Pharmacological Study of Phenolic Components in Parkinson's Disease

In this study, cell experiments were conducted to investigate the effects of extracts on cell viability and apoptosis of Parkinson model in vitro, as well as the expression of cysteine protease-3 (Caspase-3) and B lymphocytoma-2-associated X protein (BAX). The results showed that extract of phenols could improve the loss of cell viability and apoptosis induced by MPP+, and inhibit the enhanced expression of Bax and Caspase-3 by MPP+. The potential targets and signaling pathways of phenols in the treatment of Parkinson's disease were predicted by network pharmacology

endotoxinremovalinsomemedicinesandhumanserumalbuminsolutionbyaffinitymembranes

以纤维素膜为基质材料，制备了3种用于去除内毒素的亲和膜，分别为壳聚糖亲和膜（KFCC517），疏水阳离子亲和膜（KFCG316）和金属螯合物亲和膜（KFCG402）。研究了亲和膜对内毒素的吸附容量及在内毒素去除方面的应用，结果表明这3种亲和膜都可以用于多种溶液中内毒素的去除。考察了离子强度、pH值以及流速对去除效果的影响，并分析了原因。KFCC517，KFCG316，KFCG402都可用于人血清白蛋白溶液中内毒素的去除，KFCC517还可用于医药制剂如氢化可的松，葛根素，盐酸丁卡因和右旋糖苷40葡萄糖注射液中内毒素的去除，在所选择的条件下，内毒素的去除效率高于80％，有用物质的回收率为95％以上

Dynamic recrystallization behavior and microstructure evolution of high-Mn austenitic steel for application in a liquefied natural gas carrier

The hot-working behavior of high-Mn austenitic steel for liquefied natural gas carriers at the deformation temperature in the range of 1073–1273 K and the strain rate in the range of 0.01–10 s−1 was studied on a Gleeble-3800 thermomechanical simulator using a compression test. Electron backscatter diffraction was used to study the microstructure after deformation. Under each deformation condition, a peak stress appears in the stress-strain curve, which conforms to traditional dynamic recrystallization hot-working flow stress curves. A hyperbolic sine-law-type constitutive equation was established to predict the peak stress. The thermal deformation activation energy was 414.19 kJ/mol, and the stress index n was 4.94. The texture of the deformed grains consisted of strong and weak fibers along the compression direction. The main recrystallization mechanism was discontinuous dynamic recrystallization. The grain size of the discontinuous dynamic recrystallization grains tended to increase with increasing deformation temperature or decreasing strain rate. Processing maps were drawn based on the dynamic material model. At high deformation temperatures, the power consumption factor of dynamic recovery was greater than that of dynamic recrystallization, whereas at low deformation temperatures, the power consumption factor of discontinuous dynamic recrystallization was greater than that of dynamic recovery. There are two flow instability regions in the processing maps, 1243–1273 K/1-10 s−1 and 1073–1203 K/0.05–10 s−1. The formation of a ‘necklace microstructure’ was the main cause of deformation instability. The optimized process parameters for industrial production were 1243–1273 K/1-10 s−1