Sexually transmitted infection risk exposure among black and minority ethnic youth in northwest London: findings from a study translating a sexually transmitted infection risk-reduction intervention to the UK setting.

OBJECTIVES: Young black women are disproportionately affected by sexually transmitted infections (STI) in the UK, but effective interventions to address this are lacking. The Young Brent Project explored the nature and context of sexual risk-taking in young people to inform the translation of an effective clinic-based STI reduction intervention (Project SAFE) from the USA to the UK. METHODS: One-to-one in-depth interviews (n = 37) and group discussions (n = 10) were conducted among men and women aged 15-27 years from different ethnic backgrounds recruited from youth and genitourinary medicine clinic settings in Brent, London. The interviews explored the context within which STI-related risks were assessed, experienced and avoided, the skills needed to recognise risk and the barriers to behaviour change. RESULTS: Concurrent sexual partnerships, mismatched perceptions and expectations, and barriers to condom use contributed to STI risk exposure and difficulties in implementing risk-reduction strategies. Women attempted to achieve monogamy, but experienced complex and fluid sexual relationships. Low risk awareness, flawed partner risk assessments, negative perceptions of condoms and lack of control hindered condom use. Whereas men made conscious decisions, women experienced persuasion, deceit and difficulty in requesting condom use, particularly with older partners. CONCLUSIONS: Knowledge of STI and condom use skills is not enough to equip young people with the means to reduce STI risk. Interventions with young women need to place greater emphasis on: entering and maintaining healthy relationships; awareness of risks attached to different forms of concurrency and how concurrency arises; skills to redress power imbalances and building self-esteem

Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants

A series of animal experiments was conducted to characterize changes in the complex impedance of chronically implanted electrodes in neural tissue. Consistent trends in impedance changes were observed across all animals, characterized as a general increase in the measured impedance magnitude at 1 kHz. Impedance changes reach a peak approximately 7 days post-implant. Reactive responses around individual electrodes were described using immuno- and histo-chemistry and confocal microscopy. These observations were compared to measured impedance changes. Several features of impedance changes were able to differentiate between confined and extensive histological reactions. In general, impedance magnitude at 1 kHz was significantly increased in extensive reactions, starting about 4 days post-implant. Electrodes with extensive reactions also displayed impedance spectra with a characteristic change at high frequencies. This change was manifested in the formation of a semi-circular arc in the Nyquist space, suggestive of increased cellular density in close proximity to the electrode site. These results suggest that changes in impedance spectra are directly influenced by cellular distributions around implanted electrodes over time and that impedance measurements may provide an online assessment of cellular reactions to implanted devices.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58178/2/jne7_4_007.pd

Effects of Backgrounding and Growing Programs on Beef Carcass Quality and Yield

Clearly, the future of the beef cattle industry in the United States depends on the quality of the product. The majority of calves are born in the spring; therefore, to have a consistent supply of feeders entering feedlots and to take advantage of forages, a variety of stocker programs exist. Cattle enter the feedlot at varying weights and ages and from different nutritional backgrounds, and this variation could produce differences in carcass quality. The economically important measures of carcass quality are yield grade and quality grade. They are directly related: as cattle fatten in the feedlot, both quality grade and yield grade increase. Because cattle are commercially fed to fat-constant end points, it is logical to make comparisons at equal fat end points. Then, marbling (percentage Choice) becomes the primary quality criterion. We analyzed data from 534 cattle serially slaughtered and found that the percentage grading Choice increased 12 ± 1 percentage units for each 1-mm increase in rib fat. Marbling score increased 30 units (200 = slight 00) for each 1-mm increase in fat. To determine the effect of rate of winter gain on carcass quality, 372 calves over 5 yr were wintered at .23 or .61 kg/d gain. When adjusted to equal rib fat after summer grazing and finishing, there was no difference in quality grade. To test the effect of summer gain on carcass quality, 418 calves over 7 yr were followed through the feedlot after gaining .57 or .84 kg/d on grass. When compared at equal rib fat, there was no difference in quality grade. Shear force values and consumer taste panels were used to evaluate steaks from 90 cattle from calf-fed and yearling production systems. Calf-feds were 14 mo of age at slaughter and yearlings were 19 or 21 mo. Each group was serially slaughtered. There was no effect of an additional .39 cm of rib fat on shear force, juiciness, tenderness, flavor, or overall palatability. Calf-feds were significantly more tender than yearlings, but the risk of an undesirable steak from yearlings was \u3c .2% based on shear force and \u3c 2.8% based on the consumer taste panel. If cattle are fed to a common rib fat end point, and within the range of rates of winter and summer gains reported herein, we conclude that the backgrounding program has little or no effect on marbling or carcass quality grade

Multifrequency study of the ring nebula SG13

We investigate the morphology and kinematics of the interstellar medium in the environs of the open cluster Mrk50, which includes the Wolf-Rayet star WR157 and a number of early B-type stars. The analysis was performed using radio continuum images at 408 and 1420 MHz, and HI 21cm line data taken from the Canadian Galactic Plane Survey, molecular observations of the 12CO (J=1-0) line at 115 GHz from the Five College Radio Astronomy Observatory and available mid and far IR observations obtained with the MSX and IRAS satellites, respectively. This study allowed identification of the radio continuum and molecular counterpart of the ring nebula SG13, while no neutral atomic structure was found to be associated. The nebula is also detected in images in the mid and far infrared, showing the existence of dust well mixed with the ionized gas. We estimate the main physical parameters of the material linked to the nebula. The interstellar gas distribution in the environs of Mrk50 is compatible with a stellar wind bubble created by the mass loss from WR157. The distribution of young stellar object (YSO) candidates in the region shows that stellar formation activity may be present in the molecular shell that encircles the ring nebula.Comment: Accepted for publication in MNRAS, 13 pages, 11 figure

Multilingual gendered identities: female undergraduate students in London talk about heritage languages

In this paper I explore how a group of female university students, mostly British Asian and in their late teens and early twenties, perform femininities in talk about heritage languages. I argue that analysis of this talk reveals ways in which the participants enact ‘culturally intelligible’ gendered subject positions. This frequently involves negotiating the norms of ‘heteronormativity’, constituting femininity in terms of marriage, motherhood and maintenance of heritage culture and language, and ‘girl power’, constituting femininity in terms of youth, sassiness, glamour and individualism. For these young women, I ask whether higher education can become a site in which they have the opportunities to explore these identifications and examine other ways of imagining the self and what their stories suggest about ‘doing being’ a young British Asian woman in London

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria

Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report that the long isoform of the cellular FLICE-inhibitory protein (c-FLIPL), a well- known inhibitor of the extrinsic cell death initiator caspase-8, localizes at the endoplasmic reticulum (ER) and mitochondria-associated membranes (MAMs). ER morphology was disrupted and ER Ca2+-release as well as ER-mitochondria tethering were decreased in c-FLIP-/- mouse embryonic fibroblasts (MEFs). Mechanistically, c-FLIP ablation resulted in enhanced basal caspase-8 activation and in caspase-mediated processing of the ER-shaping protein reticulon-4 (RTN4) that was corrected by re-introduction of c-FLIPL and caspase inhibition, resulting in the recovery of a normal ER morphology and ER-mitochondria juxtaposition. Thus, the caspase-8 inhibitor c-FLIPL emerges as a component of the MAMs signaling platforms, where caspases appear to regulate ER morphology and ER-mitochondria crosstalk by impinging on ER-shaping proteins like the RTN4

'You were quiet - I did all the marching': Research processes involved in hearing the voices of South Asian girls

This article is available open access through the publisher’s website at the link below. Copyright @ 2011 A B Academic Publishers.This article provides insights into the outcomes of reflection following two interview approaches used to explore narratives of the lived, individual experiences of South-Asian girls living in West London. In attempting to illuminate and re-present the cultural experiences as told by these girls, the choice of interview approach became critical in allowing the voices to be effectively heard (Rogers, 2005). This article therefore considers how a semi-structured interview approach offered valuable insights into the girls' experiences but became constraining for both researcher and participant in unveiling the complexity and depth of their lives. These constraints emerged through reflection by both participants and researcher. As a result of reflexivity during the research process, the researcher moved towards the use of research conversations during the second phase of the study. Ultimately the study revealed how the girls felt empowered by the opportunity to narrate their individual experiences and tell of their lives. In narrating their reflections on being part of the research, there was a clear recognition that the process facilitated the articulation of new voices and ‘multi-voicedness’ (Moen, 2006

The Muslim problematic: Muslims, state schools and security

Muslims are folk-devils that mark the ubiquitous moral panic. For some, the idea of the Muslim problematic signifies a long and worrying trend of creeping ‘Islamification’ of state schools. For others, the discourse of the Muslim problematic reflects the ongoing racial patholigisation of Britain’s minoritised communities. One thing is for certain, the current debate marks a significant moment in the nature and function of the neoliberal state as it reframes race relation policy in Britain in the light of the security agenda. The Trojan Horse affair, surrounding claims of infiltration of radical Islam in state-run schools, marks a significant moment in the embedding of the security agenda in Britain’s inner city schools through the medium of the Prevent agenda. It argues that one of the best ways of understanding the security agenda is by locating it within a broader sociological and historical context of the functioning of the racial state