labrax) to examine how an initial impact of different sound types potentially changes over time. NaĂŻve fish showed elevated ventilation rates, indicating heightened stress, in response to impulsive additional noise (playbacks of recordings of pile-driving and seismic surveys), but not to a more continuous additional noise source (playbacks of recordings of ship passes). However, fish exposed to playbacks of pile-driving or seismic noise for 12Â weeks no longer responded with an elevated ventilation rate to the same noise type. Fish exposed long-term to playback of pile-driving noise also no longer responded to short-term playback of seismic noise. The lessened response after repeated exposure, likely driven by increased tolerance or a change in hearing threshold, helps explain why fish that experienced 12Â weeks of impulsive noise showed no differences in stress, growth or mortality compared to those reared with exposure to ambient-noise playback. Considering how responses to anthropogenic noise change with repeated exposure is important both when assessing likely fitness consequences and the need for mitigation measures.Funding was provided by CGG; SDS held a NERC KE Fellowship (NE/J500616/2). The
authors declare no conflict of interest
Comparison of measures of crowding, group size, and diversity
In ecology, diversity is often measured as the mean rarity of
species in a community. In behavioral
sciences and parasitology, mean crowding is the size of the
group to which a typical individual belongs. In this
paper, focusing mostly on the mathematical aspect, we
demonstrate that diversity and crowding are closely
related notions. We show that mean crowding can be transformed
into diversity and vice versa. Based on this
general equivalence rule, notions, relationships, and methods
developed in one field can be adapted to the other
one. In relation to crowding,we introduce the notion âeffective
number of groupsâ that corresponds to the âeffective
number of speciesâ used in diversity studies.We define new
aggregation indices thatmirror evenness indices
known from diversity theory. We also construct aggregation
profiles and orderings of populations based on
aggregation indices. By uniting the mathematical interpretation
of the ecological notion of diversity and the ethological
notion of typical group size (or crowding, in parasitology),
our insight opens a new avenue of both theoretical
andmethodological research. This is exemplified here using
real-life abundance data of avian parasites
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